KEGG T01001: 4514

Homo sapiens (human): 4514

Entry

4514              CDS       T01001

Symbol

COX3, COIII, MTCO3, MT-CO3

Name

(RefSeq) cytochrome c oxidase subunit III

K02262

cytochrome c oxidase subunit 3

Organism

hsa Homo sapiens (human)

Pathway

hsa00190

Oxidative phosphorylation

hsa01100

Metabolic pathways

hsa04260

Cardiac muscle contraction

hsa04714

Thermogenesis

hsa04932

Non-alcoholic fatty liver disease

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05208

Chemical carcinogenesis - reactive oxygen species

hsa05415

Diabetic cardiomyopathy

Module

hsa_M00154

Cytochrome c oxidase

Network

nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration

Element

N00998

Electron transfer in Complex IV

N00999

Mutation-caused aberrant Abeta to electron transfer in Complex IV

N01394

Arsenic to electron transfer in complex IV

Disease

H00068

Leber hereditary optic atrophy

H01355

Kearns-Sayre syndrome

H01368

Cytochrome c oxidase (COX) deficiency

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4514 (COX3)
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4514 (COX3)
  09159 Environmental adaptation
   04714 Thermogenesis
    4514 (COX3)
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4514 (COX3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4514 (COX3)
   05012 Parkinson disease
    4514 (COX3)
   05014 Amyotrophic lateral sclerosis
    4514 (COX3)
   05016 Huntington disease
    4514 (COX3)
   05020 Prion disease
    4514 (COX3)
   05022 Pathways of neurodegeneration - multiple diseases
    4514 (COX3)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4514 (COX3)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4514 (COX3)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4514 (COX3)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4514 (COX3)

SSDB

Motif

Pfam:

COX3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Pharos:

P00414(Tbio)

UniProt:

P00414 Q7GIM7

Structure

LinkDB

Position

MT:9207..9990

AA seq 261 aa
MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRD
VTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTG
ITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASE
YFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAW
YWHFVDVVWLFLYVSIYWWGS

NT seq 784 nt +upstreamnt +downstreamnt
atgacccaccaatcacatgcctatcatatagtaaaacccagcccatgacccctaacaggg
gccctctcagccctcctaatgacctccggcctagccatgtgatttcacttccactccata
acgctcctcatactaggcctactaaccaacacactaaccatataccaatgatggcgcgat
gtaacacgagaaagcacataccaaggccaccacacaccacctgtccaaaaaggccttcga
tacgggataatcctatttattacctcagaagtttttttcttcgcaggatttttctgagcc
ttttaccactccagcctagcccctaccccccaattaggagggcactggcccccaacaggc
atcaccccgctaaatcccctagaagtcccactcctaaacacatccgtattactcgcatca
ggagtatcaatcacctgagctcaccatagtctaatagaaaacaaccgaaaccaaataatt
caagcactgcttattacaattttactgggtctctattttaccctcctacaagcctcagag
tacttcgagtctcccttcaccatttccgacggcatctacggctcaacattttttgtagcc
acaggcttccacggacttcacgtcattattggctcaactttcctcactatctgcttcatc
cgccaactaatatttcactttacatccaaacatcactttggcttcgaagccgccgcctga
tactggcattttgtagatgtggtttgactatttctgtatgtctccatctattgatgaggg
tctt

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