KEGG T01001: 4513

Homo sapiens (human): 4513

Entry

4513              CDS       T01001

Symbol

COX2, COII, MTCO2, MT-CO2

Name

(RefSeq) cytochrome c oxidase subunit II

K02261

cytochrome c oxidase subunit 2

Organism

hsa Homo sapiens (human)

Pathway

hsa00190

Oxidative phosphorylation

hsa01100

Metabolic pathways

hsa04260

Cardiac muscle contraction

hsa04714

Thermogenesis

hsa04932

Non-alcoholic fatty liver disease

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05208

Chemical carcinogenesis - reactive oxygen species

hsa05415

Diabetic cardiomyopathy

Module

hsa_M00154

Cytochrome c oxidase

Network

nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration

Element

N00998

Electron transfer in Complex IV

N00999

Mutation-caused aberrant Abeta to electron transfer in Complex IV

N01394

Arsenic to electron transfer in complex IV

Disease

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4513 (COX2)
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4513 (COX2)
  09159 Environmental adaptation
   04714 Thermogenesis
    4513 (COX2)
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4513 (COX2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4513 (COX2)
   05012 Parkinson disease
    4513 (COX2)
   05014 Amyotrophic lateral sclerosis
    4513 (COX2)
   05016 Huntington disease
    4513 (COX2)
   05020 Prion disease
    4513 (COX2)
   05022 Pathways of neurodegeneration - multiple diseases
    4513 (COX2)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4513 (COX2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4513 (COX2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4513 (COX2)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4513 (COX2)

SSDB

Motif

Pfam:

COX2 COX2_TM Herpes_LAMP2 DUF3100 DPM3 NPCC

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Pharos:

P00403(Tchem)

UniProt:

P00403 U5Z487

Structure

LinkDB

Position

MT:7586..8269

AA seq 227 aa
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE
METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS
YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN
QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL

NT seq 684 nt +upstreamnt +downstreamnt
atggcacatgcagcgcaagtaggtctacaagacgctacttcccctatcatagaagagctt
atcacctttcatgatcacgccctcataatcattttccttatctgcttcctagtcctgtat
gcccttttcctaacactcacaacaaaactaactaatactaacatctcagacgctcaggaa
atagaaaccgtctgaactatcctgcccgccatcatcctagtcctcatcgccctcccatcc
ctacgcatcctttacataacagacgaggtcaacgatccctcccttaccatcaaatcaatt
ggccaccaatggtactgaacctacgagtacaccgactacggcggactaatcttcaactcc
tacatacttcccccattattcctagaaccaggcgacctgcgactccttgacgttgacaat
cgagtagtactcccgattgaagcccccattcgtataataattacatcacaagacgtcttg
cactcatgagctgtccccacattaggcttaaaaacagatgcaattcccggacgtctaaac
caaaccactttcaccgctacacgaccgggggtatactacggtcaatgctctgaaatctgt
ggagcaaaccacagtttcatgcccatcgtcctagaattaattcccctaaaaatctttgaa
atagggcccgtatttaccctatag

DBGET integrated database retrieval system