KEGG   Homo sapiens (human): 3937
Entry
3937              CDS       T01001                                 
Symbol
LCP2, IMD81, SLP-76, SLP76
Name
(RefSeq) lymphocyte cytosolic protein 2
  KO
K07361  lymphocyte cytosolic protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04380  Osteoclast differentiation
hsa04611  Platelet activation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa05135  Yersinia infection
Network
nt06120  Calcium signaling (viruses and bacteria)
  Element
N01106  TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
Disease
H02526  Disorders of adaptive immunity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3937 (LCP2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    3937 (LCP2)
   04650 Natural killer cell mediated cytotoxicity
    3937 (LCP2)
   04660 T cell receptor signaling pathway
    3937 (LCP2)
   04664 Fc epsilon RI signaling pathway
    3937 (LCP2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3937 (LCP2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    3937 (LCP2)
SSDB
Motif
Pfam: SH2 SAM_2 SAM_1
Other DBs
NCBI-GeneID: 3937
NCBI-ProteinID: NP_005556
OMIM: 601603
HGNC: 6529
Ensembl: ENSG00000043462
Pharos: Q13094(Tbio)
UniProt: Q13094
Structure
LinkDB
Position
5:complement(170246233..170297777)
AA seq 533 aa
MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKL
RVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQ
DGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSG
KTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTK
PPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPL
PGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHM
PGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNE
EWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKES
QVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP
NT seq 1602 nt   +upstreamnt  +downstreamnt
atggcactgaggaatgtgccctttcgctcagaggtcctgggctgggaccccgacagcctt
gctgactatttcaagaagctcaactataaggactgtgagaaggcagtgaagaagtaccac
atcgatggggctcgcttcttgaacctgacagaaaatgacatccagaagttccccaagctc
cgggtgccgattctcagtaagttaagtcaggaaatcaacaagaacgaagagaggaggagc
atcttcacacgcaaaccccaagtcccgcggtttcctgaagagacagaaagccacgaagag
gacaatgggggctggtcgtcctttgaagaagacgattatgaaagtcccaatgatgaccag
gatggggaggatgatggagactatgagtcccccaatgaggaggaagaggcacccgtggaa
gatgacgcggattatgagccgccaccctccaatgacgaggaagctctgcagaactccatc
ctgcctgccaagcctttccccaactccaactccatgtacatcgaccggcccccctctggg
aaaaccccccagcagcctcctgtgcccccccagagaccgatggccgccctcccgccccca
ccagccggccggaatcactcgccactgcccccaccccagaccaaccacgaagaacccagc
agaagcagaaaccacaaaacggcaaagctccctgctccttcaatagacagaagcacgaaa
cctcccctagatcgttcattagctccgtttgatagagaacccttcacactaggaaagaaa
ccaccattttctgacaagccctcgattccagcgggaaggtcactcggggagcatttaccc
aagattcaaaagcctcctttaccaccgaccacggaaagacatgaaaggagcagccccctg
ccagggaagaagccacctgtgccaaagcatggatggggaccagacagaagagagaatgat
gaagatgatgtgcatcagagacctttgccccagccagcactacttcctatgagctccaac
actttcccttcaagatctactaagccaagtcccatgaaccctctcccatcctctcacatg
cctggagcattctcagaaagtaacagcagttttccacagagtgcctccctgccaccatac
ttctctcaaggccctagcaacagaccacctatcagagccgaaggcagaaacttccccttg
ccacttccaaacaaacctcggcccccatcccccgcggaggaagagaattcattaaatgaa
gagtggtacgtttcttatattacccgaccagaggcagaagctgctcttagaaagataaac
