Homo sapiens (human): 5422 Help Entry 5422              CDS       T01001                                  Symbol POLA1, NSX, PDR, POLA, VEODS, p180 Name (RefSeq) DNA polymerase alpha 1, catalytic subunit   KO K02320   DNA polymerase alpha subunit A [EC:2.7.7.7] Organism hsa  Homo sapiens (human) Pathway hsa03030   DNA replication Network nt06509  DNA replication   Element N01471   Origin unwinding and elongation Disease H00658   X-linked syndromic intellectual developmental disorder H02484   X-linked reticulate pigmentary disorder with systemic manifestations Drug target Clofarabine:  D03546<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09124 Replication and repair    03030 DNA replication     5422 (POLA1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:hsa03032]     5422 (POLA1) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.7  Nucleotidyltransferases     2.7.7.7  DNA-directed DNA polymerase      5422 (POLA1) DNA replication proteins [BR:hsa03032]  Eukaryotic type   DNA Replication Elongation Factors    DNA polymerase alpha / primase complex     5422 (POLA1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_pol_B zf-DNA_Pol DNA_pol_B_exo1 DNA_pol_alpha_N DNA_pol_B_2 DUF1744 MTR4_beta-barrel Motif Other DBs NCBI-GeneID:  5422 NCBI-ProteinID:  NP_058633 OMIM:  312040 HGNC:  9173 Ensembl:  ENSG00000101868 UniProt:  P09884 Structure PDBPDBj LinkDB All DBs Position X:24693918..24996986 Genome browser AA seq 1462 aa AA seqDB search MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF LSRSGYSEVNLSKLFAGCAVKS NT seq 4389 nt NT seq  +upstreamnt  +downstreamnt atggcacctgtgcacggcgacgactctctgtcagattcagggagttttgtatcttctcga gcccggcgagaaaaaaaatcaaagaaggggcgccaagaagccctagaaagactgaaaaag gctaaagctggtgagaagtataaatatgaagtcgaggacttcacaggtgtttatgaagaa gttgatgaagaacagtattcgaagctggttcaggcacgccaggatgatgactggattgtg gatgatgatggtattggctatgtggaagatggccgagagatttttgatgatgaccttgaa gatgatgcccttgatgctgatgagaaaggaaaagatggtaaagcacgcaataaagacaag aggaatgtaaagaagctcgcagtgacaaaaccgaacaacattaagtcaatgttcattgct tgtgctggaaagaaaactgcagataaagctgtagacttgtccaaggatggtctgctaggt gacattctacaggatcttaacactgagacacctcaaataactccaccacctgtaatgata ctgaagaagaaaagatccattggagcttcaccgaatcctttctctgtgcacaccgccacg gcagttccttcaggaaaaattgcttcccctgtctccagaaaggagcctccattaactcct gttcctcttaaacgtgctgaatttgctggcgatgatgtacaggtcgagagtacagaagaa gagcaggagtcaggggcaatggagtttgaagatggtgactttgatgagcccatggaagtt gaagaggtggacctggagcctatggctgccaaggcttgggacaaagagagtgagccagca gaggaagtgaaacaagaggcggattctgggaaagggaccgtgtcctacttaggaagtttt ctcccggatgtctcttgttgggacattgatcaagaaggtgatagcagtttctcagtgcaa gaagttcaagtggattccagtcacctcccattggtaaaaggggcagatgaggaacaagta ttccacttttattggttggatgcttatgaggatcagtacaaccaaccaggtgtggtattt ctgtttgggaaagtttggattgaatcagccgagacccatgtgagctgttgtgtcatggtg aaaaatatcgagcgaacgctttacttccttccccgtgaaatgaaaattgatctaaatacg gggaaagaaacaggaactccaatttcaatgaaggatgtttatgaggaatttgatgagaaa atagcaacaaaatataaaattatgaagttcaagtctaagccagtggaaaagaactatgct tttgagatacctgatgttccagaaaaatctgagtacttggaagttaaatactcggctgaa atgccacagcttcctcaagatttgaaaggagaaactttttctcatgtatttgggaccaac acatctagcctggaactgttcttgatgaacagaaagatcaaaggaccttgttggcttgaa gtaaaaagtccacagctcttgaatcagccagtcagttggtgtaaagttgaggcaatggct