KEGG   Homo sapiens (human): 3682
Entry
3682              CDS       T01001                                 
Symbol
ITGAE, CD103, HUMINAE
Name
(RefSeq) integrin subunit alpha E
  KO
K06524  integrin alpha E
Organism
hsa  Homo sapiens (human)
Pathway
hsa04518  Integrin signaling
hsa04810  Regulation of actin cytoskeleton
Network
nt06548  Integrin signaling
  Element
N01978  Integrin alphaEbeta2 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    3682 (ITGAE)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3682 (ITGAE)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    3682 (ITGAE)
   04090 CD molecules [BR:hsa04090]
    3682 (ITGAE)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   3682 (ITGAE)
CD molecules [BR:hsa04090]
 Proteins
  3682 (ITGAE)
SSDB
Motif
Pfam: VWA Integrin_A_Ig_2 FG-GAP VWA_2 FG-GAP_3 Integrin_alpha Integrin_A_Ig_1 C2c1_Nuc-II
Other DBs
NCBI-GeneID: 3682
NCBI-ProteinID: NP_002199
OMIM: 604682
HGNC: 6147
Ensembl: ENSG00000083457
UniProt: P38570
Structure
LinkDB
Position
17:complement(3714628..3801188)
AA seq 1179 aa
MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTNQTWLLVTSPRT
KRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQVLVRRPHSLSS
ELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGEDDVNTARQRRAL
EKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMMRNFYEKCFECN
FALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVTKTASAMQHVLDSIFTSSHGSR
RKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASD
PDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQVLLGA
VGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYSYLGYAVAVLHKTCSLSYIAGA
PRYKHHGAVFELQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYH
VHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAP
LEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGL
ADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGL
REALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCF
SNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS
QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVA
SVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQ
FRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVA
VKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEEL
LKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLI
VILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN
NT seq 3540 nt   +upstreamnt  +downstreamnt
atgtggctcttccacactctgctctgcatagccagcctggccctgctggccgctttcaat
gtggatgtggcccggccctggctcacgcccaagggaggtgcccctttcgtgctcagctcc
cttctgcaccaagaccccagcaccaaccagacctggctcctggtcaccagccccagaacc
aagaggacaccagggcccctccatcgatgttcccttgtccaggatgaaatcctttgccat
cctgtagagcatgtccccatccccaaggggaggcaccggggagtgaccgttgtccggagc
caccacggtgttttgatatgcattcaagtgctggtccggcggcctcacagcctcagctca
gaactcacaggcacctgtagcctcctgggccctgacctccgtccccaggctcaggccaac
ttcttcgaccttgaaaatctcctggatccagatgcacgtgtggacactggagactgctac
agcaacaaagaaggcggtggagaagacgatgtgaacacagccaggcagcgccgggctctg
gagaaggaggaggaggaagacaaggaggaggaggaagacgaggaggaggaggaagctggc
accgagattgccatcatcctggatggctcaggaagcattgatcccccagactttcagaga
gccaaagacttcatctccaacatgatgaggaacttctatgaaaagtgttttgagtgcaac
tttgccttggtgcagtatggaggagtgatccagactgagtttgaccttcgggacagccag
gatgtgatggcctccctcgccagagtccagaacatcactcaagtggggagtgtcaccaag
actgcctcagccatgcaacacgtcttagacagcatcttcacctcaagccacggctccagg
agaaaggcatccaaggtcatggtggtgctcaccgatggtggcatattcgaggaccccctc
aaccttacgacagtcatcaactcccccaaaatgcagggtgttgagcgctttgccattggg
gtgggagaagaatttaagagtgctaggactgcgagggaactgaacctgatcgcctcagac
ccggatgagacccatgctttcaaggtgaccaactacatggcgctggatgggctgctgagc
aaactgcggtacaacatcatcagcatggaaggcacggttggagacgcccttcactaccag
ctggcacagattggcttcagtgctcagatcctggatgagcggcaggtgctgctcggcgcc
gtcggggcctttgactggtccggaggggcgttgctctacgacacacgcagccgccggggc
cgcttcctgaaccagacagcggcggcggcggcagacgcggaggctgcgcagtacagctac
ctgggttacgctgtggccgtgctgcacaagacctgcagcctctcctacatcgcgggggct
ccacggtacaaacatcatggggccgtgtttgagctccagaaggagggcagagaggccagc
ttcctgccagtgctggagggagagcagatggggtcctattttggctctgagctgtgccct
