KEGG   Homo sapiens (human): 5122
Entry
5122              CDS       T01001                                 
Symbol
PCSK1, BMIQ12, NEC1, PC1, PC1/3, PC3, SPC3
Name
(RefSeq) proprotein convertase subtilisin/kexin type 1
  KO
K01359  proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]
Organism
hsa  Homo sapiens (human)
Network
nt06544  Neuroactive ligand signaling
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
Disease
H02105  Prohormone convertase 1/3 deficiency
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5122 (PCSK1)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5122 (PCSK1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.93  proprotein convertase 1
     5122 (PCSK1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5122 (PCSK1)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5122 (PCSK1)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain Proho_convert Peptidase_S8_N OmpA_membrane
Other DBs
NCBI-GeneID: 5122
NCBI-ProteinID: NP_000430
OMIM: 162150
HGNC: 8743
Ensembl: ENSG00000175426
UniProt: P29120
LinkDB
Position
5:complement(96390333..96433248)
AA seq 753 aa
MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQ
IGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL
FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYAN
YDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM
LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKG
SIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY
TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPL
ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK
ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERE
RDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH
MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEE
GAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL
YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
NT seq 2262 nt   +upstreamnt  +downstreamnt
atggagcgaagagcctggagtctgcagtgcactgctttcgtcctcttttgcgcttggtgt
gcactgaacagtgcaaaagcgaaaaggcaatttgtcaatgaatgggcagcggagatcccc
gggggcccggaagcagcctcggccatcgccgaggagctgggctatgaccttttgggtcag
attggttcacttgaaaatcactacttattcaaacataaaaaccaccccagaaggtctcga
aggagtgcctttcatatcactaagagattatctgatgatgatcgtgtgatatgggctgaa
caacagtatgaaaaagaaagaagtaaacgttcagctctaagggactcagcactaaatctc
ttcaatgatcccatgtggaatcagcaatggtacttgcaagataccaggatgacggcagcc
ctgcccaagctggaccttcatgtgatacctgtttggcaaaaaggcattacgggcaaagga
gttgttatcaccgtactggatgatggtttggagtggaatcacacggacatttatgccaac
tatgatccagaggctagctatgattttaatgataatgaccatgatccatttccccgatat
gatcccacaaacgagaacaaacacgggaccagatgtgcaggagaaattgccatgcaagca
aataatcacaaatgcggggttggagttgcatacaattccaaagttggaggcataagaatg
ctggatggcattgtgacggatgctattgaggccagttcaattggattcaatcctggacac
gtggatatttacagtgcaagctggggccctaatgatgatgggaaaactgtggaggggcct
ggccggctagcccagaaggcttttgaatatggtgtcaaacaggggagacaggggaagggg
tccatcttcgtctgggcttcgggaaacggggggcgtcagggagataattgtgactgtgat
ggctacacagacagcatctacaccatctccatcagcagtgcctcccagcaaggcctatcc
ccctggtacgctgagaagtgctcctccacactggccacctcttacagcagcggagattac
accgaccagagaatcacgagcgctgacctgcacaatgactgcacggagacgcacacaggc
acctcggcctctgcacctctggctgctggcatcttcgctctggccctggaagcaaaccca
aatctcacctggcgagatatgcagcacctggttgtctggacctctgagtatgacccgctg
gccaataaccctggatggaaaaagaatggagcaggcttgatggtgaatagtcgatttgga
tttggcttgctaaatgccaaagctctggtggatttagctgaccccaggacctggaggagc
gtgcctgagaagaaagagtgtgttgtaaaggacaatgactttgagcccagagccctgaaa
gctaatggagaagttatcattgaaattccaacaagagcttgtgaaggacaagaaaatgct
atcaagtccctggagcatgtacaatttgaagcaacaattgaatattcccgaagaggagac
cttcatgtcacacttacttctgctgctggaactagcactgtgctcttggctgaaagagaa
cgggatacatctcctaatggctttaagaattgggacttcatgtctgttcacacatgggga
