Homo sapiens (human): 10846
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Entry
10846 CDS
T01001
Symbol
PDE10A, ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
Name
(RefSeq) phosphodiesterase 10A
KO
K18438
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:
3.1.4.17
3.1.4.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04024
cAMP signaling pathway
hsa05032
Morphine addiction
Disease
H01570
Autosomal dominant striatal degeneration
H02388
Infantile-onset limb and orofacial dyskinesia
Drug target
Aminophylline (
DG01062
):
D00227
D05429
<JP>
D11630
<US>
Balipodect:
D11245
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
<JP>
D07546
Choline theophyllinate:
D02017
Diprophylline:
D00691
<JP>
Enprofylline:
D04006
Flavoxate (
DG00477
):
D00718
<JP/US>
D07961
Gemlapodect:
D13073
Mardepodect:
D11171
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
<JP>
D07425
D07439
Prinoxodan:
D05612
Proxyphylline:
D01771
Theophylline (
DG01061
):
D00371
<JP/US>
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Trapidil:
D01220
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
10846 (PDE10A)
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
10846 (PDE10A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
10846 (PDE10A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
10846 (PDE10A)
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
10846 (PDE10A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
GAF
GAF_2
GAF_3
SpoVT_C
HD
DUF7334
Motif
Other DBs
NCBI-GeneID:
10846
NCBI-ProteinID:
NP_001372008
OMIM:
610652
HGNC:
8772
Ensembl:
ENSG00000112541
UniProt:
Q9Y233
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:complement(165327289..165988052)
Genome browser
AA seq
1055 aa
AA seq
DB search
MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
NT seq
3168 nt
NT seq
+upstream
nt +downstream
nt
atggccagcctcgaggagcctcttgctccccgcccccagggtcccctgccagcggccggg
gacgagccgggctgcggccccggcaaactccgcccggaaccccggctcagcgcggccggc
ggggggagcgcggcgggcccgggcccggcccccgagtggcctggccgtggccgggcggag
cgcgccgcgcccccgcgcccgcccctctcctccgcaggccgccccagccccgctgggggc
cccggcgccctctctgcgcgcggcggcggctgcggctgggtcgcggcccgcgctcccttg
gcgctcgccttctcgtcccgggtcccctcctcctctccatctttcttttacttctggccg
ccgccccccccgccccctccctcttttctcccctcctcatctgcctttcacctccccgtg
cgtctcccaggaagggagggcgcagcggcggcggcggcggcgggaggaggcggcgatgct
ggcggaggaggaggaggaggacaagaggcagctcccttgagcgtccccaccagcagtagt
caccgcggcggcggtggcagcggcggcgggcggcggcggctcttcctctcgcctgcgctc
cagggcttgctgcttccagcccgtgccggtccccggccgccgccgccgccccggctcccc
cttggccaggccgcccgccgcgcgggctcccccggcttccccggcgccggcccaggcggc
ggcggccaaactccgcggcgtccccagggcgccagcttcgccctcgccgccgcggccgcg
ctgctcttcggctccgacatggaagatggaccttctaataatgcgagctgcttccgaagg
ctgaccgagtgcttcctgagccccagtttgacagatgaaaaagtgaaggcatatctttct
cttcacccccaggtattagatgaatttgtatctgaaagtgttagtgcagagacagtagag
aaatggctgaagaggaagaacaacaaatcagaagatgaatcagctcctaaggaagtcagc
aggtaccaagatacgaatatgcagggagttgtatatgaactaaacagctatatagaacaa
cggttggacacaggaggagacaaccagctactcctctatgaactgagcagcatcattaaa
atagccacaaaagccgatggatttgcactgtatttccttggagagtgcaataatagcctg
tgtatattcacgccacctgggataaaggaaggaaaaccccgcctcatccctgctgggccc
atcactcagggcaccaccgtctctgcttatgtggccaagtccaggaaaacactgctagta
gaagacatccttggagatgaacgatttccaagaggtactggactggaatcagggactcgt
atccagtctgttctttgcttaccaattgtcactgcaattggtgacttgattggtattctc
gagctgtatcggcactggggcaaagaagccttctgtcttagtcaccaggaggttgcaaca
gcaaatcttgcctgggcttcagtagcaatacatcaggtgcaggtatgcagaggccttgcc
aaacagacagaattgaatgacttcctactcgacgtatcaaaaacatattttgataacata
gttgcaatagattctctacttgaacacataatgatatatgcaaaaaacctggtgaatgcc
gatcgttgtgcgcttttccaggtggaccataagaacaaggagttatattcagaccttttt
gatattggagaggaaaaggaaggaaaacctgtcttcaagaagaccaaagagataagattt
tcaattgagaaaggaattgctggccaagtagcaagaacaggggaagtcctgaacattcca
gatgcctatgcagacccacgctttaacagagaagtagacttgtacacaggctacaccacg
cggaacatcctgtgcatgcccatcgtcagccgaggcagcgtgataggtgtggtgcagatg
gtcaacaaaatcagtggcagtgccttctctaaaacagatgaaaacaacttcaaaatgttt
gccgtcttttgtgctttagccttacactgtgctaatatgtatcatagaattcgccactca
gagtgcatttaccgggtaacgatggaaaagctgtcctaccatagcatttgtacttcagaa
gagtggcaaggtctcatgcaattcacccttcccgtgcgtctctgcaaagaaattgaatta
ttccactttgacattggtccttttgaaaacatgtggcctggaatttttgtctacatggtt
catcggtcctgtgggacatcctgctttgagcttgaaaagttgtgtcgttttattatgtct
gtgaagaagaactatcggcgggttccttatcacaactggaagcatgcggtcactgtagca
cactgcatgtatgccatacttcagaacaatcacacgcttttcacagaccttgagcgcaaa
ggactgctgattgcgtgtctgtgtcatgacctggaccacaggggcttcagtaacagctac
ctgcagaagttcgaccaccctctggccgctctctactccacttccaccatggagcagcac
cacttctcccagactgtgtccatcctccagttggaagggcacaatatcttctccactctg
agctccagtgaatatgagcaggtgcttgagatcatccgcaaagccatcattgccacagac
cttgctttatactttggaaacaggaagcagttggaagagatgtaccagaccggatcacta
aaccttaataatcaatcacatagagaccgtgtaattggtttgatgatgactgcctgtgac
ctttgttctgtgacaaaactgtggcccgttacaaaattgacggcaaatgatatatatgca
gaattctgggctgagggtgatgaaatgaagaaattgggaatacagcctattcctatgatg
gacagagacaagaaggatgaagtcccccaaggccagcttgggttctacaatgccgtggcc
attccctgctatacaacccttacccagatcctccctcccacggagcctcttctgaaagca
tgcagggataatctcagtcagtgggagaaggtgattcgaggggaggagactgcaacctgg
atttcatccccatccgtggctcagaaggcagctgcatctgaagattga
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