| Entry |
|
|---|
| Symbol |
PAK1, IDDMSSD, PAKalpha, alpha-PAK, p65-PAK
|
|---|
| Name |
(RefSeq) p21 (RAC1) activated kinase 1
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa04392 | Hippo signaling pathway - multiple species |
| hsa04625 | C-type lectin receptor signaling pathway |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04660 | T cell receptor signaling pathway |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
|
|---|
| Network |
nt06124 Chemokine signaling (viruses) nt06161 Human immunodeficiency virus 1 (HIV-1) nt06526 MAPK signaling |
|---|
| Element |
| N00433 | CXCR4-GNB/G-RAC signaling pathway |
| N00434 | HIV gp120 to CXCR4-GNB/G-RAC signaling pathway |
| N01119 | RAC/CDC42-PAK-ERK signaling pathway |
|
|---|
| Disease |
| H02463 | Syndromic intellectual developmental disorder |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5058 (PAK1)
04012 ErbB signaling pathway
5058 (PAK1)
04014 Ras signaling pathway
5058 (PAK1)
04392 Hippo signaling pathway - multiple species
5058 (PAK1)
04024 cAMP signaling pathway
5058 (PAK1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
5058 (PAK1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
5058 (PAK1)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
5058 (PAK1)
04650 Natural killer cell mediated cytotoxicity
5058 (PAK1)
04660 T cell receptor signaling pathway
5058 (PAK1)
04666 Fc gamma R-mediated phagocytosis
5058 (PAK1)
04062 Chemokine signaling pathway
5058 (PAK1)
09158 Development and regeneration
04360 Axon guidance
5058 (PAK1)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5058 (PAK1)
09162 Cancer: specific types
05211 Renal cell carcinoma
5058 (PAK1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
5058 (PAK1)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
5058 (PAK1)
05130 Pathogenic Escherichia coli infection
5058 (PAK1)
05132 Salmonella infection
5058 (PAK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5058 (PAK1)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
5058 (PAK1)
03036 Chromosome and associated proteins [BR:hsa03036]
5058 (PAK1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
5058 (PAK1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: STE group
STE20 family
5058 (PAK1)
Membrane trafficking [BR:hsa04131]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
5058 (PAK1)
Endocytosis
Macropinocytosis
Kinases
5058 (PAK1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Sister chromatid separation proteins
Aurora kinases
Regulators of Aurora kinases
5058 (PAK1)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
|
|---|
| LinkDB |
|
|---|
| Position |
11:complement(77322017..77530009)
|
|---|
| AA seq |
545 aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH |
|---|
| NT seq |
1638 nt +upstreamnt +downstreamnt
atgtcaaataacggcctagacattcaagacaaacccccagcccctccgatgagaaatacc
agcactatgattggagccggcagcaaagatgctggaaccctaaaccatggttctaaacct
ctgcctccaaacccagaggagaagaaaaagaaggaccgattttaccgatccattttacct
ggagataaaacaaataaaaagaaagagaaagagcggccagagatttctctcccttcagat
tttgaacacacaattcatgtcggttttgatgctgtcacaggggagtttacgggaatgcca
gagcagtgggcccgcttgcttcagacatcaaatatcactaagtcggagcagaagaaaaac
ccgcaggctgttctggatgtgttggagttttacaactcgaagaagacatccaacagccag
aaatacatgagctttacagataagtcagctgaggattacaattcttctaatgccttgaat
gtgaaggctgtgtctgagactcctgcagtgccaccagtttcagaagatgaggatgatgat
gatgatgatgctaccccaccaccagtgattgctccacgcccagagcacacaaaatctgta
tacacacggtctgtgattgaaccacttcctgtcactccaactcgggacgtggctacatct
cccatttcacctactgaaaataacaccactccaccagatgctttgacccggaatactgag
aagcagaagaagaagcctaaaatgtctgatgaggagatcttggagaaattacgaagcata
gtgagtgtgggcgatcctaagaagaaatatacacggtttgagaagattggacaaggtgct
tcaggcaccgtgtacacagcaatggatgtggccacaggacaggaggtggccattaagcag
atgaatcttcagcagcagcccaagaaagagctgattattaatgagatcctggtcatgagg
gaaaacaagaacccaaacattgtgaattacttggacagttacctcgtgggagatgagctg
tgggttgttatggaatacttggctggaggctccttgacagatgtggtgacagaaacttgc
atggatgaaggccaaattgcagctgtgtgccgtgagtgtctgcaggctctggagttcttg
cattcgaaccaggtcattcacagagacatcaagagtgacaatattctgttgggaatggat
ggctctgtcaagctaactgactttggattctgtgcacagataaccccagagcagagcaaa
cggagcaccatggtaggaaccccatactggatggcaccagaggttgtgacacgaaaggcc
tatgggcccaaggttgacatctggtccctgggcatcatggccatcgaaatgattgaaggg
gagcctccatacctcaatgaaaaccctctgagagccttgtacctcattgccaccaatggg
accccagaacttcagaacccagagaagctgtcagctatcttccgggactttctgaaccgc
tgtctcgagatggatgtggagaagagaggttcagctaaagagctgctacagcatcaattc
ctgaagattgccaagcccctctccagcctcactccactgattgctgcagctaaggaggca
acaaagaacaatcactaa |
|---|
