KEGG   Homo sapiens (human): 3426
Entry
3426              CDS       T01001                                 
Symbol
CFI, AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF
Name
(RefSeq) complement factor I
  KO
K01333  complement factor I [EC:3.4.21.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
Network
nt06513  Complement cascade
  Element
N01495  Classical/Lectin pathway of complement cascade, C4b breakdown
N01496  Alternative pathway of complement cascade, C3b breakdown
N01527  KSHV Kaposin to classical/Lectin pathway of complement cascade, C4b breakdown
N01528  KSHV Kaposin to alternative pathway of complement cascade, C3b breakdown
Disease
H00106  Complement regulatory protein defects
H00821  Age-related macular degeneration
H01434  Atypical hemolytic uremic syndrome
H02579  C3 glomerulopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3426 (CFI)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3426 (CFI)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3426 (CFI)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3426 (CFI)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.45  complement factor I
     3426 (CFI)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   3426 (CFI)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3426 (CFI)
SSDB
Motif
Pfam: Trypsin CFAI_KAZAL Ldl_recept_a CFAI_FIMAC_N SRCR C7_KAZAL Trypsin_2
Other DBs
NCBI-GeneID: 3426
NCBI-ProteinID: NP_000195
OMIM: 217030
HGNC: 5394
Ensembl: ENSG00000205403
UniProt: P05156 A8K3L0
Structure
LinkDB
Position
4:complement(109730982..109801999)
AA seq 583 aa
MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
NT seq 1752 nt   +upstreamnt  +downstreamnt
atgaagcttcttcatgttttcctgttatttctgtgcttccacttaaggttttgcaaggtc
acttatacatctcaagaggatctggtggagaaaaagtgcttagcaaaaaaatatactcac
ctctcctgcgataaagtcttctgccagccatggcagagatgcattgagggcacctgtgtt
tgtaaactaccgtatcagtgcccaaagaatggcactgcagtgtgtgcaactaacaggaga
agcttcccaacatactgtcaacaaaagagtttggaatgtcttcatccagggacaaagttt
ttaaataacggaacatgcacagccgaaggaaagtttagtgtttccttgaagcatggaaat
acagattcagagggaatagttgaagtaaaacttgtggaccaagataagacaatgttcata
tgcaaaagcagctggagcatgagggaagccaacgtggcctgccttgaccttgggtttcaa
caaggtgctgatactcaaagaaggtttaagttgtctgatctctctataaattccactgaa
tgtctacatgtgcattgccgaggattagagaccagtttggctgaatgtacttttactaag
agaagaactatgggttaccaggatttcgctgatgtggtttgttatacacagaaagcagat
tctccaatggatgacttctttcagtgtgtgaatgggaaatacatttctcagatgaaagcc
tgtgatggtatcaatgattgtggagaccaaagtgatgaactgtgttgtaaagcatgccaa
ggcaaaggcttccattgcaaatcgggtgtttgcattccaagccagtatcaatgcaatggt
gaggtggactgcattacaggggaagatgaagttggctgtgcaggctttgcatctgtgact
caagaagaaacagaaattttgactgctgacatggatgcagaaagaagacggataaaatca
ttattacctaaactatcttgtggagttaaaaacagaatgcacattcgaaggaaacgaatt
gtgggaggaaagcgagcacaactgggagacctcccatggcaggtggcaattaaggatgcc
agtggaatcacctgtgggggaatttatattggtggctgttggattctgactgctgcacat
tgtctcagagccagtaaaactcatcgttaccaaatatggacaacagtagtagactggata
caccccgaccttaaacgtatagtaattgaatacgtggatagaattattttccatgaaaac
tacaatgcaggcacttaccaaaatgacatcgctttgattgaaatgaaaaaagacggaaac
aaaaaagattgtgagctgcctcgttccatccctgcctgtgtcccctggtctccttaccta
ttccaacctaatgatacatgcatcgtttctggctggggacgagaaaaagataacgaaaga
gtcttttcacttcagtggggtgaagttaaactaataagcaactgctctaagttttacgga
aatcgtttctatgaaaaagaaatggaatgtgcaggtacatatgatggttccatcgatgcc
