Homo sapiens (human): 1025 Help Entry 1025              CDS       T01001                                  Symbol CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK Name (RefSeq) cyclin dependent kinase 9   KO K02211   cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23] Organism hsa  Homo sapiens (human) Pathway hsa03250   Viral life cycle - HIV-1 hsa05202   Transcriptional misregulation in cancer Network nt06240  Transcription   Element N00119   MLL-AF4 fusion to transcriptional activation Drug target Dinaciclib:  D09604 Zotiraciclib (DG03058):  D11599 D11600 Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     1025 (CDK9)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     1025 (CDK9)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     1025 (CDK9)   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:hsa03021]     1025 (CDK9) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.22  cyclin-dependent kinase      1025 (CDK9)     2.7.11.23  [RNA-polymerase]-subunit kinase      1025 (CDK9) Protein kinases [BR:hsa01001]  Serine/threonine kinases: CMGC group   CDK family    1025 (CDK9) Transcription machinery [BR:hsa03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Super elongation complex (SEC)      1025 (CDK9)     Brd4/P-TEFb complex      1025 (CDK9)     7SK RNP complex      1025 (CDK9) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Pkinase_fungal Motif Other DBs NCBI-GeneID:  1025 NCBI-ProteinID:  NP_001252 OMIM:  603251 HGNC:  1780 Ensembl:  ENSG00000136807 Vega:  OTTHUMG00000020715 Pharos:  P50750(Tchem) UniProt:  P50750 A0A024R880 Structure PDB LinkDB All DBs Position 9:127786034..127790792 Genome browser AA seq 372 aa AA seqDB search MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP ATTNQTEFERVF NT seq 1119 nt NT seq  +upstreamnt  +downstreamnt atggcaaagcagtacgactcggtggagtgccctttttgtgatgaagtttccaaatacgag aagctcgccaagatcggccaaggcaccttcggggaggtgttcaaggccaggcaccgcaag accggccagaaggtggctctgaagaaggtgctgatggaaaacgagaaggaggggttcccc attacagccttgcgggagatcaagatccttcagcttctaaaacacgagaatgtggtcaac ttgattgagatttgtcgaaccaaagcttccccctataaccgctgcaagggtagtatatac ctggtgttcgacttctgcgagcatgaccttgctgggctgttgagcaatgttttggtcaag ttcacgctgtctgagatcaagagggtgatgcagatgctgcttaacggcctctactacatc cacagaaacaagatcctgcatagggacatgaaggctgctaatgtgcttatcactcgtgat ggggtcctgaagctggcagactttgggctggcccgggccttcagcctggccaagaacagc cagcccaaccgctacaccaaccgtgtggtgacactctggtaccggcccccggagctgttg ctcggggagcgggactacggcccccccattgacctgtggggtgctgggtgcatcatggca gagatgtggacccgcagccccatcatgcagggcaacacggagcagcaccaactcgccctc atcagtcagctctgcggctccatcacccctgaggtgtggccaaacgtggacaactatgag ctgtacgaaaagctggagctggtcaagggccagaagcggaaggtgaaggacaggctgaag gcctatgtgcgtgacccatacgcactggacctcatcgacaagctgctggtgctggaccct gcccagcgcatcgacagcgatgacgccctcaaccacgacttcttctggtccgaccccatg ccctccgacctcaagggcatgctctccacccacctgacgtccatgttcgagtacttggca ccaccgcgccggaagggcagccagatcacccagcagtccaccaaccagagtcgcaatccc gccaccaccaaccagacggagtttgagcgcgtcttctga