ttgaaaccagacctggtgaatgtaattaaggatgtcagtccaccaccgcttgtcgtgatg gctttcagcatgaagacaatgcagaatgcaaagaaccatcaaaatgagattattgctatg gcagctttggtccatcacagttttgcattggataaagcagccccaaagcctccctttcag tcacacttctgtgttgtgtctaaaccaaaggactgtatttttccatatgctttcaaagaa gtcattgagaaaaagaatgtgaaggttgaggttgctgcaacagaaagaacactgctaggt tttttccttgcaaaagttcacaaaattgatcctgatatcattgtgggtcataatatttat gggtttgaactggaagtactactgcagagaattaatgtgtgcaaagctcctcactggtcc aagataggtcgactgaagcgatccaacatgccaaagcttgggggccggagtggatttggt gaaagaaatgctacctgtggtcgaatgatctgtgatgtggaaatttcagcaaaggaattg attcgttgtaaaagctaccatctgtctgaacttgttcagcagattctaaaaactgaaagg gttgtaatcccaatggaaaatatacaaaatatgtacagtgaatcttctcaactgttatac ctgttggaacacacctggaaagatgccaagttcattttgcagatcatgtgtgagctaaat gttcttccattagcattgcagatcactaacatcgctgggaacattatgtccaggacgctg atgggtggacgatccgagcgtaacgagttcttgttgcttcatgcattttacgaaaacaac tatattgtgcctgacaagcagattttcagaaagcctcagcaaaaactgggagatgaagat gaagaaattgatggagataccaataaatacaagaaaggacgtaagaaagcagcttatgct ggaggcttggttttggaccccaaagttggtttttatgataagttcattttgcttctggac ttcaacagtctatatccttccatcattcaggaatttaacatttgttttacaacagtacaa agagttgcttcagaggcacagaaagttacagaggatggagaacaagaacagatccctgag ttgccagatccaagcttagaaatgggcattttgcccagagagatccggaaactggtagaa cggagaaaacaagtcaaacagctaatgaaacagcaagacttaaatccagaccttattctt cagtatgacattcgacagaaggctttgaagctcacagcgaacagtatgtatggttgcctg ggattttcctatagcagattttacgccaaaccactggctgccttggtgacatacaaagga agggagattttgatgcatacgaaagagatggtacaaaagatgaatcttgaagttatttat ggagatacagattcaattatgataaacaccaatagcaccaatctggaagaagtatttaag ttgggaaacaaggtaaaaagtgaagtgaataagttgtacaaactgcttgaaatagacatt gatggggttttcaagtctctgctactgctgaaaaaaaagaagtacgctgctctggttgtt gagccaacgtcggatgggaattatgtcaccaaacaggagctcaaaggattagatatagtt agaagagattggtgtgatcttgctaaagacactggaaactttgtgattggccagattctt tctgatcaaagccgggacactatagtggaaaacattcagaagaggctgatagaaattgga gaaaatgtgctaaatggcagtgtcccagtgagccagtttgaaattaacaaggcattgaca aaggatccccaggattaccctgataaaaaaagcctacctcatgtacatgttgccctctgg ataaattctcaaggaggcagaaaggtgaaagctggagatactgtgtcatatgtcatctgt caggatggatcaaacctcactgcaagtcagagggcctatgcgcctgagcagctgcagaaa caggataatctaaccattgacacccagtactacctggcccagcagatccacccagtcgtg gctcggatctgtgaaccaatagacggaattgatgctgtcctcattgcaacgtggttggga cttgaccccacccaatttagagttcatcattatcataaagatgaagagaatgatgctcta cttggtggcccagcacagctcactgatgaagagaaatacagggactgtgaaagattcaaa tgtccatgccctacatgtggaactgagaatatttatgataatgtctttgatggttcggga acagatatggagcccagcttgtatcgttgcagtaacatcgattgtaaggcttcacctctg acctttacagtacaactgagcaacaaattgatcatggacattagacgtttcattaaaaag tactatgatggctggttgatatgtgaagagccaacctgtcgcaatcgaactcgtcacctt ccccttcaattctcccgaactgggcctctttgcccagcctgcatgaaagctacacttcaa ccagagtattctgacaagtccctgtacacccagctgtgcttttaccggtacatttttgat gcggagtgtgcactggagaaacttactaccgatcatgagaaagataaattgaagaagcaa ttttttacccccaaagttctgcaggactacagaaaactcaagaacacagcagagcaattc ttgtcccgaagtggctactccgaagtgaatctgagcaaactcttcgctggttgtgccgtg aaatcctaa

