KEGG   Homo sapiens (human): 5122
Entry
5122              CDS       T01001                                 
Symbol
PCSK1, BMIQ12, NEC1, PC1, PC1/3, PC3, SPC3
Name
(RefSeq) neuroendocrine convertase 1 isoform 1 preproprotein
  KO
K01359  proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]
Organism
hsa  Homo sapiens (human)
Network
nt06544  Neuroactive ligand signaling
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
Disease
H02105  Prohormone convertase 1/3 deficiency
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5122 (PCSK1)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5122 (PCSK1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.93  proprotein convertase 1
     5122 (PCSK1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5122 (PCSK1)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5122 (PCSK1)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain Proho_convert OmpA_membrane
Other DBs
NCBI-GeneID: 5122
NCBI-ProteinID: NP_000430
OMIM: 162150
HGNC: 8743
Ensembl: ENSP00000308024.2
UniProt: P29120
Structure
LinkDB
Position
5:complement(96390333..96433248)
AA seq 753 aa
MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQ
IGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL
FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYAN
YDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM
LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKG
SIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY
TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPL
ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK
ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERE
RDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH
MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEE
GAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL
YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
NT seq 2262 nt   +upstreamnt  +downstreamnt
atggagcgaagagcctggagtctgcagtgcactgctttcgtcctcttttgcgcttggtgt
gcactgaacagtgcaaaagcgaaaaggcaatttgtcaatgaatgggcagcggagatcccc
gggggcccggaagcagcctcggccatcgccgaggagctgggctatgaccttttgggtcag
attggttcacttgaaaatcactacttattcaaacataaaaaccaccccagaaggtctcga
aggagtgcctttcatatcactaagagattatctgatgatgatcgtgtgatatgggctgaa
caacagtatgaaaaagaaagaagtaaacgttcagctctaagggactcagcactaaatctc
ttcaatgatcccatgtggaatcagcaatggtacttgcaagataccaggatgacggcagcc
ctgcccaagctggaccttcatgtgatacctgtttggcaaaaaggcattacgggcaaagga
gttgttatcaccgtactggatgatggtttggagtggaatcacacggacatttatgccaac
tatgatccagaggctagctatgattttaatgataatgaccatgatccatttccccgatat
gatcccacaaacgagaacaaacacgggaccagatgtgcaggagaaattgccatgcaagca
aataatcacaaatgcggggttggagttgcatacaattccaaagttggaggcataagaatg
ctggatggcattgtgacggatgctattgaggccagttcaattggattcaatcctggacac
gtggatatttacagtgcaagctggggccctaatgatgatgggaaaactgtggaggggcct
ggccggctagcccagaaggcttttgaatatggtgtcaaacaggggagacaggggaagggg
tccatcttcgtctgggcttcgggaaacggggggcgtcagggagataattgtgactgtgat
ggctacacagacagcatctacaccatctccatcagcagtgcctcccagcaaggcctatcc
ccctggtacgctgagaagtgctcctccacactggccacctcttacagcagcggagattac
accgaccagagaatcacgagcgctgacctgcacaatgactgcacggagacgcacacaggc
acctcggcctctgcacctctggctgctggcatcttcgctctggccctggaagcaaaccca
aatctcacctggcgagatatgcagcacctggttgtctggacctctgagtatgacccgctg
gccaataaccctggatggaaaaagaatggagcaggcttgatggtgaatagtcgatttgga
tttggcttgctaaatgccaaagctctggtggatttagctgaccccaggacctggaggagc
gtgcctgagaagaaagagtgtgttgtaaaggacaatgactttgagcccagagccctgaaa
gctaatggagaagttatcattgaaattccaacaagagcttgtgaaggacaagaaaatgct
atcaagtccctggagcatgtacaatttgaagcaacaattgaatattcccgaagaggagac
cttcatgtcacacttacttctgctgctggaactagcactgtgctcttggctgaaagagaa
cgggatacatctcctaatggctttaagaattgggacttcatgtctgttcacacatgggga
gagaaccctataggtacttggactttgagaattacagacatgtctggaagaattcaaaat
