 | | NETWORK: N01343 | |
| Entry |
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| Name |
ACH-CHRN-RAS-ERK signaling pathway
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| Definition |
ACh -> CHRNA7 -> Ca2+ -> RAS -> RAF -> MEK -> ERK -> CREB |
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| Expanded |
C01996 -> 1139 -> C00076 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) |
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| Class |
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| Type |
Reference
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| Gene |
| 1139 | CHRNA7; cholinergic receptor nicotinic alpha 7 subunit |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
| 10488 | CREB3; cAMP responsive element binding protein 3 |
| 1385 | CREB1; cAMP responsive element binding protein 1 |
| 1386 | ATF2; activating transcription factor 2 |
| 1388 | ATF6B; activating transcription factor 6 beta |
| 148327 | CREB3L4; cAMP responsive element binding protein 3 like 4 |
| 468 | ATF4; activating transcription factor 4 |
| 64764 | CREB3L2; cAMP responsive element binding protein 3 like 2 |
| 84699 | CREB3L3; cAMP responsive element binding protein 3 like 3 |
| 90993 | CREB3L1; cAMP responsive element binding protein 3 like 1 |
| 9586 | CREB5; cAMP responsive element binding protein 5 |
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| Metabolite |
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| Reference |
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| Authors |
Akaike A, Izumi Y |
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| Title |
Overview |
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| Journal |
In "Nicotinic Acetylcholine Receptor Signaling in Neuroprotection", pp. 1-15, Singapore, Springer (2018) DOI: 10.1007/978-981-10-8488-1 |
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| Reference |
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| Authors |
Wu CH, Lee CH, Ho YS |
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| Title |
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy. |
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| Journal |
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| LinkDB |
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