KEGG   Homo sapiens (human): 983
Entry
983               CDS       T01001                                 
Symbol
CDK1, CDC2, CDC28A, P34CDC2
Name
(RefSeq) cyclin dependent kinase 1
  KO
K02087  cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04540  Gap junction
hsa04914  Progesterone-mediated oocyte maturation
hsa05170  Human immunodeficiency virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06230  Cell cycle (cancer)
nt06512  Chromosome cohesion and segregation
  Element
N00455  CDC25-Cell cycle G2/M
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00459  WEE1-Cell cycle G2/M
N00460  HIV Vpr to WEE1-cell cycle G2M
N00499  ATR-p21-Cell cycle G2/M
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01500  Modifying of condensin I subunits
Drug target
Alvocidib (DG02041): D02880 D09868
Dinaciclib: D09604
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    983 (CDK1)
   04114 Oocyte meiosis
    983 (CDK1)
   04115 p53 signaling pathway
    983 (CDK1)
   04218 Cellular senescence
    983 (CDK1)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    983 (CDK1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    983 (CDK1)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    983 (CDK1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    983 (CDK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    983 (CDK1)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    983 (CDK1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    983 (CDK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    983 (CDK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     983 (CDK1)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     983 (CDK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   983 (CDK1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Prevention of re-replication factors
    983 (CDK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    983 (CDK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   983 (CDK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Kinase-like APH Seadorna_VP7 Choline_kinase Kdo
Other DBs
NCBI-GeneID: 983
NCBI-ProteinID: NP_001307847
OMIM: 116940
HGNC: 1722
Ensembl: ENSG00000170312
Pharos: P06493(Tchem)
UniProt: P06493
Structure
LinkDB
Position
10:60778331..60794852
AA seq 297 aa
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
NT seq 894 nt   +upstreamnt  +downstreamnt
atggaagattataccaaaatagagaaaattggagaaggtacctatggagttgtgtataag
ggtagacacaaaactacaggtcaagtggtagccatgaaaaaaatcagactagaaagtgaa
gaggaaggggttcctagtactgcaattcgggaaatttctctattaaaggaacttcgtcat
ccaaatatagtcagtcttcaggatgtgcttatgcaggattccaggttatatctcatcttt
gagtttctttccatggatctgaagaaatacttggattctatccctcctggtcagtacatg
gattcttcacttgttaagagttatttataccaaatcctacaggggattgtgttttgtcac
tctagaagagttcttcacagagacttaaaacctcaaaatctcttgattgatgacaaagga
acaattaaactggctgattttggccttgccagagcttttggaatacctatcagagtatat
acacatgaggtagtaacactctggtacagatctccagaagtattgctggggtcagctcgt
tactcaactccagttgacatttggagtataggcaccatatttgctgaactagcaactaag
aaaccacttttccatggggattcagaaattgatcaactcttcaggattttcagagctttg
ggcactcccaataatgaagtgtggccagaagtggaatctttacaggactataagaataca
tttcccaaatggaaaccaggaagcctagcatcccatgtcaaaaacttggatgaaaatggc
ttggatttgctctcgaaaatgttaatctatgatccagccaaacgaatttctggcaaaatg
gcactgaatcatccatattttaatgatttggacaatcagattaagaagatgtag

KEGG   Homo sapiens (human): 891
Entry
891               CDS       T01001                                 
Symbol
CCNB1, CCNB
Name
(RefSeq) cyclin B1
  KO
K05868  G2/mitotic-specific cyclin-B1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04914  Progesterone-mediated oocyte maturation
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06230  Cell cycle (cancer)
  Element
N00455  CDC25-Cell cycle G2/M
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00459  WEE1-Cell cycle G2/M
N00460  HIV Vpr to WEE1-cell cycle G2M
N00499  ATR-p21-Cell cycle G2/M
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    891 (CCNB1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    891 (CCNB1)
   04114 Oocyte meiosis
    891 (CCNB1)
   04115 p53 signaling pathway
    891 (CCNB1)
   04218 Cellular senescence
