KEGG ORTHOLOGY: K05697

ORTHOLOGY: K05697

Entry

K05697                      KO

Symbol

PTPN6, SHP1

Name

tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]

Pathway

map04148

Efferocytosis

map04520

Adherens junction

map04630

JAK-STAT signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map05130

Pathogenic Escherichia coli infection

map05140

Leishmaniasis

map05205

Proteoglycans in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
   04660 T cell receptor signaling pathway
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
   04662 B cell receptor signaling pathway
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6

Other DBs

GO:

0005001

Genes

HSA:	5777(PTPN6)

PTR:	748032(PTPN6)

PPS:	100990286(PTPN6)

GGO:	101137792(PTPN6)

PON:	100448471(PTPN6)

PPYG:

129010364(PTPN6)

NLE:	100599057(PTPN6)

HMH:	116472613(PTPN6)

SSYN:

129483454(PTPN6)

MCC:	714374(PTPN6)

MCF:	102133910(PTPN6)

MTHB:

126930434

MNI:	105484215(PTPN6)

CSAB:

103218491(PTPN6)

CATY:

105583047(PTPN6)

PANU:

100999491(PTPN6)

TGE:	112635581(PTPN6)

MLEU:

105541817(PTPN6)

RRO:	104680085(PTPN6)

RBB:	108542024(PTPN6)

TFN:	117090601(PTPN6)

PTEH:

111555969(PTPN6)

CANG:

105519073(PTPN6)

CJC:	100410231(PTPN6)

SBQ:	101032306(PTPN6)

CIMI:

108294988(PTPN6)

ANAN:

105731158(PTPN6)

CSYR:

103269638(PTPN6)

MMUR:

105868990(PTPN6)

LCAT:

123640090(PTPN6)

PCOQ:

105805036(PTPN6)

OGA:	100946957(PTPN6)

MMU:	15170(Ptpn6)

MCAL:

110295792(Ptpn6)

MPAH:

110314992(Ptpn6)

RNO:	116689(Ptpn6)

MCOC:

116099571(Ptpn6)

ANU:	117714883(Ptpn6)

ASYL:

127679185(Ptpn6)

MUN:	110548584(Ptpn6)

CGE:	100758996(Ptpn6)

MAUA:

110340160(Ptpn6)

PROB:

127213039(Ptpn6)

PLEU:

114708811(Ptpn6)

MORG:

121435832(Ptpn6)

MFOT:

126514923

AAMP:

119806659(Ptpn6)

NGI:	103727492(Ptpn6)

HGL:	101725029(Ptpn6)

CPOC:

100723417(Ptpn6)

CCAN:

109682813(Ptpn6)

DORD:

105991072(Ptpn6)

NCAR:

124983713

MMMA:

107154932(Ptpn6)

ITI:	101977333(Ptpn6)

OCU:

100348648

OPI:	101517856(PTPN6)

TUP:	102488290(PTPN6)

GVR:	103586398(PTPN6)

CFA:	486717(PTPN6)

CLUD:

112675367(PTPN6)

VVP:	112917324(PTPN6)

VLG:	121479639(PTPN6)

NPO:	129503493(PTPN6)

AML:	100473539(PTPN6)

UMR:	103656221(PTPN6)

UAH:	113257950(PTPN6)

UAR:	123781556(PTPN6)

ELK:

111159680

LLV:

125106086

MPUF:

101677714(PTPN6)

MNP:	132019902(PTPN6)

MLK:	131838464(PTPN6)

NVS:	122891921(PTPN6)

ORO:	101374850(PTPN6)

EJU:	114222497(PTPN6)

ZCA:	113923028(PTPN6)

MLX:	118025717(PTPN6)

NSU:	110580855(PTPN6)

LWW:	102735395(PTPN6)

FCA:	101087073(PTPN6)

PYU:	121021913(PTPN6)

PCOO:

112867900(PTPN6)

PBG:	122472392(PTPN6)

PVIV:

125170363(PTPN6)

LRUF:

124501085

LGF:	123591695(PTPN6)

AJU:

106965341

PTG:	102951517(PTPN6)

PPAD:

109276095(PTPN6)

PUC:	125918213 125918219

PLEZ:

122224185(PTPN6)

HHV:	120220450(PTPN6)

BTA:	512312(PTPN6)

BOM:	102283821(PTPN6)

BIU:	109558908(PTPN6)

BBUB:

102390574(PTPN6)

BBIS:

104992168(PTPN6)

CHX:	102190308(PTPN6)

OAS:	101108643(PTPN6)

BTAX:

128047743(PTPN6)

CSUM:

138077864(PTPN6)

