 | | NETWORK: N01072 | |
| Entry |
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| Name |
ITGA/B-RhoGEF-RhoA signaling pathway
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| Definition |
FN1 -> (ITGA+ITGB) -> PTK2 -> ARHGEF28 -> RHOA |
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| Expanded |
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> 5747 -> 64283 -> 387 |
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| Class |
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| Type |
Reference
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| Gene |
| 3672 | ITGA1; integrin subunit alpha 1 |
| 3673 | ITGA2; integrin subunit alpha 2 |
| 3674 | ITGA2B; integrin subunit alpha 2b |
| 3675 | ITGA3; integrin subunit alpha 3 |
| 3676 | ITGA4; integrin subunit alpha 4 |
| 3678 | ITGA5; integrin subunit alpha 5 |
| 3679 | ITGA7; integrin subunit alpha 7 |
| 8516 | ITGA8; integrin subunit alpha 8 |
| 3680 | ITGA9; integrin subunit alpha 9 |
| 8515 | ITGA10; integrin subunit alpha 10 |
| 22801 | ITGA11; integrin subunit alpha 11 |
| 3685 | ITGAV; integrin subunit alpha V |
| 3688 | ITGB1; integrin subunit beta 1 |
| 3690 | ITGB3; integrin subunit beta 3 |
| 3691 | ITGB4; integrin subunit beta 4 |
| 3693 | ITGB5; integrin subunit beta 5 |
| 3694 | ITGB6; integrin subunit beta 6 |
| 3695 | ITGB7; integrin subunit beta 7 |
| 3696 | ITGB8; integrin subunit beta 8 |
| 5747 | PTK2; protein tyrosine kinase 2 |
| 64283 | ARHGEF28; Rho guanine nucleotide exchange factor 28 |
| 387 | RHOA; ras homolog family member A |
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| Reference |
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| Authors |
Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD |
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| Title |
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. |
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| Journal |
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| Reference |
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| Authors |
Tomar A, Schlaepfer DD |
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| Title |
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. |
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| Journal |
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| LinkDB |
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