Homo sapiens (human): 7134 Help Entry 7134              CDS       T01001                                  Symbol TNNC1, CMD1Z, CMH13, TN-C, TNC, TNNC Name (RefSeq) troponin C1, slow skeletal and cardiac type   KO K05865   troponin C, slow skeletal and cardiac muscles Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells hsa05410   Hypertrophic cardiomyopathy hsa05414   Dilated cardiomyopathy Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00292   Hypertrophic cardiomyopathy H00294   Dilated cardiomyopathy Drug target Nelutroctiv:  D12804 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     7134 (TNNC1)  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7134 (TNNC1)    04820 Cytoskeleton in muscle cells     7134 (TNNC1)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     7134 (TNNC1)    04261 Adrenergic signaling in cardiomyocytes     7134 (TNNC1)  09160 Human Diseases   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     7134 (TNNC1)    05414 Dilated cardiomyopathy     7134 (TNNC1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7134 (TNNC1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7134 (TNNC1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 EF-hand_9 EF-hand_5 AIF-1 EF-hand_4 SPARC_Ca_bdg DUF5580_M FCaBP_EF-hand EMG1 DUF6694 Motif Other DBs NCBI-GeneID:  7134 NCBI-ProteinID:  NP_003271 OMIM:  191040 HGNC:  11943 Ensembl:  ENSG00000114854 UniProt:  P63316 Q6FH91 Structure PDB LinkDB All DBs Position 3:complement(52451100..52454041) Genome browser AA seq 161 aa AA seqDB search MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEM IDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIM LQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE NT seq 486 nt NT seq  +upstreamnt  +downstreamnt atggatgacatctacaaggctgcggtagagcagctgacagaagagcagaaaaatgagttc aaggcagccttcgacatcttcgtgctgggcgctgaggatggctgcatcagcaccaaggag ctgggcaaggtgatgaggatgctgggccagaaccccacccctgaggagctgcaggagatg atcgatgaggtggacgaggacggcagcggcacggtggactttgatgagttcctggtcatg atggttcggtgcatgaaggacgacagcaaagggaaatctgaggaggagctgtctgacctc ttccgcatgtttgacaaaaatgctgatggctacatcgacctggatgagctgaagataatg ctgcaggctacaggcgagaccatcacggaggacgacatcgaggagctcatgaaggacgga gacaagaacaacgacggccgcatcgactatgatgagttcctggagttcatgaagggtgtg gagtag

Homo sapiens (human): 7135 Help Entry 7135              CDS       T01001                                  Symbol TNNI1, SSTNI, TNN1 Name (RefSeq) troponin I1, slow skeletal type   KO K10371   troponin I, slow skeletal muscle Organism hsa  Homo sapiens (human) Pathway hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7135 (TNNI1)    04820 Cytoskeleton in muscle cells     7135 (TNNI1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7135 (TNNI1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7135 (TNNI1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Troponin Motif Other DBs NCBI-GeneID:  7135 NCBI-ProteinID:  NP_003272 OMIM:  191042 HGNC:  11945 Ensembl:  ENSG00000159173 UniProt:  P19237 LinkDB All DBs Position 1:complement(201403784..201421730) Genome browser AA seq 187 aa AA seqDB search MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSA DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDA AKSPTSQ NT seq 564 nt NT seq  +upstreamnt  +downstreamnt atgccggaagtcgagagaaaacccaagatcactgcctcccgcaaactcttgctgaagagc ctgatgctggccaaggccaaggaatgctgggagcaggagcacgaggagcgcgaggctgag aaggtgcgctacctggcagagcgcatccccacgctgcagacccgtggcctgtccctcagt gccctgcaggacctgtgccgggagctgcacgccaaggtggaggtggtggatgaggagcga tacgacattgaggccaaatgcctccacaacaccagggagattaaggacctgaagctgaag gtgatggacctccgtgggaagttcaagcgcccgcccctgcgtcgagtccgtgtctcggct gacgccatgctccgggccctgctgggctccaagcacaaggtgtccatggatctgcgggcc aacctcaagtctgtgaagaaggaagacacagagaaggagcggcctgtggaggtgggtgac tggaggaagaacgtggaggccatgtctggcatggaaggccggaagaagatgtttgatgcc gccaagtctccgacctcacaatag