ODA:	120858748(PTPN6)

CCAD:

122423792(PTPN6)

MREE:

136160056(PTPN6)

OVR:	110128140(PTPN6)

MBEZ:

129536849(PTPN6)

SSC:	100171389(PTPN6)

CFR:	102513195(PTPN6)

CBAI:

105075198

CDK:	105098192(PTPN6)

VPC:	102533120(PTPN6)

BACU:

103005216(PTPN6)

BMUS:

118901760(PTPN6)

LVE:	103086882(PTPN6)

OOR:	101289268(PTPN6)

LALB:

132529179(PTPN6)

DLE:	111176702(PTPN6)

PCAD:

102989908(PTPN6)

PSIU:

116760131(PTPN6)

NASI:

112391683(PTPN6)

ECB:	100052882(PTPN6)

EPZ:	103547027(PTPN6)

EAI:	106847314(PTPN6)

MYB:	102256821(PTPN6)

MYD:	102755999(PTPN6)

MMYO:

118649839(PTPN6)

MLF:	102431735(PTPN6)

MDT:	132227218(PTPN6)

MYUM:

139007381(PTPN6)

PKL:	118729355(PTPN6)

EFUS:

103289036(PTPN6)

MNA:	107544062(PTPN6)

DRO:	112321823(PTPN6)

SHON:

119002403(PTPN6)

AJM:	119065712(PTPN6)

PDIC:

114513480(PTPN6)

PHAS:

123810706(PTPN6)

MMF:	118623590(PTPN6)

PPAM:

129085050(PTPN6)

HAI:	109373664(PTPN6)

RFQ:	117028744(PTPN6)

PALE:

102895931(PTPN6)

PGIG:

120611673(PTPN6)

PVP:	105295941(PTPN6)

RAY:	107519829(PTPN6)

MJV:	108384835(PTPN6)

TOD:	119247764(PTPN6)

SARA:

101546555(PTPN6)

SFUM:

130016174(PTPN6)

SETR:

126006542(PTPN6)

LAV:	100676986(PTPN6)

TMU:

101358096

ETF:	101662456(PTPN6)

DNM:	101435353(PTPN6)

MDO:	100016514(PTPN6)

GAS:	123250526(PTPN6)

SHR:	100916661(PTPN6)

AFZ:

127539233

PCW:	110213796(PTPN6)

TVP:	118851808(PTPN6)

PBRV:

138171968(PTPN6)

OAA:	100089663(PTPN6)

TACU:

119946604(PTPN6)

GGA:	427947(PTPN6)

PCOC:

116240006(PTPN6)

MGP:	100541130(PTPN6)

CJO:	107318608(PTPN6)

TPAI:

128089881(PTPN6)

LMUT:

125685233(PTPN6)

NMEL:

110398321(PTPN6)

APLA:

101791271(PTPN6)

ACYG:

106047839(PTPN6)

CATA:

118247764(PTPN6)

AFUL:

116495269(PTPN6)

TGU:	100222135(PTPN6)

LSR:	110480841(PTPN6)

SCAN:

103827163(PTPN6)

PMOA:

120506447(PTPN6)

OTC:	121339302(PTPN6)

PRUF:

121351646(PTPN6)

ATRC:

139592827(PTPN6)

GFR:	102042677(PTPN6)

FAB:	101809704(PTPN6)

OMA:	130257382(PTPN6)

PHI:	102110203(PTPN6)

PMAJ:

107208334(PTPN6)

CCAE:

111938183(PTPN6)

CCW:	104687132(PTPN6)

CBRC:

103613961(PTPN6)

ACOE:

138111880(PTPN6)

ETL:	114058137(PTPN6)

ZAB:	102071941(PTPN6)

ZLE:	135453065(PTPN6)

ACHL:

103806675(PTPN6)

SVG:	106857878(PTPN6)

MMEA:

130574784(PTPN6)

HRT:	120748839(PTPN6)

SATI:

136375537(PTPN6)

CCIC:

134056720(PTPN6)

FPG:	101914570(PTPN6)

FCH:	102049222(PTPN6)

CCRI:

104157481(PTPN6)

NNT:	104400064(PTPN6)

SHAB:

115601596(PTPN6)

ACUN:

113477279(PTPN6)

TALA:

104361133(PTPN6)

ACHC:

115343498(PTPN6)

HALD:

104324396(PTPN6)

HLE:	104831778(PTPN6)

AGEN:

126049045

HHAR:

128145212(PTPN6)

GCL:

127024193

CSTI:

104550278(PTPN6)

LDI:	104350224(PTPN6)

MNB:	103782354(PTPN6)

