KEGG   Homo sapiens (human): 2897
Entry
2897              CDS       T01001                                 
Symbol
GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5
Name
(RefSeq) glutamate receptor ionotropic, kainate 1 isoform 1 precursor
  KO
K05201  glutamate receptor, ionotropic kainate 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01882  Transport of natrium, KA receptor
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2897 (GRIK1)
   04082 Neuroactive ligand signaling
    2897 (GRIK1)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2897 (GRIK1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2897 (GRIK1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2897 (GRIK1)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2897
NCBI-ProteinID: NP_000821
OMIM: 138245
HGNC: 4579
UniProt: P39086
Structure
LinkDB
Position
21:complement(29536933..29939996)
AA seq 918 aa
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI
WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG
KLIREERGIRKQSSVHTV
NT seq 2757 nt   +upstreamnt  +downstreamnt
atggagcacggcacactcctcgcccagcccgggctctggaccagggacaccagctgggca
ctcctctatttcctctgctatatcctccctcagaccgccccgcaagtactcaggatcgga
gggatttttgaaacagtggaaaatgagcctgttaatgttgaagaattagctttcaagttt
gcagtcaccagcattaacagaaaccgaaccctgatgcctaacaccacattaacctatgac
atccagagaattaacctttttgatagttttgaagcctcgcggagagcatgtgaccagctg
gctcttggtgtggctgctctctttggcccttcccatagctcctccgtcagtgctgtgcag
tctatttgcaatgctctcgaagttccacacatacagacccgctggaaacacccctcggtg
gacaacaaagatttgttttacatcaacctttacccagattatgcagctatcagcagggcg
atcctggatctggtcctctattacaactggaaaacagtgacagtggtgtatgaagacagc
acaggtctaattcgtctacaagagctcatcaaagctccctccagatataatattaaaatc
aaaatccgccagctgccctctgggaataaagatgccaagcctttactcaaggagatgaag
aaaggcaaggagttctatgtgatatttgattgttcacatgaaacagccgctgaaatcctt
aagcagattctgttcatgggcatgatgaccgagtactatcactactttttcacaaccctg
gacttatttgctttggatctggaactctataggtacagtggcgtaaacatgaccgggttt
cggctgcttaacattgacaaccctcacgtgtcatccatcattgagaagtggtccatggag
agactgcaggccccacccaggcccgagactggccttttggatggcatgatgacaactgaa
gcggctctgatgtacgatgctgtgtacatggtggccattgcctcgcaccgggcatcccag
ctgaccgtcagctccctgcagtgccatagacataagccatggcgcctcggacccagattt
atgaacctgatcaaagaggcccggtgggatggcttgactgggcatatcacctttaataaa
accaatggcttgaggaaggattttgatctggacattattagtctcaaagaggaaggaact
gaaaaggctgctggcgaagtgtctaaacacttgtataaagtgtggaagaagattgggatt
tggaattccaacagtgggcttaacatgacggacagcaacaaagacaagtccagcaatatc
actgattcattggccaacagaacactcattgtcaccaccattctggaagaaccctatgtt
atgtacaggaaatctgataagcctctatatggaaatgacagatttgaaggatattgccta
gacctgttgaaagaattgtcaaacatcctgggtttcatttatgatgttaaactagttccc
gatggcaaatatggggcccagaatgacaaaggggagtggaacgggatggttaaagaactc
atagatcacagggctgacctggcagtggctcctcttaccatcacctacgtgcgggagaaa
gtcattgacttctccaaacccttcatgaccctaggcatcagcattctctaccggaagccc
aatggtaccaatccaggcgttttctccttcctcaaccccctgtctccagatatttggatg
tatgtgctcttagcctgcttgggagtcagctgtgtactctttgtgattgcaaggtttaca
ccctacgagtggtataacccccacccatgcaaccctgactcagacgtggtggaaaacaat
tttactttactaaatagtttctggtttggagttggagctctcatgcagcaaggatcagag
