KEGG   NETWORK: N00998
Entry
N00998                      Network                                
Name
Electron transfer in Complex IV
Definition
CytC -- CxIV -> H2O
  Expanded
C00524 -- (4514+4512+4513+(1327,84701)+9377+1329+(1337,1339)+(1340,125965)+1345+(1346,1347,9167)+1349+1350+(1351,341947)) -> C00001
Class
nt06252 Mitochondrial ROS formation (cancer)
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Reference
Pathway
hsa00190  Oxidative phosphorylation
Gene
4514  COX3; cytochrome c oxidase III
4512  COX1; cytochrome c oxidase subunit I
4513  COX2; cytochrome c oxidase subunit II
1327  COX4I1; cytochrome c oxidase subunit 4I1
84701  COX4I2; cytochrome c oxidase subunit 4I2
9377  COX5A; cytochrome c oxidase subunit 5A
1329  COX5B; cytochrome c oxidase subunit 5B
1337  COX6A1; cytochrome c oxidase subunit 6A1
1339  COX6A2; cytochrome c oxidase subunit 6A2
1340  COX6B1; cytochrome c oxidase subunit 6B1
125965  COX6B2; cytochrome c oxidase subunit 6B2
1345  COX6C; cytochrome c oxidase subunit 6C
1346  COX7A1; cytochrome c oxidase subunit 7A1
1347  COX7A2; cytochrome c oxidase subunit 7A2
9167  COX7A2L; cytochrome c oxidase subunit 7A2 like
1349  COX7B; cytochrome c oxidase subunit 7B
1350  COX7C; cytochrome c oxidase subunit 7C
1351  COX8A; cytochrome c oxidase subunit 8A
341947  COX8C; cytochrome c oxidase subunit 8C
Metabolite
C00524  Cytochrome c
C00001  H2O
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:10066163
  Authors
Saraste M
  Title
Oxidative phosphorylation at the fin de siecle.
  Journal
Science 283:1488-93 (1999)
DOI:10.1126/science.283.5407.1488
Reference
PMID:26846578
  Authors
Rak M, Benit P, Chretien D, Bouchereau J, Schiff M, El-Khoury R, Tzagoloff A, Rustin P
  Title
Mitochondrial cytochrome c oxidase deficiency.
  Journal
Clin Sci (Lond) 130:393-407 (2016)
DOI:10.1042/CS20150707
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