Homo sapiens (human): 7138 Help Entry 7138              CDS       T01001                                  Symbol TNNT1, ANM, NEM5, STNT, TNT, TNTS Name (RefSeq) troponin T1, slow skeletal type   KO K10372   troponin T, slow skeletal muscle Organism hsa  Homo sapiens (human) Pathway hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00698   Nemaline myopathy Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7138 (TNNT1)    04820 Cytoskeleton in muscle cells     7138 (TNNT1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7138 (TNNT1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7138 (TNNT1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Troponin RlmN_N DUF2828 PAS Motif Other DBs NCBI-GeneID:  7138 NCBI-ProteinID:  NP_003274 OMIM:  191041 HGNC:  11948 Ensembl:  ENSG00000105048 UniProt:  P13805 LinkDB All DBs Position 19:complement(55132698..55149206) Genome browser AA seq 278 aa AA seqDB search MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE MKVRILSERKKPLDIDYMGEEQLRARSAWLPPSQPSCPAREKAQELSDWIHQLESEKFDL MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK NT seq 837 nt NT seq  +upstreamnt  +downstreamnt atgtcggacaccgaggagcaggaatatgaggaggagcagccggaagaggaggctgcggag gaggaggaggaagcccccgaagagccggagccggtggcagagccagaagaggaacgcccc aaaccaagccgccccgtggtgcctcctttgatcccgccaaagatcccagaaggggagcgc gttgacttcgatgacatccaccgcaagcgcatggagaaagacctgctggagctgcagaca ctcatcgatgtacatttcgagcagcggaagaaggaggaagaggagctggttgccttgaag gagcgcattgagcggcgccggtcagagagagccgagcaacagcgcttcagaactgagaag gaacgcgaacgtcaggctaagctggcggaggagaagatgaggaaggaagaggaagaggcc aagaagcgggcagaggatgatgccaagaaaaagaaggtgctgtccaacatgggggcccat tttggcggctacctggtcaaggcagaacagaagcgtggtaagcggcagacggggcgggag atgaaggtgcgcatcctctccgagcgtaagaagcctctggacattgactacatgggggag gaacagctccgggcccggtctgcctggctgcctccatcacagccctcctgccctgccagg gagaaagcccaggagctgtcggactggatccaccagctggagtctgagaagttcgacctg atggcgaagctgaaacagcagaaatatgagatcaacgtgctgtacaaccgcatcagccac gcccagaagttccggaagggggcagggaagggccgcgttggaggccgctggaagtga

Homo sapiens (human): 7125 Help Entry 7125              CDS       T01001                                  Symbol TNNC2, CFAP85, CMYP15, FAP85, MYONRI Name (RefSeq) troponin C2, fast skeletal type   KO K12042   troponin C, skeletal muscle Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H01810   Congenital myopathy Drug target Reldesemtiv:  D11363 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     7125 (TNNC2)  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7125 (TNNC2)    04820 Cytoskeleton in muscle cells     7125 (TNNC2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7125 (TNNC2) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7125 (TNNC2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 EF-hand_9 AIF-1 EF-hand_4 SPARC_Ca_bdg TerB DUF1456 DUF5580_M Caleosin p25-alpha SurA_N_3 DUF533 CDI_toxin_EC869_like Motif Other DBs NCBI-GeneID:  7125 NCBI-ProteinID:  NP_003270 OMIM:  191039 HGNC:  11944 Ensembl:  ENSG00000101470 UniProt:  P02585 Structure PDB LinkDB All DBs Position 20:complement(45823214..45833306) Genome browser AA seq 160 aa AA seqDB search MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAII EEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIF RASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ NT seq 483 nt NT seq  +upstreamnt  +downstreamnt atgacggaccagcaggctgaggccaggtcctacctcagcgaagagatgatcgctgagttc aaggctgcctttgacatgtttgatgctgatggtggtggggacatcagcgtcaaggagttg ggcacggtgatgaggatgctgggccagacacccaccaaggaggagctggacgccatcatc gaggaggtggatgaggacggcagcggcaccatcgacttcgaggagttcttggtcatgatg gtgcgccagatgaaagaggacgcgaaagggaagagcgaggaggagctggccgagtgcttc cgcatcttcgacaggaatgcagacggctacatcgacccggaggagctggctgagattttc agggcctccggggagcacgtgacggacgaggagatcgaatctctgatgaaagacggcgac aagaacaacgacggccgcattgacttcgacgagttcctgaagatgatggagggcgtgcag taa

