KEGG   PATHWAY: fpg03013
Entry
fpg03013                    Pathway                                
Name
Nucleocytoplasmic transport - Falco peregrinus (peregrine falcon)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
fpg03013  Nucleocytoplasmic transport
fpg03013

Other DBs
GO: 0050658
Organism
Falco peregrinus (peregrine falcon) [GN:fpg]
Gene
101910360  IPO5; importin 5 [KO:K20222]
101910441  RANBP2; E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
101910553  PNN; pinin, desmosome associated protein [KO:K13114]
101911043  RAE1; ribonucleic acid export 1 [KO:K14298]
101911239  XPOT; exportin for tRNA [KO:K14288]
101911878  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
101912165  XPO5; exportin 5 [KO:K14289]
101912172  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
101912187  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
101912521  UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
101912584  NUP205; nucleoporin 205 [KO:K14310]
101912842  CASC3; cancer susceptibility candidate 3 [KO:K14323]
101912974  SUMO1; small ubiquitin-like modifier 1 [KO:K12160]
101913064  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
101913303  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
101913537  GLE1; GLE1, RNA export mediator [KO:K18723]
101913771  NUPL2; nucleoporin like 2 [KO:K14321]
101914183  IPO9; importin 9 [KO:K20224]
101914352  UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
101914566  NUP188; nucleoporin 188 [KO:K14311]
101914583  NUP210; nucleoporin 210 [KO:K14314]
101914758  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
101915076  NUP43; nucleoporin 43 [KO:K14305]
101915213  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
101915709  ALYREF; Aly/REF export factor [KO:K12881]
101915828  THOC3; THO complex 3 [KO:K12880]
101915860  XPO1; exportin 1 [KO:K14290]
101915983  NMD3; NMD3 ribosome export adaptor [KO:K07562]
101916003  THOC5; THO complex 5 [KO:K13174]
101916190  TNPO2; transportin 2 [KO:K18727]
101916514  XPO7; exportin 7 [KO:K18460]
101916532  RANGAP1; Ran GTPase activating protein 1 [KO:K14319]
101916643  NUP133; nucleoporin 133 [KO:K14300]
101916830  NUP54; nucleoporin 54 [KO:K14308]
101916897  THOC1; THO complex 1 [KO:K12878]
101916913  TMEM33; transmembrane protein 33 [KO:K20724]
101916920  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
101916958  THOC2; THO complex 2 [KO:K12879]
101917080  TNPO1; transportin 1 [KO:K18752]
101917110  IPO13; importin 13 [KO:K25202]
101917178  SEH1L; SEH1 like nucleoporin [KO:K14299]
101917824  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
101917989  [KO:K14306]
101918165  NUP62CL; nucleoporin 62 C-terminal like [KO:K14306]
101918314  RBM8A; RNA binding motif protein 8A [KO:K12876]
101918366  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
101918570  NUP50; nucleoporin 50 [KO:K14295]
101918609  NDC1; NDC1 transmembrane nucleoporin [KO:K14315]
101918698  SNUPN; snurportin 1 [KO:K13151]
101918787  RAN; RAN, member RAS oncogene family [KO:K07936]
101919235  RANBP17; RAN binding protein 17 [KO:K24115]
101919316  AHCTF1; AT-hook containing transcription factor 1 [KO:K25129]
101919376  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
101919400  NUP214; nucleoporin 214 [KO:K14317]
101919431  EEF1A2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]
101919499  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
101919507  NUP35; nucleoporin 35 [KO:K14313]
101919668  UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
101919740  NUP107; nucleoporin 107 [KO:K14301]
101920344  [KO:K14284]
101920413  NUP93; nucleoporin 93 [KO:K14309]
101920693  AAAS; aladin WD repeat nucleoporin [KO:K14320]
101920708  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
101920721  EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
101920738  NUP160; nucleoporin 160 [KO:K14303]
101921082  XPO6; exportin 6 [KO:K25204]
101921239  IPO8; importin 8 [KO:K18755]
101921470  PHAX; phosphorylated adaptor for RNA export [KO:K14291]
101921693  IPO11; importin 11 [KO:K25201]
101921993  NUP155; nucleoporin 155 [KO:K14312]
101922133  NUP37; nucleoporin 37 [KO:K14302]
101922181  CSE1L; chromosome segregation 1 like [KO:K18423]
101922185  KPNB1; karyopherin subunit beta 1 [KO:K14293]
101922242  NUP153; nucleoporin 153 [KO:K14296]
101922662  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
101922806  XPO4; exportin 4 [KO:K25203]
101923151  SAP18; Sin3A associated protein 18 [KO:K14324]
101923206  [KO:K18655] [EC:5.6.2.7]
101923218  SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
101923558  NUP98; nucleoporin 98 [KO:K14297]
101923816  UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101923858  IPO7; importin 7 [KO:K20223]
101923946  NUP88; nucleoporin 88 [KO:K14318]
101924052  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
101924083  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
101924308  NUP85; nucleoporin 85 [KO:K14304]
101924369  UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
101924372  NUP58; nucleoporin 58 [KO:K14307]
101924479  SUMO2; small ubiquitin-like modifier 2 [KO:K12160]
101924487  THOC7; THO complex 7 [KO:K13176]
101924607  TNPO3; transportin 3 [KO:K15436]
101925024  SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
fpg03015  mRNA surveillance pathway
KO pathway
ko03013   

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