| Entry |
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| Name |
Metals to KEAP1-NRF2 signalig pathway
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| Definition |
Metals -> ROS -| KEAP1 -| NRF2 => (HMOX1,NQO1,AKR) |
|---|
| Expanded |
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -| 9817 -| 4780 => (3162,1728,(10327,1109,1645,1646,8644)) |
|---|
| Class |
nt06226 KEAP1-NRF2 signaling (cancer)
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
| H00048 | Hepatocellular carcinoma |
|
|---|
| Gene |
| 9817 | KEAP1; kelch like ECH associated protein 1 |
| 4780 | NFE2L2; nuclear factor, erythroid 2 like 2 |
| 3162 | HMOX1; heme oxygenase 1 |
| 1728 | NQO1; NAD(P)H quinone dehydrogenase 1 |
| 10327 | AKR1A1; aldo-keto reductase family 1 member A1 |
| 1109 | AKR1C4; aldo-keto reductase family 1 member C4 |
| 1645 | AKR1C1; aldo-keto reductase family 1 member C1 |
| 1646 | AKR1C2; aldo-keto reductase family 1 member C2 |
| 8644 | AKR1C3; aldo-keto reductase family 1 member C3 |
|
|---|
| Perturbant |
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| Metabolite |
| C22381 | Reactive oxygen species |
|
|---|
| Reference |
|
|---|
| Authors |
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M |
|---|
| Title |
Redox toxicology of environmental chemicals causing oxidative stress. |
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| Journal |
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| Reference |
|
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| Authors |
Penning TM |
|---|
| Title |
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Kumari S, Badana AK, G MM, G S, Malla R |
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| Title |
Reactive Oxygen Species: A Key Constituent in Cancer Survival. |
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| Journal |
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| LinkDB |
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