KEGG   Homo sapiens (human): 7248
Entry
7248              CDS       T01001                                 
Symbol
TSC1, LAM, TSC
Name
(RefSeq) TSC complex subunit 1
  KO
K07206  tuberous sclerosis 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04218  Cellular senescence
hsa04714  Thermogenesis
hsa04910  Insulin signaling pathway
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05231  Choline metabolism in cancer
Network
nt06114  PI3K signaling (viruses)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06415  PI3K signaling
nt06462  Spinocerebellar ataxia
nt06522  mTOR signaling
  Element
N00357  HPV E6 to MTOR signaling pathway
N00388  HCMV UL38 to MTOR signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00584  HSV US3 to MTOR signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N01575  TSC1/2-mTORC1 signaling pathway
N01576  STRAD/STK11- TSC signaling pathway
Disease
H00896  Lymphangioleiomyomatosis
H00915  Tuberous sclerosis complex
H01251  Focal cortical dysplasia of Taylor
H01691  Renal angiomyolipoma
H01692  Subependymal giant cell astrocytoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    7248 (TSC1)
   04151 PI3K-Akt signaling pathway
    7248 (TSC1)
   04152 AMPK signaling pathway
    7248 (TSC1)
   04150 mTOR signaling pathway
    7248 (TSC1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    7248 (TSC1)
  09143 Cell growth and death
   04218 Cellular senescence
    7248 (TSC1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    7248 (TSC1)
  09149 Aging
   04211 Longevity regulating pathway
    7248 (TSC1)
  09159 Environmental adaptation
   04714 Thermogenesis
    7248 (TSC1)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    7248 (TSC1)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    7248 (TSC1)
   05163 Human cytomegalovirus infection
    7248 (TSC1)
   05165 Human papillomavirus infection
    7248 (TSC1)
SSDB
Motif
Pfam: Hamartin
Other DBs
NCBI-GeneID: 7248
NCBI-ProteinID: NP_000359
OMIM: 605284
HGNC: 12362
Ensembl: ENSG00000165699
Pharos: Q92574(Tbio)
UniProt: Q92574 Q86WV8 X5D9D2
Structure
LinkDB
Position
9:complement(132891349..132945378)
AA seq 1164 aa
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI
LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL
KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL
HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH
ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT
QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT
SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR
KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA
AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL
DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ
PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH
SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL
RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR
QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES
VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ
RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL
EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT
PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS
LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP
SPPTPDSVGQLHIMDYNETHHEHS
NT seq 3495 nt   +upstreamnt  +downstreamnt
atggcccaacaagcaaatgtcggggagcttcttgccatgctggactcccccatgctgggt
gtgcgggacgacgtgacagctgtctttaaagagaacctcaattctgaccgtggccctatg
cttgtaaacaccttggtggattattacctggaaaccagctctcagccggcattgcacatc
ctgaccaccttgcaagagccacatgacaagcacctcttggacaggattaacgaatatgtg
ggcaaagccgccactcgtttatccatcctctcgttactgggtcatgtcataagactgcag
ccatcttggaagcataagctctctcaagcacctcttttgccttctttactaaaatgtctc
aagatggacactgacgtcgttgtcctcacaacaggcgtcttggtgttgataaccatgcta
ccaatgattccacagtctgggaaacagcatcttcttgatttctttgacatttttggccgt
ctgtcatcatggtgcctgaagaaaccaggccacgtggcggaagtctatctcgtccatctc
catgccagtgtgtacgcactctttcatcgcctttatggaatgtacccttgcaacttcgtc
tcctttttgcgttctcattacagtatgaaagaaaacctggagacttttgaagaagtggtc
aagccaatgatggagcatgtgcgaattcatccggaattagtgactggatccaaggaccat
gaactggaccctcgaaggtggaagagattagaaactcatgatgttgtgatcgagtgtgcc
aaaatctctctggatcccacagaagcctcatatgaagatggctattctgtgtctcaccaa
atctcagcccgctttcctcatcgttcagccgatgtcaccaccagcccttatgctgacaca
cagaatagctatgggtgtgctacttctaccccttactccacgtctcggctgatgttgtta
aatatgccagggcagctacctcagactctgagttccccatcgacacggctgataactgaa
ccaccacaagctactctttggagcccatctatggtttgtggtatgaccactcctccaact
tctcctggaaatgtcccacctgatctgtcacacccttacagtaaagtctttggtacaact
gcaggtggaaaaggaactcctctgggaaccccagcaacctctcctcctccagccccactc
tgtcattcggatgactacgtgcacatttcactcccccaggccacagtcacaccccccagg
aaggaagagagaatggattctgcaagaccatgtctacacagacaacaccatcttctgaat
gacagaggatcagaagagccacctggcagcaaaggttctgtcactctaagtgatcttcca
gggtttttaggtgatctggcctctgaagaagatagtattgaaaaagataaagaagaagct
gcaatatctagagaactttctgagatcaccacagcagaggcagagcctgtggttcctcga
ggaggctttgactctcccttttaccgagacagtctcccaggttctcagcggaagacccac
tcggcagcctccagttctcagggcgccagcgtgaaccctgagcctttacactcctccctg
gacaagcttgggcctgacacaccaaagcaagcctttactcccatagacctgccctgcggc
agtgctgatgaaagccctgcgggagacagggaatgccagacttctttggagaccagtatc
ttcactcccagtccttgtaaaattccacctccgacgagagtgggctttggaagcgggcag
cctcccccgtatgatcatctttttgaggtggcattgccaaagacagcccatcattttgtc
atcaggaagactgaggagctgttaaagaaagcaaaaggaaacacagaggaagatggtgtg
ccctctacctccccaatggaagtgctggacagactgatacagcagggagcagacgcgcac
agcaaggagctgaacaagttgcctttacccagcaagtctgtcgactggacccactttgga
ggctctcctccttcagatgagatccgcaccctccgagaccagttgcttttactgcacaac
cagttactctatgagcgttttaagaggcagcagcatgccctccggaacaggcggctcctc
cgcaaggtgatcaaagcagcagctctggaggaacataatgctgccatgaaagatcagttg
aagttacaagagaaggacatccagatgtggaaggttagtctgcagaaagaacaagctaga
tacaatcagctccaggagcagcgtgacactatggtaaccaagctccacagccagatcaga
cagctgcagcatgaccgagaggaattctacaaccagagccaggaattacagacgaagctg
gaggactgcaggaacatgattgcggagctgcggatagaactgaagaaggccaacaacaag
gtgtgtcacactgagctgctgctcagtcaggtttcccaaaagctctcaaacagtgagtcg
gtccagcagcagatggagttcttgaacaggcagctgttggttcttggggaggtcaacgag
ctctatttggaacaactgcagaacaagcactcagataccacaaaggaagtagaaatgatg
aaagccgcctatcggaaagagctagaaaaaaacagaagccatgttctccagcagactcag
