Homo sapiens (human): 4916
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Entry
4916 CDS
T01001
Symbol
NTRK3, GP145-TrkC, TRKC, gp145(trkC)
Name
(RefSeq) neurotrophic receptor tyrosine kinase 3
KO
K05101
neurotrophic tyrosine kinase, receptor type 3 [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04517
IgSF CAM signaling
hsa04722
Neurotrophin signaling pathway
hsa05230
Central carbon metabolism in cancer
Network
nt06528
Calcium signaling
nt06546
IgSF CAM signaling
Element
N01641
RTK-PLCG-ITPR signaling pathway
N01947
PTPRS interactions
Disease
H00043
Neuroblastoma
H01508
Salivary gland cancer
Drug target
Entrectinib:
D10926
<JP/US>
Larotrectinib (
DG02923
):
D11137
D11138
<JP/US>
Paltimatrectinib:
D12646
Repotrectinib:
D11454
<JP/US>
Taletrectinib (
DG03226
):
D12363
D12364
<JP/US>
Zurletrectinib:
D12432
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
4916 (NTRK3)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
4916 (NTRK3)
09150 Organismal Systems
09156 Nervous system
04722 Neurotrophin signaling pathway
4916 (NTRK3)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
4916 (NTRK3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
4916 (NTRK3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
4916 (NTRK3)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
TRK family [OT]
4916 (NTRK3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
I-set
LRRCT_2
ig
Ig_3
LRR_8
Ig_2
C2-set_2
LRRNT
LRR_4
LRR_5
TrkA_TMD
Haspin_kinase
LRR_NXF1-5
LRR_6
C2-set_3
Motif
Other DBs
NCBI-GeneID:
4916
NCBI-ProteinID:
NP_001012338
OMIM:
191316
HGNC:
8033
Ensembl:
ENSG00000140538
UniProt:
Q16288
X5D2R1
Structure
PDB
PDBj
LinkDB
All DBs
Position
15:complement(87859751..88256739)
Genome browser
AA seq
839 aa
AA seq
DB search
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
NT seq
2520 nt
NT seq
+upstream
nt +downstream
nt
atggatgtctctctttgcccagccaagtgtagtttctggcggattttcttgctgggaagc
gtctggctggactatgtgggctccgtgctggcttgccctgcaaattgtgtctgcagcaag
actgagatcaattgccggcggccggacgatgggaacctcttccccctcctggaagggcag
gattcagggaacagcaatgggaacgccagtatcaacatcacggacatctcaaggaatatc
acttccatacacatagagaactggcgcagtcttcacacgctcaacgccgtggacatggag
ctctacaccggacttcaaaagctgaccatcaagaactcaggacttcggagcattcagccc
agagcctttgccaagaacccccatttgcgttatataaacctgtcaagtaaccggctcacc
acactctcgtggcagctcttccagacgctgagtcttcgggaattgcagttggagcagaac
tttttcaactgcagctgtgacatccgctggatgcagctctggcaggagcagggggaggcc
aagctcaacagccagaacctctactgcatcaacgctgatggctcccagcttcctctcttc
cgcatgaacatcagtcagtgtgaccttcctgagatcagcgtgagccacgtcaacctgacc
gtacgagagggtgacaacgctgttatcacttgcaatggctctggatcaccccttcctgat
gtggactggatagtcactgggctgcagtccatcaacactcaccagaccaatctgaactgg
accaatgttcatgccatcaacttgacgctggtgaatgtgacgagtgaggacaatggcttc
accctgacgtgcattgcagagaacgtggtgggcatgagcaatgccagtgttgccctcact
gtctactatcccccacgtgtggtgagcctggaggagcctgagctgcgcctggagcactgc
atcgagtttgtggtgcgtggcaaccccccaccaacgctgcactggctgcacaatgggcag
cctctgcgggagtccaagatcatccatgtggaatactaccaagagggagagatttccgag
ggctgcctgctcttcaacaagcccacccactacaacaatggcaactataccctcattgcc
aaaaacccactgggcacagccaaccagaccatcaatggccacttcctcaaggagcccttt
ccagagagcacggataactttatcttgtttgacgaagtgagtcccacacctcctatcact
gtgacccacaaaccagaagaagacacttttggggtatccatagcagttggacttgctgct
tttgcctgtgtcctgttggtggttctcttcgtcatgatcaacaaatatggtcgacggtcc
aaatttggaatgaagggtcccgtggctgtcatcagtggtgaggaggactcagccagccca
ctgcaccacatcaaccacggcatcaccacgccctcgtcactggatgccgggcccgacact
gtggtcattggcatgactcgcatccctgtcattgagaacccccagtacttccgtcaggga
cacaactgccacaagccggacacgtatgtgcagcacattaagaggagagacatcgtgctg
aagcgagaactgggtgagggagcctttggaaaggtcttcctggccgagtgctacaacctc
agcccgaccaaggacaagatgcttgtggctgtgaaggccctgaaggatcccaccctggct
gcccggaaggatttccagagggaggccgagctgctcaccaacctgcagcatgagcacatt
gtcaagttctatggagtgtgcggcgatggggaccccctcatcatggtctttgaatacatg
aagcatggagacctgaataagttcctcagggcccatgggccagatgcaatgatccttgtg
gatggacagccacgccaggccaagggtgagctggggctctcccaaatgctccacattgcc
agtcagatcgcctcgggtatggtgtacctggcctcccagcactttgtgcaccgagacctg
gccaccaggaactgcctggttggagcgaatctgctagtgaagattggggacttcggcatg
tccagagatgtctacagcacggattattacaggctctttaatccatctggaaatgatttt
tgtatatggtgtgaggtgggaggacacaccatgctccccattcgctggatgcctcctgaa
agcatcatgtaccggaagttcactacagagagtgatgtatggagcttcggggtgatcctc
tgggagatcttcacctatggaaagcagccatggttccaactctcaaacacggaggtcatt
gagtgcattacccaaggtcgtgttttggagcggccccgagtctgccccaaagaggtgtac
gatgtcatgctggggtgctggcagagggaaccacagcagcggttgaacatcaaggagatc
tacaaaatcctccatgctttggggaaggccaccccaatctacctggacattcttggctag
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