KEGG   PATHWAY: hsl00260
Entry
hsl00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Halobacterium salinarum R1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hsl00260  Glycine, serine and threonine metabolism
hsl00260

Module
hsl_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hsl00260]
hsl_M00621  Glycine cleavage system [PATH:hsl00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Halobacterium salinarum R1 [GN:hsl]
Gene
OE_4333R  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
OE_3063F  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
OE_4722R  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
OE_3531R  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
OE_1807R  thrC2; threonine synthase [KO:K01733] [EC:4.2.3.1]
OE_4412R  thrC1; threonine synthase [KO:K01733] [EC:4.2.3.1]
OE_3941F  thrC3; threonine synthase [KO:K01733] [EC:4.2.3.1]
OE_4436R  ltaE; threonine aldolase [KO:K01620] [EC:4.1.2.48]
OE_3036F  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
OE_3653R  gpmI; phosphoglycerate mutase, 2,3-biphosphateglycerate-independent type [KO:K15633] [EC:5.4.2.12]
OE_4408F  serA1; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
OE_4405R  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
OE_3275R  gcvP1; glycine cleavage system protein P alpha subunit [KO:K00282] [EC:1.4.4.2]
OE_3274R  gcvP2; glycine cleavage system protein P beta subunit [KO:K00283] [EC:1.4.4.2]
OE_3278R  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
OE_4705R  homolog to glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
OE_4116F  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
OE_3277R  gcvH; glycine cleavage system protein H [KO:K02437]
OE_2173F  metB2; cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase) [KO:K01758] [EC:4.4.1.1]
OE_2681F  metB1; cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase) [KO:K01758] [EC:4.4.1.1]
OE_3931R  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
OE_1471F  trpA; tryptophan synthase alpha subunit [KO:K01695] [EC:4.2.1.20]
OE_1470F  trpB; tryptophan synthase beta subunit [KO:K01696] [EC:4.2.1.20]
OE_5094F  dat; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
OE_5095F  bdb; diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hsl00010  Glycolysis / Gluconeogenesis
hsl00020  Citrate cycle (TCA cycle)
hsl00230  Purine metabolism
hsl00250  Alanine, aspartate and glutamate metabolism
hsl00270  Cysteine and methionine metabolism
hsl00290  Valine, leucine and isoleucine biosynthesis
hsl00300  Lysine biosynthesis
hsl00330  Arginine and proline metabolism
hsl00460  Cyanoamino acid metabolism
hsl00470  D-Amino acid metabolism
hsl00564  Glycerophospholipid metabolism
hsl00620  Pyruvate metabolism
hsl00630  Glyoxylate and dicarboxylate metabolism
hsl00640  Propanoate metabolism
hsl00680  Methane metabolism
hsl00860  Porphyrin metabolism
hsl00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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