Homo sapiens (human): 135 Help Entry 135               CDS       T01001                                  Symbol ADORA2A, A2aR, ADORA2, RDC8 Name (RefSeq) adenosine A2a receptor   KO K04266   adenosine receptor A2a Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa05012   Parkinson disease hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Apadenoson:  D03212 Binodenoson:  D03120 Caffeine (DG00974):  D00528<JP> D01453<JP> D07603<US> Choline theophyllinate:  D02017 Ciforadenant:  D11547 Doxofylline:  D03898 Enprofylline:  D04006 Etrumadenant:  D12369 Evodenoson:  D10362 Inupadenant (DG03145):  D11978 D11979 Istradefylline:  D04641<JP/US> Preladenant:  D09717 Proxyphylline:  D01771<JP> Regadenoson (DG03262):  D05711<US> D12568<US> Sonedenoson:  D09003 Tozadenant:  D10174 Vipadenant:  D09991 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     135 (ADORA2A)    04024 cAMP signaling pathway     135 (ADORA2A)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     135 (ADORA2A)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     135 (ADORA2A)   09165 Substance dependence    05034 Alcoholism     135 (ADORA2A)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     135 (ADORA2A) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     135 (ADORA2A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx GPR_Gpa2_C Motif Other DBs NCBI-GeneID:  135 NCBI-ProteinID:  NP_000666 OMIM:  102776 HGNC:  263 Ensembl:  ENSG00000128271 UniProt:  P29274 B3KVQ4 X5DNB4 Structure PDBPDBj LinkDB All DBs Position 22:24423597..24442357 Genome browser AA seq 412 aa AA seqDB search MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS NT seq 1239 nt NT seq  +upstreamnt  +downstreamnt atgcccatcatgggctcctcggtgtacatcacggtggagctggccattgctgtgctggcc atcctgggcaatgtgctggtgtgctgggccgtgtggctcaacagcaacctgcagaacgtc accaactactttgtggtgtcactggcggcggccgacatcgcagtgggtgtgctcgccatc ccctttgccatcaccatcagcaccgggttctgcgctgcctgccacggctgcctcttcatt gcctgcttcgtcctggtcctcacgcagagctccatcttcagtctcctggccatcgccatt gaccgctacattgccatccgcatcccgctccggtacaatggcttggtgaccggcacgagg gctaagggcatcattgccatctgctgggtgctgtcgtttgccatcggcctgactcccatg ctaggttggaacaactgcggtcagccaaaggagggcaagaaccactcccagggctgcggg gagggccaagtggcctgtctctttgaggatgtggtccccatgaactacatggtgtacttc aacttctttgcctgtgtgctggtgcccctgctgctcatgctgggtgtctatttgcggatc ttcctggcggcgcgacgacagctgaagcagatggagagccagcctctgccgggggagcgg gcacggtccacactgcagaaggaggtccatgctgccaagtcactggccatcattgtgggg ctctttgccctctgctggctgcccctacacatcatcaactgcttcactttcttctgcccc gactgcagccacgcccctctctggctcatgtacctggccatcgtcctctcccacaccaat tcggttgtgaatcccttcatctacgcctaccgtatccgcgagttccgccagaccttccgc aagatcattcgcagccacgtcctgaggcagcaagaacctttcaaggcagctggcaccagt gcccgggtcttggcagctcatggcagtgacggagagcaggtcagcctccgtctcaacggc cacccgccaggagtgtgggccaacggcagtgctccccaccctgagcggaggcccaatggc tatgccctggggctggtgagtggagggagtgcccaagagtcccaggggaacacgggcctc ccagacgtggagctccttagccatgagctcaagggagtgtgcccagagccccctggccta gatgaccccctggcccaggatggagcaggagtgtcctga

Homo sapiens (human): 136 Help Entry 136               CDS       T01001                                  Symbol ADORA2B, ADORA2 Name (RefSeq) adenosine A2b receptor   KO K04267   adenosine receptor A2b Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Aminophylline (DG01062):  D00227 D05429<JP> D11630<US> Diprophylline:  D00691<JP> Enprofylline:  D04006 Etrumadenant:  D12369 Proxyphylline:  D01771<JP> Theophylline (DG01061):  D00371<JP/US> D01712 D06103 D06104 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     136 (ADORA2B)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     136 (ADORA2B)  09160 Human Diseases   09165 Substance dependence    05034 Alcoholism     136 (ADORA2B)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     136 (ADORA2B) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     136 (ADORA2B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 GPR_Gpa2_C 7TM_GPCR_Srx 7TM_GPCR_Sri Motif Other DBs NCBI-GeneID:  136 NCBI-ProteinID:  NP_000667 OMIM:  600446 HGNC:  264 Ensembl:  ENSG00000170425 UniProt:  P29275 Structure PDBPDBj LinkDB All DBs Position 17:15850362..15975746 Genome browser AA seq 332 aa AA seqDB search MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT FHKIISRYLLCQADVKSGNGQAGVQPALGVGL NT seq 999 nt NT seq  +upstreamnt  +downstreamnt atgctgctggagacacaggacgcgctgtacgtggcgctggagctggtcatcgccgcgctt tcggtggcgggcaacgtgctggtgtgcgccgcggtgggcacggcgaacactctgcagacg cccaccaactacttcctggtgtccctggctgcggccgacgtggccgtggggctcttcgcc atcccctttgccatcaccatcagcctgggcttctgcactgacttctacggctgcctcttc ctcgcctgcttcgtgctggtgctcacgcagagctccatcttcagccttctggccgtggca gtcgacagatacctggccatctgtgtcccgctcaggtataaaagtttggtcacggggacc cgagcaagaggggtcattgctgtcctctgggtccttgcctttggcatcggattgactcca ttcctggggtggaacagtaaagacagtgccaccaacaactgcacagaaccctgggatgga accacgaatgaaagctgctgccttgtgaagtgtctctttgagaatgtggtccccatgagc tacatggtatatttcaatttctttgggtgtgttctgcccccactgcttataatgctggtg atctacattaagatcttcctggtggcctgcaggcagcttcagcgcactgagctgatggac cactcgaggaccaccctccagcgggagatccatgcagccaagtcactggccatgattgtg gggatttttgccctgtgctggttacctgtgcatgctgttaactgtgtcactcttttccag ccagctcagggtaaaaataagcccaagtgggcaatgaatatggccattcttctgtcacat gccaattcagttgtcaatcccattgtctatgcttaccggaaccgagacttccgctacact tttcacaaaattatctccaggtatcttctctgccaagcagatgtcaagagtgggaatggt caggctggggtacagcctgctctcggtgtgggcctatga

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