KEGG T01001: 3800

Homo sapiens (human): 3800

Entry

3800              CDS       T01001

Symbol

KIF5C, CDCBM2, KINN, NKHC, NKHC-2, NKHC2

Name

(RefSeq) kinesin family member 5C

K10396

kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]

Organism

hsa Homo sapiens (human)

Pathway

hsa04144

Endocytosis

hsa04728

Dopaminergic synapse

hsa04814

Motor proteins

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05132

Salmonella infection

hsa05223

Non-small cell lung cancer

Network

nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06541  Cytoskeleton in neurons

Element

N00978

Anterograde axonal transport

N00979

Mutation-caused aberrant Htt to anterograde axonal transport

N01017

Mutation-caused aberrant PSEN1 to anterograde axonal transport

N01055

Mutation-caused aberrant SNCA to anterograde axonal transport

N01202

Oligomeric conformation PrPc to anterograde axonal transport

N01297

Arl8-regulated microtubule plus-end directed transport

N01298

Salmonella SifA to microtubule plus-end directed transport

N01299

Salmonella PipB2 to microtubule plus-end directed transport

N01859

Anterograde axonal/dendrite transport, Kinesin-1

Disease

H01881

Complex cortical dysplasia with other brain malformations

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3800 (KIF5C)
  09142 Cell motility
   04814 Motor proteins
    3800 (KIF5C)
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    3800 (KIF5C)
09160 Human Diseases
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    3800 (KIF5C)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3800 (KIF5C)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3800 (KIF5C)
   05012 Parkinson disease
    3800 (KIF5C)
   05014 Amyotrophic lateral sclerosis
    3800 (KIF5C)
   05016 Huntington disease
    3800 (KIF5C)
   05020 Prion disease
    3800 (KIF5C)
   05022 Pathways of neurodegeneration - multiple diseases
    3800 (KIF5C)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3800 (KIF5C)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3800 (KIF5C)
   04147 Exosome [BR:hsa04147]
    3800 (KIF5C)
Enzymes [BR:hsa01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.3  plus-end-directed kinesin ATPase
     3800 (KIF5C)
Membrane trafficking [BR:hsa04131]
Others
  Actin-binding proteins
   Others
    3800 (KIF5C)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3800 (KIF5C)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3800 (KIF5C)

SSDB

Motif

Pfam:

Kinesin Microtub_bd Cnn_1N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

2:148875227..149026759

AA seq 957 aa
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQE
QVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEV
MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTI
VICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVI
QHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE
ISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAA
KDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELS
NHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKS
LVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEES
QDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSR
LRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQA
REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENN
LEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQE
VDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK

NT seq 2874 nt +upstreamnt +downstreamnt
atggcggatccagccgaatgcagcatcaaagtgatgtgccggttccggcccctcaacgaa
gcggagatcctccgcggggacaaattcatccccaaatttaaaggcgatgagaccgtggtg
atcgggcaagggaagccatatgtcttcgacagagtgctacctcccaacacgacccaagag
caggtttacaatgcatgtgcgaagcaaattgtcaaagatgtccttgaaggttataacggg
acgatttttgcgtatgggcagacttcatcaggaaaaacccacaccatggaggggaagctg
catgacccccagctcatggggatcatcccacgaattgcccatgatatctttgaccatatc
tactccatggatgagaacctggagtttcacataaaggtttcctattttgagatctacttg
gacaaaataagggacttacttgatgtatccaagaccaacttggctgttcatgaagataaa
aacagagtcccgtatgtaaaggggtgcactgagcggtttgtgtcgagccctgaggaagtc
atggatgtaatagatgaaggcaaagcaaaccgacacgtggctgtgacaaacatgaatgaa
cacagctctagaagtcacagtatcttcctgataaatattaaacaagagaatgtagagact
gaaaaaaaactcagtgggaaactttatttggttgatttggctgggagcgaaaaggtcagc
aaaactggtgccgagggagctgttcttgacgaagctaaaaatatcaataagtctttgtct
gctcttggaaatgtgatctctgctttggcagaagggacaaaaacacatgtgccataccgg
gacagcaagatgactcggattcttcaggactctttgggtgggaactgcagaaccaccatc
gtcatttgctgttctccttctgtcttcaatgaggctgagaccaagtccacactgatgttc
ggacagagagctaagaccatcaagaatacagtctctgtgaacctagaactgacagcagaa
gaatggaagaagaaatatgaaaaagagaaagagaaaaacaagactttgaagaatgttatc
cagcatctggagatggagctaaacaggtggaggaatggagaagctgtgcctgaggatgaa
cagatcagtgccaaggaccagaagaacctggagccttgtgataacacccccatcatagac
aatattgctcctgttgttgctggcatctctacagaggagaaagagaagtacgatgaggag
atctccagtctctacagacaactggatgacaaggatgatgaaattaaccagcagagccag
ctggctgaaaagctgaagcaacagatgttggatcaggatgagcttttagcttccacaaga
agagactatgagaagatacaggaggagctgacacgtctccagattgaaaatgaggcagcc
aaggatgaggtgaaagaagttctccaggccctggaggagctggctgtcaattatgaccag
aaatcacaggaagtggaggataagacccgggccaatgagcagctgacagacgagctggcc
cagaaaacgactacattgacaaccacacagagagagctgagccagctacaagagcttagc
aaccaccagaagaaaagggcaactgagatcctgaatttgctgttgaaagatctgggggag
ataggtggaattattggcaccaatgatgtgaaaactttggcagatgtgaatggagtcatt
gaggaggagtttaccatggcccgcctgtacatcagcaagatgaagtcagaggtcaagtcc
ctggtgaaccgcagcaaacagctcgagagcgcccagatggactccaacaggaagatgaat
gccagcgagcgggagctggcagcctgccagctgctcatctcccagcacgaagccaagatc
aagtctctgacagactacatgcagaacatggaacagaagaggaggcagctagaagagtcc
caggactcgctcagcgaagagctggcaaagctccgagcccaggaaaaaatgcacgaagtc
agcttccaggataaggagaaggaacatctgacgcggttgcaggatgctgaagaaatgaag
aaggcgctggagcagcagatggagagccaccgggaagctcaccagaagcagctgtccaga
ctccgagacgaaattgaggagaagcagaaaatcattgatgagattcgggatttgaatcag
aaactgcaactggaacaggagaagcttagttctgattataacaagctgaaaatagaggac
caagagagagaaatgaagctggaaaagctcttattgctcaacgataaaagggaacaagcc
agagaagacctcaaagggctggaggagacagtgtctagagaattgcagacactgcacaac
cttcggaaactctttgtccaggatctgaccacccgagttaaaaaaagtgtggagttggac
aacgatgatggagggggcagtgctgcccagaagcagaaaatttccttcttggagaataac
ctggagcagctcaccaaagttcacaagcagctggtccgggacaacgcagacctgcgctgt
gaactgcccaagctggagaagcggctgcgtgccacggcggagcgcgtcaaggctctggag
agcgcgctgaaggaggccaaggagaacgccatgcgggaccgtaagcgctaccagcaggag
gtggatcgtatcaaggaggccgtgcgggccaagaacatggccagaagggcccattcagcc
cagatcgccaagcccatccgccccggacactacccggcctcatctccaacggccgtccat
gccattcgagggggaggaggcagctcttcaaattccactcactaccagaaataa

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