NETWORK: N00782
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Entry
N00782 Network
Name
TSH-TG signaling pathway
Definition
TSHB -> TSHR -> GNAS -> ADCY -> cAMP -> PKA -> (TTF1,
TTF2,
PAX8,
CREB) => TG
Expanded
7252 -> 7253 -> 2778 -> (107,
108,
109,
196883,
111,
112,
113,
114,
115) -> C00575 -> (5566+5567+5568) -> (7270,
8458,
7849,
10488,
1385,
1386,
1388,
148327,
468,
64764,
84699,
90993,
9586) => 7038
Class
nt06322
TRH-TSH-TH signaling
Type
Reference
Pathway
hsa04918
Thyroid hormone synthesis
Gene
7252
TSHB; thyroid stimulating hormone subunit beta
7253
TSHR; thyroid stimulating hormone receptor
2778
GNAS; GNAS complex locus
107
ADCY1; adenylate cyclase 1
108
ADCY2; adenylate cyclase 2
109
ADCY3; adenylate cyclase 3
196883
ADCY4; adenylate cyclase 4
111
ADCY5; adenylate cyclase 5
112
ADCY6; adenylate cyclase 6
113
ADCY7; adenylate cyclase 7
114
ADCY8; adenylate cyclase 8
115
ADCY9; adenylate cyclase 9
5566
PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567
PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568
PRKACG; protein kinase cAMP-activated catalytic subunit gamma
7270
TTF1; transcription termination factor 1
8458
TTF2; transcription termination factor 2
7849
PAX8; paired box 8
10488
CREB3; cAMP responsive element binding protein 3
1385
CREB1; cAMP responsive element binding protein 1
1386
ATF2; activating transcription factor 2
1388
ATF6B; activating transcription factor 6 beta
148327
CREB3L4; cAMP responsive element binding protein 3 like 4
468
ATF4; activating transcription factor 4
64764
CREB3L2; cAMP responsive element binding protein 3 like 2
84699
CREB3L3; cAMP responsive element binding protein 3 like 3
90993
CREB3L1; cAMP responsive element binding protein 3 like 1
9586
CREB5; cAMP responsive element binding protein 5
7038
TG; thyroglobulin
Metabolite
C00575
3',5'-Cyclic AMP
Reference
PMID:
11717564
Authors
Gillam MP, Kopp P
Title
Genetic defects in thyroid hormone synthesis.
Journal
Curr Opin Pediatr 13:364-72 (2001)
DOI:
10.1097/00008480-200108000-00014
Reference
PMID:
11137035
Authors
Kohn LD, Suzuki K, Nakazato M, Royaux I, Green ED
Title
Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte.
Journal
Trends Endocrinol Metab 12:10-6 (2001)
DOI:
10.1016/S1043-2760(00)00337-4
Reference
PMID:
20407074
Authors
Ohye H, Sugawara M
Title
Dual oxidase, hydrogen peroxide and thyroid diseases.
Journal
Exp Biol Med (Maywood) 235:424-33 (2010)
DOI:
10.1258/ebm.2009.009241
Reference
PMID:
20378719
Authors
Calebiro D, Nikolaev VO, Lohse MJ
Title
Imaging of persistent cAMP signaling by internalized G protein-coupled receptors.
Journal
J Mol Endocrinol 45:1-8 (2010)
DOI:
10.1677/JME-10-0014
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