Homo sapiens (human): 904 Help Entry 904               CDS       T01001                                  Symbol CCNT1, CCNT, CYCT1, HIVE1 Name (RefSeq) cyclin T1   KO K15188   cyclin T Organism hsa  Homo sapiens (human) Pathway hsa03250   Viral life cycle - HIV-1 hsa05202   Transcriptional misregulation in cancer Network nt06240  Transcription   Element N00119   MLL-AF4 fusion to transcriptional activation Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     904 (CCNT1)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     904 (CCNT1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:hsa03021]     904 (CCNT1) Transcription machinery [BR:hsa03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Super elongation complex (SEC)      904 (CCNT1)     Brd4/P-TEFb complex      904 (CCNT1)     7SK RNP complex      904 (CCNT1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Cyclin_N Motif Other DBs NCBI-GeneID:  904 NCBI-ProteinID:  NP_001231 OMIM:  143055 HGNC:  1599 Ensembl:  ENSG00000129315 Vega:  OTTHUMG00000170393 Pharos:  O60563(Tchem) UniProt:  O60563 Structure PDB LinkDB All DBs Position 12:complement(48688458..48716707) Genome browser AA seq 726 aa AA seqDB search MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP LPPLPK NT seq 2181 nt NT seq  +upstreamnt  +downstreamnt atggagggagagaggaagaacaacaacaaacggtggtatttcactcgagaacagctggaa aatagcccatcccgtcgttttggcgtggacccagataaagaactttcttatcgccagcag gcggccaatctgcttcaggacatggggcagcgtcttaacgtctcacaattgactatcaac actgctatagtatacatgcatcgattctacatgattcagtccttcacacagttccctgga aattctgtggctccagcagccttgtttctagcagctaaagtggaggagcagcccaaaaaa ttggaacatgtcatcaaggtagcacatacttgtctccatcctcaggaatcccttcctgat actagaagtgaggcttatttgcaacaagttcaagatctggtcattttagaaagcataatt ttgcagactttaggctttgaactaacaattgatcacccacatactcatgtagtaaagtgc actcaacttgttcgagcaagcaaggacttagcacagacttcttacttcatggcaaccaac agcctgcatttgaccacatttagcctgcagtacacacctcctgtggtggcctgtgtctgc attcacctggcttgcaagtggtccaattgggagatcccagtctcaactgacgggaagcac tggtgggagtatgttgacgccactgtgaccttggaacttttagatgaactgacacatgag tttctacagattttggagaaaactcccaacaggctcaaacgcatttggaattggagggca tgcgaggctgccaagaaaacaaaagcagatgaccgaggaacagatgaaaagacttcagag cagacaatcctcaatatgatttcccagagctcttcagacacaaccattgcaggtttaatg agcatgtcaacttctaccacaagtgcagtgccttccctgccagtctccgaagagtcatcc agcaacttaaccagtgtggagatgttgccgggcaagcgttggctgtcctcccaaccttct ttcaaactagaacctactcagggtcatcggactagtgagaatttagcacttacaggagtt gatcattccttaccacaggatggttcaaatgcatttatttcccagaagcagaatagtaag agtgtgccatcagctaaagtgtcactgaaagaataccgcgcgaagcatgcagaagaattg gctgcccagaagaggcaactggagaacatggaagccaatgtgaagtcacaatatgcatat gctgcccagaatctcctttctcatcatgatagccattcttcagtcattctaaaaatgccc atagagggttcagaaaaccccgagcggccttttctggaaaaggctgacaaaacagctctc aaaatgagaatcccagtggcaggtggagataaagctgcgtcttcaaaaccagaggagata aaaatgcgcataaaagtccatgctgcagctgataagcacaattctgtagaggacagtgtt acaaagagccgagagcacaaagaaaagcacaagactcacccatctaatcatcatcatcat cataatcaccactcacacaagcactctcattcccaacttccagttggtactgggaacaaa cgtcctggtgatccaaaacatagtagccagacaagcaacttagcacataaaacctatagc ttgtctagttctttttcctcttccagttctactcgtaaaaggggaccctctgaagagact ggaggggctgtgtttgatcatccagccaagattgccaagagtactaaatcctcttcccta aatttctccttcccttcacttcctacaatgggtcagatgcctgggcatagctcagacaca agtggcctttccttttcacagcccagctgtaaaactcgtgtccctcattcgaaactggat aaagggcccactggggccaatggtcacaacacgacccagacaatagactatcaagacact gtgaatatgcttcactccctgctcagtgcccagggtgttcagcccactcagcccactgca tttgaatttgttcgtccttatagtgactatctgaatcctcggtctggtggaatctcctcg agatctggcaatacagacaaaccccggccaccacctctgccatcagaacctcctccacca cttccaccccttcctaagtaa