aggcttgatacctcccaaaaacggattttggaactggaatctcacctggccaagaaagac
caccttcttttggaacagaagaaatatctagaggatgtcaaactccaggcaagaggacag
ctgcaggccgcagagagcaggtatgaggctcagaaaaggataacccaggtgtttgaattg
gagatcttagatttatatggcaggttggagaaagatggcctcctgaaaaaacttgaagaa
gaaaaagcagaagcagctgaagcagcagaagaaaggcttgactgttgtaatgacgggtgc
tcagattccatggtagggcacaatgaagaggcatctggccacaacggtgagaccaagacc
cccaggcccagcagcgcccggggcagtagtggaagcagaggtggtggaggcagcagcagc
agcagcagcgagctttctaccccagagaaacccccacaccagagggcaggcccattcagc
agtcggtgggagacgactatgggagaagcgtctgccagcatccccaccactgtgggctca
cttcccagttcaaaaagcttcctgggtatgaaggctcgagagttatttcgtaataagagc
gagagccagtgtgatgaggacggcatgaccagtagcctttctgagagcctaaagacagaa
ctgggcaaagacttgggtgtggaagccaagattcccctgaacctagatggccctcacccg
tctcccccgaccccggacagtgttggacagctacatatcatggactacaatgagactcat
catgaacacagctaa

KEGG   Homo sapiens (human): 7249
Entry
7249              CDS       T01001                                 
Symbol
TSC2, LAM, PPP1R160, TSC4
Name
(RefSeq) TSC complex subunit 2
  KO
K07207  tuberous sclerosis 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04115  p53 signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04218  Cellular senescence
hsa04714  Thermogenesis
hsa04910  Insulin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05231  Choline metabolism in cancer
Network
nt06114  PI3K signaling (viruses)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06415  PI3K signaling
nt06462  Spinocerebellar ataxia
nt06522  mTOR signaling
  Element
N00357  HPV E6 to MTOR signaling pathway
N00388  HCMV UL38 to MTOR signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00584  HSV US3 to MTOR signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N01575  TSC1/2-mTORC1 signaling pathway
N01576  STRAD/STK11- TSC signaling pathway
Disease
H00896  Lymphangioleiomyomatosis
H00915  Tuberous sclerosis complex
H01251  Focal cortical dysplasia of Taylor
H01691  Renal angiomyolipoma
H01692  Subependymal giant cell astrocytoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    7249 (TSC2)
   04151 PI3K-Akt signaling pathway
    7249 (TSC2)
   04152 AMPK signaling pathway
    7249 (TSC2)
   04150 mTOR signaling pathway
    7249 (TSC2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    7249 (TSC2)
  09143 Cell growth and death
   04115 p53 signaling pathway
    7249 (TSC2)
   04218 Cellular senescence
    7249 (TSC2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    7249 (TSC2)
   04919 Thyroid hormone signaling pathway
    7249 (TSC2)
  09149 Aging
   04211 Longevity regulating pathway
    7249 (TSC2)
  09159 Environmental adaptation
   04714 Thermogenesis
    7249 (TSC2)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    7249 (TSC2)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    7249 (TSC2)
   05163 Human cytomegalovirus infection
    7249 (TSC2)
   05165 Human papillomavirus infection
    7249 (TSC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    7249 (TSC2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     7249 (TSC2)
SSDB
Motif
Pfam: Tuberin DUF3384 Rap_GAP Telomere_reg-2 Cnd1
