Homo sapiens (human): 3339 Help Entry 3339              CDS       T01001                                  Symbol HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1 Name (RefSeq) heparan sulfate proteoglycan 2   KO K06255   basement membrane-specific heparan sulfate proteoglycan core protein Organism hsa  Homo sapiens (human) Pathway hsa04512   ECM-receptor interaction hsa04820   Cytoskeleton in muscle cells hsa05161   Hepatitis B hsa05205   Proteoglycans in cancer Network nt06539  Cytoskeleton in muscle cells   Element N01814   Extracellular matrix - Basal lamina Disease H00493   Heparan sulfate proteoglycan gene defects H01777   Schwartz-Jampel syndrome H02155   Dyssegmental dysplasia Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04512 ECM-receptor interaction     3339 (HSPG2)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     3339 (HSPG2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     3339 (HSPG2)   09172 Infectious disease: viral    05161 Hepatitis B     3339 (HSPG2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     3339 (HSPG2)    00535 Proteoglycans [BR:hsa00535]     3339 (HSPG2) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    3339 (HSPG2) Proteoglycans [BR:hsa00535]  Extracellular matrix (ECM) proteoglycans   Basement membrane proteoglycans    3339 (HSPG2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 Ig_2 ig Laminin_B V-set Laminin_G_1 Laminin_G_2 Laminin_EGF C2-set_2 Ldl_recept_a Ig_6 Laminin_G_3 C2-set EGF hEGF Motif Other DBs NCBI-GeneID:  3339 NCBI-ProteinID:  NP_005520 OMIM:  142461 HGNC:  5273 Ensembl:  ENSG00000142798 UniProt:  P98160 Structure PDB LinkDB All DBs Position 1:complement(21822244..21937310) Genome browser AA seq 4391 aa AA seqDB search MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDML ADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLE SEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTS PQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLG ISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE AMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQI RLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPE QFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQR QVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHAT SHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHC LNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCD ACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVG RLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAS THTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPG STPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMA LAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDC DTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQR GTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQG QPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGA QLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGN NIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSV PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVE VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSD AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRL PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQV VVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK RGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGST QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPA DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV AGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANN NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW HKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRL NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDS GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ LVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVV RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG YPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE RVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ PDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAH GISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCV NRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPL APDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAER LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEV SVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLC EHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPG QYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFI SLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSP GPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRA QAGANTRPCPS NT seq 13176 nt NT seq  +upstreamnt  +downstreamnt atggggtggcgggcggcgggcgcgctgctgctggcgctgctgctgcacgggcggctgctg gcggtgacccatgggctgagggcatacgatggcttgtctctgcctgaggacatagagacc gtcacagcaagccaaatgcgctggacacattcgtacctttctgatgatgaggacatgctg gctgacagcatctcaggagacgacctgggcagtggggacctgggcagcggggacttccag atggtttatttccgagccctggtgaatttcactcgctccatcgagtacagccctcagctg gaggatgcaggctccagagagttccgagaggtgtccgaggctgtggtagacacgctggag tcggagtacttgaaaattcccggagaccaggttgtcagtgtggtgttcatcaaggagctg gatggctgggtttttgtggagctggatgtgggctcggaagggaatgcggatggggctcag attcaggagatgctgctcagggtcatctccagcggctctgtggcctcctacgtcacctct ccccagggattccagttccgacgcctgggcacagtgccccagttcccaagagcctgcacg gaggccgagtttgcctgccacagctacaatgagtgtgtggccctggagtatcgctgtgac cggcggcccgactgcagggacatgtctgatgagctcaattgtgaggagccagtcctgggt atcagccccacattctctctccttgtggagacgacatctttaccgccccggccagagaca accatcatgcgacagccaccagtcacccacgctcctcagcccctgcttcccggttccgtc aggcccctgccctgtgggccccaggaggccgcatgccgcaatgggcactgcatccccaga gactacctctgcgacggacaggaggactgcgaggacggcagcgatgagctagactgtggc cccccgccaccctgtgagcccaacgagttcccctgcgggaatggacattgtgccctcaag ctgtggcgctgcgatggtgactttgactgtgaggaccgaactgatgaagccaactgcccc accaagcgtcctgaggaagtgtgcgggcccacacagttccgatgcgtctctaccaacatg tgcatcccagccagcttccactgtgacgaggagagcgactgtcctgaccggagcgacgag tttggctgcatgcccccccaggtggtgacacctccccgggagtccatccaggcttcccgg ggccagacagtgaccttcacctgcgtggccattggcgtccccacccccatcatcaattgg aggctcaactggggccacatcccctctcatcccagggtgacagtgaccagcgagggtggc cgtggcacactgatcatccgtgatgtgaaggagtcagaccagggtgcctacacctgtgag