KEGG   DRUG: Nicotine polacrilexHelp
Entry
D05157                      Drug                                   

Name
Nicotine polacrilex (USAN);
Nicorette (TN)
Class
Other
 DG01718  Drugs for addictive disorder
  DG01715  Drugs for nicotine dependence
Enzyme substrate
 DG01638  CYP2A6 substrate
Enzyme inducer
 DG01637  CYP1A2 inducer
Remark
ATC code: N07BA01
Chemical structure group: DG00994
Product (DG00994): D03365<JP/US>
Efficacy
Smoking cessation adjunct
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa05033  Nicotine addiction
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BA Drugs used in nicotine dependence
     N07BA01 Nicotine
      D05157  Nicotine polacrilex (USAN)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Nicotine
    D05157  Nicotine polacrilex (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Acetylcholine (nicotinic)
    CHRN
     D05157  Nicotine polacrilex (USAN)
Rx-to-OTC switch list in the USA [br08315.html]
 D05157
BRITE hierarchy
Other DBs
CAS: 96055-45-7
PubChem: 47206881
DrugBank: DB00184
LinkDB All DBs

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