Homo sapiens (human): 905 Help Entry 905               CDS       T01001                                  Symbol CCNT2, CYCT2 Name (RefSeq) cyclin T2   KO K15188   cyclin T Organism hsa  Homo sapiens (human) Pathway hsa03250   Viral life cycle - HIV-1 hsa05202   Transcriptional misregulation in cancer Network nt06240  Transcription   Element N00119   MLL-AF4 fusion to transcriptional activation Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     905 (CCNT2)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     905 (CCNT2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:hsa03021]     905 (CCNT2) Transcription machinery [BR:hsa03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Super elongation complex (SEC)      905 (CCNT2)     Brd4/P-TEFb complex      905 (CCNT2)     7SK RNP complex      905 (CCNT2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Cyclin_N TFIIB Motif Other DBs NCBI-GeneID:  905 NCBI-ProteinID:  NP_490595 OMIM:  603862 HGNC:  1600 Ensembl:  ENSG00000082258 Vega:  OTTHUMG00000131712 Pharos:  O60583(Tbio) UniProt:  O60583 B4DH21 Structure PDB LinkDB All DBs Position 2:134918822..134959342 Genome browser AA seq 730 aa AA seqDB search MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINT AIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDT KCDAYLQQTQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNS LHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEF LQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPS FQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSART EQLYSQKQETSLSGSQYNINFQQGPSISLHSGLHHRPDKISDHSSVKQEYTHKAGSSKHH GPISTTPGIIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKQGQSQAASSSSVTS PIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDE GSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLR SPVGLSSDGISSSSSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNS VFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDANHEYSTSSQHMDYKDTFDMLD SLLSAQGMNM NT seq 2193 nt NT seq  +upstreamnt  +downstreamnt atggcgtcgggccgtggagcttcttctcgctggttctttactcgggaacagctggagaac acgccgagccgccgctgcggagtggaggcggataaagagctctcgtgccgccagcaggcg gccaacctcatccaggagatgggacagcgtctcaatgtctctcagcttacaataaacact gcgattgtttatatgcacaggttttatatgcaccattctttcaccaaattcaacaaaaat ataatatcgtctactgcattatttttggctgcaaaagtggaagaacaggctcgaaaactt gaacatgttatcaaagtagcacatgcttgtcttcatcctctagagccactgctggatact aaatgtgatgcttaccttcaacagactcaagaactggttatacttgaaaccataatgcta caaactctaggttttgagatcaccattgaacacccacacacagatgtggtgaaatgtacc cagttagtaagagcaagcaaggatttggcacagacatcctatttcatggctaccaacagt ctgcatcttacaaccttctgtcttcagtacaaaccaacagtgatagcatgtgtatgcatt catttggcttgcaaatggtccaattgggagatccctgtatcaactgatggaaagcattgg tgggaatatgtggatcctacagttactctagaattattagatgagctaacacatgagttt