gtggacattgacatggatggaagcacggacttcttgctggtggctgctccattttaccac
gttcatggagaagaaggcagagtctacgtgtaccgtctcagcgagcaggatggttctttc
tccttggcacgcatactgagtgggcaccccgggttcaccaatgcccgctttggctttgcc
atggcggctatgggggatctcagtcaggataagctcacagatgtggccatcggggccccc
ctggaaggttttggggcagatgatggtgccagcttcggcagtgtgtatatctacaatgga
cactgggacggcctctccgccagcccctcgcagcggatcagagcctccacggtggcccca
ggactccagtacttcggcatgtccatggctggtggctttgatattagtggcgacggcctt
gccgacatcaccgtgggcactctgggccaggcggttgtgttccgctcccggcctgtggtt
cgcctgaaggtctccatggccttcacccccagcgcactgcccatcggcttcaacggcgtc
gtgaatgtccgtttatgttttgaaatcagctctgtaaccacagcctctgagtcaggcctc
cgcgaggcacttctcaacttcacgctggatgtggatgtggggaagcagaggagacggctg
cagtgttcagacgtaagaagctgtctgggctgcctgagggagtggagcagcggatcccag
ctttgtgaggacctcctgctcatgcccacagagggagagctctgtgaggaggactgcttc
tccaatgccagtgtcaaagtcagctaccagctccagacccctgagggacagacggaccat
ccccagcccatcctggaccgctacactgagccctttgccatcttccagctgccctatgag
aaggcctgcaagaataagctgttttgtgtcgcagaattacagttggccaccaccgtctct
cagcaggagttggtggtgggtctcacaaaggagctgaccctgaacattaacctaactaac
tccggggaagattcctacatgacaagcatggccttgaattaccccagaaacctgcagttg
aagaggatgcaaaagcctccctctccaaacattcagtgtgatgaccctcagccggttgct
tctgtcctgatcatgaactgcaggattggtcaccccgtcctcaagaggtcatctgctcat
gtttcagtcgtttggcagctagaggagaatgcctttccaaacaggacagcagacatcact
gtgactgtcaccaattccaatgaaagacggtctttggccaacgagacccacacccttcaa
ttcaggcatggcttcgttgcagttctgtccaaaccatccataatgtacgtgaacacaggc
caggggctttctcaccacaaagaattcctcttccatgtacatggggagaacctctttgga
gcagaataccagttgcaaatttgcgtcccaaccaaattacgaggtctccaggttgtagca
gtgaagaagctgacgaggactcaggcctccacggtgtgcacctggagtcaggagcgcgct
tgtgcgtacagttcggttcagcatgtggaagaatggcattcagtgagctgtgtcatcgct
tcagataaagaaaatgtcaccgtggctgcagagatctcctgggatcactctgaggagtta
ctaaaagatgtaactgaactgcagatccttggtgaaatatctttcaacaaatctctatat
gagggactgaatgcagagaaccacagaactaagatcactgtcgtcttcctgaaagatgag
aagtaccattctttgcctatcatcattaaaggcagcgttggtggacttctggtgttgatc
gtgattctggtcatcctgttcaagtgtggcttttttaaaagaaaatatcaacaactgaac
ttggagagcatcaggaaggcccagctgaaatcagagaatctgctcgaagaagagaattag

KEGG   Homo sapiens (human): 3695
Entry
3695              CDS       T01001                                 
Symbol
ITGB7
Name
(RefSeq) integrin subunit beta 7
  KO
K06590  integrin beta 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04514  Cell adhesion molecule (CAM) interaction
hsa04518  Integrin signaling
hsa04672  Intestinal immune network for IgA production
hsa04810  Regulation of actin cytoskeleton
hsa04820  Cytoskeleton in muscle cells
hsa05165  Human papillomavirus infection
hsa05202  Transcriptional misregulation in cancer
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06240  Transcription (cancer)
nt06548  Integrin signaling
  Element
N00124  IGH-MAF fusion to transcriptional activation
N00393  ITGA/B-RhoGAP-RhoA signaling pathway
N00951  ITGA/B-RHOG-RAC signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01070  ITGA/B-FAK-CDC42 signaling pathway
N01072  ITGA/B-RhoGEF-RhoA signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01973  Integrin alpha4beta7 signaling
N01978  Integrin alphaEbeta2 signaling
Drug target
Abrilumab: D10540
Carotegrast methyl: D09799<JP>
Etrolizumab: D09901
Trosunilimab: D13087
Valategrast hydrochloride: D10028
Vedolizumab: D08083<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    3695 (ITGB7)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    3695 (ITGB7)
   04514 Cell adhesion molecule (CAM) interaction
    3695 (ITGB7)
   04518 Integrin signaling
    3695 (ITGB7)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3695 (ITGB7)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    3695 (ITGB7)
   04810 Regulation of actin cytoskeleton
    3695 (ITGB7)
 09150 Organismal Systems
  09151 Immune system
   04672 Intestinal immune network for IgA production
    3695 (ITGB7)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    3695 (ITGB7)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    3695 (ITGB7)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    3695 (ITGB7)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    3695 (ITGB7)
