KEGG   Homo sapiens (human): 2052
Entry
2052              CDS       T01001                                 
Symbol
EPHX1, EPHX, EPOX, HYL1, MEH
Name
(RefSeq) epoxide hydrolase 1
  KO
K01253  microsomal epoxide hydrolase [EC:3.3.2.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa04976  Bile secretion
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06250  DNA adduct formation (cancer)
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01374  BaP to DNA adducts
N01375  DMBA to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2052 (EPHX1)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    2052 (EPHX1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    2052 (EPHX1)
   05207 Chemical carcinogenesis - receptor activation
    2052 (EPHX1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2052 (EPHX1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2052 (EPHX1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.9  microsomal epoxide hydrolase
     2052 (EPHX1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S33
   2052 (EPHX1)
SSDB
Motif
Pfam: Abhydrolase_1 EHN Abhydrolase_6
Other DBs
NCBI-GeneID: 2052
NCBI-ProteinID: NP_000111
OMIM: 132810
HGNC: 3401
Ensembl: ENSG00000143819
Pharos: P07099(Tchem)
UniProt: P07099 R4SBI6
LinkDB
Position
1:225810124..225845563
AA seq 455 aa
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI
HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI
EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV
ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP
SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML
YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL
ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
NT seq 1368 nt   +upstreamnt  +downstreamnt
atgtggctagaaatcctcctcacttcagtgctgggctttgccatctactggttcatctcc
cgggacaaagaggaaactttgccacttgaagatgggtggtgggggccaggcacgaggtcc
gcagccagggaggacgacagcatccgccctttcaaggtggaaacgtcagatgaggagatc
cacgacttacaccagaggatcgataagttccgtttcaccccacctttggaggacagctgc
ttccactatggcttcaactccaactacctgaagaaagtcatctcctactggcggaatgaa
tttgactggaagaagcaggtggagattctcaacagataccctcacttcaagactaagatt
gaagggctggacatccacttcatccacgtgaagcccccccagctgcccgcaggccatacc
ccgaagcccttgctgatggtgcacggctggcccggctctttctacgagttttataagatc
atcccactcctgactgaccccaagaaccatggcctgagcgatgagcacgtttttgaagtc
atctgcccttccatccctggctatggcttctcagaggcatcctccaagaaggggttcaac
tcggtggccaccgccaggatcttttacaagctgatgctgcggctgggcttccaggaattc
tacattcaaggaggggactgggggtccctgatctgcactaatatggcccagctggtgccc
agccacgtgaaaggcctgcacttgaacatggctttggttttaagcaacttctctaccctg
accctcctcctgggacagcgtttcgggaggtttcttggcctcactgagagggatgtggag
ctgctgtaccccgtcaaggagaaggtattctacagcctgatgagggagagcggctacatg
cacatccagtgcaccaagcctgacaccgtaggctctgctctgaatgactctcctgtgggt
ctggctgcctatattctagagaagttttccacctggaccaatacggaattccgatacctg
gaggatggaggcctggaaaggaagttctccctggacgacctgctgaccaacgtcatgctc
tactggacaacaggcaccatcatctcctcccagcgcttctacaaggagaacctgggacag
ggctggatgacccagaagcatgagcggatgaaggtctatgtgcccactggcttctctgcc
ttcccttttgagctattgcacacgcctgaaaagtgggtgaggttcaagtacccaaagctc
atctcctattcctacatggttcgtgggggccactttgcggcctttgaggagccggagctg
ctcgcccaggacatccgcaagttcctgtcggtgctggagcggcaatga

KEGG   Homo sapiens (human): 2053
Entry
2053              CDS       T01001                                 
Symbol
EPHX2, ABHD20, CEH, SEH
Name
(RefSeq) epoxide hydrolase 2
  KO
K08726  soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
hsa04146  Peroxisome
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
Disease
H00155  Familial hypercholesterolemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    2053 (EPHX2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    2053 (EPHX2)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    2053 (EPHX2)
   05208 Chemical carcinogenesis - reactive oxygen species