gccatgaacgcccggggcatggtgtttggcattcctgacggtgtccttgagctcgtccca caacgaggcccctgccctgacggccacttctacctggagcacagcgccgcctgcctgccc tgcttctgctttggcatcaccagcgtgtgccagagcacccgccgcttccgggaccagatc aggctgcgctttgaccaacccgatgacttcaagggtgtgaatgtgacaatgcctgcgcag cccggcacgccacccctctcctccacgcagctgcagatcgacccatccctgcacgagttc cagctagtcgacctgtcccgccgcttcctcgtccacgactccttctgggctctgcctgaa cagttcctgggcaacaaggtggactcctatggcggctccctgcgttacaacgtgcgctac gagttggcccgtggcatgctggagccagtgcagcggccggacgtggtcctcatgggtgcc gggtaccgcctcctctcccgaggccacacacccacccaacctggtgctctgaaccagcgc caggtccagttctctgaggagcactgggtccatgagtctggccggccggtgcagcgcgcg gagctgctgcaggtgctgcagagcctggaggccgtgctcatccagaccgtgtacaacacc aagatggccagcgtgggacttagcgacatcgccatggataccaccgtcacccatgccacc agccatggccgtgcccacagtgtggaggagtgcagatgccccattggctattctggcttg tcctgcgagagctgtgatgcccacttcactcgggtgcctggtgggccctacctgggcacc tgctctggttgcaattgcaatggccatgccagctcctgtgaccctgtgtatggccactgc ctgaattgccagcacaacacggaggggccacagtgcaacaagtgcaaggctggcttcttt ggggacgccatgaaggccacggccacttcctgccggccctgcccttgcccatacatcgat gcctcccgcagattctcagacacttgcttcctggacacggatggccaagccacatgtgac gcctgtgccccaggctacactggccgccgctgtgagagctgtgcccccggatacgagggc aaccccatccagcccggcgggaagtgcaggcccgtcaaccaggagattgtgcgctgtgac gagcgtggcagcatggggacctccggggaggcctgccgctgtaagaacaatgtggtgggg cgcttgtgcaatgaatgtgctgacggctctttccacctgagtacccgaaaccccgatggc tgcctcaagtgcttctgcatgggtgtcagtcgccactgcaccagctcttcatggagccgt gcccagttgcatggggcctctgaggagcctggtcacttcagcctgaccaacgccgcaagc acccacaccaccaacgagggcatcttctcccccacgcccggggaactgggattctcctcc ttccacagactcttatctggaccctacttctggagcctcccttcacgcttcctgggggac aaggtgacctcctatggaggagagctgcgcttcacagtgacccagaggtcccagccgggc tccacacccctgcacgggcagccgttggtggtgctgcaaggtaacaacatcatcctagag caccatgtggcccaggagcccagccccggccagcccagcaccttcattgtgcctttccgg gagcaagcatggcagcggcccgatgggcagccagccacacgggagcacctgctgatggca ctggcaggcatcgacaccctcctgatccgagcatcctacgcccagcagcccgctgagagc agggtctctggcatcagcatggacgtggctgtgcccgaggaaaccggccaggaccccgcg ctggaagtggaacagtgctcctgcccacccgggtaccgtgggccgtcctgccaggactgt gacacaggctacacacgcacgcccagtggcctctacctgggtacctgtgaacgctgcagc tgccatggccactcagaggcctgcgagccagaaacaggtgcctgccagggctgccagcat cacacggagggccctcggtgtgagcagtgccagccaggatactacggggacgcccagcgg gggacaccacaggactgccagctgtgcccctgctacggagaccctgctgccggccaggct gcccacacttgttttctggacacagacggccaccccacctgtgatgcgtgctccccaggc cacagtgggcgtcactgtgagaggtgcgcccctggctactatggcaaccccagccagggc cagccatgccagagagacagccaggtgccagggcccataggctgcaactgtgacccccaa ggcagcgtcagcagccagtgtgatgctgctggtcagtgccagtgcaaggcccaggtggaa ggcctcacttgcagccactgccggccccaccacttccacctgagtgccagcaacccagac ggctgcctgccctgcttctgtatgggcatcacccagcagtgcgccagctctgcctacaca cgccacctgatctccacccactttgcccctggggacttccaaggctttgccctggtgaac ccacagcgaaacagccgcctgacaggagaattcactgtggaacccgtgcccgagggtgcc cagctctcttttggcaactttgcccaactcggccatgagtccttctactggcagctgccg gagacataccagggagacaaggtggcggcctacggtgggaagttgcgatacaccctctcc tacacagcaggcccacagggcagcccactctctgaccccgatgtgcagatcacgggcaac aacatcatgctagtggcctcccagccagcgctgcagggccctgagaggaggagctacgag