ctgatgcccaaagctctatcgaccagaatagttggagggatatggtggtttttcacccta
atcatcatttcatcctacacggccaatctggctgccttcttgacagtagagagaatggaa
tcccccatagattcggcagatgatctggcaaagcaaaccaagatagaatatggggcggtt
agagatggatcaacaatgaccttcttcaagaaatcaaaaatctccacctatgagaagatg
tgggctttcatgagcagcaggcagcagaccgccctggtaagaaacagtgatgaggggatc
cagagagtgctcaccacagactacgcgctgctgatggagtccaccagcattgagtatgtg
acgcagagaaactgcaacctcactcagatcgggggcctcattgactccaaaggttacgga
gtgggaacacctattggttctccttaccgggataaaattactattgctattcttcaactc
caagaagaagggaagctgcatatgatgaaagagaagtggtggcgtgggaatggctgcccc
gaggaagacaacaaagaagccagtgccctgggagtggaaaatattggaggcatcttcatt
gttctggctgccggactggtcctttctgtatttgtagctattggagaattcatatacaaa
tcacggaagaataatgatattgaacaggctttttgtttcttttatggactgcaatgtaag
caaacccatccaaccaactccacttctggaactactttatctacggatttagaatgtggt
aaattaattcgagaggagagagggattcgaaaacagtcctcagttcatactgtgtaa

KEGG   Homo sapiens (human): 2898
Entry
2898              CDS       T01001                                 
Symbol
GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, NEDLAS
Name
(RefSeq) glutamate receptor ionotropic, kainate 2 isoform 1 precursor
  KO
K05202  glutamate receptor, ionotropic kainate 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01882  Transport of natrium, KA receptor
Disease
H00768  Autosomal recessive intellectual developmental disorder
H02894  Neurodevelopmental disorder with impaired language and ataxia and with or without seizures
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2898 (GRIK2)
   04082 Neuroactive ligand signaling
    2898 (GRIK2)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2898 (GRIK2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2898 (GRIK2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2898 (GRIK2)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2898
NCBI-ProteinID: NP_068775
OMIM: 138244
HGNC: 4580
Ensembl: ENSP00000358130.6
UniProt: Q13002 Q8IY40 A8K0H7 A0A8D9PH75
Structure
LinkDB
Position
6:101393708..102070083
AA seq 908 aa
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
NT seq 2727 nt   +upstreamnt  +downstreamnt
atgaagattattttcccgattctaagtaatccagtcttcaggcgcaccgttaaactcctg
ctctgtttactgtggattggatattctcaaggaaccacacatgtattaagatttggtggt
atttttgaatatgtggaatctggcccaatgggagctgaggaacttgcattcagatttgct
gtgaacacaattaacagaaacagaacattgctacccaatactacccttacctatgatacc
cagaagataaacctttatgatagttttgaagcatccaagaaagcctgtgatcagctgtct
cttggggtggctgccatcttcgggccttcacacagctcatcagcaaacgcagtgcagtcc
atctgcaatgctctgggagttccccacatacagacccgctggaagcaccaggtgtcagac
aacaaagattccttctatgtcagtctctacccagacttctcttcactcagccgtgccatt
ttagacctggtgcagtttttcaagtggaaaaccgtcacggttgtgtatgatgacagcact
ggtctcattcgtttgcaagagctcatcaaagctccatcaaggtataatcttcgactcaaa
attcgtcagttacctgctgatacaaaggatgcaaaacccttactaaaagaaatgaaaaga
ggcaaggagtttcatgtaatctttgattgtagccatgaaatggcagcaggcattttaaaa
caggcattagctatgggaatgatgacagaatactatcattatatctttaccactctggac
ctctttgctcttgatgttgagccctaccgatacagtggtgttaacatgacagggttcaga
atattaaatacagaaaatacccaagtctcctccatcattgaaaagtggtcgatggaacga
ttgcaggcacctccgaaacccgattcaggtttgctggatggatttatgacgactgatgct