Homo sapiens (human): 23649 Help Entry 23649             CDS       T01001                                  Symbol POLA2 Name (RefSeq) DNA polymerase alpha 2, accessory subunit   KO K02321   DNA polymerase alpha subunit B Organism hsa  Homo sapiens (human) Pathway hsa03030   DNA replication Network nt06509  DNA replication   Element N01471   Origin unwinding and elongation Drug target Clofarabine:  D03546<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09124 Replication and repair    03030 DNA replication     23649 (POLA2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:hsa03032]     23649 (POLA2) DNA replication proteins [BR:hsa03032]  Eukaryotic type   DNA Replication Elongation Factors    DNA polymerase alpha / primase complex     23649 (POLA2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_pol_E_B DPOA2_OB Pol_alpha_B_N Motif Other DBs NCBI-GeneID:  23649 NCBI-ProteinID:  NP_002680 OMIM:  620063 HGNC:  30073 Ensembl:  ENSG00000014138 UniProt:  Q14181 Structure PDBPDBj LinkDB All DBs Position 11:65261962..65305985 Genome browser AA seq 598 aa AA seqDB search MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSE ILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGS QKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGV SWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAF TPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQ VVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPL LDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHL VFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHL GAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLII PSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI NT seq 1797 nt NT seq  +upstreamnt  +downstreamnt atgtccgcatccgcccagcagctggcggaggagctgcagatcttcggcctagactgcgag gaggctctaattgagaaattggtagagctttgtgttcagtatggacagaatgaggaggga atggtaggcgagcttatagccttctgcaccagcacacataaagttggccttacctcagag atcctgaactcttttgagcatgagtttctgagcaaaagattatcgaaagccaggcatagt acctgcaaggacagtggccatgcaggagctagagacattgtttccattcaagagctaatt gaagtggaagaagaagaggaaatcctcttgaactcttacaccacaccttcaaagggttct cagaagcgagctatctctaccccagaaacccccctaacaaaaaggagtgtgtcaactcgt agcccccatcagctactctcaccgtcaagtttctctccaagtgctactccctcccagaaa tacaactcacgaagtaaccgaggagaagtggttacctccttcggcttagcacagggagta tcttggtctgggagaggaggagctggaaacatcagcctgaaggtcttgggatgtccagag gcactaactgggagctacaaatccatgtttcagaagctcccagacattcgagaagttctg acctgtaagatagaagaacttggcagcgaactcaaggaacattacaagattgaagctttc actcctttgctagccccagcacaggagcctgtcactctgctgggccagattggctgtgat agcaacgggaagctgaacaacaagtcagtgattctcgagggagaccgggaacattcctcg ggtgctcaaattccagtggatttatctgagcttaaggaatattctctgtttcctggacag gttgtaattatggaaggaatcaacaccactggtaggaaacttgttgccaccaaactctac gagggtgtgccacttccattttatcagcccactgaagaggatgcagactttgagcaaagc atggtcctggttgcctgtggaccatacaccacatctgacagcatcacgtatgaccccctg cttgacctgattgctgtcatcaaccatgaccggccagatgtctgcatcctgtttggccct ttcctggatgctaagcatgaacaggtggagaattgtctactgacaagtccatttgaagac attttcaagcagtgtctacgaacaattattgaaggcacaagaagctccggctcccacctt gtctttgtcccgtcattgagagatgtgcaccatgagcctgtgtacccccagccgcctttc agctactccgatctgtctcgagaggacaaaaagcaagtacagtttgtgtccgagccctgc agcctctccataaacggagtgatcttcggcttgacatccacagatctgcttttccacctg ggggccgaggagatcagtagttcttccggaacttcagacagattcagccgaatactcaag cacatcttgacccagaggagctactacccactctacccgccccaagaagacatggccatt gactatgagtcgttctatgtttacgcacagctgcctgtcaccccagatgtcctcatcatc ccgtcagagctgaggtacttcgtgaaggatgtcctcggctgtgtctgtgtgaaccctggg cgccttaccaaagggcaggtgggaggcaccttcgcccgactctaccttaggaggccggca gcggacggggcagagaggcagagcccatgcattgctgtgcaggtcgtcaggatctga

