KEGG   PATHWAY: gvr03440
Entry
gvr03440                    Pathway                                
Name
Homologous recombination - Galeopterus variegatus (Sunda flying lemur)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
gvr03440  Homologous recombination
gvr03440

Other DBs
GO: 0000724
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103584818  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
103584999  BLM; Bloom syndrome protein [KO:K10901] [EC:5.6.2.4]
103585299  TOP3A; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
103585470  RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
103585547  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
103585865  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 [KO:K03111]
103587016  RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
103587319  FAM175A; BRCA1-A complex subunit Abraxas [KO:K20774]
103588531  RAD51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
103588615  RAD51B; DNA repair protein RAD51 homolog 2 [KO:K10869]
103589320  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
103589565  BRE; BRCA1-A complex subunit BRE [KO:K12173]
103589614  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
103589870  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
103589977  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
103590274  MRE11A; double-strand break repair protein MRE11A isoform X1 [KO:K10865]
103590394  RAD51D; DNA repair protein RAD51 homolog 4 [KO:K10871]
103592189  TOP3B; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
103592732  RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit [KO:K10739]
103592959  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
103593084  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
103593104  UIMC1; BRCA1-A complex subunit RAP80 [KO:K20775]
103593174  BRIP1; LOW QUALITY PROTEIN: Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
103593469  XRCC3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
103594339  RPA4; replication protein A 30 kDa subunit [KO:K10741]
103594443  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
103594576  XRCC2; DNA repair protein XRCC2 [KO:K10879]
103595849  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
103596117  SYCP3; synaptonemal complex protein 3 [KO:K19528]
103596825  BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776]
103597304  TOPBP1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
103597510  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103598181  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
103599225  MUS81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
103601333  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
103601775  NBN; nibrin [KO:K10867]
103603429  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
103605276  RAD54B; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
103606981  RPA3; replication protein A 14 kDa subunit [KO:K10740]
103607907  BARD1; BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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