ctacaaatattggagaaaacgcctaataggttgaagaagattcgaaactggagggctaat caggcagctaggaaaccaaaagtagatggacaggtatcagagacaccacttcttggttca tctttggtccagaattccattttagtagatagtgtcactggtgtgcctacaaacccaagt tttcagaaaccatctacatcagcattccctgcgccagtacctctaaattcaggaaatatt tctgttcaagacagccatacatctgataatttgtcaatgctagcaacaggaatgccaagt acttcatacggtttatcatcacaccaggaatggcctcaacatcaagactcagcaaggaca gaacagctatattcacagaaacaggagacatctttgtctggtagccagtacaacatcaac ttccagcagggaccttctatatcactgcattcaggattacatcacagacctgacaaaatt tcagatcattcttctgttaagcaagaatatactcataaagcagggagcagtaaacaccat gggccaatttccactactccaggaataattcctcagaaaatgtctttagataaatataga gaaaagcgtaaactagaaactcttgatctcgatgtaagggatcattatatagctgcccag gtagaacagcagcacaaacaagggcagtcacaggcagccagcagcagttctgttacttct cccattaaaatgaaaatacctatcgcaaatactgaaaaatacatggcagacaaaaaggaa aagagtgggtcactgaaattacggattccaataccacccactgataaaagcgccagtaaa gaagaactgaaaatgaaaataaaagtttcttcttcagaaagacacagctcttctgatgaa ggcagtgggaagagcaaacattcaagcccacatattagcagagaccataaggagaagcac aaggagcatccttcaagccgccaccacaccagcagccacaagcattcccactcgcatagt ggcagcagcagcggtggcagtaaacacagtgccgacggaataccacccactgttctgagg agtcctgttggcctgagcagtgatggcatttcctctagctccagctcttcaaggaagagg ctgcatgtcaatgatgcatctcacaaccaccactccaaaatgagcaaaagttccaaaagt tcaggtagttcatctagttcttcctcctctgttaagcagtatatatcctctcacaactct gtttttaaccatcccttaccccctcctccccctgtcacataccaggtgggctacggacat ctcagcaccctcgtgaaactggacaagaagccagtggagaccaacggtcctgatgccaat cacgagtacagtacaagcagccagcatatggactacaaagacacattcgacatgctggac tcactgttaagtgcccaaggaatgaacatgtaa

Homo sapiens (human): 4298 Help Entry 4298              CDS       T01001                                  Symbol MLLT1, ENL, LTG19, YEATS1 Name (RefSeq) MLLT1 super elongation complex subunit   KO K15187   YEATS domain-containing protein 1/3 Organism hsa  Homo sapiens (human) Pathway hsa03250   Viral life cycle - HIV-1 hsa05202   Transcriptional misregulation in cancer Network nt06240  Transcription   Element N00119   MLL-AF4 fusion to transcriptional activation N00120   MLL-ENL fusion to transcriptional activation Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     4298 (MLLT1)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     4298 (MLLT1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:hsa03021]     4298 (MLLT1)    03036 Chromosome and associated proteins [BR:hsa03036]     4298 (MLLT1) Transcription machinery [BR:hsa03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Super elongation complex (SEC)      4298 (MLLT1) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HMT complexes     Dot1-containing complex      4298 (MLLT1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  YEATS AHD pYEATS Motif Other DBs NCBI-GeneID:  4298 NCBI-ProteinID:  NP_005925 OMIM:  159556 HGNC:  7134 Ensembl:  ENSG00000130382 Vega:  OTTHUMG00000180757 Pharos:  Q03111(Tbio) UniProt:  Q03111 Structure PDB LinkDB All DBs Position 19:complement(6210381..6279975) Genome browser AA seq 559 aa AA seqDB search MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF SLDETTVRKLQSCLEAVAT NT seq 1680 nt NT seq  +upstreamnt  +downstreamnt