| Entry |
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| Symbol |
IL1R1, CD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R, IL1RA, P80
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| Name |
(RefSeq) interleukin 1 receptor type 1
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| KO |
| K04386 | interleukin 1 receptor type I |
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| Organism |
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| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05163 | Human cytomegalovirus infection |
| hsa05166 | Human T-cell leukemia virus 1 infection |
| hsa05418 | Fluid shear stress and atherosclerosis |
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| Network |
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06211 Other MAPK signaling (cancer) nt06526 MAPK signaling |
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| Element |
| N00186 | IL1-IL1R-p38 signaling pathway |
| N00188 | IL1-IL1R-JNK signaling pathway |
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| Disease |
| H01117 | Chronic recurrent multifocal osteomyelitis |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3554 (IL1R1)
04064 NF-kappa B signaling pathway
3554 (IL1R1)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3554 (IL1R1)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
3554 (IL1R1)
04659 Th17 cell differentiation
3554 (IL1R1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
3554 (IL1R1)
09158 Development and regeneration
04380 Osteoclast differentiation
3554 (IL1R1)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3554 (IL1R1)
05163 Human cytomegalovirus infection
3554 (IL1R1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
3554 (IL1R1)
05131 Shigellosis
3554 (IL1R1)
09174 Infectious disease: parasitic
05146 Amoebiasis
3554 (IL1R1)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
3554 (IL1R1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:hsa04050]
3554 (IL1R1)
04090 CD molecules [BR:hsa04090]
3554 (IL1R1)
Cytokine receptors [BR:hsa04050]
Interleukin receptor families
IL1 receptor family
3554 (IL1R1)
CD molecules [BR:hsa04090]
Proteins
3554 (IL1R1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
2:102070390..102179874
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| AA seq |
569 aa
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKD
DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNL
CYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDR
LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDL
GSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISE
IESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFK
IDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCG
YKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQ
DGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPV
QRRSPSSKHQLLSPATKEKLQREAHVPLG |
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| NT seq |
1710 nt +upstreamnt +downstreamnt
atgaaagtgttactcagacttatttgtttcatagctctactgatttcttctctggaggct
gataaatgcaaggaacgtgaagaaaaaataattttagtgtcatctgcaaatgaaattgat
gttcgtccctgtcctcttaacccaaatgaacacaaaggcactataacttggtataaagat
gacagcaagacacctgtatctacagaacaagcctccaggattcatcaacacaaagagaaa
ctttggtttgttcctgctaaggtggaggattcaggacattactattgcgtggtaagaaat
tcatcttactgcctcagaattaaaataagtgcaaaatttgtggagaatgagcctaactta
tgttataatgcacaagccatatttaagcagaaactacccgttgcaggagacggaggactt
gtgtgcccttatatggagttttttaaaaatgaaaataatgagttacctaaattacagtgg
tataaggattgcaaacctctacttcttgacaatatacactttagtggagtcaaagatagg
ctcatcgtgatgaatgtggctgaaaagcatagagggaactatacttgtcatgcatcctac
acatacttgggcaagcaatatcctattacccgggtaatagaatttattactctagaggaa
aacaaacccacaaggcctgtgattgtgagcccagctaatgagacaatggaagtagacttg
ggatcccagatacaattgatctgtaatgtcaccggccagttgagtgacattgcttactgg
aagtggaatgggtcagtaattgatgaagatgacccagtgctaggggaagactattacagt
gtggaaaatcctgcaaacaaaagaaggagtaccctcatcacagtgcttaatatatcggaa
attgaaagtagattttataaacatccatttacctgttttgccaagaatacacatggtata
gatgcagcatatatccagttaatatatccagtcactaatttccagaagcacatgattggt
atatgtgtcacgttgacagtcataattgtgtgttctgttttcatctataaaatcttcaag
attgacattgtgctttggtacagggattcctgctatgattttctcccaataaaagcttca
gatggaaagacctatgacgcatatatactgtatccaaagactgttggggaagggtctacc
tctgactgtgatatttttgtgtttaaagtcttgcctgaggtcttggaaaaacagtgtgga
tataagctgttcatttatggaagggatgactacgttggggaagacattgttgaggtcatt
aatgaaaacgtaaagaaaagcagaagactgattatcattttagtcagagaaacatcaggc
ttcagctggctgggtggttcatctgaagagcaaatagccatgtataatgctcttgttcag
gatggaattaaagttgtcctgcttgagctggagaaaatccaagactatgagaaaatgcca
gaatcgattaaattcattaagcagaaacatggggctatccgctggtcaggggactttaca
cagggaccacagtctgcaaagacaaggttctggaagaatgtcaggtaccacatgccagtc
cagcgacggtcaccttcatctaaacaccagttactgtcaccagccactaaggagaaactg
caaagagaggctcacgtgcctctcgggtag |
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