KEGG   NETWORK: N01756
Entry
N01756                      Network                                
Name
PINK-Parkin-independent ubiquitin-mediated mitophagy
Definition
AMBRA1 -> PINK1 -> (PRKN,ARIH1,SIAH1,HUWE1) -> Outer_membrane_protein == (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3-II
  Expanded
55626 -> 65018 -> (5071,25820,6477,10075) -> (55669,9927,55288,89941,55847,493856,23197,23770,9868,3098) == (8878,10133,10241,8887,4077) == ((84557,81631,643246,440738)+C00350)
Class
nt06536 Mitophagy
Type
Reference
Pathway
hsa04137  Mitophagy - animal
Gene
55626  AMBRA1; autophagy and beclin 1 regulator 1
65018  PINK1; PTEN induced kinase 1
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
25820  ARIH1; ariadne RBR E3 ubiquitin protein ligase 1
6477  SIAH1; siah E3 ubiquitin protein ligase 1
10075  HUWE1; HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
55669  MFN1; mitofusin 1
9927  MFN2; mitofusin 2
55288  RHOT1; ras homolog family member T1
89941  RHOT2; ras homolog family member T2
55847  CISD1; CDGSH iron sulfur domain 1
493856  CISD2; CDGSH iron sulfur domain 2
23197  FAF2; Fas associated factor family member 2
23770  FKBP8; FKBP prolyl isomerase 8
9868  TOMM70; translocase of outer mitochondrial membrane 70
3098  HK1; hexokinase 1
8878  SQSTM1; sequestosome 1
10133  OPTN; optineurin
10241  CALCOCO2; calcium binding and coiled-coil domain 2
8887  TAX1BP1; Tax1 binding protein 1
4077  NBR1; NBR1 autophagy cargo receptor
84557  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha
81631  MAP1LC3B; microtubule associated protein 1 light chain 3 beta
643246  MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2
440738  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma
Metabolite
C00350  Phosphatidylethanolamine
Reference
PMID:37582956
  Authors
Wang S, Long H, Hou L, Feng B, Ma Z, Wu Y, Zeng Y, Cai J, Zhang DW, Zhao G
  Title
The mitophagy pathway and its implications in human diseases.
  Journal
Signal Transduct Target Ther 8:304 (2023)
DOI:10.1038/s41392-023-01503-7
Reference
PMID:34688664
  Authors
Lechado Terradas A, Zittlau KI, Macek B, Fraiberg M, Elazar Z, Kahle PJ
  Title
Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications.
  Journal
J Biol Chem 297:101339 (2021)
DOI:10.1016/j.jbc.2021.101339
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