Other DBs
NCBI-GeneID: 7249
NCBI-ProteinID: NP_000539
OMIM: 191092
HGNC: 12363
Ensembl: ENSG00000103197
Pharos: P49815(Tbio)
UniProt: P49815
Structure
LinkDB
Position
16:2047985..2089491
AA seq 1807 aa
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS
PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL
ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV
EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
EDFTEFV
NT seq 5424 nt   +upstreamnt  +downstreamnt
atggccaaaccaacaagcaaagattcaggcttgaaggagaagtttaagattctgttggga
ctgggaacaccgaggccaaatcccaggtctgcagagggtaaacagacggagtttatcatc
accgcggaaatactgagagaactgagcatggaatgtggcctcaacaatcgcatccggatg
atagggcagatttgtgaagtcgcaaaaaccaagaaatttgaagagcacgcagtggaagca
ctctggaaggcggtcgcggatctgttgcagccggagcggccgctggaggcccggcacgcg
gtgctggctctgctgaaggccatcgtgcaggggcagggcgagcgtttgggggtcctcaga
gccctcttctttaaggtcatcaaggattacccttccaacgaagaccttcacgaaaggctg
gaggttttcaaggccctcacagacaatgggagacacatcacctacttggaggaagagctg
gctgactttgtcctgcagtggatggatgttggcttgtcctcggaattccttctggtgctg
gtgaacttggtcaaattcaatagctgttacctcgacgagtacatcgcaaggatggttcag
atgatctgtctgctgtgcgtccggaccgcgtcctctgtggacatagaggtctccctgcag
gtgctggacgccgtggtctgctacaactgcctgccggctgagagcctcccgctgttcatc
gttaccctctgtcgcaccatcaacgtcaaggagctctgcgagccttgctggaagctgatg
cggaacctccttggcacccacctgggccacagcgccatctacaacatgtgccacctcatg
gaggacagagcctacatggaggacgcgcccctgctgagaggagccgtgttttttgtgggc
atggctctctggggagcccaccggctctattctctcaggaactcgccgacatctgtgttg
ccatcattttaccaggccatggcatgtccgaacgaggtggtgtcctatgagatcgtcctg
tccatcaccaggctcatcaagaagtataggaaggagctccaggtggtggcgtgggacatt
ctgctgaacatcatcgaacggctccttcagcagctccagaccttggacagcccggagctc
aggaccatcgtccatgacctgttgaccacggtggaggagctgtgtgaccagaacgagttc
cacgggtctcaggagagatactttgaactggtggagagatgtgcggaccagaggcctgag
tcctccctcctgaacctgatctcctatagagcgcagtccatccacccggccaaggacggc
tggattcagaacctgcaggcgctgatggagagattcttcaggagcgagtcccgaggcgcc
gtgcgcatcaaggtgctggacgtgctgtcctttgtgctgctcatcaacaggcagttctat
gaggaggagctgattaactcagtggtcatctcgcagctctcccacatccccgaggataaa
gaccaccaggtccgaaagctggccacccagttgctggtggacctggcagagggctgccac
acacaccacttcaacagcctgctggacatcatcgagaaggtgatggcccgctccctctcc
ccacccccggagctggaagaaagggatgtggccgcatactcggcctccttggaggatgtg
aagacagccgtcctggggcttctggtcatccttcagaccaagctgtacaccctgcctgca
agccacgccacgcgtgtgtatgagatgctggtcagccacattcagctccactacaagcac
agctacaccctgccaatcgcgagcagcatccggctgcaggcctttgacttcctgttgctg
ctgcgggccgactcactgcaccgcctgggcctgcccaacaaggatggagtcgtgcggttc
agcccctactgcgtctgcgactacatggagccagagagaggctctgagaagaagaccagc
ggccccctttctcctcccacagggcctcctggcccggcgcctgcaggccccgccgtgcgg
ctggggtccgtgccctactccctgctcttccgcgtcctgctgcagtgcttgaagcaggag
tctgactggaaggtgctgaagctggttctgggcaggctgcctgagtccctgcgctataaa
gtgctcatctttacttccccttgcagtgtggaccagctgtgctctgctctctgctccatg
ctttcaggcccaaagacactggagcggctccgaggcgccccagaaggcttctccagaact
gacttgcacctggccgtggttccagtgctgacagcattaatctcttaccataactacctg
gacaaaaccaaacagcgcgagatggtctactgcctggagcagggcctcatccaccgctgt
gccagccagtgcgtcgtggccttgtccatctgcagcgtggagatgcctgacatcatcatc
aaggcgctgcctgttctggtggtgaagctcacgcacatctcagccacagccagcatggcc