gctctaatgtatgatgctgtgcatgtggtgtctgtggccgttcaacagtttccccagatg
acagtcagttccttgcagtgtaatcgacataaaccctggcgcttcgggacccgctttatg
agtctaattaaagaggcacattgggaaggcctcacaggcagaataactttcaacaaaacc
aatggcttgagaacagattttgatttggatgtgatcagtctgaaggaagaaggtctagaa
aagattggaacgtgggatccagccagtggcctgaatatgacagaaagtcaaaagggaaag
ccagcgaacatcacagattccttatccaatcgttctttgattgttaccaccattttggaa
gagccttatgtcctttttaagaagtctgacaaacctctctatggtaatgatcgatttgaa
ggctattgcattgatctcctcagagagttatctacaatccttggctttacatatgaaatt
agacttgtggaagatgggaaatatggagcccaggatgatgccaatggacaatggaatgga
atggttcgtgaactaattgatcataaagctgaccttgcagttgctccactggctattacc
tatgttcgagagaaggtcatcgacttttccaagccctttatgacacttggaataagtatt
ttgtaccgcaagcccaatggtacaaacccaggcgtcttctccttcctgaatcctctctcc
cctgatatctggatgtatattctgctggcttacttgggtgtcagttgtgtgctctttgtc
atagccaggtttagtccttatgagtggtataatccacacccttgcaaccctgactcagac
gtggtggaaaacaattttaccttgctaaatagtttctggtttggagttggagctctcatg
cagcaaggttctgagctcatgcccaaagcactgtccaccaggatagtgggaggcatttgg
tggtttttcacacttatcatcatttcttcgtatactgctaacttagccgcctttctgaca
gtggaacgcatggaatcccctattgactctgctgatgatttagctaaacaaaccaagata
gaatatggagcagtagaggatggtgcaaccatgacttttttcaagaaatcaaaaatctcc
acgtatgacaaaatgtgggcctttatgagtagcagaaggcagtcagtgctggtcaaaagt
aatgaagaaggaatccagcgagtcctcacctctgattatgctttcctaatggagtcaaca
accatcgagtttgttacccagcggaactgtaacctgacacagattggcggccttatagac
tctaaaggttatggcgttggcactcccatgggttctccatatcgagacaaaattaccata
gcaattcttcagctgcaagaggaaggcaaactgcatatgatgaaggagaaatggtggagg
ggcaatggttgcccagaagaggagagcaaagaggccagtgccctgggggttcagaatatt
ggtggcatcttcattgttctggcagccggcttggtgctttcagtttttgtggcagtggga
gaatttttatacaaatccaaaaaaaacgctcaattggaaaagaggtccttctgtagtgcc
atggtagaagaattgaggatgtccctgaagtgccagcgtcggttaaaacataagccacag
gccccagttattgtgaaaacagaagaagttatcaacatgcacacatttaacgacagaagg
ttgccaggtaaagaaaccatggcataa

KEGG   Homo sapiens (human): 2899
Entry
2899              CDS       T01001                                 
Symbol
GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a
Name
(RefSeq) glutamate receptor ionotropic, kainate 3 precursor
  KO
K05203  glutamate receptor, ionotropic kainate 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01882  Transport of natrium, KA receptor
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2899 (GRIK3)
   04082 Neuroactive ligand signaling
    2899 (GRIK3)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2899 (GRIK3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2899 (GRIK3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2899 (GRIK3)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2899
NCBI-ProteinID: NP_000822
OMIM: 138243
HGNC: 4581
Ensembl: ENSP00000362183.3
UniProt: Q13003
LinkDB
Position
1:complement(36795527..37034515)
AA seq 919 aa
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
NT seq 2760 nt   +upstreamnt  +downstreamnt
atgaccgctccctggcggcgcctccggagtctggtttgggaatactgggccgggctcctc
gtgtgcgccttctggatcccggactcgcgcgggatgccccacgtcatccggatcggagga
atcttcgagtatgcggacggccccaacgcccaggtcatgaatgccgaggagcatgccttt
