KEGG   Homo sapiens (human): 3831
Entry
3831              CDS       T01001                                 

Gene name
KLC1, KLC, KNS2, KNS2A
Definition
(RefSeq) kinesin light chain 1
  KO
K10407  kinesin light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06125  Membrane trafficking (bacteria)
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06465  Prion disease
  Element
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3831 (KLC1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3831 (KLC1)
   05012 Parkinson disease
    3831 (KLC1)
   05014 Amyotrophic lateral sclerosis
    3831 (KLC1)
   05016 Huntington disease
    3831 (KLC1)
   05020 Prion disease
    3831 (KLC1)
   05022 Pathways of neurodegeneration - multiple diseases
    3831 (KLC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    3831 (KLC1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3831 (KLC1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     3831 (KLC1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Kinesins
     3831 (KLC1)
SSDB
Motif
Pfam: TPR_12 TPR_10 TPR_7 TPR_1 TPR_2 TPR_16 TPR_8 TPR_MalT TPR_19 TPR_17 ANAPC3 PPR RNPP_C JIP_LZII GHL5 DUF4919 COG2 TPR_11
Other DBs
NCBI-GeneID: 3831
NCBI-ProteinID: NP_891553
OMIM: 600025
HGNC: 6387
Ensembl: ENSG00000126214
Vega: OTTHUMG00000169227
Pharos: Q07866(Tbio)
UniProt: Q07866
LinkDB
Structure
PDB: 
5OJ8 3NF1

Position
14q32.33
AA seq 573 aa
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD
ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL
RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL
EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL
NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY
YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD
DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF
EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE
EVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
NT seq 1722 nt   +upstreamnt  +downstreamnt
atgtatgacaacatgtccacaatggtgtacataaaggaagacaagttggagaagcttaca
caggatgaaattatttctaagacaaagcaagtaattcaggggctggaagctttgaagaat
gagcacaattccattttacaaagtttgctggagacactgaagtgtttgaagaaagatgat
gaaagtaatttggtggaggagaaatcaaacatgatccggaagtcactggagatgttggag
ctcggcctgagtgaggcacaggttatgatggctttgtcaaatcacctgaatgctgtggag
tccgagaagcagaaactgcgtgcgcaggttcgtcgtctgtgccaggagaatcagtggcta
cgggatgaactggccaacacgcagcagaaactgcagaagagtgagcagtctgtggctcaa
ctggaggaggagaagaagcatctggagtttatgaatcagctaaaaaaatatgatgacgac
atttccccatccgaggacaaagacactgattctaccaaagagcctctggatgaccttttc
cccaatgatgaagacgacccagggcaaggaatccagcagcagcacagcagtgcagccgcg
gctgcccagcagggcggctacgagatccccgcgcggctgcggacgctccacaacctggtg
atccagtacgcctcgcaggggcgctacgaggtagctgtgcccctctgcaagcaggccctg
gaggacctggagaagacttcaggacacgaccacccggacgtggccaccatgctcaacatc
ctggccttggtgtacagggatcagaataaatacaaagatgcagctaacctactgaatgat
gccttggctattcgtgagaaaactttgggcaaagatcatcctgcggtggcggcgactttg
aataaccttgcagtcctttatggtaaaagagggaagtacaaagaagcagagccgttgtgt
aaaagagctctggaaatccgagaaaaggttttggggaaggatcaccccgatgttgccaag
cagttaaataacttggccttactgtgccagaaccagggcaagtatgaagaagtagaatat
tattatcaaagagccctcgagatctaccagacaaaactgggacctgatgaccccaacgtg
gctaagacgaaaaataacctggcatcctgctatttgaaacaaggaaagttcaagcaagca
gaaacactgtacaaagagattctcactcgtgcacatgaaagggagtttggttctgtagat
gatgaaaataaacccatctggatgcatgctgaagaaagagaagaatgcaaaggaaagcaa
aaggatgggacatcttttggagagtatggcggctggtacaaagcctgcaaagttgatagt
ccaactgttacaaccactctaaaaaaccttggggcactttacagacgtcaaggcaaattt
gaagctgcagaaacgttagaagaagctgctatgaggtctcgtaaacagggtcttgacaat
gttcacaaacagagggtggcagaagtgctcaatgaccctgagaacatggagaagcgcagg
agccgtgagagcctcaacgtggacgtggtcaagtacgagagtggccctgacggaggggag
gaagtgagtatgagcgtagagtggaacgggggcgtctctggccgagcctctttttgtgga
aaacgacagcagcagcagtggcctggaagacgccaccgctaa

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