tgtaaaggggactctggaggccccttagtctgtatggatgccaacaatgtgacttatgtc
tggggtgttgtgagttggggggaaaactgtggaaaaccagagttcccaggtgtttacacc
aaagtggccaattattttgactggattagctaccatgtaggaaggccttttatttctcag
tacaatgtataa

KEGG   Homo sapiens (human): 1378
Entry
1378              CDS       T01001                                 
Symbol
CR1, C3BR, C4BR, CD35, KN
Name
(RefSeq) complement C3b/C4b receptor 1 (Knops blood group)
  KO
K04011  complement component (3b/4b) receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04640  Hematopoietic cell lineage
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05144  Malaria
hsa05152  Tuberculosis
Network
nt06513  Complement cascade
  Element
N01496  Alternative pathway of complement cascade, C3b breakdown
Disease
H00361  Malaria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    1378 (CR1)
   04610 Complement and coagulation cascades
    1378 (CR1)
   04613 Neutrophil extracellular trap formation
    1378 (CR1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05134 Legionellosis
    1378 (CR1)
   05152 Tuberculosis
    1378 (CR1)
  09174 Infectious disease: parasitic
   05144 Malaria
    1378 (CR1)
   05140 Leishmaniasis
    1378 (CR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1378 (CR1)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    1378 (CR1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    1378 (CR1)
CD molecules [BR:hsa04090]
 Proteins
  1378 (CR1)
SSDB
Motif
Pfam: Sushi Syndecan
Other DBs
NCBI-GeneID: 1378
NCBI-ProteinID: NP_000564
OMIM: 120620
HGNC: 2334
Ensembl: ENSG00000203710
UniProt: P17927
Structure
LinkDB
Position
1:207496157..207641765
AA seq 2039 aa
MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE
FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG
IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST
NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD
FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF
CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW
SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL
VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN
AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE
PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF
VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY
DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF
QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTC
DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA
SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD
IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIST
NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
PEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD
FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIF
CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVW
SSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCL
ENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV
SGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFEL
VGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQ
PGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCE
PSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCD
EGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEIS
YACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYI
GGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISK
ELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSG
TIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQTNEENSRVLP
NT seq 6120 nt   +upstreamnt  +downstreamnt
atgggggcctcttctccaagaagcccggagcctgtcgggccgccggcgcccggtctcccc
ttctgctgcggaggatccctgctggcggttgtggtgctgcttgcgctgccggtggcctgg
ggtcaatgcaatgccccagaatggcttccatttgccaggcctaccaacctaactgatgaa
tttgagtttcccattgggacatatctgaactatgaatgccgccctggttattccggaaga
ccgttttctatcatctgcctaaaaaactcagtctggactggtgctaaggacaggtgcaga
cgtaaatcatgtcgtaatcctccagatcctgtgaatggcatggtgcatgtgatcaaaggc
atccagttcggatcccaaattaaatattcttgtactaaaggataccgactcattggttcc
tcgtctgccacatgcatcatctcaggtgatactgtcatttgggataatgaaacacctatt
tgtgacagaattccttgtgggctaccccccaccatcaccaatggagatttcattagcacc
aacagagagaattttcactatggatcagtggtgacctaccgctgcaatcctggaagcgga
gggagaaaggtgtttgagcttgtgggtgagccctccatatactgcaccagcaatgacgat
caagtgggcatctggagcggccccgcccctcagtgcattatacctaacaaatgcacgcct
ccaaatgtggaaaatggaatattggtatctgacaacagaagcttattttccttaaatgaa
gttgtggagtttaggtgtcagcctggctttgtcatgaaaggaccccgccgtgtgaagtgc
caggccctgaacaaatgggagccggagctaccaagctgctccagggtatgtcagccacct
ccagatgtcctgcatgctgagcgtacccaaagggacaaggacaacttttcacctgggcag
gaagtgttctacagctgtgagcccggctacgacctcagaggggctgcgtctatgcgctgc
acaccccagggagactggagccctgcagcccccacatgtgaagtgaaatcctgtgatgac
ttcatgggccaacttcttaatggccgtgtgctatttccagtaaatctccagcttggagca
aaagtggattttgtttgtgatgaaggatttcaattaaaaggcagctctgctagttactgt
gtcttggctggaatggaaagcctttggaatagcagtgttccagtgtgtgaacaaatcttt
tgtccaagtcctccagttattcctaatgggagacacacaggaaaacctctggaagtcttt
ccctttgggaaaacagtaaattacacatgcgacccccacccagacagagggacgagcttc
gacctcattggagagagcaccatccgctgcacaagtgaccctcaagggaatggggtttgg
agcagccctgcccctcgctgtggaattctgggtcactgtcaagccccagatcattttctg
tttgccaagttgaaaacccaaaccaatgcatctgactttcccattgggacatctttaaag
tacgaatgccgtcctgagtactacgggaggccattctctatcacatgtctagataacctg
gtctggtcaagtcccaaagatgtctgtaaacgtaaatcatgtaaaactcctccagatcca
gtgaatggcatggtgcatgtgatcacagacatccaggttggatccagaatcaactattct
tgtactacagggcaccgactcattggtcactcatctgctgaatgtatcctctcgggcaat
gctgcccattggagcacgaagccgccaatttgtcaacgaattccttgtgggctacccccc
accatcgccaatggagatttcattagcaccaacagagagaattttcactatggatcagtg
gtgacctaccgctgcaatcctggaagcggagggagaaaggtgtttgagcttgtgggtgag
ccctccatatactgcaccagcaatgacgatcaagtgggcatctggagcggcccggcccct
cagtgcattatacctaacaaatgcacgcctccaaatgtggaaaatggaatattggtatct
gacaacagaagcttattttccttaaatgaagttgtggagtttaggtgtcagcctggcttt
gtcatgaaaggaccccgccgtgtgaagtgccaggccctgaacaaatgggagccggagcta
ccaagctgctccagggtatgtcagccacctccagatgtcctgcatgctgagcgtacccaa
agggacaaggacaacttttcacccgggcaggaagtgttctacagctgtgagcccggctat
gacctcagaggggctgcgtctatgcgctgcacaccccagggagactggagccctgcagcc
cccacatgtgaagtgaaatcctgtgatgacttcatgggccaacttcttaatggccgtgtg
ctatttccagtaaatctccagcttggagcaaaagtggattttgtttgtgatgaaggattt
caattaaaaggcagctctgctagttattgtgtcttggctggaatggaaagcctttggaat
agcagtgttccagtgtgtgaacaaatcttttgtccaagtcctccagttattcctaatggg
agacacacaggaaaacctctggaagtctttccctttggaaaagcagtaaattacacatgc
gacccccacccagacagagggacgagcttcgacctcattggagagagcaccatccgctgc
acaagtgaccctcaagggaatggggtttggagcagccctgcccctcgctgtggaattctg
ggtcactgtcaagccccagatcattttctgtttgccaagttgaaaacccaaaccaatgca
tctgactttcccattgggacatctttaaagtacgaatgccgtcctgagtactacgggagg
