Homo sapiens (human): 4158
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Entry
4158 CDS
T01001
Symbol
MC2R, ACTHR
Name
(RefSeq) melanocortin 2 receptor
KO
K04200
melanocortin 2 receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04024
cAMP signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04925
Aldosterone synthesis and secretion
hsa04927
Cortisol synthesis and secretion
hsa04934
Cushing syndrome
Network
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
Disease
H00033
Adrenal carcinoma
H00256
Familial glucocorticoid deficiency
H02049
Bilateral macronodular adrenal hyperplasia
Drug target
Alsactide:
D07417
Corticotropin (
DG00492
):
D00146
<US>
D03593
D06544
Giractide (
DG01344
):
D09801
D09937
Seractide acetate:
D05827
Tetracosactide (
DG00493
):
D00284
<US>
D02105
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
4158 (MC2R)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
4158 (MC2R)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
4158 (MC2R)
04927 Cortisol synthesis and secretion
4158 (MC2R)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
4158 (MC2R)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
4158 (MC2R)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Peptide
Melanocortin
4158 (MC2R)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
7tm_1
7TM_GPCR_Srsx
7TM_GPCR_Srx
7tm_4
Motif
Other DBs
NCBI-GeneID:
4158
NCBI-ProteinID:
NP_000520
OMIM:
607397
HGNC:
6930
Ensembl:
ENSG00000185231
Pharos:
Q01718
(Tclin)
UniProt:
Q01718
Structure
PDB
PDBj
LinkDB
All DBs
Position
18:complement(13882044..13915707)
Genome browser
AA seq
297 aa
AA seq
DB search
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
NT seq
894 nt
NT seq
+upstream
nt +downstream
nt
atgaagcacattatcaactcgtatgaaaacatcaacaacacagcaagaaataattccgac
tgtcctcgtgtggttttgccggaggagatatttttcacaatttccattgttggagttttg
gagaatctgatcgtcctgctggctgtgttcaagaataagaatctccaggcacccatgtac
tttttcatctgtagcttggccatatctgatatgctgggcagcctatataagatcttggaa
aatatcctgatcatattgagaaacatgggctatctcaagccacgtggcagttttgaaacc
acagccgatgacatcatcgactccctgtttgtcctctccctgcttggctccatcttcagc
ctgtctgtgattgctgcggaccgctacatcaccatcttccacgcactgcggtaccacagc
atcgtgaccatgcgccgcactgtggtggtgcttacggtcatctggacgttctgcacgggg
actggcatcaccatggtgatcttctcccatcatgtgcccacagtgatcaccttcacgtcg
ctgttcccgctgatgctggtcttcatcctgtgcctctatgtgcacatgttcctgctggct
cgatcccacaccaggaagatctccaccctccccagagccaacatgaaaggggccatcaca
ctgaccatcctgctcggggtcttcatcttctgctgggccccctttgtgcttcatgtcctc
ttgatgacattctgcccaagtaacccctactgcgcctgctacatgtctctcttccaggtg
aacggcatgttgatcatgtgcaatgccgtcattgaccccttcatatatgccttccggagc
ccagagctcagggacgcattcaaaaagatgatcttctgcagcaggtactggtag
Homo sapiens (human): 56246
Help
Entry
56246 CDS
T01001
Symbol
MRAP, B27, C21orf61, FALP, FGD2, GCCD2, MRAP1
Name
(RefSeq) melanocortin 2 receptor accessory protein
KO
K22398
melanocortin-2 receptor accessory protein
Organism
hsa
Homo sapiens (human)
Pathway
hsa04927
Cortisol synthesis and secretion
hsa04934
Cushing syndrome
Network
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
Disease
H00256
Familial glucocorticoid deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
56246 (MRAP)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
56246 (MRAP)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MRAP
Motif
Other DBs
NCBI-GeneID:
56246
NCBI-ProteinID:
NP_848932
OMIM:
609196
HGNC:
1304
Ensembl:
ENSG00000170262
Pharos:
Q8TCY5
(Tbio)
UniProt:
Q8TCY5
Structure
PDB
PDBj
LinkDB
All DBs
Position
21:32291813..32314784
Genome browser
AA seq
172 aa
AA seq
DB search
MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM
SWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPD
QPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS
NT seq
519 nt
NT seq
+upstream
nt +downstream
nt
atggccaacgggaccaacgcctctgccccatactacagctatgaatactacctggactat
ctggacctcattcccgtggacgagaagaagctgaaagcccacaaacattccatcgtgatc
gcattctgggtgagcctggctgccttcgtggtgctgctcttcctcatcttgctctacatg
tcctggtccgcctccccgcagatgaggaacagccccaagcaccaccaaacatgcccctgg
agtcacggcctcaacctccacctctgcatccagaagtgcctgccgtgccacagggaaccc
ctggcaacctcacaggctcaggcgagctcagtggagccagggagcagaactggccctgac
cagccgctacgacaggagagctcctccaccttgcccctcgggggtttccagacccacccc
actctcctctgggaactgaccctcaatgggggtcccctcgtcaggagcaagcccagcgag
cctccccctggagacaggacctctcaattgcagagctga
DBGET
integrated database retrieval system