atcatgttccgagaggaattctggcgccggcccgatgggcagccggccacacgcgagcac ctcctgatggcactggccgacctggatgagctcctgatccgggccacgttctcctccgtg ccgctggcggccagcatcagcgcagtcagcctggaggtcgcccagccggggccctcaaac agaccccgcgccctcgaggtggaggagtgccgctgcccgccaggctacatcggtctgtcc tgccaggactgtgcccccggctacacgcgcaccgggagtgggctctacctcggccactgc gagctatgtgaatgcaatggccactcagacctgtgccacccagagactggggcctgctcg caatgccagcacaacgccgcaggggagttctgcgagctttgtgcccctggctactacgga gatgccacagccgggacgcctgaggactgccagccctgtgcctgcccactgaccaaccca gagaacatgttttcccgcacctgtgagagcctgggagccggcgggtaccgctgcacggcc tgcgaacccggctacactggccagtactgtgagcagtgtggcccaggttacgtgggtaac cccagtgtgcaagggggccagtgcctgccagagacaaaccaagccccactggtggtcgag gtccatcctgctcgaagcatagtgccccaaggtggctcccactccctgcggtgtcaggtc agtgggagcccaccccactacttctattggtcccgtgaggatgggcggcctgtgcccagc ggcacccagcagcgacatcaaggctccgagctccacttccccagcgtccagccctcggat gctggggtctacatttgcacctgccgtaatctccaccaatccaataccagccgggcagag ctgctggtcactgaggctccaagcaagcccatcacagtgactgtggaggagcagcggagc cagagcgtgcgccccggagctgacgtcaccttcatctgcacagccaaaagcaagtcccca gcctataccctggtgtggacccgcctgcacaacgggaaactgcccacccgagccatggat ttcaatggcatcctgaccattcgcaacgtccagctgagtgatgcaggcacctacgtgtgc accggctccaacatgtttgccatggaccagggcacagccactctacatgtgcaggcctcg ggcaccttgtccgcccccgtggtctccatccatccgccacagctcacagtgcagcccggg caactggcggagttccgctgcagcgccacagggagccccacgcccaccctcgagtggaca gggggccccggcggccagctccctgcgaaggcacaaatccacggcggcatcctgcgcctg ccagctgtcgagcccacggatcaggcccagtacttgtgccgagcccacagcagcgctggg cagcaggtggccagggctgtgctccacgtgcatgggggcggtgggcccagagtccaagtg agcccagagaggacccaggtccacgcaggccgcaccgtcaggctgtactgcagggctgca ggcgtgcctagcgccaccatcacctggaggaaggaagggggcagcctcccaccacaggcc cggtcagagcgcacagacatcgcgacactgctcatcccagccatcacgactgctgacgcc ggcttctacctctgcgtggccaccagccctgcaggcactgcccaggcccggatccaagtg gttgtcctttcagcctcagatgccagcccaccgccggtcaagattgagtcctcatcgcct tctgtgacagaagggcaaacactcgacctcaactgtgtggtggcagggtcagcccatgcc caggtcacctggtacaggcgagggggtagcctgcctccccacacccaggtgcacggctcc cgtctgcggctcccccaggtctcaccagctgattctggagaatatgtgtgccgtgtggag aatggatcgggccccaaggaggcctccattactgtgtctgtgctccacggcacccattct ggccccagctacaccccagtgcccggcagcacccggcccatccgcatcgagccctcctcc tcacacgtggcggaagggcagaccctggatctgaactgcgtggtgcccgggcaggcccac gcccaggtcacgtggcacaagcgtgggggcagcctccctgcccggcaccagacccacggc tcgctgctgcggctgcaccaggtgaccccggccgactcaggcgagtatgtgtgccatgtg gtgggcacctccggccccctagaggcctcagtcctggtcaccatcgaagcctctgtcatc cctggacccatcccacctgtcaggatcgagtcttcatcctccacagtggccgagggccag accctggatctgagctgcgtggtggcagggcaggcccacgcccaggtcacatggtacaag cgtgggggcagcctccctgcccggcaccaggttcgtggctcccgcctgtacatcttccag gcctcacctgccgatgcgggacagtacgtctgccgggccagcaacggcatggaggcctcc atcacggtcacagtaactgggacccagggggccaacttagcctaccctgccggcagcacc cagcccatccgcatcgagccctcctcctcgcaagtggcggaagggcagaccctggatctg aactgcgtggtgcccgggcagtcccatgcccaggtcacgtggcacaagcgtgggggcagc ctccctgtccggcaccagacccacggctccctgctgagactctaccaagcgtcccccgcc gactcgggcgagtacgtgtgccgagtgttgggcagctccgtgcctctagaggcctctgtc ctggtcaccattgagcctgcgggctcagtgcctgcacttggggtcacccccacggtccgg