KEGG T01001: 90993

Homo sapiens (human): 90993

Entry

90993             CDS       T01001

Symbol

CREB3L1, C16DELp11.2, DEL16p11.2, OASIS, OI16

Name

(RefSeq) cAMP responsive element binding protein 3 like 1

K09048

cyclic AMP-responsive element-binding protein 3

Organism

hsa Homo sapiens (human)

Pathway

hsa04022

cGMP-PKG signaling pathway

hsa04024

cAMP signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04152

AMPK signaling pathway

hsa04211

Longevity regulating pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04668

TNF signaling pathway

hsa04714

Thermogenesis

hsa04725

Cholinergic synapse

hsa04728

Dopaminergic synapse

hsa04911

Insulin secretion

hsa04915

Estrogen signaling pathway

hsa04916

Melanogenesis

hsa04918

Thyroid hormone synthesis

hsa04922

Glucagon signaling pathway

hsa04925

Aldosterone synthesis and secretion

hsa04926

Relaxin signaling pathway

hsa04927

Cortisol synthesis and secretion

hsa04928

Parathyroid hormone synthesis, secretion and action

hsa04931

Insulin resistance

hsa04934

Cushing syndrome

hsa04935

Growth hormone synthesis, secretion and action

hsa04962

Vasopressin-regulated water reabsorption

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05030

Cocaine addiction

hsa05031

Amphetamine addiction

hsa05034

Alcoholism

hsa05161

Hepatitis B

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05203

Viral carcinogenesis

hsa05207

Chemical carcinogenesis - receptor activation

hsa05215

Prostate cancer

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling

Element

N00297

ACTH-cortisol signaling pathway

N00298

CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway

N00301

Angiotensin-aldosterone signaling pathway

N00302

Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway

N00303

Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway

N00304

Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway

N00305

Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway

N00320

Mutation-activated PRKACA to ACTH-cortisol signaling pathway

N00321

Mutation-activated GNAS to ACTH-cortisol signaling pathway

N00322

Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway

N00323

Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway

N00324

CRHR-PKA-ACTH signaling pathway

N00325

Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway

N00326

Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway

N00327

Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway

N00410

DRD1-GNAS-AC-PKA signaling pathway

N00444

TNF-p38 signaling pathway

N00544

HBV HBx to CREB-mediated transcription

N00782

TSH-TG signaling pathway

N00910

GHRHR-PKA-GH signaling pathway

N00981

Mutation-caused aberrant Htt to CREB-mediated transcription

N01204

PRNP-PI3K-NOX2 signaling pathway

N01343

ACH-CHRN-RAS-ERK signaling pathway

N01351

E2-ER-RAS-ERK signaling pathway

Disease

H00506

Osteogenesis imperfecta

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    90993 (CREB3L1)
   04024 cAMP signaling pathway
    90993 (CREB3L1)
   04022 cGMP-PKG signaling pathway
    90993 (CREB3L1)
   04151 PI3K-Akt signaling pathway
    90993 (CREB3L1)
   04152 AMPK signaling pathway
    90993 (CREB3L1)
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    90993 (CREB3L1)
   04922 Glucagon signaling pathway
    90993 (CREB3L1)
   04915 Estrogen signaling pathway
    90993 (CREB3L1)
   04926 Relaxin signaling pathway
    90993 (CREB3L1)
   04935 Growth hormone synthesis, secretion and action
    90993 (CREB3L1)
   04918 Thyroid hormone synthesis
    90993 (CREB3L1)
   04928 Parathyroid hormone synthesis, secretion and action
    90993 (CREB3L1)
   04925 Aldosterone synthesis and secretion
    90993 (CREB3L1)
   04927 Cortisol synthesis and secretion
    90993 (CREB3L1)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    90993 (CREB3L1)
  09156 Nervous system
   04725 Cholinergic synapse
    90993 (CREB3L1)
   04728 Dopaminergic synapse
    90993 (CREB3L1)
  09149 Aging
   04211 Longevity regulating pathway
    90993 (CREB3L1)
  09159 Environmental adaptation
   04714 Thermogenesis
    90993 (CREB3L1)
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    90993 (CREB3L1)
   05203 Viral carcinogenesis
    90993 (CREB3L1)
  09162 Cancer: specific types
   05215 Prostate cancer
    90993 (CREB3L1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    90993 (CREB3L1)
   05161 Hepatitis B
    90993 (CREB3L1)
   05163 Human cytomegalovirus infection
    90993 (CREB3L1)
   05165 Human papillomavirus infection
    90993 (CREB3L1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    90993 (CREB3L1)
   05020 Prion disease
    90993 (CREB3L1)
  09165 Substance dependence
   05030 Cocaine addiction
    90993 (CREB3L1)
   05031 Amphetamine addiction
    90993 (CREB3L1)
   05034 Alcoholism
    90993 (CREB3L1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    90993 (CREB3L1)
   04934 Cushing syndrome
    90993 (CREB3L1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    90993 (CREB3L1)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    90993 (CREB3L1)

