KEGG   Homo sapiens (human): 3683
Entry
3683              CDS       T01001                                 
Symbol
ITGAL, CD11A, LFA-1, LFA1A
Name
(RefSeq) integrin subunit alpha L
  KO
K05718  integrin alpha L
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04514  Cell adhesion molecules
hsa04517  IgSF CAM signaling
hsa04613  Neutrophil extracellular trap formation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05144  Malaria
hsa05150  Staphylococcus aureus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05323  Rheumatoid arthritis
hsa05416  Viral myocarditis
Network
nt06546  IgSF CAM signaling
  Element
N01956  JAM1 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Efalizumab: D03959
Erlizumab: D04045
Lifitegrast (DG01389): D10374<US> D10392
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3683 (ITGAL)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    3683 (ITGAL)
   04517 IgSF CAM signaling
    3683 (ITGAL)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3683 (ITGAL)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    3683 (ITGAL)
   04650 Natural killer cell mediated cytotoxicity
    3683 (ITGAL)
   04670 Leukocyte transendothelial migration
    3683 (ITGAL)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3683 (ITGAL)
   05169 Epstein-Barr virus infection
    3683 (ITGAL)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3683 (ITGAL)
  09174 Infectious disease: parasitic
   05144 Malaria
    3683 (ITGAL)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3683 (ITGAL)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3683 (ITGAL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3683 (ITGAL)
   04515 Cell adhesion molecules [BR:hsa04515]
    3683 (ITGAL)
   04090 CD molecules [BR:hsa04090]
    3683 (ITGAL)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3683 (ITGAL)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   3683 (ITGAL)
CD molecules [BR:hsa04090]
 Proteins
  3683 (ITGAL)
SSDB
Motif
Pfam: VWA FG-GAP Integrin_A_Ig_2 Integrin_A_Ig_1 FG-GAP_3 FG-GAP_2 Integrin_alpha ITGAX-like_Ig_3 Filamin
Other DBs
NCBI-GeneID: 3683
NCBI-ProteinID: NP_002200
OMIM: 153370
HGNC: 6148
Ensembl: ENSG00000005844
UniProt: P20701 B2RAL6
Structure
LinkDB
Position
16:30472742..30523185
AA seq 1170 aa
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCD
QNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMK
DVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYV
ATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSR
GHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLL
ASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLI
GAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVA
VGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLI
PQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQD
LISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEAN
LRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQ
IPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPS
IHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFR
CPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMK
VDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDS
EQLASGQEAGDPGCLKPLHEKDSESGGGKD
NT seq 3513 nt   +upstreamnt  +downstreamnt
atgaaggattcctgcatcactgtgatggccatggcgctgctgtctgggttctttttcttc
gcgccggcctcgagctacaacctggacgtgcggggcgcgcggagcttctccccaccgcgc
gccgggaggcactttggataccgcgtcctgcaggtcggaaacggggtcatcgtgggagct
ccaggggaggggaacagcacaggaagcctctatcagtgccagtcgggcacaggacactgc
ctgccagtcaccctgagaggttccaactatacctccaagtacttgggaatgaccttggca
acagaccccacagatggaagcattttggcctgtgaccctgggctgtctcgaacgtgtgac
cagaacacctatctgagtggcctgtgttacctcttccgccagaatctgcagggtcccatg
ctgcaggggcgccctggttttcaggaatgtatcaagggcaacgtagacctggtatttctg
tttgatggttcgatgagcttgcagccagatgaatttcagaaaattctggacttcatgaag
gatgtgatgaagaaactcagcaacacttcgtaccagtttgctgctgttcagttttccaca
agctacaaaacagaatttgatttctcagattatgttaaacggaaggaccctgatgctctg
ctgaagcatgtaaagcacatgttgctgttgaccaatacctttggtgccatcaattatgtc
gcgacagaggtgttccgggaggagctgggggcccggccagatgccaccaaagtgcttatc
atcatcacggatggggaggccactgacagtggcaacatcgatgcggccaaagacatcatc
cgctacatcatcgggattggaaagcattttcagaccaaggagagtcaggagaccctccac
aaatttgcatcaaaacccgcgagcgagtttgtgaaaattctggacacatttgagaagctg
aaagatctattcactgagctgcagaagaagatctatgtcattgagggcacaagcaaacag
gacctgacttccttcaacatggagctgtcctccagcggcatcagtgctgacctcagcagg
ggccatgcagtcgtgggggcagtaggagccaaggactgggctgggggctttcttgacctg
aaggcagacctgcaggatgacacatttattgggaatgaaccattgacaccagaagtgaga
gcaggctatttgggttacaccgtgacctggctgccctcccggcaaaagacttcgttgctg
gcctcgggagcccctcgataccagcacatgggccgagtgctgctgttccaagagccacag
ggcggaggacactggagccaggtccagacaatccatgggacccagattggctcttatttc
ggtggggagctgtgtggcgtcgacgtggaccaagatggggagacagagctgctgctgatt
ggtgccccactgttctatggggagcagagaggaggccgggtgtttatctaccagagaaga
cagttggggtttgaagaagtctcagagctgcagggggaccccggctacccactcgggcgg