gaaggaagaattgtgaactggaagctgattttgcacgggacctcttctcagccagagcat
atgaagcagcctcgtgtgtacacgtcctacaacactgttcagaatgacagaagaggggtg
gagaagatggtggatccaggggaggagcagcccacacaagagaaccctaaggagaacacc
ctggtgtccaaaagccccagcagcagcagcgtagggggccggagggatgagttggaggag
ggagccccttcccaggccatgctgcgactcctgcaaagtgctttcagtaaaaactcaccg
ccaaagcaatcaccaaagaagtccccaagtgcaaagctcaacatcccttatgaaaacttc
tacgaagccctggaaaagctgaacaaaccttcccagcttaaagactctgaagacagtctg
tataatgactatgttgatgttttttataacactaaaccttacaagcacagagacgaccgg
ctgcttcaagctctggtggacattctgaatgaggaaaattaa

KEGG   Homo sapiens (human): 5126
Entry
5126              CDS       T01001                                 
Symbol
PCSK2, NEC 2, NEC-2, NEC2, PC2, SPC2
Name
(RefSeq) neuroendocrine convertase 2 isoform 1 preproprotein
  KO
K01360  proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
Organism
hsa  Homo sapiens (human)
Network
nt06544  Neuroactive ligand signaling
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5126 (PCSK2)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5126 (PCSK2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.94  proprotein convertase 2
     5126 (PCSK2)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5126 (PCSK2)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5126 (PCSK2)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain AftB_C
Other DBs
NCBI-GeneID: 5126
NCBI-ProteinID: NP_002585
OMIM: 162151
HGNC: 8744
Ensembl: ENSP00000262545.2
UniProt: P16519
LinkDB
Position
20:17226107..17484578
AA seq 638 aa
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgaagggtggttgtgtctcccagtggaaggcggccgccgggttcctcttctgtgtcatg
gtttttgcatctgctgagcgaccggtcttcacgaatcattttcttgtggagttgcataaa
gggggagaggacaaagctcgccaagttgcagcagaacacggctttggagtccgaaagctt
ccctttgctgaaggtctgtaccacttttatcacaatggccttgcaaaggccaagagaaga
cgcagcctacaccacaagcagcagctggagagagaccccagggtaaagatggctttgcag
caggaaggatttgaccgaaaaaagcgaggttacagagacatcaatgagatcgacatcaac
atgaacgatcctctttttacaaagcagtggtatctgatcaatactgggcaagctgatggc
actcctggccttgatttgaatgtggctgaagcctgggagctgggatacacagggaaaggt
gttaccattggaattatggatgatgggattgactatctccacccggacctggcctccaac
tataatgccgaagcaagttacgacttcagcagcaacgacccctatccttaccctcggtac
acagatgactggtttaacagccacgggacccgatgtgcaggagaagtttctgctgccgcc
aacaacaatatctgtggagttggagtagcatacaactccaaggttgcaggcatccggatg
ctggaccagccattcatgacagacatcatcgaggcctcctccatcagtcatatgccacag
ctgattgacatctacagcgccagctggggccccacagacaacggcaagacagtggatggg
ccccgggagctcacgctgcaggccatggccgatggcgtgaacaagggccgcggcggcaaa
ggcagcatctacgtgtgggcctccggggacggcggcagctatgacgactgcaactgcgac
ggctacgcctccagcatgtggaccatctccatcaactcagccatcaacgacggcaggact
gccctgtacgacgagagctgctcttccaccttggcttccaccttcagcaacgggaggaaa
aggaaccccgaggccggtgtggcaaccacagatttgtacggcaactgcactctgaggcat
tctgggacatctgcagctgcccccgaggcagctggtgtgtttgcactggctctggaggct
aacctgggtctgacctggcgggacatgcagcatctgactgtgctcacctccaaacggaac
cagcttcacgacgaggtccatcagtggcggcgcaatggggtcggcctggaatttaatcac
ctctttggctacggggtccttgatgcaggtgccatggtgaaaatggctaaagactggaaa
accgtgcctgagagattccactgtgtgggaggctccgtgcaggaccctgagaaaatacca
tccactggcaagttggtgctgacactcacaaccgacgcctgtgaggggaaggaaaatttt
gtccgctacctggagcatgtccaggctgtcatcacggtcaacgcaaccagaagaggagac
ctgaacatcaacatgacttcccctatgggcaccaagtccattttgctgagccggcgtcca
agggatgacgactccaaggtgggctttgacaagtggcctttcatgaccactcacacgtgg
ggggaagacgcccgaggcacctggaccctggagctgggatttgtcggcagcgccccgcag
aagggggtgctgaaggagtggaccctgatgctgcatggcactcagagtgccccgtacatc
gaccaggtggtgcgggattaccagtccaagttggccatgtccaagaaagaggagctggag
gaagagctggacgaagccgtggagagaagcctgaaaagcatccttaacaagaactag

KEGG   Homo sapiens (human): 5045
Entry
5045              CDS       T01001                                 
Symbol
FURIN, FUR, PACE, PCSK3, SPC1
Name
(RefSeq) furin isoform 1 preproprotein