    2053 (EPHX2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2053 (EPHX2)
   01002 Peptidases and inhibitors [BR:hsa01002]
    2053 (EPHX2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.76  lipid-phosphate phosphatase
     2053 (EPHX2)
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.10  soluble epoxide hydrolase
     2053 (EPHX2)
Protein phosphatases and associated proteins [BR:hsa01009]
 HAD phosphatases
  Other HAD phosphatases
   2053 (EPHX2)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S33
   2053 (EPHX2)
SSDB
Motif
Pfam: Abhydrolase_1 Hydrolase Abhydrolase_6 Hydrolase_4 HAD_2 Hydrolase_like Abhydrolase_2 Ndr E2_bind Resolvase
Other DBs
NCBI-GeneID: 2053
NCBI-ProteinID: NP_001970
OMIM: 132811
HGNC: 3402
Ensembl: ENSG00000120915
Pharos: P34913(Tchem)
UniProt: P34913
Structure
LinkDB
Position
8:27491143..27548626
AA seq 555 aa
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
NT seq 1668 nt   +upstreamnt  +downstreamnt
atgacgctgcgcgcggccgtcttcgaccttgacggggtgctggcgctgccagcggtgttc
ggcgtcctcggccgcacggaggaggccctggcgctgcccagaggacttctgaatgatgct
ttccagaaagggggaccagagggtgccactacccggcttatgaaaggagagatcacactt
tcccagtggataccactcatggaagaaaactgcaggaagtgctccgagaccgctaaagtc
tgcctccccaagaatttctccataaaagaaatctttgacaaggcgatttcagccagaaag
atcaaccgccccatgctccaggcagctctcatgctcaggaagaaaggattcactactgcc
atcctcaccaacacctggctggacgaccgtgctgagagagatggcctggcccagctgatg
tgtgagctgaagatgcactttgacttcctgatagagtcgtgtcaggtgggaatggtcaaa
cctgaacctcagatctacaagtttctgctggacaccctgaaggccagccccagtgaggtc
gtttttttggatgacatcggggctaatctgaagccagcccgtgacttgggaatggtcacc
atcctggtccaggacactgacacggccctgaaagaactggagaaagtgaccggaatccag
cttctcaataccccggcccctctgccgacctcttgcaatccaagtgacatgagccatggg
tacgtgacagtaaagcccagggtccgtctgcattttgtggagctgggctccggccctgct
gtgtgcctctgccatggatttcccgagagttggtattcttggaggtaccagatccctgct
ctggcccaggcaggttaccgggtcctagctatggacatgaaaggctatggagagtcatct
gctcctcccgaaatagaagaatattgcatggaagtgttatgtaaggagatggtaaccttc
ctggataaactgggcctctctcaagcagtgttcattggccatgactggggtggcatgctg
gtgtggtacatggctctcttctaccccgagagagtgagggcggtggccagtttgaatact
cccttcataccagcaaatcccaacatgtcccctttggagagtatcaaagccaacccagta
tttgattaccagctctacttccaagaaccaggagtggctgaggctgaactggaacagaac
ctgagtcggactttcaaaagcctcttcagagcaagcgatgagagtgttttatccatgcat
aaagtctgtgaagcgggaggactttttgtaaatagcccagaagagcccagcctcagcagg
atggtcactgaggaggaaatccagttctatgtgcagcagttcaagaagtctggtttcaga
ggtcctctaaactggtaccgaaacatggaaaggaactggaagtgggcttgcaaaagcttg
ggacggaagatcctgattccggccctgatggtcacggcggagaaggacttcgtgctcgtt
cctcagatgtcccagcacatggaggactggattccccacctgaaaaggggacacattgag
gactgtgggcactggacacagatggacaagccaaccgaggtgaatcagatcctcattaag
tggctggattctgatgcccggaacccaccggtggtctcaaagatgtag

KEGG   Homo sapiens (human): 253152
Entry
253152            CDS       T01001                                 
Symbol
EPHX4, ABHD7, EH4, EPHXRP
Name
(RefSeq) epoxide hydrolase 4
  KO
K22369  epoxide hydrolase 4 [EC:3.3.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    253152 (EPHX4)
   05208 Chemical carcinogenesis - reactive oxygen species
    253152 (EPHX4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    253152 (EPHX4)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S33
   253152 (EPHX4)
SSDB
Motif
Pfam: Abhydrolase_1 Abhydrolase_6 Hydrolase_4 Ndr PGAP1
Other DBs
NCBI-GeneID: 253152
NCBI-ProteinID: NP_775838
OMIM: 617401
HGNC: 23758
Ensembl: ENSG00000172031
Pharos: Q8IUS5(Tdark)
UniProt: Q8IUS5
LinkDB
Position
1:92029985..92063538
AA seq 362 aa
MARLRDCLPRLMLTLRSLLFWSLVYCYCGLCASIHLLKLLWSLGKGPAQTFRRPAREHPP
ACLSDPSLGTHCYVRIKDSGLRFHYVAAGERGKPLMLLLHGFPEFWYSWRYQLREFKSEY
RVVALDLRGYGETDAPIHRQNYKLDCLITDIKDILDSLGYSKCVLIGHDWGGMIAWLIAI
CYPEMVMKLIVINFPHPNVFTEYILRHPAQLLKSSYYYFFQIPWFPEFMFSINDFKVLKH