atggacaatcagtgcaccgtccaggtgaggttagagctggggcatcgcgcccaactgcgc aagaagcccaccacggaggggttcactcacgactggatggtgtttgtccgcggccccgag caatgtgacatccagcacttcgtggagaaggtggtcttctggctgcacgacagcttcccc aagcccagacgcgtgtgcaaggagcccccctacaaagtagaggagtcggggtacgctggc ttcatcatgcccatcgaggtgcacttcaaaaacaaggaggagccgaggaaggtctgcttc acctacgacctgttcctgaacctggaaggcaacccgcccgtgaaccacctgcgctgcgag aagctcaccttcaacaaccccaccacggagttccggtacaagctcctgcgggccggcggg gtgatggtaatgcccgaaggagcagacacggtgtccaggcccagtcccgactaccccatg ttacccacaattccactctctgccttctctgaccccaagaagaccaaaccatcccacggc tccaaggacgccaacaaggagagcagcaagacctccaagccacacaaggtgaccaaggag caccgggagcggccccgcaaagactccgagagcaagagctcctccaaggagctggagcgt gagcaggccaaaagctccaaggacacctcgcggaagctgggcgagggccggctgcccaag gaggagaaggcgccaccgcccaaggctgccttcaaggaacccaagatggccctgaaagag accaagctggaaagcacgtcccccaagggtgggcccccacccccacccccacccccaccc cgggcttccagcaagcggccggccaccgccgactcgccaaagcccagcgccaagaagcag aagaagagcagctcgaaggggtcccggagtgctccaggcacctcgccccgcacctcctcc tcctcctccttctcggacaagaagccggccaaggacaagagcagcaccagaggggagaag gtgaaggccgagagtgagccccgggaggccaaaaaggccctggaggtggaggagtccaac tcagaggacgaggcctccttcaagtccgagtctgcccagtcaagcccgtccaactccagc tccagctcagactccagctcagactcagacttcgagccatcccagaaccacagccaagga cccctgcgctccatggtggaggacctgcagtccgaggagtccgacgaggacgactcttcg tcaggcgaggaggctgccggcaagaccaacccggggagggactccaggttgagcttcagc gacagcgagagtgacaacagcgccgactcctccctgcccagccgtgagcccccacccccc cagaagccacccccgcccaacagcaaggtgtcaggccggaggagccccgagtcctgcagc aagcctgagaagatcctcaagaagggcacctacgacaaggcctacacggatgagctggtg gagctacaccggaggctgatggcgctgcgggagcgcaacgtgctgcagcagattgtgaat ctgatcgaggagactggccacttcaatgtcaccaacaccaccttcgacttcgacctcttc tccctggacgagaccaccgtgcgcaaactgcagagctgcctggaggccgtggccacatga

Homo sapiens (human): 4300 Help Entry 4300              CDS       T01001                                  Symbol MLLT3, AF9, YEATS3 Name (RefSeq) MLLT3 super elongation complex subunit   KO K15187   YEATS domain-containing protein 1/3 Organism hsa  Homo sapiens (human) Pathway hsa03250   Viral life cycle - HIV-1 hsa05202   Transcriptional misregulation in cancer Network nt06240  Transcription   Element N00119   MLL-AF4 fusion to transcriptional activation Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     4300 (MLLT3)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     4300 (MLLT3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:hsa03021]     4300 (MLLT3)    03036 Chromosome and associated proteins [BR:hsa03036]     4300 (MLLT3) Transcription machinery [BR:hsa03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Super elongation complex (SEC)      4300 (MLLT3) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HMT complexes     Dot1-containing complex      4300 (MLLT3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AHD YEATS pYEATS BET Motif Other DBs NCBI-GeneID:  4300 NCBI-ProteinID:  NP_004520 OMIM:  159558 HGNC:  7136 Ensembl:  ENSG00000171843 Vega:  OTTHUMG00000019650 Pharos:  P42568(Tbio) UniProt:  P42568 A0A0S2Z448 Structure PDB LinkDB All DBs Position 9:complement(20341669..20622499) Genome browser AA seq 568 aa AA seqDB search MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK PLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD EVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILE VKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITN TTFDFDLCSLDKTTVRKLQSYLETSGTS NT seq 1707 nt NT seq  +upstreamnt  +downstreamnt atggctagctcgtgtgccgtgcaggtgaagctggagctggggcaccgcgcccaggtgagg aaaaaacccaccgtggagggcttcacccacgactggatggtgttcgtacgcggtccggag cacagtaacatacagcactttgtggagaaagtcgtcttccacttgcacgaaagctttcct aggccaaaaagagtgtgcaaagatccaccttacaaagtagaagaatctgggtatgctggt ttcattttgccaattgaagtttattttaaaaacaaggaagaacctaggaaagtccgcttt gattatgacttattcctgcatcttgaaggccatccaccagtgaatcacctccgctgtgaa aagctaactttcaacaaccccacagaggactttaggagaaagttgctgaaggcaggaggg gaccctaataggagtattcataccagcagcagcagcagcagcagcagtagcagcagcagc agcagcagcagcagcagcagtagcagcagcagcagcagcagcagcagcagcagtagcagc agcagtagcagcagcagcagcagcagtagtaccagtttttcaaagcctcacaaattaatg aaggagcacaaggaaaaaccttctaaagactccagagaacataaaagtgccttcaaagaa ccttccagggatcacaacaaatcttccaaagaatcctctaagaaacccaaagaaaataaa ccactgaaagaagagaaaatagttcctaagatggccttcaaggaacctaaacccatgtca aaagagccaaaaccagatagtaacttactcaccatcaccagtggacaagataagaaggct cctagtaaaaggccgcccatttcagattctgaagaactctcagccaaaaaaaggaaaaag agtagctcagaggctttatttaaaagtttttctagcgcaccaccactgatactcacttgt tctgctgacaaaaaacagataaaagataaatctcatgtcaagatgggaaaggtcaaaatt gaaagtgagacatcagagaagaagaaatcaacgttaccgccatttgatgatattgtggat cccaatgattcagatgtggaggagaatatatcctctaaatctgattctgaacaacccagt cctgccagctccagctccagctccagctccagcttcacaccatcccagaccaggcaacaa ggtcctttgaggtctataatgaaagatctgcattctgatgacaatgaggaggaatcagat gaagtggaggataacgacaatgactctgaaatggagaggcctgtaaatagaggaggcagc cgaagtcgcagagttagcttaagtgatggcagcgatagtgaaagcagttctgcttcttca cccctacatcacgaacctccaccacccttactaaaaaccaacaacaaccagattcttgaa gtgaaaagtccaataaagcaaagcaaatcagataagcaaataaagaatggtgaatgtgac aaggcatacctagatgaactggtagagcttcacagaaggttaatgacattgagagaaaga cacattctgcagcagatcgtgaaccttatagaagaaactggacactttcatatcacaaac acaacatttgattttgatctttgctcgctggacaaaaccacagtccgtaaactacagagt tacctggaaacatctggaacatcctga

Homo sapiens (human): 84444 Help Entry 84444             CDS       T01001                                  Symbol DOT1L, DOT1, KMT4 Name (RefSeq) DOT1 like histone lysine methyltransferase   KO K11427   [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360] Organism hsa  Homo sapiens (human) Pathway hsa00310   Lysine degradation hsa01100   Metabolic pathways hsa05202   Transcriptional misregulation in cancer Network nt06240  Transcription   Element N00119   MLL-AF4 fusion to transcriptional activation Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00310 Lysine degradation     84444 (DOT1L)  09160 Human Diseases   09161 Cancer: overview    05202 Transcriptional misregulation in cancer     84444 (DOT1L)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     84444 (DOT1L) Enzymes [BR:hsa01000]  2. Transferases   2.1  Transferring one-carbon groups    2.1.1  Methyltransferases     2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase      84444 (DOT1L) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HMTs (histone