KEGG   NETWORK: N00999
Entry
N00999                      Network                                

Name
Mutation-caused aberrant Abeta to electron transfer in Complex IV
Definition
APP* -> Abeta -| CxIV -> H2O
  Expanded
351v1 -> (C16515,C16514) -| (4514+4512+4513+(1327,84701)+9377+1329+(1337,1339)+(1340,125965)+1345+(1346,1347,9167)+1349+1350+(1351,341947)) -> C00001
Class
nt06418 Oxidative phosphorylation
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
4514  COX3; cytochrome c oxidase III
4512  COX1; cytochrome c oxidase subunit I
4513  COX2; cytochrome c oxidase subunit II
1327  COX4I1; cytochrome c oxidase subunit 4I1
84701  COX4I2; cytochrome c oxidase subunit 4I2
9377  COX5A; cytochrome c oxidase subunit 5A
1329  COX5B; cytochrome c oxidase subunit 5B
1337  COX6A1; cytochrome c oxidase subunit 6A1
1339  COX6A2; cytochrome c oxidase subunit 6A2
1340  COX6B1; cytochrome c oxidase subunit 6B1
125965  COX6B2; cytochrome c oxidase subunit 6B2
1345  COX6C; cytochrome c oxidase subunit 6C
1346  COX7A1; cytochrome c oxidase subunit 7A1
1347  COX7A2; cytochrome c oxidase subunit 7A2
9167  COX7A2L; cytochrome c oxidase subunit 7A2 like
1349  COX7B; cytochrome c oxidase subunit 7B
1350  COX7C; cytochrome c oxidase subunit 7C
1351  COX8A; cytochrome c oxidase subunit 8A
341947  COX8C; cytochrome c oxidase subunit 8C
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
C00001  H2O
Reference
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
  Authors
Lin MT, Beal MF
  Title
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
  Journal
Nature 443:787-95 (2006)
DOI:10.1038/nature05292
Reference
  Authors
Rodolfo C, Ciccosanti F, Giacomo GD, Piacentini M, Fimia GM
  Title
Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.
  Journal
Expert Rev Proteomics 7:519-42 (2010)
DOI:10.1586/epr.10.43
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