caggatggcacatttctggtcagagacagctctaaaaaaacaacaaccaatccatatgtc
ctcatggtgttgtacaaagataaagtttacaacatccagatccgttatcagaaggaaagt
caagtttacttgttgggaactggactccgagggaaagaggactttctgtctgtgtcagat
attattgactacttcaggaaaatgccacttctgctcattgatgggaaaaaccgaggttcc
agataccagtgcacattaacgcatgctgcagggtacccatag

KEGG   Homo sapiens (human): 9402
Entry
9402              CDS       T01001                                 
Symbol
GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38
Name
(RefSeq) GRB2 related adaptor protein 2
  KO
K07366  GRB2-related adaptor protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04660  T cell receptor signaling pathway
Network
nt06120  Calcium signaling (viruses and bacteria)
  Element
N01106  TCR-NFAT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    9402 (GRAP2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    9402 (GRAP2)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   9402 (GRAP2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH2 SH3_2 DUF5348 SH2_2 SH3_3 NADH_dhqG_C DUF2076
Other DBs
NCBI-GeneID: 9402
NCBI-ProteinID: NP_001278753
OMIM: 604518
HGNC: 4563
Ensembl: ENSG00000100351
Pharos: O75791(Tbio)
UniProt: O75791 Q6FI14
Structure
LinkDB
Position
22:39893820..39973721
AA seq 330 aa
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFH
EGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTE
KFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRP
SMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDIN
DGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEV
LDSSNPSWWTGRLHNKLGLFPANYVAPMTR
NT seq 993 nt   +upstreamnt  +downstreamnt
atggaagctgttgccaagtttgatttcactgcttcaggtgaggatgaactgagctttcac
actggagatgttttgaagattttaagtaaccaagaggagtggtttaaggcggagcttggg
agccaggaaggatatgtgcccaagaatttcatagacatccagtttcccaaatggtttcac
gaaggcctctctcgacaccaggcagagaacttactcatgggcaaggaggttggcttcttc
atcatccgggccagccagagctccccaggggacttctccatctctgtcaggcatgaggat
gacgttcaacacttcaaggtcatgcgagacaacaagggtaattactttctgtggactgag
aagtttccatccctaaataagctggtagactactacaggacaaattccatctccagacag
aagcagatcttccttagagacagaacccgagaagaccagggtcaccggggcaacagcctg
gaccggaggtcccagggaggcccacacctcagtggggctgtgggagaagaaatccgacct
tcgatgaaccggaagctgtcggatcaccccccgacccttcccctgcagcagcaccagcac
cagccacagcctccgcaatatgccccagcgccccagcagctgcagcagcccccacagcag
cgatatctgcagcaccaccatttccaccaggaacgccgaggaggcagccttgacataaat
gatgggcattgtggcaccggcttgggcagtgaaatgaatgcggccctcatgcatcggaga
cacacagacccagtgcagctccaggcggcagggcgagtgcggtgggcccgggcgctgtat
gactttgaggccctggaggatgacgagctggggttccacagcggggaggtggtggaggtc
ctggatagctccaacccatcctggtggaccggccgcctgcacaacaagctgggcctcttc
cctgccaactacgtggcacccatgacccgataa

KEGG   Homo sapiens (human): 27040
Entry
27040             CDS       T01001                                 
Symbol
LAT, IMD52, LAT1, pp36
Name
(RefSeq) linker for activation of T cells
  KO
K07362  linker for activation of T cells family member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa05135  Yersinia infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06120  Calcium signaling (viruses and bacteria)
  Element
N01106  TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
Disease
