Entry
Symbol
HSPG2
Name
basement membrane-specific heparan sulfate proteoglycan core protein
Pathway
Disease
H00493 Heparan sulfate proteoglycan gene defects
H01777 Schwartz-Jampel syndrome
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09120 Genetic Information Processing
09125 Information processing in viruses
03272 Virion - Hepatitis viruses
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
09140 Cellular Processes
09142 Cell motility
04820 Cytoskeleton in muscle cells
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
09172 Infectious disease: viral
05161 Hepatitis B
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
00535 Proteoglycans
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
Exosome [BR:ko04147 ]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
Proteoglycans [BR:ko00535 ]
Extracellular matrix (ECM) proteoglycans
Basement membrane proteoglycans
K06255 HSPG2; heparan sulfate proteoglycan 2 (perlecan)
BRITE hierarchy
Genes
» show all
Taxonomy UniProt
Reference
Authors
Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV
Title
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
Journal
J Biol Chem 267:8544-57 (1992)
Sequence
Reference
Authors
Whitelock JM, Melrose J, Iozzo RV
Title
Diverse cell signaling events modulated by perlecan.
Journal
LinkDB
All DBs