tttggagaagccatcactgctctgacagacatcaacggcgatgggctggtagacgtggct
gtgggggcccctctggaggagcagggggctgtgtacatcttcaatgggaggcacgggggg
cttagtccccagccaagtcagcggatagaagggacccaagtgctctcaggaattcagtgg
tttggacgctccatccatggggtgaaggaccttgaaggggatggcttggcagatgtggct
gtgggggctgagagccagatgatcgtgctgagctcccggcccgtggtggatatggtcacc
ctgatgtccttctctccagctgagatcccagtgcatgaagtggagtgctcctattcaacc
agtaacaagatgaaagaaggagttaatatcacaatctgtttccagatcaagtctctcatc
ccccagttccaaggccgcctggttgccaatctcacttacactctgcagctggatggccac
cggaccagaagacgggggttgttcccaggagggagacatgaactcagaaggaatatagct
gtcaccaccagcatgtcatgcactgacttctcatttcatttcccggtatgtgttcaagac
ctcatctcccccatcaatgtttccctgaatttctctctttgggaggaggaagggacaccg
agggaccaaagggcgcagggcaaggacataccgcccatcctgagaccctccctgcactcg
gaaacctgggagatcccttttgagaagaactgtggggaggacaagaagtgtgaggcaaac
ttgagagtgtccttctctcctgcaagatccagagccctgcgtctaactgcttttgccagc
ctctctgtggagctgagcctgagtaacttggaagaagatgcttactgggtccagctggac
ctgcacttccccccgggactctccttccgcaaggtggagatgctgaagccccatagccag
atacctgtgagctgcgaggagcttcctgaagagtccaggcttctgtccagggcattatct
tgcaatgtgagctctcccatcttcaaagcaggccactcggttgctctgcagatgatgttt
aatacactggtaaacagctcctggggggactcggttgaattgcacgccaatgtgacctgt
aacaatgaggactcagacctcctggaggacaactcagccactaccatcatccccatcctg
taccccatcaacatcctcatccaggaccaagaagactccacactctatgtcagtttcacc
cccaaaggccccaagatccaccaagtcaagcacatgtaccaggtgaggatccagccttcc
atccacgaccacaacatacccaccctggaggctgtggttggggtgccacagcctcccagc
gaggggcccatcacacaccagtggagcgtgcagatggagcctcccgtgccctgccactat
gaggatctggagaggctcccggatgcagctgagccttgtctccccggagccctgttccgc
tgccctgttgtcttcaggcaggagatcctcgtccaagtgatcgggactctggagctggtg
ggagagatcgaggcctcttccatgttcagcctctgcagctccctctccatctccttcaac
agcagcaagcatttccacctctatggcagcaacgcctccctggcccaggttgtcatgaag
gttgacgtggtgtatgagaagcagatgctctacctctacgtgctgagcggcatcgggggg
ctgctgctgctgctgctcattttcatagtgctgtacaaggttggtttcttcaaacggaac
ctgaaggagaagatggaggctggcagaggtgtcccgaatggaatccctgcagaagactct
gagcagctggcatctgggcaagaggctggggatcccggctgcctgaagcccctccatgag
aaggactctgagagtggtggtggcaaggactga

KEGG   Homo sapiens (human): 3689
Entry
3689              CDS       T01001                                 
Symbol
ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Name
(RefSeq) integrin subunit beta 2
  KO
K06464  integrin beta 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04390  Hippo signaling pathway
hsa04514  Cell adhesion molecules
hsa04517  IgSF CAM signaling
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05166  Human T-cell leukemia virus 1 infection
hsa05323  Rheumatoid arthritis
hsa05416  Viral myocarditis
Network
nt06546  IgSF CAM signaling
  Element
N01956  JAM1 interactions
N01958  JAM3 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00099  Leukocyte adhesion deficiency
Drug target
Erlizumab: D04045
Fuzapladib sodium hydrate: D11919
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3689 (ITGB2)
   04390 Hippo signaling pathway
    3689 (ITGB2)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    3689 (ITGB2)
   04517 IgSF CAM signaling
    3689 (ITGB2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3689 (ITGB2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3689 (ITGB2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3689 (ITGB2)
   04613 Neutrophil extracellular trap formation
    3689 (ITGB2)
   04650 Natural killer cell mediated cytotoxicity
    3689 (ITGB2)
   04670 Leukocyte transendothelial migration
    3689 (ITGB2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3689 (ITGB2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3689 (ITGB2)
   05134 Legionellosis
    3689 (ITGB2)
   05150 Staphylococcus aureus infection
    3689 (ITGB2)
   05152 Tuberculosis
    3689 (ITGB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3689 (ITGB2)
   05144 Malaria
    3689 (ITGB2)
   05140 Leishmaniasis
    3689 (ITGB2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3689 (ITGB2)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3689 (ITGB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3689 (ITGB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3689 (ITGB2)
   04515 Cell adhesion molecules [BR:hsa04515]
    3689 (ITGB2)
   04090 CD molecules [BR:hsa04090]
    3689 (ITGB2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3689 (ITGB2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3689 (ITGB2)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3689 (ITGB2)
CD molecules [BR:hsa04090]
 Proteins
  3689 (ITGB2)
SSDB
Motif
Pfam: Integrin_beta EGF_integrin Integrin_B_tail Integrin_b_cyt PSI_integrin I-EGF_1 EGF_2 vWA_SIBA-E
Other DBs
NCBI-GeneID: 3689
NCBI-ProteinID: NP_000202
OMIM: 600065
HGNC: 6155
Ensembl: ENSG00000160255
UniProt: P05107 A0A494C0X7
Structure
LinkDB
Position
21:complement(44885953..44928815)
AA seq 769 aa
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSI
RCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFR
RAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFV
NTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAM
MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD
YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAY
NKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATEC
IQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKN
CECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTIN
CERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV
CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGR
TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLL
VIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
NT seq 2310 nt   +upstreamnt  +downstreamnt
atgctgggcctgcgccccccactgctcgccctggtggggctgctctccctcgggtgcgtc
ctctctcaggagtgcacgaagttcaaggtcagcagctgccgggaatgcatcgagtcgggg
cccggctgcacctggtgccagaagctgaacttcacagggccgggggatcctgactccatt
cgctgcgacacccggccacagctgctcatgaggggctgtgcggctgacgacatcatggac
cccacaagcctcgctgaaacccaggaagaccacaatgggggccagaagcagctgtcccca
caaaaagtgacgctttacctgcgaccaggccaggcagcagcgttcaacgtgaccttccgg
cgggccaagggctaccccatcgacctgtactatctgatggacctctcctactccatgctt
gatgacctcaggaatgtcaagaagctaggtggcgacctgctccgggccctcaacgagatc
accgagtccggccgcattggcttcgggtccttcgtggacaagaccgtgctgccgttcgtg
aacacgcaccctgataagctgcgaaacccatgccccaacaaggagaaagagtgccagccc
ccgtttgccttcaggcacgtgctgaagctgaccaacaactccaaccagtttcagaccgag
gtcgggaagcagctgatttccggaaacctggatgcacccgagggtgggctggacgccatg
atgcaggtcgccgcctgcccggaggaaatcggctggcgcaacgtcacgcggctgctggtg
tttgccactgatgacggcttccatttcgcgggcgacgggaagctgggcgccatcctgacc
cccaacgacggccgctgtcacctggaggacaacttgtacaagaggagcaacgaattcgac
tacccatcggtgggccagctggcgcacaagctggctgaaaacaacatccagcccatcttc
gcggtgaccagtaggatggtgaagacctacgagaaactcaccgagatcatccccaagtca
gccgtgggggagctgtctgaggactccagcaatgtggtccatctcattaagaatgcttac
aataaactctcctccagggtcttcctggatcacaacgccctccccgacaccctgaaagtc
acctacgactccttctgcagcaatggagtgacgcacaggaaccagcccagaggtgactgt
gatggcgtgcagatcaatgtcccgatcaccttccaggtgaaggtcacggccacagagtgc
atccaggagcagtcgtttgtcatccgggcgctgggcttcacggacatagtgaccgtgcag
gttcttccccagtgtgagtgccggtgccgggaccagagcagagaccgcagcctctgccat
ggcaagggcttcttggagtgcggcatctgcaggtgtgacactggctacattgggaaaaac
tgtgagtgccagacacagggccggagcagccaggagctggaaggaagctgccggaaggac
aacaactccatcatctgctcagggctgggggactgtgtctgcgggcagtgcctgtgccac
accagcgacgtccccggcaagctgatatacgggcagtactgcgagtgtgacaccatcaac
tgtgagcgctacaacggccaggtctgcggcggcccggggagggggctctgcttctgcggg
aagtgccgctgccacccgggctttgagggctcagcgtgccagtgcgagaggaccactgag
ggctgcctgaacccgcggcgtgttgagtgtagtggtcgtggccggtgccgctgcaacgta
tgcgagtgccattcaggctaccagctgcctctgtgccaggagtgccccggctgcccctca
ccctgtggcaagtacatctcctgcgccgagtgcctgaagttcgaaaagggcccctttggg
aagaactgcagcgcggcgtgtccgggcctgcagctgtcgaacaaccccgtgaagggcagg
acctgcaaggagagggactcagagggctgctgggtggcctacacgctggagcagcaggac
gggatggaccgctacctcatctatgtggatgagagccgagagtgtgtggcaggccccaac
atcgccgccatcgtcgggggcaccgtggcaggcatcgtgctgatcggcattctcctgctg
gtcatctggaaggctctgatccacctgagcgacctccgggagtacaggcgctttgagaag
gagaagctcaagtcccagtggaacaatgataatccccttttcaagagcgccaccacgacg
gtcatgaaccccaagtttgctgagagttag

KEGG   Homo sapiens (human): 3684
Entry
3684              CDS       T01001                                 
Symbol
ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Name
(RefSeq) integrin subunit alpha M
  KO
K06461  integrin alpha M
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04514  Cell adhesion molecules
hsa04517  IgSF CAM signaling
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04640  Hematopoietic cell lineage
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05146  Amoebiasis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Network
nt06240  Transcription (cancer)
nt06275  Acute myeloid leukemia
nt06546  IgSF CAM signaling
  Element
N00112  AML1-ETO fusion to PU.1-mediated transcription
N01958  JAM3 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
Drug target
Fuzapladib sodium hydrate: D11919
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3684 (ITGAM)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    3684 (ITGAM)
   04517 IgSF CAM signaling
    3684 (ITGAM)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3684 (ITGAM)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3684 (ITGAM)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3684 (ITGAM)
   04610 Complement and coagulation cascades
    3684 (ITGAM)
   04613 Neutrophil extracellular trap formation
    3684 (ITGAM)
   04670 Leukocyte transendothelial migration
    3684 (ITGAM)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    3684 (ITGAM)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    3684 (ITGAM)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3684 (ITGAM)
   05134 Legionellosis
    3684 (ITGAM)
   05150 Staphylococcus aureus infection