H02526  Disorders of adaptive immunity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    27040 (LAT)
   04015 Rap1 signaling pathway
    27040 (LAT)
   04064 NF-kappa B signaling pathway
    27040 (LAT)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    27040 (LAT)
   04660 T cell receptor signaling pathway
    27040 (LAT)
   04658 Th1 and Th2 cell differentiation
    27040 (LAT)
   04659 Th17 cell differentiation
    27040 (LAT)
   04664 Fc epsilon RI signaling pathway
    27040 (LAT)
   04666 Fc gamma R-mediated phagocytosis
    27040 (LAT)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    27040 (LAT)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    27040 (LAT)
SSDB
Motif
Pfam: LAT
Other DBs
NCBI-GeneID: 27040
NCBI-ProteinID: NP_055202
OMIM: 602354
HGNC: 18874
Ensembl: ENSG00000213658
Pharos: O43561(Tbio)
UniProt: O43561 A0A024QZD6
LinkDB
Position
16:28984803..28990784
AA seq 262 aa
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPW
PPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRG
AQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAP
ALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALS
SQEAEEVEEEGAPDYENLQELN
NT seq 789 nt   +upstreamnt  +downstreamnt
atggaggaggccatcctggtcccctgcgtgctggggctcctgctgctgcccatcctggcc
atgttgatggcactgtgtgtgcactgccacagactgccaggctcctacgacagcacatcc
tcagatagtttgtatccaaggggcatccagttcaaacggcctcacacggttgccccctgg
ccacctgcctacccacctgtcacctcctacccacccctgagccagccagacctgctcccc
atcccaagatccccgcagccccttgggggctcccaccggacgccatcttcccggcgggat
tctgatggtgccaacagtgtggcgagctacgagaacgagggtgcgtctgggatccgaggt
gcccaggctgggtggggagtctggggtccgtcctggactaggctgacccctgtgtcgtta
cccccagaaccagcctgtgaggatgcggatgaggatgaggacgactatcacaacccaggc
tacctggtggtgcttcctgacagcaccccggccactagcactgctgccccatcagctcct
gcactcagcacccctggcatccgagacagtgccttctccatggagtccattgatgattac
gtgaacgttccggagagcggggagagcgcagaagcgtctctggatggcagccgggagtat
gtgaatgtgtcccaggaactgcatcctggagcggctaagactgagcctgccgccctgagt
tcccaggaggcagaggaagtggaggaagagggggctccagattacgagaatctgcaggag
ctgaactga

KEGG   Homo sapiens (human): 7409
Entry
7409              CDS       T01001                                 
Symbol
VAV1, VAV
Name
(RefSeq) vav guanine nucleotide exchange factor 1
  KO
K05730  guanine nucleotide exchange factor VAV
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
hsa05205  Proteoglycans in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06120  Calcium signaling (viruses and bacteria)
  Element
N01106  TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    7409 (VAV1)
   04024 cAMP signaling pathway
    7409 (VAV1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7409 (VAV1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    7409 (VAV1)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    7409 (VAV1)
   04660 T cell receptor signaling pathway
    7409 (VAV1)
   04662 B cell receptor signaling pathway
    7409 (VAV1)
   04664 Fc epsilon RI signaling pathway
    7409 (VAV1)
   04666 Fc gamma R-mediated phagocytosis
    7409 (VAV1)
   04670 Leukocyte transendothelial migration
    7409 (VAV1)
   04062 Chemokine signaling pathway
