KEGG   Homo sapiens (human): 52
Entry
52                CDS       T01001                                 
Symbol
ACP1, HAAP, LMW-PTP, LMWPTP
Name
(RefSeq) acid phosphatase 1
  KO
K14394  low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.2 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00730  Thiamine metabolism
hsa00740  Riboflavin metabolism
hsa01100  Metabolic pathways
hsa04520  Adherens junction
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06223  TNF signaling
  Element
N01411  Metals to NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    52 (ACP1)
   00740 Riboflavin metabolism
    52 (ACP1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    52 (ACP1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    52 (ACP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    52 (ACP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.2  acid phosphatase
     52 (ACP1)
    3.1.3.48  protein-tyrosine-phosphatase
     52 (ACP1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class II PTPs
   Low molecular weight PTPs (LMWPTPs)
    52 (ACP1)
SSDB
Motif
Pfam: LMWPc
Other DBs
NCBI-GeneID: 52
NCBI-ProteinID: NP_004291
OMIM: 171500
HGNC: 122
Ensembl: ENSG00000143727
Pharos: P24666(Tchem)
UniProt: P24666 Q59EH3
Structure
LinkDB
Position
2:264947..278283
AA seq 158 aa
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
NT seq 477 nt   +upstreamnt  +downstreamnt
atggcggaacaggctaccaagtccgtgctgtttgtgtgtctgggtaacatttgtcgatca
cccattgcagaagcagttttcaggaaacttgtaaccgatcaaaacatctcagagaattgg
agggtagacagcgcggcaacttccgggtatgagatagggaacccccctgactaccgaggg
cagagctgcatgaagaggcacggcattcccatgagccacgttgcccggcagattaccaaa
gaagattttgccacatttgattatatactatgtatggatgaaagcaatctgagagatttg
aatagaaaaagtaatcaagttaaaacctgcaaagctaaaattgaactacttgggagctat
gatccacaaaaacaacttattattgaagatccctattatgggaatgactctgactttgag
acggtgtaccagcagtgtgtcaggtgctgcagagcgttcttggagaaggcccactga

KEGG   Homo sapiens (human): 5781
Entry
5781              CDS       T01001                                 
Symbol
PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Name
(RefSeq) protein tyrosine phosphatase non-receptor type 11
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04360  Axon guidance
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04931  Insulin resistance
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05211  Renal cell carcinoma
hsa05220  Chronic myeloid leukemia
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06223  TNF signaling
nt06517  TLR signaling
  Element
N00926  Escherichia Tir to TLR2/4-MAPK signaling pathway
N01411  Metals to NFKB signaling pathway
Disease
H00523  Noonan syndrome and related disorders
H01018  Metachondromatosis
H01738  Noonan syndrome
H01984  Leopard syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02541  Juvenile myelomonocytic leukemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5781 (PTPN11)
   04630 JAK-STAT signaling pathway
    5781 (PTPN11)
   04072 Phospholipase D signaling pathway
    5781 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5781 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    5781 (PTPN11)
   04670 Leukocyte transendothelial migration
    5781 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5781 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    5781 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    5781 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5781 (PTPN11)
   05208 Chemical carcinogenesis - reactive oxygen species
    5781 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5781 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    5781 (PTPN11)
   05211 Renal cell carcinoma
    5781 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    5781 (PTPN11)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    5781 (PTPN11)
   05130 Pathogenic Escherichia coli infection
    5781 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5781 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5781 (PTPN11)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     5781 (PTPN11)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    5781 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 5781