    3684 (ITGAM)
   05152 Tuberculosis
    3684 (ITGAM)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3684 (ITGAM)
   05140 Leishmaniasis
    3684 (ITGAM)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3684 (ITGAM)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3684 (ITGAM)
   04515 Cell adhesion molecules [BR:hsa04515]
    3684 (ITGAM)
   04090 CD molecules [BR:hsa04090]
    3684 (ITGAM)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3684 (ITGAM)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3684 (ITGAM)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3684 (ITGAM)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   3684 (ITGAM)
CD molecules [BR:hsa04090]
 Proteins
  3684 (ITGAM)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Adhesion molecules of cell surface
   3684 (ITGAM)
SSDB
Motif
Pfam: ITGAX-like_Ig_3 VWA FG-GAP Integrin_A_Ig_2 Integrin_A_Ig_1 VWA_2 Integrin_alpha FG-GAP_3 BROMI_C
Other DBs
NCBI-GeneID: 3684
NCBI-ProteinID: NP_000623
OMIM: 120980
HGNC: 6149
Ensembl: ENSG00000169896
UniProt: P11215
Structure
LinkDB
Position
16:31259975..31332877
AA seq 1152 aa
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQR
GSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVK
GLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQL
KKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFN
ITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL
NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT
SNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLV
LGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAP
HYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAI
GAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVD
LTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKS
TRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPN
CIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDL
SITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQ
RSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKAN
VTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNL
GQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVV
NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT
LLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDM
MSEGGPPGAEPQ
NT seq 3459 nt   +upstreamnt  +downstreamnt
atggctctcagagtccttctgttaacagccttgaccttatgtcatgggttcaacttggac
actgaaaacgcaatgaccttccaagagaacgcaaggggcttcgggcagagcgtggtccag
cttcagggatccagggtggtggttggagccccccaggagatagtggctgccaaccaaagg
ggcagcctctaccagtgcgactacagcacaggctcatgcgagcccatccgcctgcaggtc
cccgtggaggccgtgaacatgtccctgggcctgtccctggcagccaccaccagcccccct
cagctgctggcctgtggtcccaccgtgcaccagacttgcagtgagaacacgtatgtgaaa
gggctctgcttcctgtttggatccaacctacggcagcagccccagaagttcccagaggcc
ctccgagggtgtcctcaagaggatagtgacattgccttcttgattgatggctctggtagc
atcatcccacatgactttcggcggatgaaggagtttgtctcaactgtgatggagcaatta
aaaaagtccaaaaccttgttctctttgatgcagtactctgaagaattccggattcacttt
accttcaaagagttccagaacaaccctaacccaagatcactggtgaagccaataacgcag
ctgcttgggcggacacacacggccacgggcatccgcaaagtggtacgagagctgtttaac
atcaccaacggagcccgaaagaatgcctttaagatcctagttgtcatcacggatggagaa
aagtttggcgatcccttgggatatgaggatgtcatccctgaggcagacagagagggagtc
attcgctacgtcattggggtgggagatgccttccgcagtgagaaatcccgccaagagctt
aataccatcgcatccaagccgcctcgtgatcacgtgttccaggtgaataactttgaggct
ctgaagaccattcagaaccagcttcgggagaagatctttgcgatcgagggtactcagaca
ggaagtagcagctcctttgagcatgagatgtctcaggaaggcttcagcgctgccatcacc
tctaatggccccttgctgagcactgtggggagctatgactgggctggtggagtctttcta
tatacatcaaaggagaaaagcaccttcatcaacatgaccagagtggattcagacatgaat
gatgcttacttgggttatgctgccgccatcatcttacggaaccgggtgcaaagcctggtt
ctgggggcacctcgatatcagcacatcggcctggtagcgatgttcaggcagaacactggc
atgtgggagtccaacgctaatgtcaagggcacccagatcggcgcctacttcggggcctcc
ctctgctccgtggacgtggacagcaacggcagcaccgacctggtcctcatcggggccccc
cattactacgagcagacccgagggggccaggtgtccgtgtgccccttgcccagggggagg
gctcggtggcagtgtgatgctgttctctacggggagcagggccaaccctggggccgcttt
ggggcagccctaacagtgctgggggacgtaaatggggacaagctgacggacgtggccatt
ggggccccaggagaggaggacaaccggggtgctgtttacctgtttcacggaacctcagga
tctggcatcagcccctcccatagccagcggatagcaggctccaagctctctcccaggctc
cagtattttggtcagtcactgagtgggggccaggacctcacaatggatggactggtagac
ctgactgtaggagcccaggggcacgtgctgctgctcaggtcccagccagtactgagagtc
aaggcaatcatggagttcaatcccagggaagtggcaaggaatgtatttgagtgtaatgat
caggtggtgaaaggcaaggaagccggagaggtcagagtctgcctccatgtccagaagagc
acacgggatcggctaagagaaggacagatccagagtgttgtgacttatgacctggctctg
gactccggccgcccacattcccgcgccgtcttcaatgagacaaagaacagcacacgcaga
cagacacaggtcttggggctgacccagacttgtgagaccctgaaactacagttgccgaat
tgcatcgaggacccagtgagccccattgtgctgcgcctgaacttctctctggtgggaacg
ccattgtctgctttcgggaacctccggccagtgctggcggaggatgctcagagactcttc
acagccttgtttccctttgagaagaattgtggcaatgacaacatctgccaggatgacctc
agcatcaccttcagtttcatgagcctggactgcctcgtggtgggtgggccccgggagttc
aacgtgacagtgactgtgagaaatgatggtgaggactcctacaggacacaggtcaccttc