cgattttctgccaacatcatcaacaggaacaggactctgctgcccaacacaaccttgacc
tatgacatacagaggattcacttccatgacagcttcgaggcgaccaaaaaggcctgtgac
cagctggcactgggcgtggtggcgatcttcggcccatcacagggctcctgcaccaatgcc
gtccagtccatctgcaatgccctggaggtgccccacatccagctgcgttggaagcaccac
ccgctggacaacaaggacaccttctacgtgaacctctaccccgactacgcctcgctcagc
catgccatcctcgacctggtccagtacctcaagtggcggtcagccaccgtggtctatgac
gacagtacagggctcatccgactgcaggagctcatcatggccccatcaagatacaacatc
cgcctgaagatccgtcagctccccatcgactctgacgactcgcgccccttgctcaaggag
atgaagcgaggccgggaattccgcattatcttcgactgcagccacactatggcggcccag
atcctcaagcaggccatggccatgggcatgatgactgagtactaccacttcatcttcacc
actctggatctctacgctttagacctggagccctaccgctactcaggcgtgaacctgaca
ggattccggattctcaatgtggacaacccacacgtctcggccattgtggagaagtggtcc
atggagcggctgcaggcagctccccggtccgagtctggcctgctggatggagtgatgatg
actgatgcagccttactgtacgacgccgtccatatcgtgtccgtgtgctaccagcgggca
ccacagatgaccgtgaactccctgcagtgccatcggcacaaggcctggcgctttggcggc
cgcttcatgaacttcatcaaggaggctcaatgggaaggattaactggacgaattgttttc
aacaaaactagtggcttgcggacggattttgatctggacatcatcagcctgaaagaggat
ggcctggagaaggttggggtgtggagtcctgccgacgggctcaacatcactgaggttgcc
aaaggccgaggccctaatgtcaccgactctctgacaaacagatcactcattgtcaccaca
gtgctggaggagcccttcgtcatgtttcggaaatcagacaggacgctatacgggaatgac
cggttcgagggctactgcatcgacctgctaaaggagctggcccacatccttggtttctcc
tatgagatccggctggtggaggacggcaagtacggggcacaggatgacaagggccagtgg
aacggcatggtcaaggagctcatcgaccacaaggcagatctggccgtggcccccctgacc
atcacccatgttcgagagaaggccatcgacttctccaagcccttcatgacacttggtgtg
agcatcctgtatcgaaagcccaatggcaccaaccccagcgtcttctccttcctcaatccc
ctgtccccagacatctggatgtatgttctcctcgcctacctgggggtcagctgtgtcctc
ttcgtcatcgccaggttcagcccttatgagtggtacgatgctcacccctgcaaccctggc
tccgaggtggtggaaaataacttcactctgcttaacagcttctggtttggaatgggatcc
ctgatgcagcaagggtctgagctgatgcccaaagccctgtccacacgcatcattggtggc
atctggtggttcttcacgctcatcatcatctcttcctacacggccaacctggctgccttt
ctgaccgtggagcgcatggaatcacccattgactctgctgatgacctggccaagcaaacc
aaaatcgagtatggggctgtcaaggatggggccaccatgaccttcttcaagaaatccaag
atctccaccttcgagaagatgtgggccttcatgagcagcaagccatcggcgctggtgaag
aacaacgaggagggcatccagagggccctgacggccgactacgcgctgctcatggagtcc
accaccatcgagtacgtcacgcagaggaactgcaacctcacccagatcgggggcctcatt
gactccaagggctacggcatcggcacgcccatgggctccccataccgggacaagatcacc
atcgccatcctgcagcttcaggaggaggacaagctgcatatcatgaaggagaagtggtgg
cggggcagcgggtgtcctgaggaggaaaacaaagaggccagtgccctggggatccagaag
atcgggggcatcttcattgtcctggccgccgggctggtcctctctgtgctggtggccgtg
ggcgagtttgtgtacaagctccgcaaaacagcagagagagagcagcgttccttctgcagc
accgtggccgatgagatccgtttctcccttacctgccagcgtcgagtcaagcacaagcct
cagcctcccatgatggtcaagactgacgccgtcatcaacatgcacacattcaatgaccgc
cggcttcccggcaaggacagcatggcctgcagcacatccttagcccctgtgttcccctag

KEGG   Homo sapiens (human): 2900
Entry
2900              CDS       T01001                                 
Symbol
GRIK4, EAA1, GRIK, GluK4, GluK4-2, KA1
Name
(RefSeq) glutamate receptor ionotropic, kainate 4 isoform 1 precursor
  KO
K05204  glutamate receptor, ionotropic kainate 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01882  Transport of natrium, KA receptor
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2900 (GRIK4)
