KEGG   NETWORK: N00302
Entry
N00302                      Network                                
Name
Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
Definition
(CACNA1D*,CACNA1H*) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone
  Expanded
(776v1,8912v1) -> C00076 -> (801,805,808) -> (8536,57118,57172,815,816,817,818,814) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) => 1585 -> C01780
Class
nt06316 Renin-angiotensin-aldosterone signaling
Type
Variant
Disease
H01603  Primary aldosteronism
Gene
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D
8912  CACNA1H; calcium voltage-gated channel subunit alpha1 H
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
8536  CAMK1; calcium/calmodulin dependent protein kinase I
57118  CAMK1D; calcium/calmodulin dependent protein kinase ID
57172  CAMK1G; calcium/calmodulin dependent protein kinase IG
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814  CAMK4; calcium/calmodulin dependent protein kinase IV
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
1585  CYP11B2; cytochrome P450 family 11 subfamily B member 2
Variant
776v1 (CACNA1D*)  CACNA1D mutation
8912v1 (CACNA1H*)  CACNA1H mutation
Metabolite
C00076  Calcium cation
C01780  Aldosterone
Reference
PMID:27445975
  Authors
El Ghorayeb N, Bourdeau I, Lacroix A
  Title
Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism.
  Journal
Front Endocrinol (Lausanne) 7:72 (2016)
DOI:10.3389/fendo.2016.00072
Reference
PMID:23913001
  Authors
Scholl UI, Goh G, Stolting G, de Oliveira RC, Choi M, Overton JD, Fonseca AL, Korah R, Starker LF, Kunstman JW, Prasad ML, Hartung EA, Mauras N, Benson MR, Brady T, Shapiro JR, Loring E, Nelson-Williams C, Libutti SK, Mane S, Hellman P, Westin G, Akerstrom G, Bjorklund P, Carling T, Fahlke C, Hidalgo P, Lifton RP
  Title
Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism.
  Journal
Nat Genet 45:1050-4 (2013)
DOI:10.1038/ng.2695
Reference
PMID:28400483
  Authors
Fernandes-Rosa FL, Boulkroun S, Zennaro MC
  Title
Somatic and inherited mutations in primary aldosteronism.
  Journal
J Mol Endocrinol 59:R47-R63 (2017)
DOI:10.1530/JME-17-0035
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