Homo sapiens (human): 5557 Help Entry 5557              CDS       T01001                                  Symbol PRIM1, PDIL, p49 Name (RefSeq) DNA primase subunit 1   KO K02684   DNA primase small subunit [EC:2.7.7.102] Organism hsa  Homo sapiens (human) Pathway hsa03030   DNA replication Network nt06509  DNA replication   Element N01471   Origin unwinding and elongation Disease H02625   Primordial dwarfism-immunodeficiency-lipodystrophy syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09124 Replication and repair    03030 DNA replication     5557 (PRIM1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:hsa03032]     5557 (PRIM1) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.7  Nucleotidyltransferases     2.7.7.102  DNA primase AEP      5557 (PRIM1) DNA replication proteins [BR:hsa03032]  Eukaryotic type   DNA Replication Elongation Factors    DNA polymerase alpha / primase complex     5557 (PRIM1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_primase_S Motif Other DBs NCBI-GeneID:  5557 NCBI-ProteinID:  NP_000937 OMIM:  176635 HGNC:  9369 Ensembl:  ENSG00000198056 UniProt:  P49642 Structure PDBPDBj LinkDB All DBs Position 12:complement(56731580..56752323) Genome browser AA seq 420 aa AA seqDB search METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSF NNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRR CCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSA VRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESW DKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQY CFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAI STNEEEKEENEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSDLQKDF NT seq 1263 nt NT seq  +upstreamnt  +downstreamnt atggagacgtttgaccccaccgagctgcccgagctgcttaaactttattaccggaggctc tttccctactctcagtactatcgctggctcaactacggtggagtgataaagaattacttt caacaccgtgaattttcattcacattgaaagatgatatttacattcgctaccaatccttc aacaaccagagtgatctggaaaaggagatgcagaaaatgaatccatacaagattgatata ggcgcagtatattctcacagacccaatcaacacaatacagtgaagctgggagctttccag gctcaggaaaaagaactggtatttgacattgacatgacagactatgacgatgtgaggaga tgttgtagttctgcagacatatgtcctaagtgctggaccctcatgacaatggccatacgc atcattgacagagcattgaaggaggactttggatttaagcatcgtctctgggtatattct ggaaggagaggtgttcattgttgggtctgtgatgaatcagttagaaaactgtcttctgca gtacgttctgggatagttgagtatttgagccttgtaaagggtggtcaagacgttaaaaag aaagttcacctaagtgaaaaaattcacccttttatcagaaaatctataaacataataaaa aaatactttgaagaatatgccttggttaatcaagatattctcgaaaataaagaaagctgg gataagattttagcccttgttcctgaaacaattcatgatgaacttcaacaaagcttccaa aagtctcacaattcacttcagcgttgggagcacttgaagaaagtagccagcagatatcag aataacatcaaaaatgacaaatatggaccctggctggagtgggagattatgctccagtac tgttttccacggctggatatcaatgtcagcaaaggaatcaatcatctactgaagagccct tttagtgttcatcctaaaacaggtcgcatatctgtgcctattgatttgcagaaagtggac cagtttgatccatttactgttccgaccataagcttcatctgccgtgaattggatgccatt tccactaatgaagaggaaaaagaggagaatgaagctgaatctgatgtcaaacatagaacc agagattataagaagaccagtctagcaccttatgtgaaagtttttgaacattttcttgaa aatctggataaatcccgaaaaggagaacttcttaagaagagtgatttacaaaaagatttc tga