    7409 (VAV1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7409 (VAV1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    7409 (VAV1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7409 (VAV1)
SSDB
Motif
Pfam: RhoGEF SH3_1 SH3_2 CAMSAP_CH CH SH2 SH3_9 C1_1 PH CDC24 C1_2 DUF3104 LZ3wCH
Other DBs
NCBI-GeneID: 7409
NCBI-ProteinID: NP_005419
OMIM: 164875
HGNC: 12657
Ensembl: ENSG00000141968
Pharos: P15498(Tchem)
UniProt: P15498 Q96D37 B2R8B5
Structure
LinkDB
Position
19:6772708..6857361
AA seq 845 aa
MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS
EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI
EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA
REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL
DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM
DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ
GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF
YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF
QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH
GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI
MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS
TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED
YSEYC
NT seq 2538 nt   +upstreamnt  +downstreamnt
atggagctgtggcgccaatgcacccactggctcatccagtgccgggtgctgccgcccagc
caccgcgtgacctgggatggggctcaggtgtgtgaactggcccaggccctccgggatggt
gtccttctgtgtcagctgcttaacaacctgctaccccatgccatcaacctgcgtgaggtc
aacctgcgcccccagatgtcccagttcctgtgccttaagaacattagaaccttcctgtcc
acctgctgtgagaagttcggcctcaagcggagcgagctcttcgaagcctttgacctcttc
gatgtgcaggattttggcaaggtcatctacaccctgtctgctctgtcctggaccccgatc
gcccagaacagggggatcatgcccttccccaccgaggaggagagtgtaggtgatgaagac
atctacagtggcctgtccgaccagatcgacgacacggtggaggaggatgaggacctgtat
gactgcgtggagaatgaggaggcggaaggcgacgagatctatgaggacctcatgcgctcg
gagcccgtgtccatgccgcccaagatgacagagtatgacaagcgctgctgctgcctgcgg
gagatccagcagacggaggagaagtacactgacacgctgggctccatccagcagcatttc
ttgaagcccctgcaacggttcctgaaacctcaagacattgagatcatctttatcaacatt
gaggacctgcttcgtgttcatactcacttcctaaaggagatgaaggaagccctgggcacc
cctggcgcagccaatctctaccaggtcttcatcaaatacaaggagaggttcctcgtctat
ggccgctactgcagccaggtggagtcagccagcaaacacctggaccgtgtggccgcagcc
cgggaggacgtgcagatgaagctggaggaatgttctcagagagccaacaacgggaggttc
accctgcgggacctgctgatggtgcctatgcagcgagttctcaaatatcacctccttctc
caggagctggtgaaacacacgcaggaggcgatggagaaggagaacctgcggctggccctg
gatgccatgagggacctggctcagtgcgtgaacgaggtcaagcgagacaacgagacactg
cgacagatcaccaatttccagctgtccattgagaacctggaccagtctctggctcactat
ggccggcccaagatcgacggggaactcaagatcacctcggtggaacggcgctccaagatg
gacaggtatgccttcctgctcgacaaagctctactcatctgtaagcgcaggggagactcc
tatgacctcaaggactttgtaaacctgcacagcttccaggttcgggatgactcttcagga
gaccgagacaacaagaagtggagccacatgttcctcctgatcgaggaccaaggtgcccag
ggctatgagctgttcttcaagacaagagaattgaagaagaagtggatggagcagtttgag
atggccatctccaacatctatccggagaatgccaccgccaacgggcatgacttccagatg
ttctcctttgaggagaccacatcctgcaaggcctgtcagatgctgcttagaggtaccttc
tatcagggctaccgctgccatcggtgccgggcatctgcacacaaggagtgtctggggagg
gtccctccatgtggccgacatgggcaagatttcccaggaactatgaagaaggacaaacta
catcgcagggctcaggacaaaaagaggaatgagctgggtctgcccaagatggaggtgttt
caggaatactacgggcttcctccaccccctggagccattggaccctttctacggctcaac
cctggagacattgtggagctcacgaaggctgaggctgaacagaactggtgggagggcaga
aatacatctactaatgaaattggctggtttccttgtaacagggtgaagccctatgtccat
