KEGG   PATHWAY: ko00190
Entry
ko00190                     Pathway                                
Name
Oxidative phosphorylation
Class
Metabolism; Energy metabolism
Pathway map
ko00190  Oxidative phosphorylation
ko00190

Module
M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:ko00190]
M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:ko00190]
M00144  NADH:quinone oxidoreductase, prokaryotes [PATH:ko00190]
M00145  NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria [PATH:ko00190]
M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:ko00190]
M00147  NADH dehydrogenase (ubiquinone) 1 beta subcomplex [PATH:ko00190]
M00148  Succinate dehydrogenase (ubiquinone) [PATH:ko00190]
M00149  Succinate dehydrogenase, prokaryotes [PATH:ko00190]
M00150  Fumarate reductase, prokaryotes [PATH:ko00190]
M00151  Cytochrome bc1 complex respiratory unit [PATH:ko00190]
M00152  Cytochrome bc1 complex [PATH:ko00190]
M00153  Cytochrome bd ubiquinol oxidase [PATH:ko00190]
M00154  Cytochrome c oxidase [PATH:ko00190]
M00155  Cytochrome c oxidase, prokaryotes [PATH:ko00190]
M00156  Cytochrome c oxidase, cbb3-type [PATH:ko00190]
M00157  F-type ATPase, prokaryotes and chloroplasts [PATH:ko00190]
M00158  F-type ATPase, eukaryotes [PATH:ko00190]
M00159  V/A-type ATPase, prokaryotes [PATH:ko00190]
M00160  V-type ATPase, eukaryotes [PATH:ko00190]
M00416  Cytochrome aa3-600 menaquinol oxidase [PATH:ko00190]
M00417  Cytochrome o ubiquinol oxidase [PATH:ko00190]
Drug
D02140  Thonzonium bromide (USAN)
D09872  Bedaquiline (USAN/INN)
D09873  Bedaquiline fumarate (JAN/USAN)
Orthology
K00233  frdA, fdrA; succinate dehydrogenase flavoprotein subunit
K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00239  sdhA, frdA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
K00240  sdhB, frdB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
K00241  sdhC, frdC; succinate dehydrogenase cytochrome b subunit
K00242  sdhD, frdD; succinate dehydrogenase membrane anchor subunit
K00244  frdA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
K00245  frdB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
K00246  frdC; succinate dehydrogenase subunit C
K00247  frdD; succinate dehydrogenase subunit D
K00330  nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2]
K00331  nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2]
K00332  nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2]
K00333  nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2]
K00334  nuoE; NADH-quinone oxidoreductase subunit E [EC:7.1.1.2]
K00335  nuoF; NADH-quinone oxidoreductase subunit F [EC:7.1.1.2]
K00336  nuoG; NADH-quinone oxidoreductase subunit G [EC:7.1.1.2]
K00337  nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2]
K00338  nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2]
K00339  nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2]
K00340  nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2]
K00341  nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2]
K00342  nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2]
K00343  nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2]
K00404  ccoN; cytochrome c oxidase cbb3-type subunit I [EC:7.1.1.9]
K00405  ccoO; cytochrome c oxidase cbb3-type subunit II
K00406  ccoP; cytochrome c oxidase cbb3-type subunit III
K00407  ccoQ; cytochrome c oxidase cbb3-type subunit IV
K00410  fbcH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit
K00411  UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414  QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1
K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
K00416  QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6
K00417  QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7
K00418  QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8
K00419  QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9
K00420  QCR10, UQCR; ubiquinol-cytochrome c reductase subunit 10
K00424  cydX; cytochrome bd-I ubiquinol oxidase subunit X [EC:7.1.1.7]
K00425  cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7]
K00426  cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]
K00937  ppk1; polyphosphate kinase [EC:2.7.4.1]
K01507  ppa; inorganic pyrophosphatase [EC:3.6.1.1]
K01535  PMA1, PMA2; H+-transporting ATPase [EC:7.1.2.1]
