KEGG   NETWORK: N01413
Entry
N01413                      Network                                

Name
Metals to KEAP1-NRF2 signalig pathway
Definition
Metals -> ROS -| KEAP1 -| NRF2 => (HMOX1,NQO1,AKR)
  Expanded
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -| 9817 -| 4780 => (3162,1728,(10327,1109,1645,1646,8644))
Class
nt06226 KEAP1-NRF2 signaling
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00021  Renal cell carcinoma
H00024  Prostate cancer
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00048  Hepatocellular carcinoma
H00054  Nasopharyngeal cancer
Gene
9817  KEAP1; kelch like ECH associated protein 1
4780  NFE2L2; nuclear factor, erythroid 2 like 2
3162  HMOX1; heme oxygenase 1
1728  NQO1; NAD(P)H quinone dehydrogenase 1
10327  AKR1A1; aldo-keto reductase family 1 member A1
1109  AKR1C4; aldo-keto reductase family 1 member C4
1645  AKR1C1; aldo-keto reductase family 1 member C1
1646  AKR1C2; aldo-keto reductase family 1 member C2
8644  AKR1C3; aldo-keto reductase family 1 member C3
Perturbant
C06269 (Metals)  Arsenic
C01413 (Metals)  Cadmium
C19171 (Metals)  Cobalt
C06268 (Metals)  Chromium
C06696 (Metals)  Lead
C00023 (Metals)  Iron
C00291 (Metals)  Nickel
Metabolite
C22381  Reactive oxygen species
Reference
  Authors
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M
  Title
Redox toxicology of environmental chemicals causing oxidative stress.
  Journal
Redox Biol 34:101475 (2020)
DOI:10.1016/j.redox.2020.101475
Reference
  Authors
Penning TM
  Title
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
  Journal
Chem Res Toxicol 27:1901-17 (2014)
DOI:10.1021/tx500298n
Reference
  Authors
Kumari S, Badana AK, G MM, G S, Malla R
  Title
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
  Journal
Biomark Insights 13:1177271918755391 (2018)
DOI:10.1177/1177271918755391
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