Homo sapiens (human): 7136 Help Entry 7136              CDS       T01001                                  Symbol TNNI2, AMCD2B, DA2B, DA2B1, FSSV, fsTnI Name (RefSeq) troponin I2, fast skeletal type   KO K12043   troponin I, fast skeletal muscle Organism hsa  Homo sapiens (human) Pathway hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00811   Distal arthrogryposis Drug target Reldesemtiv:  D11363 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7136 (TNNI2)    04820 Cytoskeleton in muscle cells     7136 (TNNI2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7136 (TNNI2) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7136 (TNNI2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Troponin Tup_N DUF919 DUF2408 Laminin_II Prominin SKA2 Motif Other DBs NCBI-GeneID:  7136 NCBI-ProteinID:  NP_001139301 OMIM:  191043 HGNC:  11946 Ensembl:  ENSG00000130598 UniProt:  P48788 Structure PDB LinkDB All DBs Position 11:1838981..1841678 Genome browser AA seq 182 aa AA seqDB search MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSE VQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSAD AMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFES ES NT seq 549 nt NT seq  +upstreamnt  +downstreamnt atgggagatgaggagaagcggaacagggccatcacggcccgcaggcagcacctgaagagt gtgatgctgcagatagcggccacggagctggagaaggaggagagccgccgtgaggcagag aagcagaactacctggcggagcactgcccgccgctgcatatcccgggctccatgtctgaa gtgcaggagctctgcaaacagctgcacgccaagatcgatgcggctgaagaggagaagtac gacatggaggtgagggtgcagaagaccagcaaggagctggaggacatgaaccagaagcta tttgatctgcggggcaagttcaagcggcccccactgcggagggtgcgcatgtcggccgat gccatgctcaaggccctgctgggctcgaagcacaaggtgtgcatggacctgagggccaac ctgaagcaggtcaagaaggaggacacagagaaggagcgggacctgcgagacgtgggtgac tggaggaagaacatcgaggagaagtctggcatggagggccggaagaagatgtttgagtcc gagtcctag

Homo sapiens (human): 7140 Help Entry 7140              CDS       T01001                                  Symbol TNNT3, DA2B2, TNTF, beta-TnTF Name (RefSeq) troponin T3, fast skeletal type   KO K12046   troponin T, fast skeletal muscle Organism hsa  Homo sapiens (human) Pathway hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00811   Distal arthrogryposis Drug target Reldesemtiv:  D11363 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7140 (TNNT3)    04820 Cytoskeleton in muscle cells     7140 (TNNT3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7140 (TNNT3) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7140 (TNNT3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Troponin DUF4250 Motif Other DBs NCBI-GeneID:  7140 NCBI-ProteinID:  NP_006748 OMIM:  600692 HGNC:  11950 Ensembl:  ENSG00000130595 UniProt:  P45378 LinkDB All DBs Position 11:1919552..1938702 Genome browser AA seq 258 aa AA seqDB search MSDEEVEQVEEQYEEEEEAQEEEEVQEDTAEEDAEEEKPRPKLTAPKIPEGEKVDFDDIQ KKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNR LAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILA ERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQK HSKKAGTPAKGKVGGRWK NT seq 777 nt NT seq  +upstreamnt  +downstreamnt atgtctgacgaggaagttgaacaggtggaggagcagtacgaagaagaagaggaagcccag gaggaagaggaagttcaagaagacaccgcagaggaggacgcggaagaggagaaaccgaga cccaaactcactgctcctaagatcccagaaggggagaaagtggacttcgatgacatccag aagaagcgtcagaacaaagacctaatggagctccaggccctcatcgacagccactttgaa gcccggaagaaggaggaggaggagctggtcgctctcaaagagagaatcgagaagcgccgt gcagagagagcggagcagcagaggattcgtgcagagaaggagagggagcgccagaacaga ctggcggaggaaaaggccagaagggaggaggaggatgccaagaggagggcagaggacgac ctgaagaagaagaaagctctgtcttccatgggagccaactacagcagctacctggccaag gctgaccagaagagaggcaagaagcagacagcccgggaaatgaagaagaagattctggct gagagacgcaagccgctcaacatcgatcaccttggtgaagacaaactgagggacaaggcc aaggagctctgggagaccctgcaccagctggagattgacaagttcgagtttggggagaag ctgaaacgccagaaatatgacatcaccacgctcaggagccgcattgaccaggcccagaag cacagcaagaaggctgggaccccagccaagggcaaagtcggcgggcgctggaagtag