K01542  ATP4A; H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
K01543  ATP4B; H+/K+-exchanging ATPase subunit beta [EC:7.2.2.19]
K01544  ATP12A; non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19]
K01549  TIM11, ATP21; F-type H+-transporting ATP synthase subunit e
K02107  ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H
K02108  ATPF0A, atpB; F-type H+-transporting ATPase subunit a
K02109  ATPF0B, atpF; F-type H+-transporting ATPase subunit b
K02110  ATPF0C, atpE; F-type H+-transporting ATPase subunit c
K02111  ATPF1A, atpA; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
K02112  ATPF1B, atpD; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
K02113  ATPF1D, atpH; F-type H+-transporting ATPase subunit delta
K02114  ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon
K02115  ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma
K02117  ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1]
K02118  ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B
K02119  ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C
K02120  ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D
K02121  ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E
K02122  ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F
K02123  ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I
K02124  ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K
K02125  ATPeF08, MTATP8, ATP8; F-type H+-transporting ATPase subunit 8
K02126  ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a
K02127  ATPeF0B, ATP5F1, ATP4; F-type H+-transporting ATPase subunit b
K02128  ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c
K02129  ATPeF0E, ATP5I; F-type H+-transporting ATPase subunit e
K02130  ATPeF0F, ATP5J2; F-type H+-transporting ATPase subunit f
K02131  ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6
K02132  ATPeF1A, ATP5A1, ATP1; F-type H+-transporting ATPase subunit alpha
K02133  ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02134  ATPeF1D, ATP5D, ATP16; F-type H+-transporting ATPase subunit delta
K02135  ATPeF1E, ATP5E, ATP15; F-type H+-transporting ATPase subunit epsilon
K02136  ATPeF1G, ATP5C1, ATP3; F-type H+-transporting ATPase subunit gamma
K02137  ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O
K02138  ATPeF0D, ATP5H, ATP7; F-type H+-transporting ATPase subunit d
K02139  ATPeFF, ATP17; F-type H+-transporting ATPase subunit f
K02140  ATPeFG, ATP5L, ATP20; F-type H+-transporting ATPase subunit g
K02141  ATPeFH, ATP14; F-type H+-transporting ATPase subunit h
K02142  ATPeFJ, ATP18; F-type H+-transporting ATPase subunit j
K02143  ATPeFK, ATP19; F-type H+-transporting ATPase subunit k
K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
K02147  ATPeV1B, ATP6B; V-type H+-transporting ATPase subunit B
K02148  ATPeV1C, ATP6C; V-type H+-transporting ATPase subunit C
K02149  ATPeV1D, ATP6M; V-type H+-transporting ATPase subunit D
K02150  ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E
K02151  ATPeV1F, ATP6S14; V-type H+-transporting ATPase subunit F
K02152  ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G
K02153  ATPeV0E, ATP6H; V-type H+-transporting ATPase subunit e
K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
K02256  COX1; cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02257  COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]
K02258  COX11, ctaG; cytochrome c oxidase assembly protein subunit 11
K02259  COX15, ctaA; heme a synthase [EC:1.17.99.9]
K02260  COX17; cytochrome c oxidase assembly protein subunit 17
K02261  COX2; cytochrome c oxidase subunit 2
K02262  COX3; cytochrome c oxidase subunit 3
K02263  COX4; cytochrome c oxidase subunit 4
K02264  COX5A; cytochrome c oxidase subunit 5a
K02265  COX5B; cytochrome c oxidase subunit 5b
K02266  COX6A; cytochrome c oxidase subunit 6a
K02267  COX6B; cytochrome c oxidase subunit 6b
K02268  COX6C; cytochrome c oxidase subunit 6c
K02269  COX7; cytochrome c oxidase subunit 7
K02270  COX7A; cytochrome c oxidase subunit 7a
K02271  COX7B; cytochrome c oxidase subunit 7b
K02272  COX7C; cytochrome c oxidase subunit 7c
K02273  COX8; cytochrome c oxidase subunit 8
K02274  coxA, ctaD; cytochrome c oxidase subunit I [EC:7.1.1.9]
K02275  coxB, ctaC; cytochrome c oxidase subunit II [EC:7.1.1.9]