   05414 Dilated cardiomyopathy
    3695 (ITGB7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3695 (ITGB7)
   04515 Cell adhesion molecules [BR:hsa04515]
    3695 (ITGB7)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3695 (ITGB7)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3695 (ITGB7)
SSDB
Motif
Pfam: Integrin_beta Integrin_b_cyt PSI_integrin EGF_2 I-EGF_1 EGF_integrin EGF_Teneurin vWA_SIBA-E
Other DBs
NCBI-GeneID: 3695
NCBI-ProteinID: NP_000880
OMIM: 147559
HGNC: 6162
Ensembl: ENSG00000139626
UniProt: P26010
Structure
LinkDB
Position
12:complement(53191323..53207251)
AA seq 798 aa
MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPS
CAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGA
TQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLV
RLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQ
AFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKL
GGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELS
KLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREG
KAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSD
TQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGK
GHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSG
DMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTG
PLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKG
ADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKS
AITTTINPRFQEADSPTL
NT seq 2397 nt   +upstreamnt  +downstreamnt
atggtggctttgccaatggtccttgttttgctgctggtcctgagcagaggtgagagtgaa
ttggacgccaagatcccatccacaggggatgccacagaatggcggaatcctcacctgtcc
atgctggggtcctgccagccagccccctcctgccagaagtgcatcctctcacaccccagc
tgtgcatggtgcaagcaactgaacttcaccgcgtcgggagaggcggaggcgcggcgctgc
gcccgacgagaggagctgctggctcgaggctgcccgctggaggagctggaggagccccgc
ggccagcaggaggtgctgcaggaccagccgctcagccagggcgcccgcggagagggtgcc
acccagctggcgccgcagcgggtccgggtcacgctgcggcctggggagccccagcagctc
caggtccgcttccttcgtgctgagggatacccggtggacctgtactaccttatggacctg
agctactccatgaaggacgacctggaacgcgtgcgccagctcgggcacgctctgctggtc
cggctgcaggaagtcacccattctgtgcgcattggttttggttcctttgtggacaaaacg
gtgctgccctttgtgagcacagtaccctccaaactgcgccacccctgccccacccggctg
gagcgctgccagtcaccattcagctttcaccatgtgctgtccctgacgggggacgcacaa
gccttcgagcgggaggtggggcgccagagtgtgtccggcaatctggactcgcctgaaggt
ggcttcgatgccattctgcaggctgcactctgccaggagcagattggctggagaaatgtg
tcccggctgctggtgttcacttcagacgacacattccatacagctggggacgggaagttg
ggcggcattttcatgcccagtgatgggcactgccacttggacagcaatggcctctacagt
cgcagcacagagtttgactacccttctgtgggtcaggtagcccaggccctctctgcagca
aatatccagcccatctttgctgtcaccagtgccgcactgcctgtctaccaggagctgagt
aaactgattcctaagtctgcagttggggagctgagtgaggactccagcaacgtggtacag
ctcatcatggatgcttataatagcctgtcttccaccgtgacccttgaacactcttcactc
cctcctggggtccacatttcttacgaatcccagtgtgagggtcctgagaagagggagggt
aaggctgaggatcgaggacagtgcaaccacgtccgaatcaaccagacggtgactttctgg
gtttctctccaagccacccactgcctcccagagccccatctcctgaggctccgggccctt
ggcttctcagaggagctgattgtggagttgcacacgctgtgtgactgtaattgcagtgac
acccagccccaggctccccactgcagtgatggccagggacacctacaatgtggtgtatgc
agctgtgcccctggccgcctaggtcggctctgtgagtgctctgtggcagagctgtcctcc
ccagacctggaatctgggtgccgggctcccaatggcacagggcccctgtgcagtggaaag
ggtcactgtcaatgtggacgctgcagctgcagtggacagagctctgggcatctgtgcgag
tgtgacgatgccagctgtgagcgacatgagggcatcctctgcggaggctttggtcgctgc
caatgtggagtatgtcactgtcatgccaaccgcacgggcagagcatgcgaatgcagtggg
gacatggacagttgcatcagtcccgagggagggctctgcagtgggcatggacgctgcaaa
tgcaaccgctgccagtgcttggacggctactatggtgctctatgcgaccaatgcccaggc
tgcaagacaccatgcgagagacaccgggactgtgcagagtgtggggccttcaggactggc
ccactggccaccaactgcagtacagcttgtgcccataccaatgtgaccctggccttggcc
cctatcttggatgatggctggtgcaaagagcggaccctggacaaccagctgttcttcttc
ttggtggaggatgacgccagaggcacggtcgtgctcagagtgagaccccaagaaaaggga
gcagaccacacgcaggccattgtgctgggctgcgtagggggcatcgtggcagtggggctg
gggctggtcctggcttaccggctctcggtggaaatctatgaccgccgggaatacagtcgc
tttgagaaggagcagcaacaactcaactggaagcaggacagtaatcctctctacaaaagt
gccatcacgaccaccatcaatcctcgctttcaagaggcagacagtcccactctctga

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