ggccctcctcaggacctgtctgttcatctctggtacgcaggccccatggagcgggcaggg
gcagagagcatcctggccaaccgctcggacgggactttcttggtgcggcagagggtgaag
gatgcagcagaatttgccatcagcattaaatataacgtcgaggtcaagcacattaaaatc
atgacagcagaaggactgtaccggatcacagagaaaaaggctttccgggggcttacggag
ctggtggagttttaccagcagaactctctaaaggattgcttcaagtctctggacaccacc
ttgcagttccccttcaaggagcctgaaaagagaaccatcagcaggccagcagtgggaagc
acaaagtattttggcacagccaaagcccgctatgacttctgcgcccgagaccgatcagag
ctgtcgctcaaggagggtgacatcatcaagatccttaacaagaagggacagcaaggctgg
tggcgaggggagatctatggccgggttggctggttccctgccaactacgtggaggaagat
tattctgaatactgctga

KEGG   Homo sapiens (human): 7410
Entry
7410              CDS       T01001                                 
Symbol
VAV2, VAV-2
Name
(RefSeq) vav guanine nucleotide exchange factor 2
  KO
K05730  guanine nucleotide exchange factor VAV
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
hsa05205  Proteoglycans in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06120  Calcium signaling (viruses and bacteria)
  Element
N01106  TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    7410 (VAV2)
   04024 cAMP signaling pathway
    7410 (VAV2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7410 (VAV2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    7410 (VAV2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    7410 (VAV2)
   04660 T cell receptor signaling pathway
    7410 (VAV2)
   04662 B cell receptor signaling pathway
    7410 (VAV2)
   04664 Fc epsilon RI signaling pathway
    7410 (VAV2)
   04666 Fc gamma R-mediated phagocytosis
    7410 (VAV2)
   04670 Leukocyte transendothelial migration
    7410 (VAV2)
   04062 Chemokine signaling pathway
    7410 (VAV2)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7410 (VAV2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    7410 (VAV2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7410 (VAV2)
SSDB
Motif
Pfam: RhoGEF CAMSAP_CH SH3_2 CH SH3_1 SH3_9 SH2 C1_1 PH CDC24 C1_2 PH_10 zf-RING-like zf-RING_16
Other DBs
NCBI-GeneID: 7410
NCBI-ProteinID: NP_001127870
OMIM: 600428
HGNC: 12658
Ensembl: ENSG00000160293
Pharos: P52735(Tbio)
UniProt: P52735
Structure
LinkDB
Position
9:complement(133761894..133992324)
AA seq 878 aa
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY
LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG
DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
NT seq 2637 nt   +upstreamnt  +downstreamnt
atggagcagtggcggcagtgcggccgctggctcatcgattgcaaggtcctgccgcccaac
caccgggtggtgtggccctcggccgtggtcttcgacctggcgcaggcgctgcgcgacggg
gtccttctgtgccagctgctgcacaacctctcccccggctccatcgacctcaaggacatc
aacttccggccgcagatgtcccagtttctgtgtttgaagaacatacgcaccttcctgaaa
gtctgccacgataaatttggattaaggaacagcgagctgtttgacccctttgacctcttc
gatgtgcgagactttggaaaggtcatctccgcggtgtcgaggctctccctgcacagcatc
gcgcagaacaaagggatcaggccttttccctcagaggagaccacagagaatgacgatgac
gtctaccgcagcctggaggagctggccgacgagcatgacctgggggaggacatctacgac
tgcgtcccgtgtgaggatggaggggacgacatctacgaggacatcatcaaggtggaggtg
cagcagcccatgattagatacatgcagaaaatgggcatgactgaagatgacaagaggaac
tgctgcctgctggagatccaggagaccgaggccaagtactaccgcaccctggaggacatt
gagaagaactacatgagccccctgcggctggtgctgagcccggcggacatggcagctgtc
ttcattaacctggaggacctgatcaaggtgcatcacagcttcctgagggccatcgacgtg