atcgagtcatcgtcttcgcaagtggccgaggggcagaccctggacctgaactgcctcgtt gctggtcaggcccatgcccaggtcacgtggcacaagcgcgggggcagcctcccggcccgg caccaggtgcatggctcgaggctacgcctgctccaggtgaccccagctgattcaggggag tacgtgtgccgtgtggtcggcagctcaggtacccaggaagcctcagtccttgtcaccatc cagcagcgccttagtggctcccactcccagggtgtggcgtaccccgtccgcatcgagtcc tcctcagcctccctggccaatggacacaccctggacctcaactgcctggttgccagccag gctccccacaccatcacctggtataagcgtggaggcagcttacccagccggcaccagatc gtgggctcccggctgcggatccctcaggtgactccggcagactcgggcgagtacgtgtgt cacgtcagtaacggtgcaggctcccgggagacctcgctcatcgtcaccatccagggcagc ggttcctcccacgtgcccagcgtctccccaccgatcaggatcgagtcgtcttcccccacg gtggtggaagggcagaccttggatctgaactgcgtggtcgccaggcagccccaggctatc atcacatggtacaagcgtgggggcagccttccctcccgacaccagacccatggctcccac ctgcggttgcaccaaatgtctgtggctgactcgggcgagtatgtgtgccgggccaacaac aacatcgatgccctggaggcctccatcgtcatctccgtctcccctagcgccggcagcccc tccgcccctggcagctccatgcccatcagaattgagtcatcctcctcacacgtggccgaa ggggagaccctggatctgaactgcgtggtccccgggcaggcccatgcccaggtcacttgg cacaagcgtgggggcagcctccccagtcaccatcagacccgcggctcacggctgcggctg caccatgtgtccccggccgactcgggtgaatacgtgtgccgggtgatgggcagctctggc cccctggaggcctcagtcctggtcaccatcgaagcctctggctcaagtgctgtccacgtc cccgccccaggtggagccccacccatccgcatcgagccctcctcctcccgagtggcagaa gggcagaccctggatctgaagtgcgtggtgcccgggcaggcccacgcccaggtcacgtgg cacaagcgtggaggaaacctccctgcccggcaccaggtccacggcccactgctgaggctg aaccaggtgtccccggctgactctggcgagtactcgtgccaagtgaccggaagctcaggc accctggaggcatctgtcctggtcacaattgagccctccagcccaggacccattcctgct ccaggactggcccagcccatctacatcgaggcctcctcttcacacgtgactgaagggcag actctggatctgaactgtgtggtgcccgggcaggcccatgcccaggtcacgtggtacaag cgcgggggcagcctccccgcccggcaccagacccatggctcccagctgcggctccacctc gtctcccctgccgactcaggcgagtatgtgtgtcgtgcagccagcggcccaggccctgag caagaagcctccttcacagtcaccgtcccgcccagtgaggggtcttcctaccgccttagg agcccggtcatctccatcgacccgcccagcagcaccgtgcagcagggccaggatgccagc ttcaagtgcctcatccatgacggggcagcccccatcagcctcgagtggaagacccggaac caggagctggaggacaacgtccacatcagtcccaatggctccatcatcaccatcgtgggc acccggcccagcaaccacggtacctaccgctgcgtggcctccaatgcctacggtgtggcc cagagtgtggtgaacctcagtgtgcacgggccccctacagtgtccgtgctccccgagggc cccgtgtgggtgaaagtgggaaaggctgtcaccctggagtgtgtcagtgccggggagccc cgctcctctgctcgttggacccggatcagcagcacccctgccaagttggagcagcggaca tatgggctcatggacagccacgcggtgctgcagatttcatcagctaaaccatcagatgcg ggcacttatgtgtgccttgctcagaatgcactaggcacagcacagaagcaggtggaggtg atcgtggacacgggcgccatggccccaggggcccctcaggtccaagctgaagaagctgag ctgactgtggaggctggacacacggccaccttgcgctgctcagccacaggcagccccgcg cccaccatccactggtccaagctgcgttccccactgccctggcagcaccggctggaaggt gacacactcatcataccccgggtagcccagcaggactcgggccagtacatctgcaatgcc actagccctgctgggcacgctgaggccaccatcatcctgcacgtggagagcccaccatat gccaccacggtcccagagcacgcttcggtgcaggcaggggagacggtgcagctccagtgc ctggctcacgggacacccccactcaccttccagtggagccgcgtgggcagcagccttcct gggagggcgaccgccaggaacgagctgctgcactttgagcgtgcagcccctgaggactca ggccgctaccgctgccgggtcaccaacaaggtgggctcagccgaggcctttgcccagctg ctcgtccaaggccctcccggctctctccctgccacctccatcccagcagggtccacgccc accgtgcaggtcacgcctcagctagagaccaagagcattggggccagcgttgagttccac