Homo sapiens (human): 91662
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Entry
91662 CDS
T01001
Symbol
NLRP12, CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
Name
(RefSeq) NLR family pyrin domain containing 12
KO
K20865
NACHT, LRR and PYD domains-containing protein 12
Organism
hsa
Homo sapiens (human)
Pathway
hsa04621
NOD-like receptor signaling pathway
Network
nt06521
NLR signaling
Element
N01569
NALP12 inflammasome signaling pathway
Disease
H02159
Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
91662 (NLRP12)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04054 Pattern recognition receptors [BR:
hsa04054
]
91662 (NLRP12)
Pattern recognition receptors [BR:
hsa04054
]
Cytoplasmic pattern recognition receptors
NOD-like receptors
91662 (NLRP12)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NACHT
NLRC4_HD2
PYRIN
LRR_6
NOD2_WH
FISNA
LRR_4
nSTAND3
NB-ARC
AAA_25
AAA_16
Motif
Other DBs
NCBI-GeneID:
91662
NCBI-ProteinID:
NP_653288
OMIM:
609648
HGNC:
22938
Ensembl:
ENSG00000142405
UniProt:
P59046
Structure
PDB
LinkDB
All DBs
Position
19:complement(53793584..53824403)
Genome browser
AA seq
1061 aa
AA seq
DB search
MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL
YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN
GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE
DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG
VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL
LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK
RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
NT seq
3186 nt
NT seq
+upstream
nt +downstream
nt
atgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactc
gaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaa
ggcaagatcccctggggaagcatggagaaggccggtcccctggaaatggcccagctgctc
atcacccacttcgggccagaggaggcctggaggttggctctcagcacctttgagcggata
aacaggaaggacctgtgggagagaggacagagagaggacctggtgagggataccccacct
ggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcact
ccaagaaaagatccccaggaaacctacagggactatgtccgcaggaaattccggctcatg
gaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctc
ctgctggtgaaggagcactcaaaccccatgcaggtccagcagcagcttctggacacaggc
cggggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctcttt
gagccagacgaggagcgccccgagccaccgcgcaccgtggtcatgcaaggcgcggcaggg
ataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttc
caaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacg
gaatgcagcatgcaagacctcatcttcagctgctggcctgagcccagcgcgcctctccag
gagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaag
ccttctttccacgatcctcagggaccctggtgcctctgctgggaggagaaacggcccacg
gagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatc
accacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtg
gagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaat
gcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcaccatg
tgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggt
ggggggctgttgagacagacgtccaggaccaccactgcagtgtacatgctctacctgctg
agtctgatgcaacccaagccgggggccccgcgcctccagcccccacccaaccagagaggg
ttgtgctccttggcggcagatgggctctggaatcagaaaatcctatttgaggagcaggac
ctccggaagcacggcctagacggggaagacgtctctgccttcctcaacatgaacatcttc
cagaaggacatcaactgtgagaggtactacagcttcatccacttgagtttccaggaattc
tttgcagctatgtactatatcctggacgagggggagggcggggcaggcccagaccaggac
gtgaccaggctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagc
cgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgc
tggaaggtctcgccgcacatcaagatggacctgttgcagtggatccaaagcaaagctcag
agcgacggctccaccctgcagcagggctccttggagttcttcagctgcttgtacgagatc
caggaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaac
attgcctccaagatggagcacatggtctcctcgttctgtctgaagcgctgcaggagcgcc
caggtgctgcacttgtatggcgccacctacagcgcggacggggaagaccgcgcgaggtgc
tccgcaggagcgcacacgctgttggtgcagctaccagagaggaccgttctgctggacgcc
tacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctg
taccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacacccc
aactgcaaacttcagaacctgaggctgaagaggtgccgcatctccagctcagcctgcgag