gagaaccctataggtacttggactttgagaattacagacatgtctggaagaattcaaaat
gaaggaagaattgtgaactggaagctgattttgcacgggacctcttctcagccagagcat
atgaagcagcctcgtgtgtacacgtcctacaacactgttcagaatgacagaagaggggtg
gagaagatggtggatccaggggaggagcagcccacacaagagaaccctaaggagaacacc
ctggtgtccaaaagccccagcagcagcagcgtagggggccggagggatgagttggaggag
ggagccccttcccaggccatgctgcgactcctgcaaagtgctttcagtaaaaactcaccg
ccaaagcaatcaccaaagaagtccccaagtgcaaagctcaacatcccttatgaaaacttc
tacgaagccctggaaaagctgaacaaaccttcccagcttaaagactctgaagacagtctg
tataatgactatgttgatgttttttataacactaaaccttacaagcacagagacgaccgg
ctgcttcaagctctggtggacattctgaatgaggaaaattaa

KEGG   Homo sapiens (human): 5126
Entry
5126              CDS       T01001                                 
Symbol
PCSK2, NEC_2, NEC-2, NEC2, PC2, SPC2
Name
(RefSeq) proprotein convertase subtilisin/kexin type 2
  KO
K01360  proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
Organism
hsa  Homo sapiens (human)
Network
nt06544  Neuroactive ligand signaling
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5126 (PCSK2)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5126 (PCSK2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.94  proprotein convertase 2
     5126 (PCSK2)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5126 (PCSK2)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5126 (PCSK2)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain Peptidase_S8_N
Other DBs
NCBI-GeneID: 5126
NCBI-ProteinID: NP_002585
OMIM: 162151
HGNC: 8744
Ensembl: ENSG00000125851
UniProt: P16519
LinkDB
Position
20:17226107..17484578
AA seq 638 aa
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgaagggtggttgtgtctcccagtggaaggcggccgccgggttcctcttctgtgtcatg
gtttttgcatctgctgagcgaccggtcttcacgaatcattttcttgtggagttgcataaa
gggggagaggacaaagctcgccaagttgcagcagaacacggctttggagtccgaaagctt
ccctttgctgaaggtctgtaccacttttatcacaatggccttgcaaaggccaagagaaga
cgcagcctacaccacaagcagcagctggagagagaccccagggtaaagatggctttgcag
caggaaggatttgaccgaaaaaagcgaggttacagagacatcaatgagatcgacatcaac
atgaacgatcctctttttacaaagcagtggtatctgatcaatactgggcaagctgatggc
actcctggccttgatttgaatgtggctgaagcctgggagctgggatacacagggaaaggt
gttaccattggaattatggatgatgggattgactatctccacccggacctggcctccaac
tataatgccgaagcaagttacgacttcagcagcaacgacccctatccttaccctcggtac
acagatgactggtttaacagccacgggacccgatgtgcaggagaagtttctgctgccgcc
aacaacaatatctgtggagttggagtagcatacaactccaaggttgcaggcatccggatg
ctggaccagccattcatgacagacatcatcgaggcctcctccatcagtcatatgccacag
ctgattgacatctacagcgccagctggggccccacagacaacggcaagacagtggatggg
ccccgggagctcacgctgcaggccatggccgatggcgtgaacaagggccgcggcggcaaa
ggcagcatctacgtgtgggcctccggggacggcggcagctatgacgactgcaactgcgac
ggctacgcctccagcatgtggaccatctccatcaactcagccatcaacgacggcaggact
gccctgtacgacgagagctgctcttccaccttggcttccaccttcagcaacgggaggaaa
aggaaccccgaggccggtgtggcaaccacagatttgtacggcaactgcactctgaggcat
tctgggacatctgcagctgcccccgaggcagctggtgtgtttgcactggctctggaggct
aacctgggtctgacctggcgggacatgcagcatctgactgtgctcacctccaaacggaac
cagcttcacgacgaggtccatcagtggcggcgcaatggggtcggcctggaatttaatcac
ctctttggctacggggtccttgatgcaggtgccatggtgaaaatggctaaagactggaaa
accgtgcctgagagattccactgtgtgggaggctccgtgcaggaccctgagaaaatacca
tccactggcaagttggtgctgacactcacaaccgacgcctgtgaggggaaggaaaatttt
gtccgctacctggagcatgtccaggctgtcatcacggtcaacgcaaccagaagaggagac
ctgaacatcaacatgacttcccctatgggcaccaagtccattttgctgagccggcgtcca
agggatgacgactccaaggtgggctttgacaagtggcctttcatgaccactcacacgtgg
ggggaagacgcccgaggcacctggaccctggagctgggatttgtcggcagcgccccgcag
aagggggtgctgaaggagtggaccctgatgctgcatggcactcagagtgccccgtacatc
gaccaggtggtgcgggattaccagtccaagttggccatgtccaagaaagaggagctggag
gaagagctggacgaagccgtggagagaagcctgaaaagcatccttaacaagaactag

KEGG   Homo sapiens (human): 5045
Entry
5045              CDS       T01001                                 