SSDB

Motif

Pfam:

bZIP_1 bZIP_2 bZIP_Maf LMBR1 Spc29 HAUS-augmin3 UQCC2_CBP6 TPR_MLP1_2 Prominin RNase_Y_N SKA2 DUF4404 APG6_N EcsC

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

11:46277662..46321409

AA seq 519 aa
MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFD
DPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQDAEHGAWALG
HKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQL
PVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTA
ISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKN
KISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLVTNK
ISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTASQM
PSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTK
YLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS

NT seq 1560 nt +upstreamnt +downstreamnt
atggacgccgtcttggaacccttcccggccgacaggctgttccccggatccagcttcctg
gacttgggggatctgaacgagtcggacttcctcaacaatgcgcactttcctgagcacctg
gaccactttacggagaacatggaggacttctccaatgacctgttcagcagcttctttgat
gaccctgtgctggatgagaagagccctctattggacatggaactggactcccctacgcca
ggcatccaggcggagcacagctactccctgagcggcgactcagcgccccagagccccctt
gtgcccatcaagatggaggacaccacccaagatgcagagcatggagcatgggcgctggga
cacaaactgtgctccatcatggtgaagcaggagcagagcccggagctgcccgtggaccct
ctggctgccccctcggccatggctgccgcggccgccatggccaccaccccgctgctgggc
ctcagccccttgtccaggctgcccatcccccaccaggccccgggagagatgactcagctg
ccagtgatcaaagcagagcctctggaggtgaaccagttcctcaaagtgacaccggaggac
ctggtgcagatgcctccgacgccccccagcagccatggcagtgacagcgacggctcccag
agtccccgctctctgcccccctccagccctgtcaggcccatggcgcgctcctccacggcc
atctccacctccccactcctcactgcccctcacaaattacaggggacatcagggccactg
ctcctgacagaggaggagaagcggaccctgattgctgagggctaccccatccccacaaaa
ctccccctcaccaaagccgaggagaaggccttgaagagagtccggaggaaaatcaagaac
aagatctcagcccaggagagccgtcgtaagaagaaggagtatgtggagtgtctagaaaag
aaggtggagacatttacatctgagaacaatgaactgtggaagaaggtggagaccctggag
aatgccaacaggaccctgctccagcagctgcagaaactccagactctggtcaccaacaag
atctccagaccttacaagatggccgccacccagactgggacctgcctcatggtggcagcc
ttgtgctttgttctggtgctgggctccctcgtgccctgccttcccgagttctcctccggc
tcccagactgtgaaggaagaccccctggccgcagacggcgtctacacggccagccagatg
ccctcccgaagcctcctattctacgatgacggggcaggcttatgggaagatggccgcagc
accctgctgcccatggagcccccagatggctgggaaatcaaccccggggggccggcagag
cagcggccccgggaccacctgcagcatgatcacctggacagcacccacgagaccaccaag
tacctgagtgaggcctggcctaaagacggtggaaacggcaccagccccgacttctcccac
tccaaggagtggttccacgacagggatctgggccccaacaccaccatcaaactctcctag

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