   04082 Neuroactive ligand signaling
    2900 (GRIK4)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2900 (GRIK4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2900 (GRIK4)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2900 (GRIK4)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3
Other DBs
NCBI-GeneID: 2900
NCBI-ProteinID: NP_001269399
OMIM: 600282
HGNC: 4582
UniProt: Q16099 A0A8D9PH79 B2RAP6
LinkDB
Position
11:120511748..120988906
AA seq 956 aa
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG
KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK
VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY
YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG
PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV
TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG
TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP
VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA
DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF
LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK
RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS
VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ
LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE
NT seq 2871 nt   +upstreamnt  +downstreamnt
atgccccgcgtctcggcgcctttggtgctgcttcctgcgtggctcgtgatggtcgcctgc
agcccgcactccttgaggatcgctgctatcttggacgaccccatggagtgcagcagaggg
gagcggctctccatcaccctggccaagaaccgcatcaaccgcgctcctgagaggctgggc
aaggccaaggtcgaagtggacatctttgagcttctcagagacagcgagtacgagactgca
gaaaccatgtgtcagatcctccccaagggggtggtcgctgtcctcggaccatcgtccagc
ccagcctccagctccatcatcagcaacatctgtggagagaaggaggtccctcacttcaaa
gtggccccagaggagttcgtcaagttccagttccagagattcacaaccctgaacctccac
cccagcaacactgacatcagcgtggctgtagctgggatcctgaacttcttcaactgcacc
accgcctgcctcatctgtgccaaagcagaatgccttttaaacctagagaagctgctccgg
caattccttatctccaaggacacgctgtccgtccgcatgctggatgacacccgggacccc
accccgctcctcaaggagatccgggacgacaagaccgccaccatcatcatccacgccaac
gcctccatgtcccacaccatcctcctgaaggcagccgaacttgggatggtgtcagcctat
tacacatacatcttcactaatctggagttctcactccagagaatggacagccttgtggat
gatcgtgtcaacatcctgggattttccattttcaaccaatcccatgctttcttccaagag
tttgcccagagcctcaaccagtcctggcaggagaactgtgaccatgtgcccttcactggg
cctgcgctctcctcggccctgctgtttgatgctgtctatgctgtggtgactgcggtgcag
gaactgaaccggagccaagagatcggcgtgaagcccttgtcctgcggctcggcccagatc
tggcagcacggcaccagcctcatgaactacctgcgcatggtagaattggaaggtcttacc
ggccacattgaattcaacagcaaaggccagaggtccaactacgctttgaaaatcttacag
ttcacaaggaatggttttcggcagatcggccagtggcacgtggcagagggcctcagcatg
gacagccacctctatgcctccaacatctcggacactctcttcaacaccaccctggtcgtc
accaccatcctggagaacccatatttaatgctgaaggggaaccaccaggagatggaaggc
aatgaccgctacgagggcttctgtgtggacatgctcaaggagctggcagagatcctccga
ttcaactacaagatccgcctggttggggatggcgtgtacggcgttcccgaggccaacggc
acctggacgggaatggtcggggagctgatcgctaggaaagcagatctggctgtggcaggc
ctcaccattacagctgaacgggagaaggtgattgatttctctaagccattcatgactctg
ggaattagcattctttaccgcgttcatatgggacgcaaacccggctatttctccttcctg
gacccattttctccgggcgtctggctcttcatgcttctagcctatctggccgtcagctgt
gtcctcttcctggtggctcggttgacgccctacgagtggtacagcccacacccatgtgcc
