KEGG T01001: 3799

Homo sapiens (human): 3799

Entry

3799              CDS       T01001

Symbol

KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC

Name

(RefSeq) kinesin family member 5B

K10396

kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]

Organism

hsa Homo sapiens (human)

Pathway

hsa04144

Endocytosis

hsa04728

Dopaminergic synapse

hsa04814

Motor proteins

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05132

Salmonella infection

hsa05223

Non-small cell lung cancer

Network

nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06541  Cytoskeleton in neurons

Element

N00978

Anterograde axonal transport

N00979

Mutation-caused aberrant Htt to anterograde axonal transport

N01017

Mutation-caused aberrant PSEN1 to anterograde axonal transport

N01055

Mutation-caused aberrant SNCA to anterograde axonal transport

N01202

Oligomeric conformation PrPc to anterograde axonal transport

N01297

Arl8-regulated microtubule plus-end directed transport

N01298

Salmonella SifA to microtubule plus-end directed transport

N01299

Salmonella PipB2 to microtubule plus-end directed transport

N01859

Anterograde axonal/dendrite transport, Kinesin-1

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3799 (KIF5B)
  09142 Cell motility
   04814 Motor proteins
    3799 (KIF5B)
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    3799 (KIF5B)
09160 Human Diseases
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    3799 (KIF5B)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3799 (KIF5B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3799 (KIF5B)
   05012 Parkinson disease
    3799 (KIF5B)
   05014 Amyotrophic lateral sclerosis
    3799 (KIF5B)
   05016 Huntington disease
    3799 (KIF5B)
   05020 Prion disease
    3799 (KIF5B)
   05022 Pathways of neurodegeneration - multiple diseases
    3799 (KIF5B)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3799 (KIF5B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3799 (KIF5B)
   04147 Exosome [BR:hsa04147]
    3799 (KIF5B)
Enzymes [BR:hsa01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.3  plus-end-directed kinesin ATPase
     3799 (KIF5B)
Membrane trafficking [BR:hsa04131]
Others
  Actin-binding proteins
   Others
    3799 (KIF5B)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3799 (KIF5B)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3799 (KIF5B)

SSDB

Motif

Pfam:

Kinesin Microtub_bd DUF7310

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

10:complement(32009015..32056425)

AA seq 963 aa
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ
VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY
SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK
TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE
NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL
EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ
DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD
RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG
KQV

NT seq 2892 nt +upstreamnt +downstreamnt
atggcggacctggccgagtgcaacatcaaagtgatgtgtcgcttcagacctctcaacgag
tctgaagtgaaccgcggcgacaagtacatcgccaagtttcagggagaagacacggtcgtg
atcgcgtccaagccttatgcatttgatcgggtgttccagtcaagcacatctcaagagcaa
gtgtataatgactgtgcaaagaagattgttaaagatgtacttgaaggatataatggaaca
atatttgcatatggacaaacatcctctgggaagacacacacaatggagggtaaacttcat
gatccagaaggcatgggaattattccaagaatagtgcaagatatttttaattatatttac
tccatggatgaaaatttggaatttcatattaaggtttcatattttgaaatatatttggat
aagataagggacctgttagatgtttcaaagaccaacctttcagttcatgaagacaaaaac
cgagttccctatgtaaaggggtgcacagagcgttttgtatgtagtccagatgaagttatg
gataccatagatgaaggaaaatccaacagacatgtagcagttacaaatatgaatgaacat
agctctaggagtcacagtatatttcttattaatgtcaaacaagagaacacacaaacggaa
caaaagctgagtggaaaactttatctggttgatttagctggtagtgaaaaggttagtaaa
actggagctgaaggtgctgtgctggatgaagctaaaaacatcaacaagtcactttctgct
cttggaaatgttatttctgctttggctgagggtagtacatatgttccatatcgagatagt
aaaatgacaagaatccttcaagattcattaggtggcaactgtagaaccactattgtaatt
tgctgctctccatcatcatacaatgagtctgaaacaaaatctacactcttatttggccaa
agggccaaaacaattaagaacacagtttgtgtcaatgtggagttaactgcagaacagtgg
aaaaagaagtatgaaaaagaaaaagaaaaaaataagatcctgcggaacactattcagtgg
cttgaaaatgagctcaacagatggcgtaatggggagacggtgcctattgatgaacagttt
gacaaagagaaagccaacttggaagctttcacagtggataaagatattactcttaccaat
gataaaccagcaaccgcaattggagttataggaaattttactgatgctgaaagaagaaag
tgtgaagaagaaattgctaaattatacaaacagcttgatgacaaggatgaagaaattaac
cagcaaagtcaactggtagagaaactgaagacgcaaatgttggatcaggaggagcttttg
gcatctaccagaagggatcaagacaatatgcaagctgagctgaatcgccttcaagcagaa
aatgatgcctctaaagaagaagtgaaagaagttttacaggccctagaagaacttgctgtc
aattatgatcagaagtctcaggaagttgaagacaaaactaaggaatatgaattgcttagt
gatgaattgaatcagaaatcggcaactttagcgagtatagatgctgagcttcagaaactt
aaggaaatgaccaaccaccagaaaaaacgagcagctgagatgatggcatctttactaaaa
gaccttgcagaaataggaattgctgtgggaaataatgatgtaaagcagcctgagggaact
ggcatgatagatgaagagttcactgttgcaagactctacattagcaaaatgaagtcagaa
gtaaaaaccatggtgaaacgttgcaagcagttagaaagcacacaaactgagagcaacaaa
aaaatggaagaaaatgaaaaggagttagcagcatgtcagcttcgtatctctcaacatgaa
gccaaaatcaagtcattgactgaataccttcaaaatgtggaacaaaagaaaagacagttg
gaggaatctgtcgatgccctcagtgaagaactagtccagcttcgagcacaagagaaagtc
catgaaatggaaaaggagcacttaaataaggttcagactgcaaatgaagttaagcaagct
gttgaacagcagatccagagccatagagaaactcatcaaaaacagatcagtagtttgaga
gatgaagtagaagcaaaagcaaaacttattactgatcttcaagaccaaaaccagaaaatg
atgttagagcaggaacgtctaagagtagaacatgagaagttgaaagccacagatcaggaa
aagagcagaaaactacatgaacttacggttatgcaagatagacgagaacaagcaagacaa
gacttgaagggtttggaagagacagtggcaaaagaacttcagactttacacaacctgcgc
aaactctttgttcaggacctggctacaagagttaaaaagagtgctgagattgattctgat
gacaccggaggcagcgctgctcagaagcaaaaaatctcctttcttgaaaataatcttgaa
cagctcactaaagtgcacaaacagttggtacgtgataatgcagatctccgctgtgaactt
cctaagttggaaaagcgacttcgagctacagctgagagagtgaaagctttggaatcagca
ctgaaagaagctaaagaaaatgcatctcgtgatcgcaaacgctatcagcaagaagtagat
cgcataaaggaagcagtcaggtcaaagaatatggccagaagagggcattctgcacagatt
gctaaacctattcgtcccgggcaacatccagcagcttctccaactcacccaagtgcaatt
cgtggaggaggtgcatttgttcagaacagccagccagtggcagtgcgaggtggaggaggc
aaacaagtgtaa

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