KEGG   Homo sapiens (human): 84699
Entry
84699             CDS       T01001                                 
Symbol
CREB3L3, CREB-H, CREBH, HYST1481, HYTG2
Name
(RefSeq) cAMP responsive element binding protein 3 like 3
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Disease
H01637  Hypertriglyceridemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    84699 (CREB3L3)
   04024 cAMP signaling pathway
    84699 (CREB3L3)
   04022 cGMP-PKG signaling pathway
    84699 (CREB3L3)
   04151 PI3K-Akt signaling pathway
    84699 (CREB3L3)
   04152 AMPK signaling pathway
    84699 (CREB3L3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    84699 (CREB3L3)
   04922 Glucagon signaling pathway
    84699 (CREB3L3)
   04915 Estrogen signaling pathway
    84699 (CREB3L3)
   04926 Relaxin signaling pathway
    84699 (CREB3L3)
   04935 Growth hormone synthesis, secretion and action
    84699 (CREB3L3)
   04918 Thyroid hormone synthesis
    84699 (CREB3L3)
   04928 Parathyroid hormone synthesis, secretion and action
    84699 (CREB3L3)
   04916 Melanogenesis
    84699 (CREB3L3)
   04925 Aldosterone synthesis and secretion
    84699 (CREB3L3)
   04927 Cortisol synthesis and secretion
    84699 (CREB3L3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    84699 (CREB3L3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    84699 (CREB3L3)
  09156 Nervous system
   04725 Cholinergic synapse
    84699 (CREB3L3)
   04728 Dopaminergic synapse
    84699 (CREB3L3)
  09149 Aging
   04211 Longevity regulating pathway
    84699 (CREB3L3)
  09159 Environmental adaptation
   04714 Thermogenesis
    84699 (CREB3L3)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    84699 (CREB3L3)
   05203 Viral carcinogenesis
    84699 (CREB3L3)
  09162 Cancer: specific types
   05215 Prostate cancer
    84699 (CREB3L3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    84699 (CREB3L3)
   05161 Hepatitis B
    84699 (CREB3L3)
   05163 Human cytomegalovirus infection
    84699 (CREB3L3)
   05165 Human papillomavirus infection
    84699 (CREB3L3)
  09164 Neurodegenerative disease
   05016 Huntington disease
    84699 (CREB3L3)
   05020 Prion disease
    84699 (CREB3L3)
  09165 Substance dependence
   05030 Cocaine addiction
    84699 (CREB3L3)
   05031 Amphetamine addiction
    84699 (CREB3L3)
   05034 Alcoholism
    84699 (CREB3L3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    84699 (CREB3L3)
   04934 Cushing syndrome
    84699 (CREB3L3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    84699 (CREB3L3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    84699 (CREB3L3)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf KASH_CCD Mit_KHE1 OppC_N pEK499_p136 ZapB DUF1664
Other DBs
NCBI-GeneID: 84699
NCBI-ProteinID: NP_115996
OMIM: 611998
HGNC: 18855
Ensembl: ENSG00000060566
Pharos: Q68CJ9(Tbio)
UniProt: Q68CJ9
LinkDB
Position
19:4153631..4173054
AA seq 461 aa
MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDS
DDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGK
GPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTV
KDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYE
ERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLL
EQLKKLQAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFS
RTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGSPGADWGFQDTANLTNSTEELDN
ATLVLRNATEGLGQVALLDWVAPGPSTGSGRAGLEAAGDEL
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgaatacggatttagctgctggaaagatggcttctgctgcctgctccatggaccccatc
gacagctttgagctcctggatctcctgtttgaccggcaggacggcatcctgagacacgtg
gagctgggcgagggctggggtcacgtcaaggaccagcaggtcctgccaaaccccgactct
gacgacttcctcagctccatcctgggctctggagactcactgcccagctccccactctgg
tcccccgaaggcagtgatagtggcatctccgaagacctcccctccgacccccaggacacc
cctccacgcagcggaccagccacctcccccgccggctgccatcctgcccagcctggcaag
gggccctgcctctcctatcatcctggcaactcttgctccaccacaaccccagggccagtg
atccaagtacctgaagcctctgtgaccatagacctggaaatgtggagcccaggaggaagg
atctgtgctgagaagccggctgatccggtggacctgtccccacgatgcaatctcaccgtg
aaagacctcctcctttcgggcagcagtggggacctgcaacagcatcacctgggggcctcc
tacctcctgcgacctggggctgggcactgtcaggagctggtgctcaccgaggatgagaag
aagctgctggctaaagaaggcatcaccctgcccactcagctgcccctcactaagtacgag
gagcgagtgctgaaaaaaatccgccggaaaatccggaacaagcagtcggcgcaagaaagc
aggaagaagaagaaggaatatatcgatggcctggagactcggatgtcagcttgcactgct
cagaatcaggagttacagaggaaagtcttgcatctcgagaagcaaaacctgtccctcttg
gagcaactgaagaaactccaggccattgtggtgcagtccaccagcaagtcagcccagaca
ggcacctgtgtcgcagtcctgttgctgtcctttgccctcatcatcctcccctccatcagc
ccttttggccccaacaaaaccgagagccctggggactttgcgcctgtacgagtgttctcc
agaactttgcacaacgatgctgcctcccgcgtggctgctgatgctgtgccaggctccgag
gccccaggaccccgacccgaggctgacacaacccgagaagagtctccaggaagccccggg
gcagactggggcttccaggacaccgcgaacctgaccaattcgacggaggagctggacaac
gccaccctggtcctgaggaatgcaacagaggggctgggccaggtcgccctgctggactgg
gtggcgcctgggccgagcactggctcaggacgtgcagggctggaggcggcgggagacgag
ctgtga

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