cagggccggtgcaacctcctggtgaaccagtactccctgggcaacagcctctggtttccg
gtcggggggttcatgcagcaaggctccaccatcgcccctcgcgccttatccacccgctgt
gtcagtggcgtctggtgggcattcacgctgatcatcatctcatcctacacggccaacctg
gcagccttcctgaccgtgcagcgcatggatgtgcccattgagtcagtggatgacctggct
gaccagaccgccattgaatatggcacaattcacggaggctccagcatgaccttcttccaa
aattcccgctaccagacctaccaacgcatgtggaattacatgtattccaagcagcccagc
gtgttcgtgaagagcacagaggagggaatcgccagggtgttgaattccaactacgccttc
ctcctggaatccaccatgaacgagtactatcggcagcgaaactgcaacctcactcagatt
gggggcctgctggacaccaagggctatgggattggcatgccagtcggctcggttttccgg
gacgagtttgatctggccattctccagctgcaggagaacaaccgcctggagatcctgaag
cgcaaatggtgggaaggagggaagtgccccaaggaggaagatcacagagctaaaggcctg
ggaatggagaatattggtggaatctttgtggttcttatttgtggcttaatcgtggccatt
tttatggctatgttggagtttttatggactctcagacactcagaagcaactgaggtgtcc
gtctgccaggagatggtgaccgagctgcgcagcattatcctgtgtcaggacagtatccac
ccccgccggcggcgcgccgcagtcccgccgccccggccccccatccccgaggagcgccga
ccgcggggcacggcgacgctcagcaacgggaagctgtgcggggcaggggagcccgaccag
ctcgcgcagagactggcgcaggaggccgccctggtggcccgcggctgcacgcacatccgc
gtctgccccgagtgccgccgcttccagggcctgcgggcacggccgtcgcccgcccgcagc
gaggagagcctggagtgggagaaaaccaccaacagcagcgagcccgagtag

KEGG   Homo sapiens (human): 2901
Entry
2901              CDS       T01001                                 
Symbol
GRIK5, EAA2, GRIK2, GluK5, KA2
Name
(RefSeq) glutamate receptor ionotropic, kainate 5 isoform 2 precursor
  KO
K05205  glutamate receptor, ionotropic kainate 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01882  Transport of natrium, KA receptor
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2901 (GRIK5)
   04082 Neuroactive ligand signaling
    2901 (GRIK5)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2901 (GRIK5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2901 (GRIK5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2901 (GRIK5)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2901
NCBI-ProteinID: NP_002079
OMIM: 600283
HGNC: 4583
Ensembl: ENSP00000470251.1
UniProt: Q16478
LinkDB
Position
19:complement(41998324..42070206)
AA seq 980 aa
MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK
ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV
GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG
FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY
KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP
ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG
RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT
TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS
WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD
PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV
GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD
QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL
LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR
KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS
VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG
SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA
TSPPRPRPGPAGPRELAEHE
NT seq 2943 nt   +upstreamnt  +downstreamnt