methyltransferases)     HKMTs (histone lysine methyltransferases)      84444 (DOT1L)    HMT complexes     Dot1-containing complex      84444 (DOT1L) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DOT1 Motif Other DBs NCBI-GeneID:  84444 NCBI-ProteinID:  NP_115871 OMIM:  607375 HGNC:  24948 Ensembl:  ENSG00000104885 Vega:  OTTHUMG00000150431 Pharos:  Q8TEK3(Tchem) UniProt:  Q8TEK3 Structure PDB LinkDB All DBs Position 19:2163933..2232578 Genome browser AA seq 1537 aa AA seqDB search MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTA NPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQK EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLL KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK SCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGY ELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIV LRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL AGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGA EPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPL PEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHG QDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI ERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSP LQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLK GEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLS GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN NT seq 4614 nt NT seq  +upstreamnt  +downstreamnt atgggggagaagctggagctgagactgaagtcgcccgtgggggctgagcccgccgtctac ccgtggccgctgccggtctacgataaacatcacgatgctgctcatgaaatcatcgagacc atccgatgggtctgtgaagaaatcccggatctcaagctcgctatggagaattacgtttta attgactatgacaccaaaagcttcgagagcatgcagaggctctgcgacaagtacaaccgt gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg cggccgtccactggactcctgcgccatatcctgcagcaggtctacaaccactcggtgacc gaccccgagaagctcaacaactacgagcccttctcccccgaggtgtacggggagacctcc ttcgacctggtggcccagatgattgatgagatcaagatgaccgacgacgacctgtttgtg gacttggggagcggtgtgggccaggtcgtgctccaggttgctgctgccaccaactgcaaa catcactatggcgtcgagaaagcagacatcccggccaagtatgcggagaccatggaccgc gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacattggagaga ggcgatttcctctcagaagagtggagggagcgaatcgccaacacgagtgttatatttgtg aataattttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg aaggaaggtggcagaatcgtgtcctcgaaaccctttgcacctctgaacttcagaataaac agtagaaacttgagtgacatcggcaccatcatgcgcgtggtggagctctcgcccctgaag ggctcggtgtcgtggacggggaagccagtctcctactacctgcacactatcgaccgcacc atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaggaggca gcccggcgccgccagcagcgcgagagcaagagcaacgcggccacgcccactaagggccca gagggcaaggtggccggccccgccgacgcccccatggactctggtgctgaggaagagaag gcgggagcagccaccgtgaagaagccgtctccctccaaagcccgcaagaagaagctaaac aagaaggggaggaagatggctggccgcaagcgcgggcgccccaagaagatgaacactgcg aaccccgagcggaagcccaagaagaaccaaactgcactggatgccctgcacgctcagacc gtgtctcagacggcggcctcctcaccccaggatgcctacagatcccctcacagcccgttc taccagctacctccgagcgtgcagcggcactcccccaacccgctgctggtggcgcccacc ccgcccgcgctgcagaagcttctagagtccttcaagatccagtacctgcagttcctggca tacacaaagaccccccagtacaaggccagcctgcaggagctgctgggccaggagaaggag aagaacgcccagctcctgggtgcggctcagcagctcctcagccactgccaggcccagaag