tccgtgatggtggggggcagcacgctggccaaggtcttcctcgatttcaaggaaaggctt
ctgatctacggggagtactgcagccacatggagcacgcccagaacacactgaaccagctc
ctggccagccgggaggacttcaggcagaaagtcgaggagtgcacactgaaggtccaggat
ggaaaatttaagctgcaagacctgctggtggtccccatgcagagggtgctcaaataccac
ctgctcttgaaggagcttctgagccattctgcggaacggcctgagaggcagcagctcaaa
gaagcactggaagccatgcaggacttggcgatgtacatcaatgaagttaaacgggacaag
gagaccttgaggaaaatcagcgaatttcagagttctatagaaaatttgcaagtgaaactg
gaggaatttggaagaccaaagattgacggggaactgaaagtccggtccatagtcaaccac
accaagcaggacaggtacttgttcctgtttgacaaggtggtcatcgtctgcaagcggaag
ggctacagctacgagctcaaggagatcatcgagctgctgttccacaagatgaccgacgac
cccatgaacaacaaggacgtcaagaagtctcacgggaaaatgtggtcctacggcttctac
ctaattcaccttcaaggaaagcagggcttccagtttttctgcaaaacagaagatatgaag
aggaagtggatggagcagtttgagatggccatgtcaaacatcaagccagacaaagccaat
gccaaccaccacagtttccagatgtacacgtttgacaagaccaccaactgcaaagcctgc
aaaatgttcctcaggggcaccttctaccagggatacatgtgtaccaagtgtggcgtcggg
gcacacaaggagtgcctggaagtgatacctccctgcaagttcacttctcctgcagatctg
gacgcctccggagcgggaccaggtcccaagatggtggccatgcagaattaccatggcaac
ccagcccctcccgggaagcctgtgctgaccttccagacgggcgacgtgcttgagctgctg
aggggcgaccctgagtctccgtggtgggagggtcgtctggtacaaaccaggaagtcaggg
tatttccccagctcatctgtgaagccctgccctgtggatggaaggccgcccatcagccgg
ccgccatcccgggagatcgactacactgcatacccctggtttgcaggtaacatggagagg
cagcagacggacaacctgctcaagtcccacgccagcgggacctacctgatcagggagcgg
cctgccgaggctgagcgctttgcaataagcatcaagttcaatgatgaggtgaagcacatc
aaggtggtggagaaggacaactggatccacatcacagaggccaagaaattcgacagcctc
ctggagttggtggagtactaccagtgccactcactgaaggagagcttcaagcagctggac
accacactcaagtacccctacaagtcccgggaacgttcggcctccagggcctccagccgg
tccccagcttcctgtgcttcctacaacttttcttttctcagtcctcagggcctcagcttt
gcttctcagggcccctccgctcccttctggtcagtgttcacgccccgcgtcatcggcaca
gctgtggccaggtataactttgccgcccgagatatgagggagctttcgctgcgggagggt
gacgtggtgaggatctacagccgcatcggcggagaccagggctggtggaagggcgagacc
aacggacggattggctggtttccttcaacgtacgtagaagaggagggcatccagtga

KEGG   Homo sapiens (human): 10451
Entry
10451             CDS       T01001                                 
Symbol
VAV3
Name
(RefSeq) vav guanine nucleotide exchange factor 3
  KO
K05730  guanine nucleotide exchange factor VAV
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
hsa05205  Proteoglycans in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06120  Calcium signaling (viruses and bacteria)
  Element
N01106  TCR-NFAT signaling pathway
N01108  Yersinia YopH to TCR-NFAT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    10451 (VAV3)
   04024 cAMP signaling pathway
    10451 (VAV3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    10451 (VAV3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10451 (VAV3)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    10451 (VAV3)
   04660 T cell receptor signaling pathway
    10451 (VAV3)
   04662 B cell receptor signaling pathway
    10451 (VAV3)
   04664 Fc epsilon RI signaling pathway
    10451 (VAV3)
   04666 Fc gamma R-mediated phagocytosis
    10451 (VAV3)
   04670 Leukocyte transendothelial migration
    10451 (VAV3)
   04062 Chemokine signaling pathway
    10451 (VAV3)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    10451 (VAV3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    10451 (VAV3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    10451 (VAV3)