  KO
K01349  furin [EC:3.4.21.75]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa04382  Cornified envelope formation
Network
nt06544  Neuroactive ligand signaling
nt06545  Cornified envelope formation
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    5045 (FURIN)
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    5045 (FURIN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5045 (FURIN)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5045 (FURIN)
   04131 Membrane trafficking [BR:hsa04131]
    5045 (FURIN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.75  furin
     5045 (FURIN)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5045 (FURIN)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5045 (FURIN)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Others
   Others
    5045 (FURIN)
SSDB
Motif
Pfam: Peptidase_S8 S8_pro-domain P_proprotein Furin-like_2 VSP DUF357 YicS
Other DBs
NCBI-GeneID: 5045
NCBI-ProteinID: NP_001276752
OMIM: 136950
HGNC: 8568
UniProt: P09958
Structure
LinkDB
Position
15:90868588..90883457
AA seq 794 aa
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
NT seq 2385 nt   +upstreamnt  +downstreamnt
atggagctgaggccctggttgctatgggtggtagcagcaacaggaaccttggtcctgcta
gcagctgatgctcagggccagaaggtcttcaccaacacgtgggctgtgcgcatccctgga
ggcccagcggtggccaacagtgtggcacggaagcatgggttcctcaacctgggccagatc
ttcggggactattaccacttctggcatcgaggagtgacgaagcggtccctgtcgcctcac
cgcccgcggcacagccggctgcagagggagcctcaagtacagtggctggaacagcaggtg
gcaaagcgacggactaaacgggacgtgtaccaggagcccacagaccccaagtttcctcag
cagtggtacctgtctggtgtcactcagcgggacctgaatgtgaaggcggcctgggcgcag
ggctacacagggcacggcattgtggtctccattctggacgatggcatcgagaagaaccac
ccggacttggcaggcaattatgatcctggggccagttttgatgtcaatgaccaggaccct
gacccccagcctcggtacacacagatgaatgacaacaggcacggcacacggtgtgcgggg
gaagtggctgcggtggccaacaacggtgtctgtggtgtaggtgtggcctacaacgcccgc
attggaggggtgcgcatgctggatggcgaggtgacagatgcagtggaggcacgctcgctg
ggcctgaaccccaaccacatccacatctacagtgccagctggggccccgaggatgacggc
aagacagtggatgggccagcccgcctcgccgaggaggccttcttccgtggggttagccag
ggccgaggggggctgggctccatctttgtctgggcctcggggaacgggggccgggaacat
gacagctgcaactgcgacggctacaccaacagtatctacacgctgtccatcagcagcgcc
acgcagtttggcaacgtgccgtggtacagcgaggcctgctcgtccacactggccacgacc
tacagcagtggcaaccagaatgagaagcagatcgtgacgactgacttgcggcagaagtgc
acggagtctcacacgggcacctcagcctctgcccccttagcagccggcatcattgctctc
accctggaggccaataagaacctcacatggcgggacatgcaacacctggtggtacagacc
tcgaagccagcccacctcaatgccaacgactgggccaccaatggtgtgggccggaaagtg
agccactcatatggctacgggcttttggacgcaggcgccatggtggccctggcccagaat
tggaccacagtggccccccagcggaagtgcatcatcgacatcctcaccgagcccaaagac
atcgggaaacggctcgaggtgcggaagaccgtgaccgcgtgcctgggcgagcccaaccac
atcactcggctggagcacgctcaggcgcggctcaccctgtcctataatcgccgtggcgac
ctggccatccacctggtcagccccatgggcacccgctccaccctgctggcagccaggcca
catgactactccgcagatgggtttaatgactgggccttcatgacaactcattcctgggat
gaggatccctctggcgagtgggtcctagagattgaaaacaccagcgaagccaacaactat
gggacgctgaccaagttcaccctcgtactctatggcaccgcccctgaggggctgcccgta
cctccagaaagcagtggctgcaagaccctcacgtccagtcaggcctgtgtggtgtgcgag
gaaggcttctccctgcaccagaagagctgtgtccagcactgccctccagggttcgccccc
caagtcctcgatacgcactatagcaccgagaatgacgtggagaccatccgggccagcgtc
tgcgccccctgccacgcctcatgtgccacatgccaggggccggccctgacagactgcctc
agctgccccagccacgcctccttggaccctgtggagcagacttgctcccggcaaagccag
agcagccgagagtccccgccacagcagcagccacctcggctgcccccggaggtggaggcg
gggcaacggctgcgggcagggctgctgccctcacacctgcctgaggtggtggccggcctc
agctgcgccttcatcgtgctggtcttcgtcactgtcttcctggtcctgcagctgcgctct
ggctttagttttcggggggtgaaggtgtacaccatggaccgtggcctcatctcctacaag
gggctgccccctgaagcctggcaggaggagtgcccgtctgactcagaagaggacgagggc
cggggcgagaggaccgcctttatcaaagaccagagcgccctctga

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