gaggagatcaggaggctgtttcagcaaaaattggatgagctgggtgtgaaggcgctgacc tacaacgacctgattcaagcgcagaaggagatctccgcccataaccagcagctgcgggag cagtcggagcagctggagcaggacaaccgcgcgctccgcggccagagcttgcagctgctc aaggctcgctgcgaggagctgcagctggactgggccacgctgtcgctggagaagctgttg aaggagaagcaggccctgaagagccagatctcggagaagcagaggcactgcctggagctg cagatcagcattgtggagctagagaagagccagcggcagcaggagctcctgcagctcaag tcctgtgtgccgcctgacgacgccctgtccctgcacctgcgtgggaagggcgccctgggc cgcgagctggagcctgacgccagccggctgcacctggagctggactgcaccaagttctcg ctgcctcacttgagcagcatgagcccggagctctccatgaacggccaggctgctggctat gagctctgcggtgtgctgagccggccttcgtcgaagcagaacacgccccagtacctggcc tcacccctggaccaggaggtggtgccctgtacccctagccacgtcggccggccgcgcctg gagaagctgtctggcctagccgcacccgactacactaggctgtccccggccaagattgtg ctgaggcggcacctgagccaggaccacacggtgcccggcaggccggctgccagtgagctg cattcgagagctgagcacaccaaggagaacggccttccctaccagagccccagcgtgcct ggcagcatgaagctgagccctcaggacccgcggcccctgtcccctggggccttgcagctt gctggagagaagagcagtgagaagggcctgagagagcgcgcctacggcagcagcggggag ctcatcaccagcctgcccatcagcatcccgctcagcaccgtgcagcccaacaagctcccg gtcagcattcccctggccagcgtggtgctgcccagccgcgccgagagggcgaggagcacc cccagtcccgtgctgcagccccgtgacccctcgtccacacttgaaaagcagattggtgct aatgcccacggtgctgggagcagaagccttgccctggcccccgcaggcttctcctacgct ggctcggtggccatcagcggggccttggcgggcagcccggcctctctcacacctggagcc gagccggccaccttggatgagtcctccagctctgggagcctttttgccaccgtggggtcc cgcagctccacgccacagcaccccctgctgctggcacagccccggaactcgcttcctgcc tctcccgcccaccagctctcctccagtccccggcttggtggggccgcccagggcccgttg cccgaggccagcaagggagacctgccctccgattccggcttctcagatcctgagagtgaa gccaagaggaggattgtgttcaccatcaccactggtgcgggcagtgccaagcagtcgccc tccagcaagcacagccccctgaccgccagcgcccgtggggactgtgtgccgagccacggg caggacagtcgcaggcgcggccggcggaagcgagcatctgcggggacgcccagcttgagc gcaggcgtgtcccccaagcgccgagccctgccgtccgtcgctggccttttcacacagcct tcggggtctcccctcaacctcaactccatggtcagtaacatcaaccagcccctggagatt acagccatctcgtccccggagacctccctgaagagctcccctgtgccctaccaggaccac gaccagccccccgtgctcaagaaggagcggcctctgagccagaccaatggggcacactac tccccactcacctcagacgaggagccaggctctgaggacgagcccagcagtgctcgaatt gagagaaaaattgcaacaatctccttagaaagcaaatctcccccgaaaaccttggaaaat ggtggtggcttggcgggaaggaagcccgcgcccgccggcgagccagtcaatagcagcaag tggaagtccaccttctcgcccatctccgacatcggcctggccaagtcggcggacagcccg ctgcaggccagctccgccctcagccagaactccctgttcacgttccggcccgccctggag gagccctctgccgatgccaagctggccgctcaccccaggaaaggctttcccggctccctg tcgggggctgacggactcagcccgggcaccaaccctgccaacggctgcaccttcggcggg ggcctggccgcggacctgagtttacacagcttcagtgatggtgcttctcttccccacaag ggccccgaggcggccggcctgagctccccgctgagcttcccctcgcagcgcggcaaggag ggctcggacgccaaccctttcctgagcaagaggcagctggacggcctggctgggctgaag ggcgagggcagccgcggcaaggaggcaggggagggcggcctaccgctgtgcgggcccacg gacaagaccccactgctgagcggcaaggccgccaaggcccgggaccgcgaggtcgacctc aagaatggccacaacctcttcatctctgcggcggccgtgcctcccggaagcctcctcagc ggccccggcctggccccggcggcgtcctccgcaggcggcgcggcgtcctccgcccagacg caccggtccttcctgggccccttcccgccgggaccgcagttcgcgctcggccccatgtcc ctgcaggccaacctcggctccgtggccggctcctccgtgctgcagtcgctgttcagctct gtgccggccgccgcaggcctggtgcacgtgtcgtccgctgccaccagactgaccaactcg cacgccatgggcagcttttccggggtggcaggcggcacagttggaggtaactag

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