Homo sapiens (human): 5558 Help Entry 5558              CDS       T01001                                  Symbol PRIM2, PRIM2A, p58 Name (RefSeq) DNA primase subunit 2   KO K02685   DNA primase large subunit Organism hsa  Homo sapiens (human) Pathway hsa03030   DNA replication Network nt06509  DNA replication   Element N01471   Origin unwinding and elongation Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09124 Replication and repair    03030 DNA replication     5558 (PRIM2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:hsa03032]     5558 (PRIM2) DNA replication proteins [BR:hsa03032]  Eukaryotic type   DNA Replication Elongation Factors    DNA polymerase alpha / primase complex     5558 (PRIM2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_primase_lrg Motif Other DBs NCBI-GeneID:  5558 NCBI-ProteinID:  NP_000938 OMIM:  176636 HGNC:  9370 Ensembl:  ENSG00000146143 UniProt:  P49643 Structure PDBPDBj LinkDB All DBs Position 6:57221540..57646850 Genome browser AA seq 509 aa AA seqDB search MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLG VSYVKGTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWF IQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLSGLKLGF ESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAV QSDERLQPLLNHLSHSYTGQDYSTQGNVGKISLDQIDLLSTKSFPPCMRQLHKALRENHH LRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRT DYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHY QVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILNGGKDIKKEPIQPETPQPKPSVQKT KDASSALASLNSSLEMDMEGLEDYFSEDS NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atggagttttctggaagaaagtggaggaagctgaggttggcaggtgaccagaggaatgct tcctaccctcattgccttcagttttacttgcagccaccttctgaaaacatatctttaata gaatttgaaaacttggctattgatagagttaaattgttaaaatcagttgaaaatcttgga gtgagctatgtgaaaggaactgaacaataccagagtaagttggagagtgagcttcggaag ctcaagttttcctacagagaaaacttagaagatgaatatgaaccacgaagaagagatcat atttctcattttattttgcggcttgcttattgccagtctgaagaacttagacgctggttc attcaacaagaaatggatctccttcgatttagatttagtattttacccaaggataaaatt caggatttcttaaaggatagccaattgcagtttgaggctataagtgatgaagagaagact cttcgagaacaggagattgttgcctcatcaccaagtttaagtggacttaagttggggttc gagtccatttataagatcccttttgctgatgctctggatttgtttcgaggaaggaaagtc tatttggaagatggctttgcttacgtaccacttaaggacattgtggcaatcatcctgaat gaatttagagccaaactgtccaaggctttggcattaacagccaggtccttgcctgctgtg cagtctgatgaaagacttcagcctctgctcaatcacctcagtcattcctacactggccaa gattacagtacccagggaaatgttgggaagatttctttagatcagattgatttgctttct accaaatccttcccaccttgcatgcgtcagttacataaagccttgcgggaaaatcaccat cttcgtcatggaggccgaatgcagtatggcctatttctgaagggcattggtttaactttg gaacaggcattgcagttctggaagcaagaatttatcaaaggaaagatggatccagacaag tttgataaaggttactcttacaacatccgtcacagctttggaaaggaaggcaagaggaca gactatacacctttcagttgcctgaagattattctgtccaatccaccaagccaaggggat tatcatgggtgcccattccgtcacagtgatccagagctgctgaagcaaaagttgcagtca tacaagatctctcctggagggataagccagattttggatttagtaaaggggacacattac caggtagcctgtcaaaaatactttgagatgatacacaatgtggatgattgtggcttttct ttgaatcatcctaatcagttcttttgtgagagccaacgtattctaaatggtggtaaagac ataaagaaggaacctatccaaccagaaactcctcaacccaaaccaagtgtccagaaaacc aaggatgcatcatctgctctggcctctttaaattcctctctggaaatggatatggaagga ctagaagattactttagtgaagattcttag

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