    891 (CCNB1)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    891 (CCNB1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    891 (CCNB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    891 (CCNB1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    891 (CCNB1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Prevention of re-replication factors
    891 (CCNB1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Cyclins
    891 (CCNB1)
SSDB
Motif
Pfam: Cyclin_N Cyclin_C Adeno_E1A Trypan_PARP
Other DBs
NCBI-GeneID: 891
NCBI-ProteinID: NP_114172
OMIM: 123836
HGNC: 1579
Ensembl: ENSG00000134057
Pharos: P14635(Tchem)
UniProt: P14635
Structure
LinkDB
Position
5:69167150..69178245
AA seq 433 aa
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
ALVQDLAKAVAKV
NT seq 1302 nt   +upstreamnt  +downstreamnt
atggcgctccgagtcaccaggaactcgaaaattaatgctgaaaataaggcgaagatcaac
atggcaggcgcaaagcgcgttcctacggcccctgctgcaacctccaagcccggactgagg
ccaagaacagctcttggggacattggtaacaaagtcagtgaacaactgcaggccaaaatg
cctatgaagaaggaagcaaaaccttcagctactggaaaagtcattgataaaaaactacca
aaacctcttgaaaaggtacctatgctggtgccagtgccagtgtctgagccagtgccagag
ccagaacctgagccagaacctgagcctgttaaagaagaaaaactttcgcctgagcctatt
ttggttgatactgcctctccaagcccaatggaaacatctggatgtgcccctgcagaagaa
gacctgtgtcaggctttctctgatgtaattcttgcagtaaatgatgtggatgcagaagat
ggagctgatccaaacctttgtagtgaatatgtgaaagatatttatgcttatctgagacaa
cttgaggaagagcaagcagtcagaccaaaatacctactgggtcgggaagtcactggaaac
atgagagccatcctaattgactggctagtacaggttcaaatgaaattcaggttgttgcag
gagaccatgtacatgactgtctccattattgatcggttcatgcagaataattgtgtgccc
aagaagatgctgcagctggttggtgtcactgccatgtttattgcaagcaaatatgaagaa
atgtaccctccagaaattggtgactttgcttttgtgactgacaacacttatactaagcac
caaatcagacagatggaaatgaagattctaagagctttaaactttggtctgggtcggcct
ctacctttgcacttccttcggagagcatctaagattggagaggttgatgtcgagcaacat
actttggccaaatacctgatggaactaactatgttggactatgacatggtgcactttcct
ccttctcaaattgcagcaggagctttttgcttagcactgaaaattctggataatggtgaa
tggacaccaactctacaacattacctgtcatatactgaagaatctcttcttccagttatg
cagcacctggctaagaatgtagtcatggtaaatcaaggacttacaaagcacatgactgtc
aagaacaagtatgccacatcgaagcatgctaagatcagcactctaccacagctgaattct
gcactagttcaagatttagccaaggctgtggcaaaggtgtaa

KEGG   Homo sapiens (human): 9133
Entry
9133              CDS       T01001                                 
Symbol
CCNB2, HsT17299
Name
(RefSeq) cyclin B2
  KO
K21770  G2/mitotic-specific cyclin-B2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04914  Progesterone-mediated oocyte maturation
hsa05166  Human T-cell leukemia virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06230  Cell cycle (cancer)
  Element
N00455  CDC25-Cell cycle G2/M
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00459  WEE1-Cell cycle G2/M
N00460  HIV Vpr to WEE1-cell cycle G2M
N00499  ATR-p21-Cell cycle G2/M
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    9133 (CCNB2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9133 (CCNB2)
   04114 Oocyte meiosis
    9133 (CCNB2)
   04115 p53 signaling pathway
    9133 (CCNB2)
   04218 Cellular senescence
    9133 (CCNB2)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    9133 (CCNB2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    9133 (CCNB2)
   05170 Human immunodeficiency virus 1 infection
    9133 (CCNB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    9133 (CCNB2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    9133 (CCNB2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Prevention of re-replication factors
    9133 (CCNB2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Cyclins
    9133 (CCNB2)
SSDB
Motif
Pfam: Cyclin_N Cyclin_C
Other DBs
NCBI-GeneID: 9133
NCBI-ProteinID: NP_004692
OMIM: 602755
HGNC: 1580
Ensembl: ENSG00000157456
Pharos: O95067(Tbio)
UniProt: O95067
LinkDB
Position
15:59105146..59125045
AA seq 398 aa
MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPV
QPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKEENLCQAFSDALLCKIEDI
DNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKF
RLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNA
YTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDM
VHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTK
FIAIKNKYASSKLLKISMIPQLNSKAVKDLASPLIGRS
NT seq 1197 nt   +upstreamnt  +downstreamnt
