| Entry |
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| Name |
Arsenic to electron transfer in complex IV
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| Definition |
As -- AS3MT >> GSTO1 -> MMA -| CxIV |
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| Expanded |
C20296 -- 57412 >> 9446 -> C07295 -| (4514+4512+4513+(1327,84701)+9377+1329+(1337,1339)+(1340,125965)+1345+(1346,1347,9167)+1349+1350+(1351,341947)) |
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| Class |
nt06252 Mitochondrial ROS formation (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 57412 | AS3MT; arsenite methyltransferase |
| 9446 | GSTO1; glutathione S-transferase omega 1 |
| 4514 | COX3; cytochrome c oxidase subunit III |
| 4512 | COX1; cytochrome c oxidase subunit I |
| 4513 | COX2; cytochrome c oxidase subunit II |
| 1327 | COX4I1; cytochrome c oxidase subunit 4I1 |
| 84701 | COX4I2; cytochrome c oxidase subunit 4I2 |
| 9377 | COX5A; cytochrome c oxidase subunit 5A |
| 1329 | COX5B; cytochrome c oxidase subunit 5B |
| 1337 | COX6A1; cytochrome c oxidase subunit 6A1 |
| 1339 | COX6A2; cytochrome c oxidase subunit 6A2 |
| 1340 | COX6B1; cytochrome c oxidase subunit 6B1 |
| 125965 | COX6B2; cytochrome c oxidase subunit 6B2 |
| 1345 | COX6C; cytochrome c oxidase subunit 6C |
| 1346 | COX7A1; cytochrome c oxidase subunit 7A1 |
| 1347 | COX7A2; cytochrome c oxidase subunit 7A2 |
| 9167 | COX7A2L; cytochrome c oxidase subunit 7A2 like |
| 1349 | COX7B; cytochrome c oxidase subunit 7B |
| 1350 | COX7C; cytochrome c oxidase subunit 7C |
| 1351 | COX8A; cytochrome c oxidase subunit 8A |
| 341947 | COX8C; cytochrome c oxidase subunit 8C |
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| Perturbant |
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| Metabolite |
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| Reference |
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| Authors |
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD |
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| Title |
Molecular features in arsenic-induced lung tumors. |
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| Journal |
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| Reference |
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| Authors |
Henkler F, Brinkmann J, Luch A |
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| Title |
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics. |
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| Journal |
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| Reference |
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| Authors |
Faita F, Cori L, Bianchi F, Andreassi MG |
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| Title |
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies. |
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| Journal |
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| Reference |
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| Authors |
Clewell HJ, Thomas RS, Gentry PR, Crump KS, Kenyon EM, El-Masri HA, Yager JW |
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| Title |
Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report. |
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| Journal |
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| LinkDB |
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