tgtgctgtgcccagcgaccggggtacccagctccgttggttcaaggaagggggtcagctg cctccgggtcacagcgtgcaggatggggtgctccgaatccagaacttggaccagagctgc caagggacgtatatatgccaggcccatggaccttgggggaaggcccaggccagtgcccag ctggttatccaagccctgccctcggtgctcatcaacatccggacctctgtgcagaccgtg gtggttggccacgccgtggagttcgaatgcctggcactgggtgaccccaagcctcaggtg acatggagcaaagttggagggcacctgcggccaggcattgtgcagagcggaggtgtcgtc aggatcgcccacgtagagctggctgatgcgggacagtatcgctgcactgccaccaacgca gctggcaccacacaatcccacgtcctgctgcttgtgcaagccttgccccagatctcaatg ccccaagaagtccgtgtgcctgctggttctgcagctgtcttcccctgcatagcctcaggc taccccactcctgacatcagctggagcaagctggatggcagcctgccacctgacagccgc ctggagaacaacatgctgatgctgccctcagtccgaccccaggacgcaggtacctacgtc tgcaccgccactaaccgccagggcaaggtcaaagcctttgcccacctgcaggtgccagag cgggtggtgccctacttcacgcagaccccctactccttcctaccgctgcccaccatcaag gatgcctacaggaagttcgagatcaagatcaccttccggcccgactcagccgatgggatg ctgctgtacaatgggcagaagcgagtcccagggagccccaccaacctggccaaccggcag cccgacttcatctccttcggcctcgtggggggaaggcccgagttccggttcgatgcaggc tcaggcatggccaccatccgccatcccacaccactggccctgggccatttccacaccgtg accctgctgcgcagcctcacccagggctccctgattgtgggtgacctggccccggtcaat gggacctcccagggcaagttccagggcctggatctgaacgaggaactctacctgggtggc tatcctgactatggtgccatccccaaggcggggctgagcagcggcttcataggctgtgtc cgggagctgcgcatccagggcgaggagatcgtcttccatgacctcaacctcacggcgcac ggcatctcccactgccccacctgtcgggaccggccctgccagaatggcggtcagtgccat gactctgagagcagcagctacgtgtgcgtctgcccagctggcttcaccgggagccgctgt gagcactcgcaggccctgcactgccatccagaggcctgtgggcccgacgccacctgtgtg aaccggcctgacggtcgaggctacacctgccgctgccacctgggccgctcggggttgcgg tgtgaggaaggtgtgacagtgaccaccccctcgctgtcgggtgctggctcctacctggca ctgcccgccctcaccaacacacaccacgagctacgcctggacgtggagttcaagccactc gcccctgacggggtcctgctgttcagcggggggaagagcgggcctgtggaggacttcgtg tccctggcgatggtgggcggccacctggagttccgctatgagttggggtcagggctggcc gttctgcggagcgccgagccgctggccctgggccgctggcaccgtgtgtctgcagagcgt ctcaacaaggacggcagcctgcgggtgaatggtggacgccctgtgctgcgctcctcgccc ggcaagagccagggcctcaacctgcacaccctgctctacctggggggtgtggagccttcc gtgccactgtccccggccaccaacatgagcgctcacttccgcggctgtgtgggcgaggtg tcagtgaatggcaaacggctggacctcacctacagtttcctaggcagccagggcatcggg caatgctatgatagctccccatgtgagcgccagccttgccaacatggtgccacgtgcatg cccgctggcgagtatgagttccagtgcctgtgtcgagatggattcaaaggagacctgtgt gagcacgaggagaacccctgccagctccgtgaaccctgtctgcatgggggcacctgccag ggcacccgctgcctctgcctccctggcttctctggcccacgctgccaacaaggctctgga catggcatagcagagtccgactggcatcttgaaggcagcgggggcaatgatgcccctggg cagtacggagcctatttccacgatgatggcttcctcgccttccctggccatgtcttctcc aggagcctgcccgaggtgcccgagaccatcgagctggaggttcggaccagcacagccagt ggcctcctgctctggcagggtgtggaggtgggagaggccggccaaggcaaggacttcatc agcctcgggcttcaagacgggcaccttgtcttcaggtaccagctgggtagtggggaggcc cgcctggtctctgaggaccccatcaatgacggcgagtggcaccgggtgacagcactgcgg gagggccgcagaggttccatccaagtcgacggtgaggagctggtcagcggccggtcccca ggtcccaacgtggcagtcaacgccaagggcagcgtctacatcggcggagcccctgacgtg gccacgctgaccgggggcagattctcctcaggcatcacaggctgtgtcaagaacctggtg ctgcactcggcccgacccggcgccccgcccccacagcccctggacctgcagcaccgcgcc caggccggggccaacacacgcccctgcccctcgtag

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