ttcttcccgcttgacctgtcctaccggaaggtgtccacgctccagaaccagcgctcacag
cgatcctggcgcctggcctgtgagtctgcctcctccaccgaagtgtctggggccttgaag
agcaccagctgcagcataaaccaccccatcttcccggaaaactcagaggtcacctttaat
atcacgtttgatgtagactctaaggcttcccttggaaacaaactgctcctcaaggccaat
gtgaccagtgagaacaacatgcccagaaccaacaaaaccgaattccaactggagctgccg
gtgaaatatgctgtctacatggtggtcaccagccatggggtctccactaaatatctcaac
ttcacggcctcagagaataccagtcgggtcatgcagcatcaatatcaggtcagcaacctg
gggcagaggagcctccccatcagcctggtgttcttggtgcccgtccggctgaaccagact
gtcatatgggaccgcccccaggtcaccttctccgagaacctctcgagtacgtgccacacc
aaggagcgcttgccctctcactccgactttctggctgagcttcggaaggcccccgtggtg
aactgctccatcgctgtctgccagagaatccagtgtgacatcccgttctttggcatccag
gaagaattcaatgctaccctcaaaggcaacctctcgtttgactggtacatcaagacctcg
cataaccacctcctgatcgtgagcacagctgagatcttgtttaacgattccgtgttcacc
ctgctgccgggacagggggcgtttgtgaggtcccagacggagaccaaagtggagccgttc
gaggtccccaaccccctgccgctcatcgtgggcagctctgtcgggggactgctgctcctg
gccctcatcaccgccgcgctgtacaagctcggcttcttcaagcggcaatacaaggacatg
atgagtgaagggggtcccccgggggccgaaccccagtag

KEGG   Homo sapiens (human): 3689
Entry
3689              CDS       T01001                                 
Symbol
ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Name
(RefSeq) integrin subunit beta 2
  KO
K06464  integrin beta 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04390  Hippo signaling pathway
hsa04514  Cell adhesion molecules
hsa04517  IgSF CAM signaling
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05166  Human T-cell leukemia virus 1 infection
hsa05323  Rheumatoid arthritis
hsa05416  Viral myocarditis
Network
nt06546  IgSF CAM signaling
  Element
N01956  JAM1 interactions
N01958  JAM3 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00099  Leukocyte adhesion deficiency
Drug target
Erlizumab: D04045
Fuzapladib sodium hydrate: D11919
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3689 (ITGB2)
   04390 Hippo signaling pathway
    3689 (ITGB2)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    3689 (ITGB2)
   04517 IgSF CAM signaling
    3689 (ITGB2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3689 (ITGB2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3689 (ITGB2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3689 (ITGB2)
   04613 Neutrophil extracellular trap formation
    3689 (ITGB2)
   04650 Natural killer cell mediated cytotoxicity
    3689 (ITGB2)
   04670 Leukocyte transendothelial migration
    3689 (ITGB2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3689 (ITGB2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3689 (ITGB2)
   05134 Legionellosis
    3689 (ITGB2)
   05150 Staphylococcus aureus infection
    3689 (ITGB2)
   05152 Tuberculosis
    3689 (ITGB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3689 (ITGB2)
   05144 Malaria
    3689 (ITGB2)
   05140 Leishmaniasis
    3689 (ITGB2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3689 (ITGB2)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3689 (ITGB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3689 (ITGB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3689 (ITGB2)
   04515 Cell adhesion molecules [BR:hsa04515]
    3689 (ITGB2)
   04090 CD molecules [BR:hsa04090]
    3689 (ITGB2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3689 (ITGB2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3689 (ITGB2)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3689 (ITGB2)
CD molecules [BR:hsa04090]
 Proteins
  3689 (ITGB2)
SSDB
Motif
Pfam: Integrin_beta EGF_integrin Integrin_B_tail Integrin_b_cyt PSI_integrin I-EGF_1 EGF_2 vWA_SIBA-E
Other DBs
NCBI-GeneID: 3689
NCBI-ProteinID: NP_000202
OMIM: 600065
HGNC: 6155
Ensembl: ENSG00000160255
UniProt: P05107 A0A494C0X7
Structure
LinkDB
Position
21:complement(44885953..44928815)
AA seq 769 aa
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSI
RCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFR
RAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFV
NTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAM
MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD
YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAY
NKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATEC
IQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKN
CECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTIN
CERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV
CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGR
TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLL
VIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
NT seq 2310 nt   +upstreamnt  +downstreamnt
atgctgggcctgcgccccccactgctcgccctggtggggctgctctccctcgggtgcgtc
ctctctcaggagtgcacgaagttcaaggtcagcagctgccgggaatgcatcgagtcgggg
cccggctgcacctggtgccagaagctgaacttcacagggccgggggatcctgactccatt
cgctgcgacacccggccacagctgctcatgaggggctgtgcggctgacgacatcatggac