LFTSHSTGIGRKGCQLTTEDLEAYIYVFSQPGALSGPINHYRNIFSCLPLKHHMVTTPTL
LLWGENDAFMEVEMAEVTKIYVKNYFRLTILSEASHWLQQDQPDIVNKLIWTFLKEETRK
KD
NT seq 1089 nt   +upstreamnt  +downstreamnt
atggcgaggctgcgggattgcctgccccgcctgatgctcacgctccggtccctgctcttc
tggtccctggtctactgctactgcgggctctgcgcctccatccacctgctcaaacttttg
tggagcctcggcaaggggccggcgcagaccttccggcggcccgcccgggagcaccctccc
gcgtgcctgagcgacccctccttgggcacccactgctacgtgcggatcaaggattcaggg
ttaagatttcactatgttgctgctggagaaagaggcaaaccacttatgctgctgcttcat
ggatttccagaattctggtattcttggcgttaccaactgagagaatttaaaagtgaatat
cgagttgtagcactggatttgagaggttatggagaaacagatgctcccattcatcgacag
aattataaattggattgtctaattacagatataaaggatattttagattctttagggtat
agcaaatgtgttcttattggccatgactgggggggcatgattgcttggctaattgccatc
tgttatcctgaaatggtgatgaagcttattgttattaacttccctcatccaaatgtattt
acagaatatattttacgacaccctgctcagctgttgaaatccagttattattacttcttc
caaataccatggttcccagaatttatgttctcaataaatgatttcaaggttttgaaacat
ctgtttaccagtcacagcactggcattggaagaaaaggatgccaattaacaacagaggat
cttgaagcttatatttatgtcttttctcagcctggagcattaagtggcccaattaaccat
taccgaaatatcttcagctgcctgcctctcaaacatcacatggtgaccactccaacacta
ctactgtggggagagaatgacgcattcatggaggttgagatggctgaagtcacaaagatt
tatgttaaaaactatttcaggctaactattttgtcagaagccagtcattggcttcagcaa
gaccaacctgacatagtgaacaaattgatatggacatttctaaaagaagaaacaagaaaa
aaagattga

KEGG   Homo sapiens (human): 79852
Entry
79852             CDS       T01001                                 
Symbol
EPHX3, ABHD9, EH3
Name
(RefSeq) epoxide hydrolase 3
  KO
K22368  epoxide hydrolase 3 [EC:3.3.2.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    79852 (EPHX3)
   05208 Chemical carcinogenesis - reactive oxygen species
    79852 (EPHX3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    79852 (EPHX3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.10  soluble epoxide hydrolase
     79852 (EPHX3)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S33
   79852 (EPHX3)
SSDB
Motif
Pfam: Abhydrolase_1 Abhydrolase_6 Hydrolase_4 FSH1 Ndr
Other DBs
NCBI-GeneID: 79852
NCBI-ProteinID: NP_001136358
OMIM: 617400
HGNC: 23760
Ensembl: ENSG00000105131
Pharos: Q9H6B9(Tbio)
UniProt: Q9H6B9
LinkDB
Position
19:complement(15226919..15237008)
AA seq 360 aa
MPELVVTALLAPSRLSLKLLRAFMWSLVFSVALVAAAVYGCIALTHVLCRPRRGCCGRRR
SASPACLSDPSLGEHGFLNLKSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREF
QSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGALLAW
HFSIYYPSLVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDFQ
ILKTTLTHRKTGIPCLTPSELEAFLYNFSQPGGLTGPLNYYRNLFRNFPLEPQELTTPTL
LLWGEKDTYLELGLVEAIGSRFVPGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDLLD
NT seq 1083 nt   +upstreamnt  +downstreamnt
atgccggagctggtggtgaccgcgctgctggcgccgtcgcgcctgtcgctgaagctgctg
cgcgccttcatgtggagcctggtgttctcggtggcgctggtggccgcggcggtctacggc
tgcatagcgctcacgcacgtgctgtgccggccccggcgcggctgctgcgggcgccgtcgg
agcgcgtcccccgcctgcctgagcgacccctcgctgggtgagcacggtttcctgaacctc
aagagctcgggcctgcgtctgcactatgtctcggctggacgaggtaacggacccctcatg
ctgtttctgcacggcttccctgagaactggttctcctggcgttaccagctccgggagttc
cagagccgcttccatgttgtggctgtggacttgcgaggctatggcccctcggatgcacct
cgggatgtggactgctacacaatcgacctgctgctggtggacatcaaagatgtcatccta
ggcctgggttactcgaagtgcatccttgtggcccatgactggggtgccctccttgcctgg
catttctccatctactacccatccctggtcgagcggatggttgtggtcagtggtgccccc
atgtcggtgtaccaagactattccctgcaccacatcagccagttcttccgttcccactac
atgttcctgttccagctgccctggctgcccgagaagctgctgtctatgtctgactttcag
attctgaagaccaccctcacccaccgcaagacaggcatcccatgcttgacccccagcgag
ctcgaggccttcctttataacttctcacagcctggtggcctcactgggcccctcaactac
taccgaaacctcttcaggaacttccccctggaaccccaggagctgaccacacccacattg
ctgctgtggggggagaaggacacttacttggagctggggctggtggaagccatcggcagc
cgctttgtgccgggccgcttggaggcccacatcctgccaggcatagggcattggatccca
cagagcaacccccaggagatgcaccagtacatgtgggccttcttgcaagacctgctggac
tag

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