| | NETWORK: N01756 | |
Entry |
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Name |
PINK-Parkin-independent ubiquitin-mediated mitophagy
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Definition |
AMBRA1 -> PINK1 -> (PRKN,ARIH1,SIAH1,HUWE1) -> Outer_membrane_protein == (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3-II |
Expanded |
55626 -> 65018 -> (5071,25820,6477,10075) -> (55669,9927,55288,89941,55847,493856,23197,23770,9868,3098) == (8878,10133,10241,8887,4077) == ((84557,81631,643246,440738)+C00350) |
Class |
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Type |
Reference
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Pathway |
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Gene |
55626 | AMBRA1; autophagy and beclin 1 regulator 1 |
65018 | PINK1; PTEN induced kinase 1 |
5071 | PRKN; parkin RBR E3 ubiquitin protein ligase |
25820 | ARIH1; ariadne RBR E3 ubiquitin protein ligase 1 |
6477 | SIAH1; siah E3 ubiquitin protein ligase 1 |
10075 | HUWE1; HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 |
55288 | RHOT1; ras homolog family member T1 |
89941 | RHOT2; ras homolog family member T2 |
55847 | CISD1; CDGSH iron sulfur domain 1 |
493856 | CISD2; CDGSH iron sulfur domain 2 |
23197 | FAF2; Fas associated factor family member 2 |
23770 | FKBP8; FKBP prolyl isomerase 8 |
9868 | TOMM70; translocase of outer mitochondrial membrane 70 |
8878 | SQSTM1; sequestosome 1 |
10241 | CALCOCO2; calcium binding and coiled-coil domain 2 |
8887 | TAX1BP1; Tax1 binding protein 1 |
4077 | NBR1; NBR1 autophagy cargo receptor |
84557 | MAP1LC3A; microtubule associated protein 1 light chain 3 alpha |
81631 | MAP1LC3B; microtubule associated protein 1 light chain 3 beta |
643246 | MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2 |
440738 | MAP1LC3C; microtubule associated protein 1 light chain 3 gamma |
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Metabolite |
C00350 | Phosphatidylethanolamine |
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Reference |
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Authors |
Wang S, Long H, Hou L, Feng B, Ma Z, Wu Y, Zeng Y, Cai J, Zhang DW, Zhao G |
Title |
The mitophagy pathway and its implications in human diseases. |
Journal |
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Reference |
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Authors |
Lechado Terradas A, Zittlau KI, Macek B, Fraiberg M, Elazar Z, Kahle PJ |
Title |
Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications. |
Journal |
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LinkDB |
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