cccacaagcctcgctgaaacccaggaagaccacaatgggggccagaagcagctgtcccca
caaaaagtgacgctttacctgcgaccaggccaggcagcagcgttcaacgtgaccttccgg
cgggccaagggctaccccatcgacctgtactatctgatggacctctcctactccatgctt
gatgacctcaggaatgtcaagaagctaggtggcgacctgctccgggccctcaacgagatc
accgagtccggccgcattggcttcgggtccttcgtggacaagaccgtgctgccgttcgtg
aacacgcaccctgataagctgcgaaacccatgccccaacaaggagaaagagtgccagccc
ccgtttgccttcaggcacgtgctgaagctgaccaacaactccaaccagtttcagaccgag
gtcgggaagcagctgatttccggaaacctggatgcacccgagggtgggctggacgccatg
atgcaggtcgccgcctgcccggaggaaatcggctggcgcaacgtcacgcggctgctggtg
tttgccactgatgacggcttccatttcgcgggcgacgggaagctgggcgccatcctgacc
cccaacgacggccgctgtcacctggaggacaacttgtacaagaggagcaacgaattcgac
tacccatcggtgggccagctggcgcacaagctggctgaaaacaacatccagcccatcttc
gcggtgaccagtaggatggtgaagacctacgagaaactcaccgagatcatccccaagtca
gccgtgggggagctgtctgaggactccagcaatgtggtccatctcattaagaatgcttac
aataaactctcctccagggtcttcctggatcacaacgccctccccgacaccctgaaagtc
acctacgactccttctgcagcaatggagtgacgcacaggaaccagcccagaggtgactgt
gatggcgtgcagatcaatgtcccgatcaccttccaggtgaaggtcacggccacagagtgc
atccaggagcagtcgtttgtcatccgggcgctgggcttcacggacatagtgaccgtgcag
gttcttccccagtgtgagtgccggtgccgggaccagagcagagaccgcagcctctgccat
ggcaagggcttcttggagtgcggcatctgcaggtgtgacactggctacattgggaaaaac
tgtgagtgccagacacagggccggagcagccaggagctggaaggaagctgccggaaggac
aacaactccatcatctgctcagggctgggggactgtgtctgcgggcagtgcctgtgccac
accagcgacgtccccggcaagctgatatacgggcagtactgcgagtgtgacaccatcaac
tgtgagcgctacaacggccaggtctgcggcggcccggggagggggctctgcttctgcggg
aagtgccgctgccacccgggctttgagggctcagcgtgccagtgcgagaggaccactgag
ggctgcctgaacccgcggcgtgttgagtgtagtggtcgtggccggtgccgctgcaacgta
tgcgagtgccattcaggctaccagctgcctctgtgccaggagtgccccggctgcccctca
ccctgtggcaagtacatctcctgcgccgagtgcctgaagttcgaaaagggcccctttggg
aagaactgcagcgcggcgtgtccgggcctgcagctgtcgaacaaccccgtgaagggcagg
acctgcaaggagagggactcagagggctgctgggtggcctacacgctggagcagcaggac
gggatggaccgctacctcatctatgtggatgagagccgagagtgtgtggcaggccccaac
atcgccgccatcgtcgggggcaccgtggcaggcatcgtgctgatcggcattctcctgctg
gtcatctggaaggctctgatccacctgagcgacctccgggagtacaggcgctttgagaag
gagaagctcaagtcccagtggaacaatgataatccccttttcaagagcgccaccacgacg
gtcatgaaccccaagtttgctgagagttag

KEGG   Homo sapiens (human): 2243
Entry
2243              CDS       T01001                                 
Symbol
FGA, AMYLD2, Fib2
Name
(RefSeq) fibrinogen alpha chain
  KO
K03903  fibrinogen alpha chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
hsa04610  Complement and coagulation cascades
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06514  Coagulation cascade
nt06546  IgSF CAM signaling
  Element
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
N01513  Common pathway of coagulation cascade, fibrinogen to fibrin
N01962  ICAM1 interactions
Disease
H00222  Congenital fibrinogen deficiency
H00223  Inherited thrombophilia
H00845  Familial amyloidosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    2243 (FGA)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2243 (FGA)
   04611 Platelet activation
    2243 (FGA)
   04613 Neutrophil extracellular trap formation
    2243 (FGA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    2243 (FGA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2243 (FGA)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2243 (FGA)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2243 (FGA)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   2243 (FGA)
 Hyaluronan
  Extracellular matrix or blood plasma proteins
   2243 (FGA)
SSDB
Motif
Pfam: Fibrinogen_C Fib_alpha Fibrinogen_aC
Other DBs
NCBI-GeneID: 2243
NCBI-ProteinID: NP_000499
OMIM: 134820
HGNC: 3661
Ensembl: ENSG00000171560
CPD: C00290 C00952
UniProt: P02671
Structure
LinkDB
Position
4:complement(154583126..154590742)
AA seq 866 aa
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDW
NYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSA
NNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSC
RGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQ
LQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSS
GPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTW
NPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNV
SPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTK
EVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEF
VSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKS
YKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFS
VYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQR
GSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSH
NNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENG
VVWVSFRGADYSLRAVRMKIRPLVTQ
NT seq 2601 nt   +upstreamnt  +downstreamnt
atgttttccatgaggatcgtctgcctggtcctaagtgtggtgggcacagcatggactgca
gatagtggtgaaggtgactttctagctgaaggaggaggcgtgcgtggcccaagggttgtg
gaaagacatcaatctgcctgcaaagattcagactggcccttctgctctgatgaagactgg