DPUB:

104299453(PTPN6)

PPUS:

135182081(PTPN6)

AVIT:

104268600(PTPN6)

BRHI:

104495620(PTPN6)

EGZ:	104126541(PTPN6)

NNI:	104009493(PTPN6)

PCRI:

104030230(PTPN6)

PCAO:

104050459(PTPN6)

PADL:

103920898(PTPN6)

AFOR:

103905456(PTPN6)

FGA:	104083071(PTPN6)

GSTE:

104261659(PTPN6)

CLV:	102092597(PTPN6)

MUI:	104534321(PTPN6)

PGUU:

104464806(PTPN6)

PLET:

104616886(PTPN6)

EHS:	104515693(PTPN6)

CMAC:

104483855(PTPN6)

CUCA:

104064361(PTPN6)

TEO:	104381036(PTPN6)

BREG:

104630457(PTPN6)

OHA:	104327133(PTPN6)

ACAR:

104530610(PTPN6)

CPEA:

104389465(PTPN6)

CVF:	104292944(PTPN6)

RTD:	128904218(PTPN6)

CRID:

134524109(PTPN6)

AAM:

106497267

AROW:

112973000(PTPN6)

NPD:	112960153(PTPN6)

TGT:	104565659(PTPN6)

DNE:	112991073(PTPN6)

SCAM:

104150722(PTPN6)

ASN:	102374529(PTPN6)

AMJ:	106737112(PTPN6)

CPOO:

109319380(PTPN6)

GGN:	109304343(PTPN6)

PSS:	102450493(PTPN6)

CMY:	102932473(PTPN6)

CCAY:

125622654(PTPN6)

DCC:	119858545(PTPN6)

CPIC:

101943173(PTPN6)

TST:	117885696(PTPN6)

CABI:

116821041(PTPN6)

MRV:	120401894(PTPN6)

ACS:	100560131 100568003(ptpn6)

ASAO:

132767528(PTPN6)

PVT:	110084628(PTPN6)

SUND:

121922064

PBI:	103066339(PTPN6)

PMUR:

107285777(PTPN6)

CTIG:

120306107(PTPN6)

TSR:	106552603(PTPN6)

PGUT:

117661828(PTPN6)

APRI:

131192330(PTPN6)

PTEX:

113444442(PTPN6)

NSS:	113424506(PTPN6)

VKO:	123033209(PTPN6)

PMUA:

114587712(PTPN6)

PRAF:

128404593(PTPN6)

ZVI:	118097466(PTPN6)

HCG:	128342818(PTPN6)

GJA:	107116796(PTPN6)

STOW:

125437170(PTPN6)

EMC:	129345591(PTPN6)

XLA:	100380954(ptpn6.L) 108696044 108697335(ptpn6.S)

XTR:	100144699(ptpn6) 100486059

NPR:	108784384(PTPN6)

RTEM:

120946621(PTPN6)

BBUF:

121003752(PTPN6)

BGAR:

122941187(PTPN6)

PWL:	138303705(PTPN6)

MUO:	115458415(PTPN6)

GSH:	117350751(PTPN6)

DRE:	335573(ptpn6)

SRX:	107714609 107724803

SANH:

107671911 107704909

SGH:	107552793 107587794(ptpn6)

CCAR:

109104852 109104853(ptpn6)

CAUA:

113081688 113099588 113116069

CGIB:

127975018 128030587

PTET:

122360202(ptpn6)

LROH:

127178613(ptpn6)

OMC:	131521845(ptpn6)

PPRM:

120484723(ptpn6)

RKG:	130090841(ptpn6)

MAMB:

125243434(ptpn6)

CIDE:

127497061

CERY:

137034000(ptpn6)

MASI:

127452822 127453922

TROS:

130557522(ptpn6)

TDW:	130432822(ptpn6)

MANU:

129448479(ptpn6)

PDAB:

135727510 135788862

IPU:	108263538(ptpn6)

IFU:	128617512(ptpn6)

PHYP:

113525151

SMEO:

124385189(ptpn6)

TFD:	113647758(ptpn6)

TVC:	132846297(ptpn6)

CGAR:

128520034(ptpn6)

NGRA:

132886352(ptpn6)

TRN:	134310860(ptpn6)

AMEX:

103022912(ptpn6)

CMAO:

118820578(ptpn6)

EEE:

113574797

CHAR:

105901656(ptpn6)

SPIL:

134082434(ptpn6)

TRU:	101073366(ptpn6)

TFS:	130532949(ptpn6)

TNG:	GSTEN00015322G001

LCO:	104932546(ptpn6)

NCC:

104967151

TBEN:

117494727(ptpn6)

CGOB:

115021685(ptpn6)

PGEO:

117460592(ptpn6)

GACU:

117556349(ptpn6)

EMAC:

134861252(ptpn6)

ELY:	117265764(ptpn6)

EFO:	125893118(ptpn6)

PLEP:

121945251(ptpn6)

SLUC:

116049713(ptpn6)

ECRA:

117946221(ptpn6)

ESP:	116691237(ptpn6)

PFLV:

114557481(ptpn6)

GAT:	120810824(ptpn6)

PPUG:

119197227(ptpn6)

AFB:	129109523(ptpn6)

CLUM:

117745446(ptpn6)

PSWI:

130213446(ptpn6)

CANA:

137781100(ptpn6)

CVE:	137891184(ptpn6)

MSAM:

119897428(ptpn6)

SCHU:

122882032(ptpn6)

CUD:	121512963(ptpn6)

SPUL:

138584046(ptpn6)

LMIX:

132983038(ptpn6)

ALAT:

119006330(ptpn6)

ASTR:

137601192(ptpn6)

MZE:	101478586(ptpn6)

ONL:	100707029(ptpn6)

OAU:	116323764(ptpn6)

OLA:	101174216(ptpn6)

OML:	112143660(ptpn6)

CSAI:

133434886(ptpn6)

XMA:	102235723(ptpn6)

XCO:	114142163(ptpn6)

XHE:	116717758(ptpn6)

PRET:

103477996(ptpn6)

PFOR:

103136745(ptpn6)

PLAI:

106951118(ptpn6)

PMEI:

106905232

GAF:	122831001(ptpn6)

PPRL:

129371184(ptpn6)

CVG:	107082167(ptpn6)

CTUL:

119783058(ptpn6)

GMU:	124866249(ptpn6)

NFU:	107379459(ptpn6)

KMR:	108235407(ptpn6)

ALIM:

106529151(ptpn6)

NWH:	119409702(ptpn6)

AOCE:

111585704(ptpn6)

EJA:	138194064(ptpn6)

BFRE:

138619315(ptpn6)

MCEP:

125016922(ptpn6)

CSEM:

103387950(ptpn6)

POV:	109633267(ptpn6)

SSEN:

122774110(ptpn6)

SSOE:

131471860(ptpn6)

HHIP:

117776793(ptpn6)

HSP:	118113189(ptpn6)

PPLT:

128448990(ptpn6)

SMAU:

118314987(ptpn6)

LCF:

108880748

SDU:	111230057(ptpn6)

SLAL:

111669899(ptpn6)

XGL:	120784084(ptpn6)

HCQ:	109515280(ptpn6)

SSCV:

125975696(ptpn6)

SBIA:

133500700(ptpn6)

PEE:	133401418(ptpn6)

PTAO:

133479867(ptpn6)

BPEC:

110163058(ptpn6)

ENY:	140374018(ptpn6)

MALB:

109966237(ptpn6)

BSPL:

114842920(ptpn6)

SJO:	128365833(ptpn6)

SSCO:

133982919(ptpn6)

GMH:	115553946(ptpn6)

SASA:

100195421(ptn6) 106576571(PTN6)

STRU:

115177393 115187775

OTW:	112226113 112247624

OMY:	110509434 110509511

OGO:	123998095 124005241

ONE:	115125830 115140776

OKI:	109900589 109906269

OKE:	118374221 118380317

OMM:	135520577 135521903

OCLA:

139389532 139422179

SALP:

112074551 112081040

SNH:	120048592 120048714

CCLU:

121542962 121586205

ELS:	105029958(ptpn6)

OEP:	134023584(ptpn6)

SFM:	108925851(ptpn6)

PKI:	111835379(ptpn6)

AANG:

118231462(ptpn6)

AROT:

135240354(ptpn6)

CCOG:

133124729(ptpn6)

LOC:	102689026(ptpn6)

PSPA:

121296520 121325953

ARUT:

117425781(ptpn6)

PSEX:

120535733(ptpn6)

LCM:

102352106

» show all

Reference

PMID:11266449

Authors

Keilhack H, Muller M, Bohmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Gunther B, Muller T, Birchmeier C, Bohmer FD

Title

Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.

Journal

J Cell Biol 152:325-34 (2001)
DOI:10.1083/jcb.152.2.325

Sequence

[hsa:5777]

Reference

PMID:1732748

Authors

Yi TL, Cleveland JL, Ihle JN

Title

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

Journal

Mol Cell Biol 12:836-46 (1992)
DOI:10.1128/MCB.12.2.836

Sequence

[hsa:5777]

LinkDB

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