KEGG   NETWORK: N00999
Entry
N00999                      Network                                
Name
Mutation-caused aberrant Abeta to electron transfer in Complex IV
Definition
APP* -> Abeta -| CxIV -> H2O
  Expanded
351v1 -> (C16515,C16514) -| (4514+4512+4513+(1327,84701)+9377+1329+(1337,1339)+(1340,125965)+1345+(1346,1347,9167)+1349+1350+(1351,341947)) -> C00001
Class
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
4514  COX3; cytochrome c oxidase III
4512  COX1; cytochrome c oxidase subunit I
4513  COX2; cytochrome c oxidase subunit II
1327  COX4I1; cytochrome c oxidase subunit 4I1
84701  COX4I2; cytochrome c oxidase subunit 4I2
9377  COX5A; cytochrome c oxidase subunit 5A
1329  COX5B; cytochrome c oxidase subunit 5B
1337  COX6A1; cytochrome c oxidase subunit 6A1
1339  COX6A2; cytochrome c oxidase subunit 6A2
1340  COX6B1; cytochrome c oxidase subunit 6B1
125965  COX6B2; cytochrome c oxidase subunit 6B2
1345  COX6C; cytochrome c oxidase subunit 6C
1346  COX7A1; cytochrome c oxidase subunit 7A1
1347  COX7A2; cytochrome c oxidase subunit 7A2
9167  COX7A2L; cytochrome c oxidase subunit 7A2 like
1349  COX7B; cytochrome c oxidase subunit 7B
1350  COX7C; cytochrome c oxidase subunit 7C
1351  COX8A; cytochrome c oxidase subunit 8A
341947  COX8C; cytochrome c oxidase subunit 8C
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
C00001  H2O
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:17051205
  Authors
Lin MT, Beal MF
  Title
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
  Journal
Nature 443:787-95 (2006)
DOI:10.1038/nature05292
Reference
PMID:20653508
  Authors
Rodolfo C, Ciccosanti F, Giacomo GD, Piacentini M, Fimia GM
  Title
Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.
  Journal
Expert Rev Proteomics 7:519-42 (2010)
DOI:10.1586/epr.10.43
LinkDB

DBGET integrated database retrieval system