NCBI-ProteinID: NP_002825
OMIM: 176876
HGNC: 9644
Ensembl: ENSG00000179295
Pharos: Q06124(Tchem)
UniProt: Q06124
Structure
LinkDB
Position
12:112418947..112509918
AA seq 593 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgacatcgcggagatggtttcacccaaatatcactggtgtggaggcagaaaacctactg
ttgacaagaggagttgatggcagttttttggcaaggcctagtaaaagtaaccctggagac
ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gattactatgacctgtatggaggggagaaatttgccactttggctgagttggtccagtat
tacatggaacatcacgggcaattaaaagagaagaatggagatgtcattgagcttaaatat
cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacatctctctgggaaa
gaagcagagaaattattaactgaaaaaggaaaacatggtagttttcttgtacgagagagc
cagagccaccctggagattttgttctttctgtgcgcactggtgatgacaaaggggagagc
aatgacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatacgac
gttggtggaggagaacggtttgattctttgacagatcttgtggaacattataagaagaat
cctatggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgt
ataaatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaa
cttctctacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaa
aacatcctgccctttgatcataccagggttgtcctacacgatggtgatcccaatgagcct
gtttcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat
tcaaagcccaaaaagagttacattgccacacaaggctgcctgcaaaacacggtgaatgac
ttttggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatat
ggcgtcatgcgtgttaggaacgtcaaagaaagcgccgctcatgactatacgctaagagaa
cttaaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccacttt
cggacctggccggaccacggcgtgcccagcgaccctgggggcgtgctggacttcctggag
gaggtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagt
gctggaattggccggacagggacgttcattgtgattgatattcttattgacatcatcaga
gagaaaggtgttgactgcgatattgacgttcccaaaaccatccagatggtgcggtctcag
aggtcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcat
tatattgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcac
gaatatacaaatattaagtattctctagcggaccagacgagtggagatcagagccctctc
ccgccttgtactccaacgccaccctgtgcagaaatgagagaagacagtgctagagtctat
gaaaacgtgggcctgatgcaacagcagaaaagtttcagatga

KEGG   Homo sapiens (human): 5795
Entry
5795              CDS       T01001                                 
Symbol
PTPRJ, CD148, DEP1, HPTP_eta, HPTPeta, R-PTP-ETA, R-PTP-J, SCC1
Name
(RefSeq) protein tyrosine phosphatase receptor type J
  KO
K05698  receptor-type tyrosine-protein phosphatase eta [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04520  Adherens junction
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06223  TNF signaling
  Element
N01411  Metals to NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    5795 (PTPRJ)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    5795 (PTPRJ)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5795 (PTPRJ)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    5795 (PTPRJ)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     5795 (PTPRJ)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Receptor PTPs
    5795 (PTPRJ)
CD molecules [BR:hsa04090]
 Proteins
  5795 (PTPRJ)
SSDB
Motif
Pfam: Y_phosphatase fn3 PTP_tm DSPc PTPlike_phytase Y_phosphatase3 Interfer-bind
Other DBs
NCBI-GeneID: 5795
NCBI-ProteinID: NP_002834
OMIM: 600925
HGNC: 9673
Ensembl: ENSG00000149177
Pharos: Q12913(Tbio)
UniProt: Q12913 Q9NPR5
Structure
LinkDB
Position
11:47980559..48170839
AA seq 1337 aa
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP
SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT
LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL
IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA
SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV
TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF
EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE
VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY
SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS
RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY
ENLAPVTTFGKTNGYIA
NT seq 4014 nt   +upstreamnt  +downstreamnt
atgaagccggcggcgcgggaggcgcggctgcctccgcgctcgcccgggctgcgctgggcg
ctgccgctgctgctgctgctgctgcgcctgggccagatcctgtgcgcaggtggcacccct