Homo sapiens (human): 7134 Help Entry 7134              CDS       T01001                                  Symbol TNNC1, CMD1Z, CMH13, TN-C, TNC, TNNC Name (RefSeq) troponin C1, slow skeletal and cardiac type   KO K05865   troponin C, slow skeletal and cardiac muscles Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells hsa05410   Hypertrophic cardiomyopathy hsa05414   Dilated cardiomyopathy Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00292   Hypertrophic cardiomyopathy H00294   Dilated cardiomyopathy Drug target Nelutroctiv:  D12804 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     7134 (TNNC1)  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7134 (TNNC1)    04820 Cytoskeleton in muscle cells     7134 (TNNC1)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     7134 (TNNC1)    04261 Adrenergic signaling in cardiomyocytes     7134 (TNNC1)  09160 Human Diseases   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     7134 (TNNC1)    05414 Dilated cardiomyopathy     7134 (TNNC1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7134 (TNNC1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7134 (TNNC1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 EF-hand_9 EF-hand_5 AIF-1 EF-hand_4 SPARC_Ca_bdg DUF5580_M FCaBP_EF-hand EMG1 DUF6694 Motif Other DBs NCBI-GeneID:  7134 NCBI-ProteinID:  NP_003271 OMIM:  191040 HGNC:  11943 Ensembl:  ENSG00000114854 UniProt:  P63316 Q6FH91 Structure PDB LinkDB All DBs Position 3:complement(52451100..52454041) Genome browser AA seq 161 aa AA seqDB search MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEM IDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIM LQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE NT seq 486 nt NT seq  +upstreamnt  +downstreamnt atggatgacatctacaaggctgcggtagagcagctgacagaagagcagaaaaatgagttc aaggcagccttcgacatcttcgtgctgggcgctgaggatggctgcatcagcaccaaggag ctgggcaaggtgatgaggatgctgggccagaaccccacccctgaggagctgcaggagatg atcgatgaggtggacgaggacggcagcggcacggtggactttgatgagttcctggtcatg atggttcggtgcatgaaggacgacagcaaagggaaatctgaggaggagctgtctgacctc ttccgcatgtttgacaaaaatgctgatggctacatcgacctggatgagctgaagataatg ctgcaggctacaggcgagaccatcacggaggacgacatcgaggagctcatgaaggacgga gacaagaacaacgacggccgcatcgactatgatgagttcctggagttcatgaagggtgtg gagtag

Homo sapiens (human): 7137 Help Entry 7137              CDS       T01001                                  Symbol TNNI3, CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI Name (RefSeq) troponin I3, cardiac type   KO K12044   troponin I, cardiac muscle Organism hsa  Homo sapiens (human) Pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells hsa05410   Hypertrophic cardiomyopathy hsa05414   Dilated cardiomyopathy hsa05415   Diabetic cardiomyopathy Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00292   Hypertrophic cardiomyopathy H00294   Dilated cardiomyopathy H01219   Restrictive cardiomyopathy Drug target Nelutroctiv:  D12804 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     7137 (TNNI3)  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7137 (TNNI3)    04820 Cytoskeleton in muscle cells     7137 (TNNI3)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     7137 (TNNI3)    04261 Adrenergic signaling in cardiomyocytes     7137 (TNNI3)  09160 Human Diseases   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     7137 (TNNI3)    05414 Dilated cardiomyopathy     7137 (TNNI3)    05415 Diabetic cardiomyopathy     7137 (TNNI3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7137 (TNNI3) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7137 (TNNI3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Troponin Troponin-I_N Tup_N DUF919 DUF3738 CorA Motif Other DBs NCBI-GeneID:  7137 NCBI-ProteinID:  NP_000354 OMIM:  191044 HGNC:  11947 Ensembl:  ENSG00000129991 UniProt:  P19429 Q6FGX2 Structure PDB LinkDB All DBs Position 19:complement(55151767..55157732) Genome browser AA seq 210 aa AA seqDB search MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQE LEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTK NITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKED TEKENREVGDWRKNIDALSGMEGRKKKFES NT seq 633 nt NT seq  +upstreamnt  +downstreamnt atggcggatgggagcagcgatgcggctagggaacctcgccctgcaccagccccaatcaga cgccgctcctccaactaccgcgcttatgccacggagccgcacgccaagaaaaaatctaag atctccgcctcgagaaaattgcagctgaagactctgctgctgcagattgcaaagcaagag ctggagcgagaggcggaggagcggcgcggagagaaggggcgcgctctgagcacccgctgc cagccgctggagttggccgggctgggcttcgcggagctgcaggacttgtgccgacagctc cacgcccgtgtggacaaggtggatgaagagagatacgacatagaggcaaaagtcaccaag aacatcacggagattgcagatctgactcagaagatctttgaccttcgaggcaagtttaag cggcccaccctgcggagagtgaggatctctgcagatgccatgatgcaggcgctgctgggg gcccgggctaaggagtccctggacctgcgggcccacctcaagcaggtgaagaaggaggac accgagaaggaaaaccgggaggtgggagactggcgcaagaacatcgatgcactgagtgga atggagggccgcaagaaaaagtttgagagctga