gacctctctgcagctctcatagccaataagaatttgacaaggatggatctcagtggcaac
ggcgttggattcccaggcatgatgctgctttgcgagggcctgcggcatccccagtgcagg
ctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggagatggct
tctgtgctcggcaccaacccacatctggttgagttggacctgacaggaaatgcactggag
gatttgggcctgaggttactatgccagggactgaggcacccagtctgcagactacggact
ttgtggctgaagatctgccgcctcactgctgctgcctgtgacgagctggcctcaactctc
agtgtgaaccagagcctgagagagctggacctgagcctgaatgagctgggggacctcggg
gtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctgcggttg
ggcatctgccggctgggctctgccgcctgtgagggtctttctgtggtgctccaggccaac
cacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttg
ctggctgaggggctgcaacatcccgcctgcagactccagaaactgtggctggatagctgt
ggcctcacagccaaggcttgtgagaatctttacttcaccctggggatcaaccagaccttg
accgacctttacctgaccaacaacgccctaggggacacaggtgtccgactgctttgcaag
cggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaat
aaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggc
tgctga
Homo sapiens (human): 29108
Help
Entry
29108 CDS
T01001
Symbol
PYCARD, ASC, CARD5, TMS, TMS-1, TMS1
Name
(RefSeq) PYD and CARD domain containing
KO
K12799
apoptosis-associated speck-like protein containing a CARD
Organism
hsa
Homo sapiens (human)
Pathway
hsa04217
Necroptosis
hsa04621
NOD-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05164
Influenza A
hsa05417
Lipid and atherosclerosis
Network
nt06170
Influenza A virus (IAV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06521
NLR signaling
Element
N00742
NLRP3 inflammasome signaling pathway
N00743
IAV NS1 to NLRP3 inflammasome signaling pathway
N00864
Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00865
Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00866
Yersinia YopM to Pyrin Inflammasome signaling pathway
N00867
NLRC4 inflammasome signaling pathway
N00868
Pyrin inflammasome signaling pathway
N00933
Escherichia NleA to NLRP3 inflammasome signaling pathway
N00934
Non-canonical inflammasome signaling pathway
N00948
Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N00949
Shigella IpaB to NLRC4 Inflammasome signaling pathway
N01567
NLRP1 inflammasome signaling pathway
N01568
Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
N01569
NALP12 inflammasome signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
29108 (PYCARD)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
29108 (PYCARD)
04623 Cytosolic DNA-sensing pathway
29108 (PYCARD)
04625 C-type lectin receptor signaling pathway
29108 (PYCARD)
09160 Human Diseases
09172 Infectious disease: viral
05164 Influenza A
29108 (PYCARD)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
29108 (PYCARD)
05132 Salmonella infection
29108 (PYCARD)
05131 Shigellosis
29108 (PYCARD)
05135 Yersinia infection
29108 (PYCARD)
05133 Pertussis
29108 (PYCARD)
05134 Legionellosis
29108 (PYCARD)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
29108 (PYCARD)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CARD
PYRIN
Motif
Other DBs
NCBI-GeneID:
29108
NCBI-ProteinID:
NP_037390
OMIM:
606838
HGNC:
16608
Ensembl:
ENSG00000103490
UniProt:
Q9ULZ3
Structure
PDB
LinkDB
All DBs
Position
16:complement(31201486..31202760)
Genome browser
AA seq
195 aa
AA seq
DB search
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
LRESQSYLVEDLERS
NT seq
588 nt
NT seq
+upstream
nt +downstream
nt
atggggcgcgcgcgcgacgccatcctggatgcgctggagaacctgaccgccgaggagctc
aagaagttcaagctgaagctgctgtcggtgccgctgcgcgagggctacgggcgcatcccg
cggggcgcgctgctgtccatggacgccttggacctcaccgacaagctggtcagcttctac
ctggagacctacggcgccgagctcaccgctaacgtgctgcgcgacatgggcctgcaggag
atggccgggcagctgcaggcggccacgcaccagggctctggagccgcgccagctgggatc
caggcccctcctcagtcggcagccaagccaggcctgcactttatagaccagcaccgggct
gcgcttatcgcgagggtcacaaacgttgagtggctgctggatgctctgtacgggaaggtc
ctgacggatgagcagtaccaggcagtgcgggccgagcccaccaacccaagcaagatgcgg
aagctcttcagtttcacaccagcctggaactggacctgcaaggacttgctcctccaggcc
ctaagggagtcccagtcctacctggtggaggacctggagcggagctga
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integrated database retrieval system