aactacaaatgcccttctggctgcaggatgaaagggttgattgatgaagtcaatcaagat
tttacaaacagaataaataagctcaaaaattcactatttgaatatcagaagaacaataag
gattctcattcgttgaccactaatataatggaaattttgagaggcgatttttcctcagcc
aataaccgtgataatacctacaaccgagtgtcagaggatctgagaagcagaattgaagtc
ctgaagcgcaaagtcatagaaaaagtacagcatatccagcttctgcagaaaaatgttaga
gctcagttggttgatatgaaacgactggaggtggacattgatattaagatccgatcttgt
cgagggtcatgcagtagggctttagctcgtgaagtagatctgaaggactatgaagatcag
cagaagcaacttgaacaggtcattgccaaagacttacttccctctagagataggcaacac
ttaccactgataaaaatgaaaccagttccagacttggttcccggaaattttaagagccag
cttcagaaggtacccccagagtggaaggcattaacagacatgccgcagatgagaatggag
ttagagagacctggtggaaatgagattactcgaggaggctccacctcttatggaaccgga
tcagagacggaaagccccaggaaccctagcagtgctggaagctggaactctgggagctct
ggacctggaagtactggaaaccgaaaccctgggagctctgggactggagggactgcaacc
tggaaacctgggagctctggacctggaagtactggaagctggaactctgggagctctgga
actggaagtactggaaaccaaaaccctgggagccctagacctggtagtaccggaacctgg
aatcctggcagctctgaacgcggaagtgctgggcactggacctctgagagctctgtatct
ggtagtactggacaatggcactctgaatctggaagttttaggccagatagcccaggctct
gggaacgcgaggcctaacaacccagactggggcacatttgaagaggtgtcaggaaatgta
agtccagggacaaggagagagtaccacacagaaaaactggtcacttctaaaggagataaa
gagctcaggactggtaaagagaaggtcacctctggtagcacaaccaccacgcgtcgttca
tgctctaaaaccgttactaagactgttattggtcctgatggtcacaaagaagttaccaaa
gaagtggtgacctccgaagatggttctgactgtcccgaggcaatggatttaggcacattg
tctggcataggtactctggatgggttccgccataggcaccctgatgaagctgccttcttc
gacactgcctcaactggaaaaacattcccaggtttcttctcacctatgttaggagagttt
gtcagtgagactgagtctaggggctcagaatctggcatcttcacaaatacaaaggaatcc
agttctcatcaccctgggatagctgaattcccttcccgtggtaaatcttcaagttacagc
aaacaatttactagtagcacgagttacaacagaggagactccacatttgaaagcaagagc
tataaaatggcagatgaggccggaagtgaagccgatcatgaaggaacacatagcaccaag
agaggccatgctaaatctcgccctgtcagagactgtgatgatgtcctccaaacacatcct
tcaggtacccaaagtggcattttcaatatcaagctaccgggatccagtaagattttttct
gtttattgcgatcaagagaccagtttgggaggatggcttttgatccagcaaagaatggat
ggatcactgaattttaaccggacctggcaagactacaagagaggtttcggcagcctgaat
gacgagggggaaggagaattctggctaggcaatgactacctccacttactaacccaaagg
ggctctgttcttagggttgaattagaggactgggctgggaatgaagcttatgcagaatat
cacttccgggtaggctctgaggctgaaggctatgccctccaagtctcctcctatgaaggc
actgcgggtgatgctctgattgagggttccgtagaggaaggggcagagtacacctctcac
aacaacatgcagttcagcacctttgacagggatgcagaccagtgggaagagaactgtgca
gaagtctatgggggaggctggtggtataataactgccaagcagccaatctcaatggaatc
tactaccctgggggctcctatgacccaaggaataacagtccttatgagattgagaatgga
gtggtctgggtttcctttagaggggcagattattccctcagggctgttcgcatgaaaatt
aggccccttgtgacccaatag

KEGG   Homo sapiens (human): 2244
Entry
2244              CDS       T01001                                 
Symbol
FGB, HEL-S-78p
Name
(RefSeq) fibrinogen beta chain
  KO
K03904  fibrinogen beta chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
hsa04610  Complement and coagulation cascades
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06514  Coagulation cascade
nt06546  IgSF CAM signaling
  Element
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
N01513  Common pathway of coagulation cascade, fibrinogen to fibrin
N01962  ICAM1 interactions
Disease
H00222  Congenital fibrinogen deficiency
H00223  Inherited thrombophilia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    2244 (FGB)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2244 (FGB)
   04611 Platelet activation
    2244 (FGB)
   04613 Neutrophil extracellular trap formation
    2244 (FGB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    2244 (FGB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2244 (FGB)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2244 (FGB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   2244 (FGB)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   2244 (FGB)
 Hyaluronan
  Extracellular matrix or blood plasma proteins
   2244 (FGB)
SSDB
Motif
Pfam: Fibrinogen_C Fib_alpha CALCOCO1 MitMem_reg SF-assemblin
Other DBs
NCBI-GeneID: 2244
NCBI-ProteinID: NP_005132
OMIM: 134830
HGNC: 3662
Ensembl: ENSG00000171564
CPD: C00290 C02404
UniProt: P02675 V9HVY1
Structure
LinkDB
Position
4:154562980..154572807
AA seq 491 aa
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLR
PAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQE
RPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ
LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKE
CEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYK
QGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFT
VQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDP
RKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKM
SMKIRPFFPQQ
NT seq 1476 nt   +upstreamnt  +downstreamnt
atgaaaaggatggtttcttggagcttccacaaacttaaaaccatgaaacatctattattg
ctactattgtgtgtttttctagttaagtcccaaggtgtcaacgacaatgaggagggtttc
ttcagtgcccgtggtcatcgaccccttgacaagaagagagaagaggctcccagcctgagg
cctgccccaccgcccatcagtggaggtggctatcgggctcgtccagccaaagcagctgcc
