KEGG   NETWORK: N01641
Entry
N01641                      Network                                
Name
RTK-PLCG-ITPR signaling pathway
Definition
GF -> RTK -> PLCG -> IP3 -> ITPR -> Ca2+(cyto)
  Expanded
(1950,5154,5155,56034,80310,2246,2247,2248,2249,8822,2251,2252,2253,2254,2255,8823,2250,8817,26281,27006,9965,26291,8074,7422,7423,7424,2277,4803,3082,4485,2668) -> (1956,2064,2065,2066,5156,5159,2260,2263,2261,2264,2321,2324,3791,4914,4915,4916,4233,4486,5979) -> (5335,5336) -> C01245 -> (3708,3709,3710) -> C00076
Class
nt06528 Calcium signaling
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
1950  EGF; epidermal growth factor
5154  PDGFA; platelet derived growth factor subunit A
5155  PDGFB; platelet derived growth factor subunit B
56034  PDGFC; platelet derived growth factor C
80310  PDGFD; platelet derived growth factor D
2246  FGF1; fibroblast growth factor 1
2247  FGF2; fibroblast growth factor 2
2248  FGF3; fibroblast growth factor 3
2249  FGF4; fibroblast growth factor 4
8822  FGF17; fibroblast growth factor 17
2251  FGF6; fibroblast growth factor 6
2252  FGF7; fibroblast growth factor 7
2253  FGF8; fibroblast growth factor 8
2254  FGF9; fibroblast growth factor 9
2255  FGF10; fibroblast growth factor 10
8823  FGF16; fibroblast growth factor 16
2250  FGF5; fibroblast growth factor 5
8817  FGF18; fibroblast growth factor 18
26281  FGF20; fibroblast growth factor 20
27006  FGF22; fibroblast growth factor 22
9965  FGF19; fibroblast growth factor 19
26291  FGF21; fibroblast growth factor 21
8074  FGF23; fibroblast growth factor 23
7422  VEGFA; vascular endothelial growth factor A
7423  VEGFB; vascular endothelial growth factor B
7424  VEGFC; vascular endothelial growth factor C
2277  VEGFD; vascular endothelial growth factor D
4803  NGF; nerve growth factor
3082  HGF; hepatocyte growth factor
4485  MST1; macrophage stimulating 1
2668  GDNF; glial cell derived neurotrophic factor
1956  EGFR; epidermal growth factor receptor
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
2065  ERBB3; erb-b2 receptor tyrosine kinase 3
2066  ERBB4; erb-b2 receptor tyrosine kinase 4
5156  PDGFRA; platelet derived growth factor receptor alpha
5159  PDGFRB; platelet derived growth factor receptor beta
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
2261  FGFR3; fibroblast growth factor receptor 3
2264  FGFR4; fibroblast growth factor receptor 4
2321  FLT1; fms related receptor tyrosine kinase 1
2324  FLT4; fms related receptor tyrosine kinase 4
3791  KDR; kinase insert domain receptor
4914  NTRK1; neurotrophic receptor tyrosine kinase 1
4915  NTRK2; neurotrophic receptor tyrosine kinase 2
4916  NTRK3; neurotrophic receptor tyrosine kinase 3
4233  MET; MET proto-oncogene, receptor tyrosine kinase
4486  MST1R; macrophage stimulating 1 receptor
5979  RET; ret proto-oncogene
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:30745293
  Authors
Prole DL, Taylor CW
  Title
Structure and Function of IP(3) Receptors.
  Journal
Cold Spring Harb Perspect Biol 11:cshperspect.a035063 (2019)
DOI:10.1101/cshperspect.a035063
LinkDB

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