atggcgctgctccgacgcccgacggtgtccagtgatttggagaatattgacacaggagtt
aattctaaagttaagagtcatgtgactattaggcgaactgttttagaagaaattggaaat
agagttacaaccagagcagcacaagtagctaagaaagctcagaacaccaaagttccagtt
caacccaccaaaacaacaaatgtcaacaaacaactgaaacctactgcttctgtcaaacca
gtacagatggaaaagttggctccaaagggtccttctcccacacctgaggatgtctccatg
aaggaagagaatctctgccaagctttttctgatgccttgctctgcaaaatcgaggacatt
gataacgaagattgggagaaccctcagctctgcagtgactacgttaaggatatctatcag
tatctcaggcagctggaggttttgcagtccataaacccacatttcttagatggaagagat
ataaatggacgcatgcgtgccatcctagtggattggctggtacaagtccactccaagttt
aggcttctgcaggagactctgtacatgtgcgttggcattatggatcgatttttacaggtt
cagccagtttcccggaagaagcttcaattagttgggattactgctctgctcttggcttcc
aagtatgaggagatgttttctccaaatattgaagactttgtttacatcacagacaatgct
tataccagttcccaaatccgagaaatggaaactctaattttgaaagaattgaaatttgag
ttgggtcgacccttgccactacacttcttaaggcgagcatcaaaagccggggaggttgat
gttgaacagcacactttagccaagtatttgatggagctgactctcatcgactatgatatg
gtgcattatcatccttctaaggtagcagcagctgcttcctgcttgtctcagaaggttcta
ggacaaggaaaatggaacttaaagcagcagtattacacaggatacacagagaatgaagta
ttggaagtcatgcagcacatggccaagaatgtggtgaaagtaaatgaaaacttaactaaa
ttcatcgccatcaagaataagtatgcaagcagcaaactcctgaagatcagcatgatccct
cagctgaactcaaaagccgtcaaagaccttgcctccccactgataggaaggtcctag

KEGG   Homo sapiens (human): 85417
Entry
85417             CDS       T01001                                 
Symbol
CCNB3, CYCB3
Name
(RefSeq) cyclin B3
  KO
K21771  G2/mitotic-specific cyclin-B3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04914  Progesterone-mediated oocyte maturation
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06230  Cell cycle (cancer)
  Element
N00455  CDC25-Cell cycle G2/M
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00459  WEE1-Cell cycle G2/M
N00460  HIV Vpr to WEE1-cell cycle G2M
N00499  ATR-p21-Cell cycle G2/M
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    85417 (CCNB3)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    85417 (CCNB3)
   04218 Cellular senescence
    85417 (CCNB3)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    85417 (CCNB3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    85417 (CCNB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    85417 (CCNB3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    85417 (CCNB3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Prevention of re-replication factors
    85417 (CCNB3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Cyclins
    85417 (CCNB3)
SSDB
Motif
Pfam: Cyclin_N Cyclin_C
Other DBs
NCBI-GeneID: 85417
NCBI-ProteinID: NP_149020
OMIM: 300456
HGNC: 18709
Ensembl: ENSG00000147082
Pharos: Q8WWL7(Tbio)
UniProt: Q8WWL7
LinkDB
Position
X:50202713..50351914
AA seq 1395 aa
MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR
SAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPV
VASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKK
CSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQR
KQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFR
KPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKED
SLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSI
KEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIE
EAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQ
EMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSH
LKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLA
IQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTME
EESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNK
QPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTE
KEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQE
KPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKED
TFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPT
TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVG
KSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKER
EEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK
DKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPI
AYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYW
VPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKL
EEILNCDCEAQGLVL
NT seq 4188 nt   +upstreamnt  +downstreamnt
atgctactgccactaccaccccagagctccaaacctgtgcctaagaaatctcagtccagc
aaaattgtgcccagtcatcatgacccatctgaaaagacgggggagaattgccaaacgaag