ccattctctatcacatgtctagataacctggtctggtcaagtcccaaagatgtctgtaaa
cgtaaatcatgtaaaactcctccagatccagtgaatggcatggtgcatgtgatcacagac
atccaggttggatccagaatcaactattcttgtactacagggcaccgactcattggtcac
tcatctgctgaatgtatcctctcaggcaatactgcccattggagcacgaagccgccaatt
tgtcaacgaattccttgtgggctacccccaaccatcgccaatggagatttcattagcacc
aacagagagaattttcactatggatcagtggtgacctaccgctgcaatcttggaagcaga
gggagaaaggtgtttgagcttgtgggtgagccctccatatactgcaccagcaatgacgat
caagtgggcatctggagcggccccgcccctcagtgcattatacctaacaaatgcacgcct
ccaaatgtggaaaatggaatattggtatctgacaacagaagcttattttccttaaatgaa
gttgtggagtttaggtgtcagcctggctttgtcatgaaaggaccccgccgtgtgaagtgc
caggccctgaacaaatgggagccagagttaccaagctgctccagggtgtgtcagccgcct
ccagaaatcctgcatggtgagcataccccaagccatcaggacaacttttcacctgggcag
gaagtgttctacagctgtgagcctggctatgacctcagaggggctgcgtctctgcactgc
acaccccagggagactggagccctgaagccccgagatgtgcagtgaaatcctgtgatgac
ttcttgggtcaactccctcatggccgtgtgctatttccacttaatctccagcttggggca
aaggtgtcctttgtctgtgatgaagggtttcgcttaaagggcagttccgttagtcattgt
gtcttggttggaatgagaagcctttggaataacagtgttcctgtgtgtgaacatatcttt
tgtccaaatcctccagctatccttaatgggagacacacaggaactccctctggagatatt
ccctatggaaaagaaatatcttacacatgtgacccccacccagacagagggatgaccttc
aacctcattggggagagcaccatccgctgcacaagtgaccctcatgggaatggggtttgg
agcagccctgcccctcgctgtgaactttctgttcgtgctggtcactgtaaaaccccagag
cagtttccatttgccagtcctacgatcccaattaatgactttgagtttccagtcgggaca
tctttgaattatgaatgccgtcctgggtattttgggaaaatgttctctatctcctgccta
gaaaacttggtctggtcaagtgttgaagacaactgtagacgaaaatcatgtggacctcca
ccagaacccttcaatggaatggtgcatataaacacagatacacagtttggatcaacagtt
aattattcttgtaatgaagggtttcgactcattggttccccatctactacttgtctcgtc
tcaggcaataatgtcacatgggataagaaggcacctatttgtgagatcatatcttgtgag
ccacctccaaccatatccaatggagacttctacagcaacaatagaacatcttttcacaat
ggaacggtggtaacttaccagtgccacactggaccagatggagaacagctgtttgagctt
gtgggagaacggtcaatatattgcaccagcaaagatgatcaagttggtgtttggagcagc
cctccccctcggtgtatttctactaataaatgcacagctccagaagttgaaaatgcaatt
agagtaccaggaaacaggagtttctttaccctcactgagatcatcagatttagatgtcag
cccgggtttgtcatggtagggtcccacactgtgcagtgccagaccaatggcagatggggg
cccaagctgccacactgctccagggtgtgtcagccgcctccagaaatcctgcatggtgag
cataccctaagccatcaggacaacttttcacctgggcaggaagtgttctacagctgtgag
cccagctatgacctcagaggggctgcgtctctgcactgcacgccccagggagactggagc
cctgaagcccctagatgtacagtgaaatcctgtgatgacttcctgggccaactccctcat
ggccgtgtgctacttccacttaatctccagcttggggcaaaggtgtcctttgtttgcgat
gaagggttccgattaaaaggcaggtctgctagtcattgtgtcttggctggaatgaaagcc
ctttggaatagcagtgttccagtgtgtgaacaaatcttttgtccaaatcctccagctatc
cttaatgggagacacacaggaactccctttggagatattccctatggaaaagaaatatct
tacgcatgcgacacccacccagacagagggatgaccttcaacctcattggggagagctcc
atccgctgcacaagtgaccctcaagggaatggggtttggagcagccctgcccctcgctgt
gaactttctgttcctgctgcctgcccacatccacccaagatccaaaacgggcattacatt
ggaggacacgtatctctatatcttcctgggatgacaatcagctacatttgtgaccccggc
tacctgttagtgggaaagggcttcattttctgtacagaccagggaatctggagccaattg
gatcattattgcaaagaagtaaattgtagcttcccactgtttatgaatggaatctcgaag
gagttagaaatgaaaaaagtatatcactatggagattatgtgactttgaagtgtgaagat
gggtatactctggaaggcagtccctggagccagtgccaggcggatgacagatgggaccct
cctctggccaaatgtacctctcgtacacatgatgctctcatagttggcactttatctggt
acgatcttctttattttactcatcattttcctctcttggataattctaaagcacagaaaa
ggcaataatgcacatgaaaaccctaaagaagtggctatccatttacattctcaaggaggc
agcagcgttcatccccgaactctgcaaacaaatgaagaaaatagcagggtccttccttga

DBGET integrated database retrieval system