atgccggctgagctgctgctgctgctgattgttgccttcgccagccccagctgccaggtg
ctctcatcactgcgcatggctgcaatcctggatgatcagacagtgtgtggccgcggtgag
cgtctggccttggccttggcccgggagcagatcaacgggatcatcgaggtcccagccaag
gcccgagtggaagtagacatctttgagctgcagcgggacagccagtacgagaccacggac
accatgtgtcagatcttacccaaaggggttgtgtctgtccttgggccctcctctagccca
gcatctgcctccaccgtgagccatatctgtggagagaaggagatcccccacatcaaggtg
ggtcccgaggagacaccccgccttcagtaccttcgcttcgcgtctgtcagcctgtacccc
agtaacgaggacgtcagcttggcggtctcccgaatcctcaagtccttcaactacccctcg
gccagcctcatctgcgccaaggctgagtgcctgctgcgattggaggaactggtgcgtggc
ttcctcatctccaaggagacgctgtcagtgaggatgttggacgacagccgggaccccaca
ccactgctcaaggagatccgtgatgacaaggtgtccaccatcatcatcgacgccaacgcc
tccatctcccacctcatcctccgtaaggcctcggaactgggaatgacctcagcgttttac
aagtacatcctcaccaccatggacttccccatcctgcatctggacggtattgtggaggac
tcctccaacatcctgggcttctccatgttcaacacgtcccaccccttctaccctgagttt
gtccgcagcctcaacatgtcctggagggagaactgtgaagccagcacctacctgggccct
gcgctgtcagccgccctgatgtttgacgccgtgcacgtggtggtgagcgctgtccgagag
ctgaaccgcagccaggagatcggtgtgaagcctctggcctgtacatcggccaacatttgg
ccccacgggaccagcctcatgaactacctgcgcatggtagagtatgatgggctgaccggg
cgggtcgagttcaacagcaaagggcagagaaccaactacaccctgcgcatcctagaaaag
tcccggcagggccaccgtgagattggggtgtggtactctaaccgcaccctggccatgaat
gccaccaccctggacatcaacctgtcgcagacactggccaacaagaccctggtggtcaca
accatcctggagaacccatacgtcatgcgccggcccaacttccaggccctgtcggggaac
gaacgcttcgagggcttctgcgtggacatgctgcgggagctggccgagctgctgcgcttc
cgctaccgcctgcggttggtggaggatgggctgtacggggcgcccgagcccaacggctcc
tggacgggcatggttggcgagctcatcaaccggaaggcagacctggctgtggccgccttc
accatcacagctgagcgggagaaggtcatcgacttttccaagccctttatgaccctgggg
atcagcatcctctaccgagtgcacatgggccgcaagcctggctacttctccttcctggac
cccttctcccctgctgtgtggctcttcatgcttcttgcctacctggctgtcagctgcgtc
ctgtttctggctgccaggctgagcccctatgagtggtataacccacacccatgcctgcgg
gcacgcccccacatcctggagaaccagtacacgctgggcaacagcctgtggtttcccgtg
gggggcttcatgcagcagggctcggagatcatgccccgggcgctgtccacgcgctgtgtc
agcggagtctggtgggccttcaccttgatcatcatctcctcctacacggccaacctggcc
gccttcctcaccgtgcagcgcatggaggtgcctgtggagtcggccgatgacctggcagat
cagaccaacatcgagtatggcaccatccacgccggctccaccatgaccttcttccagaat
tcacggtaccaaacgtaccagcgcatgtggaactacatgcagtcgaagcagcccagcgtg
ttcgtcaagagcacagaagagggcattgcccgcgtcctcaactcccgctacgccttcctg
ctcgagtccaccatgaacgaataccaccggcgcctcaactgcaacctcacccagatcggg
ggactcctcgacaccaagggctacggcattggcatgccgctgggctccccgttccgggat
gagatcacactggccatcctgcagcttcaggagaacaaccggctggagatcctgaagcgc
aagtggtgggaggggggccggtgccccaaggaggaggaccatcgagctaaaggtttgggc
atggagaacattggtggcatttttatcgtgctcatctgtggcctcatcattgctgtcttc
gtggcggtcatggaattcatatggtccacacggaggtcagctgagtccgaggaggtgtcg
gtgtgccaggagatgctgcaggagctgcgccacgccgtttcttgccgcaagacgtcgcgt
tcccgccggcgccgacgcccgggcggcccgagccgggccctgctgtcactgcgcgcggtc
cgcgagatgcgcctcagcaacggcaagctctactcggccggcgcgggcggggatgcgggc
agcgcgcacgggggcccgcagcgcctcctggacgacccggggccccccagcggagcccga
cccgccgcccccaccccctgcacccacgtgcgcgtctgccaggagtgccggcgcatccag
gcgctgcgggcctcgggggccggcgcgcctccgcgtggcctgggcgtccccgccgaagcc
accagcccgccccggccgcggcctggccccgccggcccccgggagctggcggagcacgag
tga

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