KEGG   NETWORK: N01411
Entry
N01411                      Network                                
Name
Metals to NFKB signaling pathway
Definition
Metals -> ROS -| PTP -| SRC -> ABL -> PKD -> IKK -> NFKBIA -> NFKB
  Expanded
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -| (52,5781,5795) -| 6714 -> (25,27) -> (23683,25865,5587) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06223 TNF signaling (cancer)
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00021  Renal cell carcinoma
H00024  Prostate cancer
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00048  Hepatocellular carcinoma
H00054  Nasopharyngeal cancer
Gene
52  ACP1; acid phosphatase 1
5781  PTPN11; protein tyrosine phosphatase non-receptor type 11
5795  PTPRJ; protein tyrosine phosphatase receptor type J
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
27  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase
23683  PRKD3; protein kinase D3
25865  PRKD2; protein kinase D2
5587  PRKD1; protein kinase D1
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
C06269 (Metals)  Arsenic
C01413 (Metals)  Cadmium
C19171 (Metals)  Cobalt
C06268 (Metals)  Chromium
C06696 (Metals)  Lead
C00023 (Metals)  Iron
C00291 (Metals)  Nickel
Metabolite
C22381  Reactive oxygen species
Reference
PMID:15769673
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
PMID:20370557
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
PMID:15024053
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004
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