KEGG   DRUG: Nicotine polacrilex
Entry
D05157                      Drug                                   
Name
Nicotine polacrilex (USP);
Nicorette (TN)
Class
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
Unclassified
 DG01715  Drugs for nicotine dependence
Remark
ATC code: N07BA01
Chemical structure group: DG00994
Product (DG00994): D03365<JP/US>
Efficacy
Smoking cessation adjunct
Target
CHRN [HSA:1134 1135 1136 1137 1138 8973 1139 55584 57053 1140 1141 1142 1143 1144 1145 1146] [KO:K04803 K04804 K04805 K04806 K04807 K04808 K04809 K04810 K04811 K04812 K04813 K04814 K04815 K04816 K04817 K04818]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa05033  Nicotine addiction
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
CYP induction: CYP1A2 [HSA:1544]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BA Drugs used in nicotine dependence
     N07BA01 Nicotine
      D05157  Nicotine polacrilex (USP)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Nicotine
    D05157  Nicotine polacrilex (USP)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00994  Nicotine
    D05157  Nicotine polacrilex
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00994  Nicotine
    D05157  Nicotine polacrilex
 Unclassified
  DG01715  Drugs for nicotine dependence
   DG00994  Nicotine
    D05157  Nicotine polacrilex
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Acetylcholine (nicotinic)
    CHRN
     D05157  Nicotine polacrilex (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05157
Rx-to-OTC switch list in the USA [br08315.html]
 D05157
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   DG00994  Nicotine
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00994  Nicotine
 Unclassified
  DG01715  Drugs for nicotine dependence
   DG00994  Nicotine
Other DBs
CAS: 96055-45-7
PubChem: 47206881
LinkDB

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