actcaaaagaaagtagaaagaaaagcccctgatgctggaggctgtcttcacgctgaccca
gacctgggggtgttgtgtcctacaggatgtcagttgcaagaggctttgctacaacaggaa
aggccaatcagaaatagtgttgatgagttaaataacaatgtggaagctgtttcccagacc
tcctcttcttcctttcagtacatgtatttgctgaaagacctgtggcaaaagaggcagaag
caagtaaaagataatgaaaatgtagtcaatgagtactcctcagaactggaaaagcaccaa
ttatatatagatgagactgtgaatagcaatatcccaactaaccttcgtgtgcttcgttca
atcctggaaaacctgagaagcaaaatacaaaagttagaatctgatgtctcagctcaaatg
gaatattgtcgcaccccatgcactgtcagttgcaatattcctgtggtgtctggcaaagaa
tgtgaggaaattatcaggaaaggaggtgaaacatctgaaatgtatctcattcaacctgac
agttctgtcaaaccgtatagagtatactgtgacatgaatacagaaaatggaggatggaca
gtgattcagaaccgtcaagacggtagtgttgactttggcaggaaatgggatccatataaa
cagggatttggaaatgttgcaaccaacacagatgggaagaattactgtggcctaccaggt
gaatattggcttggaaatgataaaattagccagcttaccaggatgggacccacagaactt
ttgatagaaatggaggactggaaaggagacaaagtaaaggctcactatggaggattcact
gtacagaatgaagccaacaaataccagatctcagtgaacaaatacagaggaacagccggt
aatgccctcatggatggagcatctcagctgatgggagaaaacaggaccatgaccattcac
aacggcatgttcttcagcacgtatgacagagacaatgacggctggttaacatcagatccc
agaaaacagtgttctaaagaagacggtggtggatggtggtataatagatgtcatgcagcc
aatccaaacggcagatactactggggtggacagtacacctgggacatggcaaagcatggc
acagatgatggtgtagtatggatgaattggaaggggtcatggtactcaatgaggaagatg
agtatgaagatcaggcccttcttcccacagcaatag

KEGG   Homo sapiens (human): 2266
Entry
2266              CDS       T01001                                 
Symbol
FGG
Name
(RefSeq) fibrinogen gamma chain
  KO
K03905  fibrinogen gamma chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
hsa04610  Complement and coagulation cascades
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06514  Coagulation cascade
nt06546  IgSF CAM signaling
  Element
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
N01513  Common pathway of coagulation cascade, fibrinogen to fibrin
N01962  ICAM1 interactions
Disease
H00222  Congenital fibrinogen deficiency
H00223  Inherited thrombophilia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    2266 (FGG)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2266 (FGG)
   04611 Platelet activation
    2266 (FGG)
   04613 Neutrophil extracellular trap formation
    2266 (FGG)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    2266 (FGG)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    2266 (FGG)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2266 (FGG)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2266 (FGG)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2266 (FGG)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   2266 (FGG)
 Hyaluronan
  Extracellular matrix or blood plasma proteins
   2266 (FGG)
SSDB
Motif
Pfam: Fibrinogen_C Fib_alpha TMF_DNA_bd
Other DBs
NCBI-GeneID: 2266
NCBI-ProteinID: NP_068656
OMIM: 134850
HGNC: 3694
Ensembl: ENSG00000171557
CPD: C00290
UniProt: P02679
Structure
LinkDB
Position
4:complement(154604136..154612656)
AA seq 453 aa
MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQT
KVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIM
KYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQ
DIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEG
FGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKY
RLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGW
WMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTI
GEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL
NT seq 1362 nt   +upstreamnt  +downstreamnt
atgagttggtccttgcacccccggaatttaattctctacttctatgctcttttatttctc
tcttcaacatgtgtagcatatgttgctaccagagacaactgctgcatcttagatgaaaga
ttcggtagttattgtccaactacctgtggcattgcagatttcctgtctacttatcaaacc
aaagtagacaaggatctacagtctttggaagacatcttacatcaagttgaaaacaaaaca
tcagaagtcaaacagctgataaaagcaatccaactcacttataatcctgatgaatcatca
aaaccaaatatgatagacgctgctactttgaagtccaggaaaatgttagaagaaattatg
aaatatgaagcatcgattttaacacatgactcaagtattcgatatttgcaggaaatatat
aattcaaataatcaaaagattgttaacctgaaagagaaggtagcccagcttgaagcacag
tgccaggaaccttgcaaagacacggtgcaaatccatgatatcactgggaaagattgtcaa
gacattgccaataagggagctaaacagagcgggctttactttattaaacctctgaaagct
aaccagcaattcttagtctactgtgaaatcgatgggtctggaaatggatggactgtgttt
cagaagagacttgatggcagtgtagatttcaagaaaaactggattcaatataaagaagga
tttggacatctgtctcctactggcacaacagaattttggctgggaaatgagaagattcat
ttgataagcacacagtctgccatcccatatgcattaagagtggaactggaagactggaat
ggcagaaccagtactgcagactatgccatgttcaaggtgggacctgaagctgacaagtac
cgcctaacatatgcctacttcgctggtggggatgctggagatgcctttgatggctttgat
tttggcgatgatcctagtgacaagtttttcacatcccataatggcatgcagttcagtacc
tgggacaatgacaatgataagtttgaaggcaactgtgctgaacaggatggatctggttgg
tggatgaacaagtgtcacgctggccatctcaatggagtttattaccaaggtggcacttac
tcaaaagcatctactcctaatggttatgataatggcattatttgggccacttggaaaacc
cggtggtattccatgaagaaaaccactatgaagataatcccattcaacagactcacaatt
ggagaaggacagcaacaccacctggggggagccaaacaggtcagaccagagcaccctgcg
gaaacagaatatgactcactttaccctgaggatgatttgtag

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