KEGG   Homo sapiens (human): 10846
Entry
10846             CDS       T01001                                 
Symbol
PDE10A, ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
Name
(RefSeq) phosphodiesterase 10A
  KO
K18438  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04024  cAMP signaling pathway
hsa05032  Morphine addiction
Disease
H01570  Autosomal dominant striatal degeneration
H02388  Infantile-onset limb and orofacial dyskinesia
Drug target
Aminophylline (DG01062): D00227 D05429<JP> D11630<US>
Balipodect: D11245
Bemoradan: D03075
Bucladesine (DG00230): D01238<JP> D07546
Choline theophyllinate: D02017
Diprophylline: D00691<JP>
Enprofylline: D04006
Flavoxate (DG00477): D00718<JP/US> D07961
Gemlapodect: D13073
Mardepodect: D11171
Moxaverine (DG00045): D07089 D08238
Oxagrelate: D05278
Papaverine (DG00043): D02218<JP> D07425 D07439
Prinoxodan: D05612
Proxyphylline: D01771
Theophylline (DG01061): D00371<JP/US> D01712 D06103 D06104
Theosalicin: D09822
Tibenelast sodium: D06132
Trapidil: D01220<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    10846 (PDE10A)
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    10846 (PDE10A)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    10846 (PDE10A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.17  3',5'-cyclic-nucleotide phosphodiesterase
     10846 (PDE10A)
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     10846 (PDE10A)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3 SpoVT_C HD DUF7334
Other DBs
NCBI-GeneID: 10846
NCBI-ProteinID: NP_001124162
OMIM: 610652
HGNC: 8772
Ensembl: ENSG00000112541
UniProt: Q9Y233
Structure
LinkDB
Position
6:complement(165327289..165988052)
AA seq 789 aa
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD
GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG
PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV
AQKAAASED
NT seq 2370 nt   +upstreamnt  +downstreamnt
atggaagatggaccttctaataatgcgagctgcttccgaaggctgaccgagtgcttcctg
agccccagtttgacagatgaaaaagtgaaggcatatctttctcttcacccccaggtatta
gatgaatttgtatctgaaagtgttagtgcagagacagtagagaaatggctgaagaggaag
aacaacaaatcagaagatgaatcagctcctaaggaagtcagcaggtaccaagatacgaat
atgcagggagttgtatatgaactaaacagctatatagaacaacggttggacacaggagga
gacaaccagctactcctctatgaactgagcagcatcattaaaatagccacaaaagccgat
ggatttgcactgtatttccttggagagtgcaataatagcctgtgtatattcacgccacct
gggataaaggaaggaaaaccccgcctcatccctgctgggcccatcactcagggcaccacc
gtctctgcttatgtggccaagtccaggaaaacactgctagtagaagacatccttggagat
gaacgatttccaagaggtactggactggaatcagggactcgtatccagtctgttctttgc
ttaccaattgtcactgcaattggtgacttgattggtattctcgagctgtatcggcactgg
ggcaaagaagccttctgtcttagtcaccaggaggttgcaacagcaaatcttgcctgggct
tcagtagcaatacatcaggtgcaggtatgcagaggccttgccaaacagacagaattgaat
gacttcctactcgacgtatcaaaaacatattttgataacatagttgcaatagattctcta
cttgaacacataatgatatatgcaaaaaacctggtgaatgccgatcgttgtgcgcttttc
caggtggaccataagaacaaggagttatattcagacctttttgatattggagaggaaaag
gaaggaaaacctgtcttcaagaagaccaaagagataagattttcaattgagaaaggaatt
gctggccaagtagcaagaacaggggaagtcctgaacattccagatgcctatgcagaccca
cgctttaacagagaagtagacttgtacacaggctacaccacgcggaacatcctgtgcatg
cccatcgtcagccgaggcagcgtgataggtgtggtgcagatggtcaacaaaatcagtggc
agtgccttctctaaaacagatgaaaacaacttcaaaatgtttgccgtcttttgtgcttta
gccttacactgtgctaatatgtatcatagaattcgccactcagagtgcatttaccgggta
acgatggaaaagctgtcctaccatagcatttgtacttcagaagagtggcaaggtctcatg
caattcacccttcccgtgcgtctctgcaaagaaattgaattattccactttgacattggt
ccttttgaaaacatgtggcctggaatttttgtctacatggttcatcggtcctgtgggaca
tcctgctttgagcttgaaaagttgtgtcgttttattatgtctgtgaagaagaactatcgg
cgggttccttatcacaactggaagcatgcggtcactgtagcacactgcatgtatgccata
cttcagaacaatcacacgcttttcacagaccttgagcgcaaaggactgctgattgcgtgt
ctgtgtcatgacctggaccacaggggcttcagtaacagctacctgcagaagttcgaccac
cctctggccgctctctactccacttccaccatggagcagcaccacttctcccagactgtg
tccatcctccagttggaagggcacaatatcttctccactctgagctccagtgaatatgag
caggtgcttgagatcatccgcaaagccatcattgccacagaccttgctttatactttgga
aacaggaagcagttggaagagatgtaccagaccggatcactaaaccttaataatcaatca
catagagaccgtgtaattggtttgatgatgactgcctgtgacctttgttctgtgacaaaa
ctgtggcccgttacaaaattgacggcaaatgatatatatgcagaattctgggctgagggt
gatgaaatgaagaaattgggaatacagcctattcctatgatggacagagacaagaaggat
gaagtcccccaaggccagcttgggttctacaatgccgtggccattccctgctatacaacc
cttacccagatcctccctcccacggagcctcttctgaaagcatgcagggataatctcagt
cagtgggagaaggtgattcgaggggaggagactgcaacctggatttcatccccatccgtg
gctcagaaggcagctgcatctgaagattga

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