atatctccatcttcacttcaggagtctccatcttcacttcagggagcactcaaaaagaga
tcagcttttgaagatctcactaatgcttctcaatgtcaacctgtccagcccaagaaagaa
gccaataaagagtttgtaaaagttgtttccaagaagataaacaggaacacacatgctctt
ggactggccaaaaagaataagcggaatctaaaatggcataagctggaagtcacaccagta
gtagcctctactaccgtggtaccaaacattatggagaaaccactcattctagacatatcc
accacctccaaaacacccaacactgaggaggcatctctcttcagaaagccattagtttta
aaggaggaacccactattgaggatgaaacccttatcaataagtcattatctttaaaaaag
tgctcaaatcatgaggaggtgtccttactggaaaagctacagcccctgcaggaggagagt
gacagtgatgatgcgtttgttatagagccaatgacttttaagaagacacataaaactgag
gaggcagccatcaccaagaagacattatccttaaagaagaagatgtgtgcaagtcagcgg
aagcagtcctgccaggaagagtcgttggctgtgcaggatgtcaatatggaagaggattcc
ttctttatggagtcaatgagttttaagaagaagcctaaaactgaggagtcaatccccacc
cataagttatcatctttaaagaagaaatgtaccatttatgggaagatatgccactttagg
aagccaccagtattgcagacaaccatctgtggagcaatgtcctccattaagaagcctacc
actgagaaggagacacttttccaagagctatctgtattgcaagagaaacacaccactgag
catgagatgtccatcttgaagaaatcattggccttgcagaagaccaactttaaagaggat
tcccttgttaaggagtcgttagcctttaagaagaagcctagcactgaggaggcaatcatg
atgccagtaatattgaaggagcagtgcatgactgaggggaagaggtcccgtctgaagcca
ttagtattgcaggagatcacctctggagagaagtcgctcattatgaagccattgtccatt
aaagaaaagccatctactgagaaggagtccttttcccaggaaccatctgcattgcaaaag
aagcacaccactcaggaggaggtttccatcttaaaggagccctcgtccttgctaaagtct
ccaactgaggagtcaccttttgatgaggctttggcttttacaaagaagtgtaccattgag
gaggcaccccccaccaagaagcctttaattttaaagaggaagcatgccactcaggggaca
atgtcccacttgaagaaaccactaatattacagaccacctctggagaaaagtcacttatt
aaggagccactgccctttaaagaagaaaaagtgtctttaaagaaaaagtgtaccacacaa
gagatgatgtccatctgtccagaactgttggactttcaggatatgattggtgaagataag
aattctttctttatggagccaatgtcatttaggaagaaccctacaactgaggagacagta
cttaccaagacatcgttgtctttacaggaaaagaaaattactcaggggaagatgtcccac
ttaaagaagccactggtcttgcagaagatcacttctgaggaggagtcattctataagaag
ctgttgccctttaagatgaaatctacaacggaagaaaagttcctctcccaggaaccatct
gcattgaaagagaagcataccaccttgcaggaagtgtccctctcaaaagagtcattggcc
atccaagagaaggctaccactgaggaggaattctctcaggaactattttcattgcatgtt
aagcataccaacaaaagtgggtccctcttccaggaggctttggtcttgcaagagaagact
gatgccgaagaggattccttgaagaacttgttggctttgcaggagaaaagcaccatggaa
gaagagtcccttatcaataagctattggctctgaaggaggagctttctgctgaggcagcc
acaaacatacagacacaattatctttaaagaagaagtccacttctcatggaaaagtgttc
ttcctgaagaagcagttggctttgaatgagaccatcaatgaagaggagttccttaataag
cagccactggccttggaggggtatcccagcattgcggagggggagaccctcttcaagaag
cttttggccatgcaggaggagcccagcattgagaaggaagctgtcctcaaggagcccact
attgacacagaagctcactttaaggaacctttggccttgcaggaggagcccagcactgag
aaggaggctgtcctcaaggagcccagtgttgacacagaagctcactttaaggaaactttg
gccttgcaggagaagcccagcattgagcaggaggccctctttaagcgacactcagctttg
tgggagaagcccagcactgagaaggagaccatcttcaaggagtctttggacttgcaagag
aagcccagcattaagaaagagaccctcctcaaaaagccattagccttgaagatgtctacc
atcaatgaggcagtcctcttcgaagatatgatagctctgaatgagaaacccaccactggg
aaggagttgtccttcaaggagccattagccttacaagagagtcccacctacaaggaagac
acctttctcaaaacattgttggtcccccaagttggaaccagcccaaatgtgtctagcact
gcccctgaatccataaccagcaagtccagcattgctaccatgaccagtgtgggcaaatct
ggtaccatcaatgaggcattcctcttcgaagatatgataactctgaatgagaaacccacc
actgggaaggagttgtccttcaaggagccattggccttacaagagagtcccacctgcaag
gaagacacctttctggaaacattcttgatcccccaaattggaaccagcccatatgtgttt
agcaccacccctgaatccataacagagaagtccagcattgcaaccatgaccagcgtgggc
aagtccaggaccaccaccgagtccagtgcatgtgaatctgcttctgataaacctgtctca
ccacaggccaagggaacaccaaaggagataaccccacgggaagatattgatgaggacagc
agtgatccaagtttcaacccaatgtatgccaaggaaatcttcagttacatgaaagagaga
gaggaacagtttatacttacagattacatgaacaggcagattgaaatcaccagtgacatg
agggccattcttgtggactggttggtggaggtgcaggtgtcctttgagatgacccatgag
accctgtacttggcagtgaagctggtggatctctacctaatgaaggcagtatgcaagaag
gataagttacaactccttggtgccactgcctttatgattgcagcaaaatttgaggagcac
aactcacctcgtgtggatgactttgtgtacatctgtgatgataattatcagcgatctgag
gtactcagcatggaaatcaacatcctgaacgtcctcaaatgtgacattaacattcccatc
gcctaccattttctgcgcagatatgctaggtgtatccacaccaacatgaagacactgacc
ttgtcccgctacatctgcgagatgaccctgcaggaataccactatgtccaggagaaggct
tccaagctagctgctgcctccttactcctggccctctacatgaagaagctcggatactgg
gttcccttcctggagcattacagtggctacagtatctctgagcttcaccccttggtcaga
cagctgaacaaactgctgactttcagttcttacgatagtctcaaggctgtgtattacaag
tattctcacccggtcttctttgaagtcgccaaaatccctgccttggatatgttgaagctg
gaggagattttgaactgtgattgtgaggctcagggcctggtactctag

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