KEGG   Homo sapiens (human): 5423
Entry
5423              CDS       T01001                                 
Symbol
POLB
Name
(RefSeq) DNA polymerase beta
  KO
K02330  DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06504  Base excision repair
  Element
N00511  HTLV-1 Tax to E47-mediated transcription
N01433  Base excision and strand cleavage by monofunctional glycosylase
N01434  Base excision and strand cleavage by bifunctional glycosylase
N01435  Base excision and strand cleavage by NEIL glycosylase
N01436  Long patch BER
N01437  Short patch BER
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    5423 (POLB)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    5423 (POLB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5423 (POLB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5423 (POLB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5423 (POLB)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Short Patch-BER factors
     5423 (POLB)
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    X-family DNA polymerases
     5423 (POLB)
SSDB
Motif
Pfam: DNA_pol_B_palm HHH_8 DNA_pol_lambd_f DNA_pol_B_thumb HHH_5 HHH Cdd1 HHH_2 NTP_transf_2
Other DBs
NCBI-GeneID: 5423
NCBI-ProteinID: NP_002681
OMIM: 174760
HGNC: 9174
Ensembl: ENSG00000070501
UniProt: P06746
Structure
LinkDB
Position
8:42338494..42371808
AA seq 335 aa
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
NT seq 1008 nt   +upstreamnt  +downstreamnt
atgagcaaacggaaggcgccgcaggagactctcaacgggggaatcaccgacatgctcaca
gaactcgcaaactttgagaagaacgtgagccaagctatccacaagtacaatgcttacaga
aaagcagcatctgttatagcaaaatacccacacaaaataaagagtggagctgaagctaag
aaattgcctggagtaggaacaaaaattgctgaaaagattgatgagtttttagcaactgga
aaattacgtaaactggaaaagattcggcaggatgatacgagttcatccatcaatttcctg
actcgagttagtggcattggtccatctgctgcaaggaagtttgtagatgaaggaattaaa
acactagaagatctcagaaaaaatgaagataaattgaaccatcatcagcgaattgggctg
aaatattttggggactttgaaaaaagaattcctcgtgaagagatgttacaaatgcaagat
attgtactaaatgaagttaaaaaagtggattctgaatacattgctacagtctgtggcagt
ttcagaagaggtgcagagtccagtggtgacatggatgttctcctgacccatcccagcttc
acttcagaatcaaccaaacagccaaaactgttacatcaggttgtggagcagttacaaaag
gttcattttatcacagataccctgtcaaagggtgagacaaagttcatgggtgtttgccag
cttcccagtaaaaatgatgaaaaagaatatccacacagaagaattgatatcaggttgata
cccaaagatcagtattactgtggtgttctctatttcactgggagtgatattttcaataag
aatatgagggctcatgccctagaaaagggtttcacaatcaatgagtacaccatccgtccc
ttgggagtcactggagttgcaggagaacccctgccagtggatagtgaaaaagacatcttt
gattacatccagtggaaataccgggaacccaaggaccggagcgaatga

KEGG   Homo sapiens (human): 7515
Entry
7515              CDS       T01001                                 
Symbol
XRCC1, RCC, SCAR26
Name
(RefSeq) X-ray repair cross complementing 1
  KO
K10803  DNA-repair protein XRCC1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
Network
nt06502  Nucleotide excision repair
nt06504  Base excision repair
  Element
N01431  Core NER reaction
N01434  Base excision and strand cleavage by bifunctional glycosylase
N01435  Base excision and strand cleavage by NEIL glycosylase
N01437  Short patch BER
Disease
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    7515 (XRCC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    7515 (XRCC1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Short Patch-BER factors
     7515 (XRCC1)
SSDB
Motif
Pfam: XRCC1_N BRCT BRCT_2 PTCB-BRCT LIG3_BRCT
Other DBs
NCBI-GeneID: 7515
NCBI-ProteinID: NP_006288
OMIM: 194360
HGNC: 12828
Ensembl: ENSG00000073050
UniProt: P18887 B2RCY5 Q59HH7
Structure
LinkDB
Position
19:complement(43543311..43575527)
AA seq 633 aa
MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI
GNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAA
AEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDE
SANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQE
SPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPR
GEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHL
ICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSGG
SGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDN
GAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELP
DFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMD
NPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA
NT seq 1902 nt   +upstreamnt  +downstreamnt
atgccggagatccgcctccgccatgtcgtgtcctgcagcagccaggactcgactcactgt
gcagaaaatcttctcaaggcagacacttaccgaaaatggcgggcagccaaggcaggcgag
aagaccatctctgtggtcctacagttggagaaggaggagcagatacacagtgtggacatt
gggaatgatggctcagctttcgtggaggtgctggtgggcagttcagctggaggcgctggg
gagcaagactatgaggtccttctggtcacctcatctttcatgtccccttccgagagccgc
agtggctcaaaccccaaccgcgttcgcatgtttgggcctgacaagctggtccgggcagcc
gccgagaagcgctgggaccgggtcaaaattgtttgcagccagccctacagcaaggactcc
ccctttggcttgagttttgtacggtttcatagccccccagacaaagatgaggcagaggcc
ccgtcccagaaggtgacagtgaccaagcttggccagttccgtgtgaaggaggaggatgag
agcgccaactctctgaggccgggggctctcttcttcagccggatcaacaagacatcccca
gtcacagccagcgacccagcaggacctagctatgcagctgctaccctccaggcttctagt
gctgcctcctcagcctctccagtctccagggccataggcagcacctccaagccccaggag
tctcccaaagggaagaggaagttggatttgaaccaagaagaaaagaagacccccagcaaa
ccaccagcccagctgtcgccatctgttcccaagagacctaaattgccagctccaactcgt
accccagccacagccccagtccctgcccgagcacagggggcagtgacaggcaaaccccga
ggagaaggcaccgagcccagacgaccccgagctggcccagaggagctggggaagatcctt
cagggtgtggtagtggtgctgagtggcttccagaaccccttccgctccgagctgcgagat
aaggccctagagcttggggccaagtatcggccagactggacccgggacagcacgcacctc
atctgtgcctttgccaacacccccaagtacagccaggtcctaggcctgggaggccgcatc
gtgcgtaaggagtgggtgctggactgtcaccgcatgcgtcggcggctgccctcccagagg
tacctcatggcagggccaggttccagcagtgaggaggatgaggcctctcacagcggtggc
agcggagatgaagcccccaagcttcctcagaagcaaccccagaccaaaaccaagcccact
caggcagctggacccagctcaccccagaagcccccaacccctgaagagaccaaagcagcc
tcaccagtgctccaggaagatatagacattgagggggtacagtcagaaggacaggacaat
ggggcggaagattctggggacacagaggatgagctgaggagggtggcagagcagaaggaa
cacagactgccccctggccaggaggagaatggggaagacccgtatgcaggctccacggat
gagaacacggacagtgaggaacaccaggagcctcctgatctgccagtccctgagctccca
gatttcttccagggcaagcacttctttctttacggggagttccctggggacgagcggcgg
aaactcatccgatacgtcacagccttcaatggggagctcgaggactatatgagtgaccgg
gttcagtttgtgatcacagcacaggaatgggatcccagctttgaggaggccctgatggac
aacccctccctggcattcgttcgtccccgatggatctacagttgcaatgagaagcagaag
ttacttcctcaccagctctatggggtggtgccgcaagcctga

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