Symbol
FURIN, FUR, PACE, PCSK3, SPC1
Name
(RefSeq) furin, paired basic amino acid cleaving enzyme
  KO
K01349  furin [EC:3.4.21.75]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
Network
nt06544  Neuroactive ligand signaling
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    5045 (FURIN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5045 (FURIN)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5045 (FURIN)
   04131 Membrane trafficking [BR:hsa04131]
    5045 (FURIN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.75  furin
     5045 (FURIN)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5045 (FURIN)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5045 (FURIN)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Others
   Others
    5045 (FURIN)
SSDB
Motif
Pfam: Peptidase_S8 S8_pro-domain P_proprotein Furin-like_2 VSP DUF357
Other DBs
NCBI-GeneID: 5045
NCBI-ProteinID: NP_001276752
OMIM: 136950
HGNC: 8568
Ensembl: ENSG00000140564
UniProt: P09958
Structure
LinkDB
Position
15:90868588..90883457
AA seq 794 aa
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
NT seq 2385 nt   +upstreamnt  +downstreamnt
atggagctgaggccctggttgctatgggtggtagcagcaacaggaaccttggtcctgcta
gcagctgatgctcagggccagaaggtcttcaccaacacgtgggctgtgcgcatccctgga
ggcccagcggtggccaacagtgtggcacggaagcatgggttcctcaacctgggccagatc
ttcggggactattaccacttctggcatcgaggagtgacgaagcggtccctgtcgcctcac
cgcccgcggcacagccggctgcagagggagcctcaagtacagtggctggaacagcaggtg
gcaaagcgacggactaaacgggacgtgtaccaggagcccacagaccccaagtttcctcag
cagtggtacctgtctggtgtcactcagcgggacctgaatgtgaaggcggcctgggcgcag
ggctacacagggcacggcattgtggtctccattctggacgatggcatcgagaagaaccac
ccggacttggcaggcaattatgatcctggggccagttttgatgtcaatgaccaggaccct
gacccccagcctcggtacacacagatgaatgacaacaggcacggcacacggtgtgcgggg
gaagtggctgcggtggccaacaacggtgtctgtggtgtaggtgtggcctacaacgcccgc
attggaggggtgcgcatgctggatggcgaggtgacagatgcagtggaggcacgctcgctg
ggcctgaaccccaaccacatccacatctacagtgccagctggggccccgaggatgacggc
aagacagtggatgggccagcccgcctcgccgaggaggccttcttccgtggggttagccag
ggccgaggggggctgggctccatctttgtctgggcctcggggaacgggggccgggaacat
gacagctgcaactgcgacggctacaccaacagtatctacacgctgtccatcagcagcgcc
acgcagtttggcaacgtgccgtggtacagcgaggcctgctcgtccacactggccacgacc
tacagcagtggcaaccagaatgagaagcagatcgtgacgactgacttgcggcagaagtgc
acggagtctcacacgggcacctcagcctctgcccccttagcagccggcatcattgctctc
accctggaggccaataagaacctcacatggcgggacatgcaacacctggtggtacagacc
tcgaagccagcccacctcaatgccaacgactgggccaccaatggtgtgggccggaaagtg
agccactcatatggctacgggcttttggacgcaggcgccatggtggccctggcccagaat
tggaccacagtggccccccagcggaagtgcatcatcgacatcctcaccgagcccaaagac
atcgggaaacggctcgaggtgcggaagaccgtgaccgcgtgcctgggcgagcccaaccac
atcactcggctggagcacgctcaggcgcggctcaccctgtcctataatcgccgtggcgac
ctggccatccacctggtcagccccatgggcacccgctccaccctgctggcagccaggcca
catgactactccgcagatgggtttaatgactgggccttcatgacaactcattcctgggat
gaggatccctctggcgagtgggtcctagagattgaaaacaccagcgaagccaacaactat
gggacgctgaccaagttcaccctcgtactctatggcaccgcccctgaggggctgcccgta
cctccagaaagcagtggctgcaagaccctcacgtccagtcaggcctgtgtggtgtgcgag
gaaggcttctccctgcaccagaagagctgtgtccagcactgccctccagggttcgccccc
caagtcctcgatacgcactatagcaccgagaatgacgtggagaccatccgggccagcgtc
tgcgccccctgccacgcctcatgtgccacatgccaggggccggccctgacagactgcctc
agctgccccagccacgcctccttggaccctgtggagcagacttgctcccggcaaagccag
agcagccgagagtccccgccacagcagcagccacctcggctgcccccggaggtggaggcg
gggcaacggctgcgggcagggctgctgccctcacacctgcctgaggtggtggccggcctc
agctgcgccttcatcgtgctggtcttcgtcactgtcttcctggtcctgcagctgcgctct
ggctttagttttcggggggtgaaggtgtacaccatggaccgtggcctcatctcctacaag
gggctgccccctgaagcctggcaggaggagtgcccgtctgactcagaagaggacgagggc
cggggcgagaggaccgcctttatcaaagaccagagcgccctctga

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