SSDB
Motif
Pfam: RhoGEF SH3_2 CAMSAP_CH CH SH3_1 SH3_9 SH2 C1_1 PH CDC24 Filamin PH_10 LZ3wCH Prok-RING_1 zf-RING_16 C1_2 zf-RING-like
Other DBs
NCBI-GeneID: 10451
NCBI-ProteinID: NP_006104
OMIM: 605541
HGNC: 12659
Ensembl: ENSG00000134215
Pharos: Q9UKW4(Tbio)
UniProt: Q9UKW4
Structure
LinkDB
Position
1:complement(107571161..107965180)
AA seq 847 aa
MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
TYVEEDE
NT seq 2544 nt   +upstreamnt  +downstreamnt
atggagccgtggaagcagtgcgcgcagtggctcatccattgcaaggtgctgcccaccaac
caccgggtgacctgggactcggctcaggtgttcgaccttgcgcagaccctccgcgatgga
gtcctgctctgccagctgcttaacaacctccgggcgcactccatcaacctgaaggagatc
aacctgaggccgcagatgtcccagtttctctgtttgaagaacataaggacatttctcacg
gcctgttgtgagacgtttggaatgaggaaaagtgaacttttcgaggcatttgacttgttt
gatgttcgtgactttggaaaggttatagaaacattatcacgactttctcgaacacctata
gcattggccacaggaatcaggcccttcccaacagaagaaagcattaatgatgaagacatc
tacaaaggccttcctgatttaatagatgaaacccttgtggaagatgaagaagatctctat
gactgtgtttatggggaagatgaaggtggagaagtctatgaggacttaatgaaggcagag
gaagcacatcagcccaaatgtccagaaaatgatatacgaagttgttgtctagcagaaatt
aagcagacagaagaaaaatatacagaaactttggagtcaatagaaaagtatttcatggca
ccactaaaaagatttctgacagcagcagaatttgattcagtattcatcaacattcctgaa
cttgtaaaacttcatcggaacctaatgcaagagattcatgattccattgtaaataaaaat
gaccagaacttgtaccaagtttttattaactacaaggaaagattggttatttacgggcag
tactgcagtggagtggagtcagccatctctagtttagactacatttctaagacaaaagaa
gatgtcaaactgaaattagaggaatgttccaaaagagcaaataatgggaaatttactctt
cgagacttgcttgtggttcctatgcaacgtgttttaaagtaccaccttctcctccaggaa
ctggtcaaacataccactgatccgactgagaaggcaaatctgaaactggctcttgatgcc
atgaaggacttggcacaatatgtgaatgaagtgaaaagagataatgagacccttcgtgaa
attaaacagtttcagctatctatagagaatttgaaccaaccagttttgctttttggacga
cctcagggagatggtgaaattcgaataaccactctagacaagcataccaaacaagaaagg
catatcttcttatttgatttggcagtgatcgtatgtaagagaaaaggtgataactatgaa
atgaaggaaataatagatcttcagcagtacaagatagccaataatcctacaaccgataaa
gaaaacaaaaagtggtcttatggcttctacctcatccatacccaaggacaaaatgggtta
gaattttattgcaaaacaaaagatttaaagaagaaatggctagaacagtttgaaatggct
ttgtctaacataagaccagactatgcagactccaatttccacgacttcaagatgcatacc
ttcactcgagtcacatcctgcaaagtctgccagatgctcctgaggggaacattttatcaa
ggctatttatgttttaagtgtggagcgagagcacacaaagaatgtttgggaagagtagac
aattgtggcagagttaattctggtgaacaagggacactcaaactaccagagaaacggacc
aatggactgcgaagaactcctaaacaggtggatccaggtttaccaaagatgcaggtcatt
aggaactattctggaacaccacccccagctctgcatgaaggaccccctttacagctccag
gccggggataccgttgaacttctgaaaggagatgcacacagtctgttttggcagggcaga
aatttagcatctggagaggttggattttttccaagtgatgcagtcaagccttgcccatgt
gtgcccaaaccagtagattattcttgccaaccctggtatgctggagcaatggaaagattg
caagcagagaccgaacttattaatagggtaaatagtacttaccttgtgaggcacaggacc
aaagagtcaggagaatatgcaattagcattaagtacaataatgaagcaaagcacatcaag
attttaacaagagatggcttttttcacattgcagaaaatagaaaatttaaaagtttaatg
gaacttgtggagtactacaagcatcattctctcaaggaagggttcagaaccttagataca
actctgcagtttccatacaaggagccagaacattcagctggacagaggggtaatagagca
ggcaacagcttgttaagtccaaaagtgctgggcattgccatcgctcggtatgacttctgt
gcaagagatatgagagagttgtccttgttgaaaggagatgtggtgaagatttacacaaag
atgagtgcaaatggctggtggagaggagaagtaaatggcagggtgggctggtttccatcc
acatatgtggaagaggatgaataa

DBGET integrated database retrieval system