Homo sapiens (human): 7139 Help Entry 7139              CDS       T01001                                  Symbol TNNT2, CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT Name (RefSeq) troponin T2, cardiac type   KO K12045   troponin T, cardiac muscle Organism hsa  Homo sapiens (human) Pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04814   Motor proteins hsa04820   Cytoskeleton in muscle cells hsa05410   Hypertrophic cardiomyopathy hsa05414   Dilated cardiomyopathy Network nt06539  Cytoskeleton in muscle cells   Element N01818   Actin thin filament, muscle contraction Disease H00292   Hypertrophic cardiomyopathy H00294   Dilated cardiomyopathy H01216   Left ventricular noncompaction H01219   Restrictive cardiomyopathy Drug target Nelutroctiv:  D12804 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09142 Cell motility    04814 Motor proteins     7139 (TNNT2)    04820 Cytoskeleton in muscle cells     7139 (TNNT2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     7139 (TNNT2)    04261 Adrenergic signaling in cardiomyocytes     7139 (TNNT2)  09160 Human Diseases   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     7139 (TNNT2)    05414 Dilated cardiomyopathy     7139 (TNNT2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     7139 (TNNT2) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Troponins      7139 (TNNT2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Troponin Motif Other DBs NCBI-GeneID:  7139 NCBI-ProteinID:  NP_001263274 OMIM:  191045 HGNC:  11949 Ensembl:  ENSG00000118194 UniProt:  P45379 Structure PDB LinkDB All DBs Position 1:complement(201359014..201377680) Genome browser AA seq 298 aa AA seqDB search MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK NT seq 897 nt NT seq  +upstreamnt  +downstreamnt atgtctgacatagaagaggtggtggaagagtacgaggaggaggagcaggaagaagcagct gttgaagaagaggaggactggagagaggacgaagacgagcaggaggaggcagcggaagag gatgctgaagcagaggctgagaccgaggagaccagggcagaagaagatgaagaagaagag gaagcaaaggaggctgaagatggcccaatggaggagtccaaaccaaagcccaggtcgttc atgcccaacttggtgcctcccaagatccccgatggagagagagtggactttgatgacatc caccggaagcgcatggagaaggacctgaatgagttgcaggcgctgatcgaggctcacttt gagaacaggaagaaagaggaggaggagctcgtttctctcaaagacaggatcgagagacgt cgggcagagcgggccgagcagcagcgcatccggaatgagcgggagaaggagcggcagaac cgcctggctgaagagagggctcgacgagaggaggaggagaacaggaggaaggctgaggat gaggcccggaagaagaaggctttgtccaacatgatgcattttgggggttacatccagaag caggcccagacagagcggaaaagtgggaagaggcagactgagcgggaaaagaagaagaag attctggctgagaggaggaaggtgctggccattgaccacctgaatgaagatcagctgagg gagaaggccaaggagctgtggcagagcatctataacttggaggcagagaagttcgacctg caggagaagttcaagcagcagaaatatgagatcaatgttctccgaaacaggatcaacgat aaccagaaagtctccaagacccgcgggaaggctaaagtcaccgggcgctggaaatag

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