gtcccactgctggagttcctgtccactctggccaggctgccgcacctctacaggaacttt
gccgcggagcagtatgccagtgtgttcgccatctccctgccgtacaccaacccctccaag
tttaatcagtacatcgtgtgtctggcccatcacgtcatagccatgtggttcatcaggtgc
cgcctgcccttccggaaggattttgtccctttcatcactaagggcctgcggtccaatgtc
ctcttgtcttttgatgacacccccgagaaggacagcttcagggcccggagtactagtctc
aacgagagacccaagagtctgaggatagccagaccccccaaacaaggcttgaataactct
ccacccgtgaaagaattcaaggagagctctgcagccgaggccttccggtgccgcagcatc
agtgtgtctgaacatgtggtccgcagcaggatacagacgtccctcaccagtgccagcttg
gggtctgcagatgagaactccgtggcccaggctgacgatagcctgaaaaacctccacctg
gagctcacggaaacctgtctggacatgatggctcgatacgtcttctccaacttcacggct
gtcccgaagaggtctcctgtgggcgagttcctcctagcgggtggcaggaccaaaacctgg
ctggttgggaacaagcttgtcactgtgacgacaagcgtgggaaccgggacccggtcgtta
ctaggcctggactcgggggagctgcagtccggcccggagtcgagctccagccccggggtg
catgtgagacagaccaaggaggcgccggccaagctggagtcccaggctgggcagcaggtg
tcccgtggggcccgggatcgggtccgttccatgtcggggggccatggtcttcgagttggc
gccctggacgtgccggcctcccagttcctgggcagtgccacttctccaggaccacggact
gcaccagccgcgaaacctgagaaggcctcagctggcacccgggttcctgtgcaggagaag
acgaacctggcggcctatgtgcccctgctgacccagggctgggcggagatcctggtccgg
aggcccacagggaacaccagctggctgatgagcctggagaacccgctcagccctttctcc
tcggacatcaacaacatgcccctgcaggagctgtctaacgccctcatggcggctgagcgc
ttcaaggagcaccgggacacagccctgtacaagtcactgtcggtgccggcagccagcacg
gccaaaccccctcctctgcctcgctccaacacagtggcctctttctcctccctgtaccag
tccagctgccaaggacagctgcacaggagcgtttcctgggcagactccgccgtggtcatg
gaggagggaagtccgggcgaggttcctgtgctggtggagcccccagggttggaggacgtt
gaggcagcgctaggcatggacaggcgcacggatgcctacagcaggtcgtcctcagtctcc
agccaggaggagaagtcgctccacgcggaggagctggttggcaggggcatccccatcgag
cgagtcgtctcctcggagggtggccggccctctgtggacctctccttccagccctcgcag
cccctgagcaagtccagctcctctcccgagctgcagactctgcaggacatcctcggggac
cctggggacaaggccgacgtgggccggctgagccctgaggttaaggcccggtcacagtca
gggaccctggacggggaaagtgctgcctggtcggcctcgggcgaagacagtcggggccag
cccgagggtcccttgccttccagctccccccgctcgcccagtggcctccggccccgaggt
tacaccatctccgactcggccccatcacgcaggggcaagagagtagagagggacgcctta
aagagcagagccacagcctccaatgcagagaaagtgccaggcatcaaccccagtttcgtg
ttcctgcagctctaccattcccccttctttggcgacgagtcaaacaagccaatcctgctg
cccaatgagtcacagtcctttgagcggtcggtgcagctcctcgaccagatcccatcatac
gacacccacaagatcgccgtcctgtatgttggagaaggccagagcaacagcgagctcgcc
atcctgtccaatgagcatggctcctacaggtacacggagttcctgacgggcctgggccgg
ctcatcgagctgaaggactgccagccggacaaggtgtacctgggaggcctggacgtgtgt
ggtgaggacggccagttcacctactgctggcacgatgacatcatgcaagccgtcttccac
atcgccaccctgatgcccaccaaggacgtggacaagcaccgctgcgacaagaagcgccac
ctgggcaacgactttgtgtccattgtctacaatgactccggtgaggacttcaagcttggc
accatcaagggccagttcaactttgtccacgtgatcgtcaccccgctggactacgagtgc
aacctggtgtccctgcagtgcaggaaagacatggagggccttgtggacaccagcgtggcc
aagatcgtgtctgaccgcaacctgcccttcgtggcccgccagatggccctgcacgcaaat
atggcctcacaggtgcatcatagccgctccaaccccaccgatatctacccctccaagtgg
attgcccggctccgccacatcaagcggctccgccagcggatctgcgaggaagccgcctac
tccaaccccagcctacctctggtgcaccctccgtcccatagcaaagcccctgcacagact
ccagccgagcccacacctggctatgaggtgggccagcggaagcgcctcatctcctcggtg
gaggacttcaccgagtttgtgtga

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