agtccaattcctgacccttcagtagcaactgttgccacaggggaaaatggcataacgcag
atcagcagtacagcagaatcctttcataaacagaatggaactggaacacctcaggtggaa
acaaacaccagtgaggatggtgaaagctctggagccaacgatagtttaagaacacctgaa
caaggatctaatgggactgatggggcatctcaaaaaactcccagtagcactgggcccagt
cctgtgtttgacattaaagctgtttccatcagtccaaccaatgtgatcttaacttggaaa
agtaatgacacagctgcttctgagtacaagtatgtagtaaagcataagatggaaaatgag
aagacaattactgttgtgcatcaaccatggtgtaacatcacaggcttacgtccagcgact
tcatatgtattctccatcactccaggaataggcaatgagacttggggagatcccagagtc
ataaaagtcatcacagagccgatcccagtttctgatctccgtgttgccctcacgggtgtg
aggaaggctgctctctcctggagcaatggcaatggcactgcctcctgccgggttcttctt
gaaagcattggaagccatgaggagttgactcaagactcaagacttcaggtcaatatctcg
ggcctgaagccaggggttcaatacaacatcaacccgtatcttctacaatcaaataagaca
aagggagaccccttgggcacagaaggtggcttggatgccagcaatacagagagaagccgg
gcagggagccccaccgcccctgtgcatgatgagtccctcgtgggacctgtggacccatcc
tccggccagcagtcccgagacacggaagtcctgcttgtcgggttagagcctggcacccga
tacaatgccaccgtttattcccaagcagcgaatggcacagaaggacagccccaggccata
gagttcaggacaaatgctattcaggtttttgacgtcaccgctgtgaacatcagtgccaca
agcctgaccctgatctggaaagtcagcgataacgagtcgtcatctaactatacctacaag
atacatgtggcgggggagacagattcttccaatctcaacgtcagtgagcctcgcgctgtc
atccccggactccgctccagcaccttctacaacatcacagtgtgtcctgtcctaggtgac
atcgagggcacgccgggcttcctccaagtgcacaccccccctgttccagtttctgacttc
cgagtgacagtggtcagcacgacggagatcggcttagcatggagcagccatgatgcagaa
tcatttcagatgcatatcacacaggagggagctggcaattctcgggtagaaataaccacc
aaccaaagtattatcattggtggcttgttccctggaaccaagtattgctttgaaatagtt
ccaaaaggaccaaatgggactgaaggggcatctcggacagtttgcaatagaactgttccc
agtgcagtgtttgacatccacgtggtctacgtcaccaccacggagatgtggctggactgg
aagagccctgacggtgcttccgagtatgtctaccatttagtcatagagtccaagcatggc
tctaaccacacaagcacgtatgacaaagcgattactctccagggcctgattccgggcacc
ttatataacatcaccatctctccagaagtggaccacgtctggggggaccccaactccact
gcacagtacacacggcccagcaatgtgtccaacattgatgtaagtaccaacaccacagca
gcaactttaagttggcagaactttgatgacgcctctcccacgtactcctactgccttctt
attgagaaggctggaaattccagcaacgcaacacaagtagtcacggacattggaattact
gacgctacagtcactgaattaatacctggctcatcatacacagtggagatctttgcacaa
gtaggggatgggatcaagtcactggaacctggccggaagtcattctgtacagatcctgcg
tccatggcctccttcgactgcgaagtggtccccaaagagccagccctggttctcaaatgg
acctgccctcctggcgccaatgcaggctttgagctggaggtcagcagtggagcctggaac
aatgcgacccacctggagagctgctcctctgagaatggcactgagtatagaacggaagtc
acgtatttgaatttttctacctcgtacaacatcagcatcaccactgtgtcctgtggaaag
atggcagcccccacccggaacacctgcactactggcatcacagatccccctcctccagat
ggatcccctaatattacatctgtcagtcacaattcagtaaaggtcaagttcagtggattt
gaagccagccacggacccatcaaagcctatgctgtcattctcaccaccggggaagctggt
cacccttctgcagatgtcctgaaatacacgtatgaggatttcaaaaagggagcctcagat
acttatgtgacatacctcataagaacagaagaaaagggacgttctcagagcttgtctgaa
gttttgaaatatgaaattgacgttgggaatgagtcaaccacacttggttattacaatggg
aagctggaacctctgggctcctaccgggcttgtgtggctggcttcaccaacattaccttc
caccctcaaaacaaggggctcattgatggggctgagagctatgtgtccttcagtcgctac
tcagatgctgtttccttgccccaggatccaggtgtcatctgtggagcggtttttggctgt
atctttggtgccctggttattgtgactgtgggaggcttcatcttctggagaaagaagagg
aaagatgcaaagaataatgaagtgtccttttctcaaattaaacctaaaaaatctaagtta
atcagagtggagaattttgaggcctacttcaagaagcagcaagctgactccaactgtggg
ttcgcagaggaatacgaagatctgaagcttgttggaattagtcaacctaaatatgcagca
gaactggctgagaatagaggaaagaatcgctataataatgttctgccctatgatatttcc
cgtgtcaaactttcggtccagacccattcaacggatgactacatcaatgccaactacatg
cctggctaccactccaagaaagattttattgccacacaaggacctttaccgaacactttg
aaagatttttggcgtatggtttgggagaaaaatgtatatgccatcattatgttgactaaa
tgtgttgaacagggaagaaccaaatgtgaggagtattggccctccaagcaggctcaggac
tatggagacataactgtggcaatgacatcagaaattgttcttccggaatggaccatcaga
gatttcacagtgaaaaatatccagacaagtgagagtcaccctctgagacagttccatttc
acctcctggccagaccacggtgttcccgacaccactgacctgctcatcaacttccggtac
ctcgttcgtgactacatgaagcagagtcctcccgaatcgccgattctggtgcattgcagt
gctggggtcggaaggacgggcactttcattgccattgatcgtctcatctaccagatagag
aatgagaacaccgtggatgtgtatgggattgtgtatgaccttcgaatgcataggccttta
atggtgcagacagaggaccagtatgttttcctcaatcagtgtgttttggatattgtcaga
tcccagaaagactcaaaagtagatcttatctaccagaacacaactgcaatgacaatctat
gaaaaccttgcgcccgtgaccacatttggaaagaccaatggttacatcgcctaa

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