K02276  coxC, ctaE; cytochrome c oxidase subunit III [EC:7.1.1.9]
K02277  coxD, ctaF; cytochrome c oxidase subunit IV [EC:7.1.1.9]
K02297  cyoA; cytochrome o ubiquinol oxidase subunit II [EC:7.1.1.3]
K02298  cyoB; cytochrome o ubiquinol oxidase subunit I [EC:7.1.1.3]
K02299  cyoC; cytochrome o ubiquinol oxidase subunit III
K02300  cyoD; cytochrome o ubiquinol oxidase subunit IV
K02826  qoxA; cytochrome aa3-600 menaquinol oxidase subunit II [EC:7.1.1.5]
K02827  qoxB; cytochrome aa3-600 menaquinol oxidase subunit I [EC:7.1.1.5]
K02828  qoxC; cytochrome aa3-600 menaquinol oxidase subunit III [EC:7.1.1.5]
K02829  qoxD; cytochrome aa3-600 menaquinol oxidase subunit IV [EC:7.1.1.5]
K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
K03878  ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03885  ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]
K03886  qcrA; quinol---cytochrome c reductase iron-sulfur subunit, bacillus type [EC:7.1.1.8]
K03887  qcrB; quinol---cytochrome c reductase cytochrome b subunit, bacillus type [EC:7.1.1.8]
K03888  qcrC; quinol---cytochrome c reductase cytochrome c subunit, bacillus type [EC:7.1.1.8]
K03889  qcrC; quinol---cytochrome-c reductase cytochrome c subunit [EC:7.1.1.8]
K03890  qcrA; quinol---cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K03891  qcrB; quinol---cytochrome-c reductase cytochrome b subunit [EC:7.1.1.8]
K03934  NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03942  NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K03957  NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K03967  NDUFC1; NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
K05572  ndhA; NAD(P)H-quinone oxidoreductase subunit 1 [EC:7.1.1.2]
K05573  ndhB; NAD(P)H-quinone oxidoreductase subunit 2 [EC:7.1.1.2]
K05574  ndhC; NAD(P)H-quinone oxidoreductase subunit 3 [EC:7.1.1.2]
K05575  ndhD; NAD(P)H-quinone oxidoreductase subunit 4 [EC:7.1.1.2]
K05576  ndhE; NAD(P)H-quinone oxidoreductase subunit 4L [EC:7.1.1.2]
K05577  ndhF; NAD(P)H-quinone oxidoreductase subunit 5 [EC:7.1.1.2]
K05578  ndhG; NAD(P)H-quinone oxidoreductase subunit 6 [EC:7.1.1.2]
K05579  ndhH; NAD(P)H-quinone oxidoreductase subunit H [EC:7.1.1.2]
K05580  ndhI; NAD(P)H-quinone oxidoreductase subunit I [EC:7.1.1.2]
K05581  ndhJ; NAD(P)H-quinone oxidoreductase subunit J [EC:7.1.1.2]
K05582  ndhK; NAD(P)H-quinone oxidoreductase subunit K [EC:7.1.1.2]
K05583  ndhL; NAD(P)H-quinone oxidoreductase subunit L [EC:7.1.1.2]
K05584  ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]
K05585  ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]
K05586  hoxE; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2]
K05587  hoxF; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2]
K05588  hoxU; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2]
K06019  ppaX; pyrophosphatase PpaX [EC:3.6.1.1]
K08738  CYC; cytochrome c
K11351  NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K11352  NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K11725  LHPP; phospholysine phosphohistidine inorganic pyrophosphate phosphatase [EC:3.6.1.1 3.1.3.-]
K11726  NURF38; nucleosome-remodeling factor 38 kDa subunit [EC:3.6.1.1]
K13378  nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:7.1.1.2]
K13380  nuoBCD; NADH-quinone oxidoreductase subunit B/C/D [EC:7.1.1.2]
K15408  coxAC; cytochrome c oxidase subunit I+III [EC:7.1.1.9]
K15862  ccoNO; cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9]
K15863  nuoLM; NADH-quinone oxidoreductase subunit L/M [EC:7.1.1.2]
K15986  ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]
K18859  sdhD, frdD; succinate dehydrogenase subunit D
K18860  sdhD, frdD; succinate dehydrogenase subunit D
K22468  ppk2; polyphosphate kinase [EC:2.7.4.34]
K22501  appX; cytochrome bd-II ubiquinol oxidase subunit AppX [EC:7.1.1.7]
K24007  soxD; cytochrome aa3-type oxidase subunit SoxD
K24008  soxC; cytochrome aa3-type oxidase subunit III
K24009  soxB; cytochrome aa3-type oxidase subunit I
K24010  soxA; cytochrome aa3-type oxidase subunit II
K24011  soxM; cytochrome aa3-type oxidase subunit I/III
K25801  SDH4; succinate dehydrogenase (ubiquinone) subunit 4
K25995  frdB, fdrB; succinate dehydrogenase iron-sulfur subunit
K25996  frdC, fdrC; succinate dehydrogenase subunit C
K27109  ctaF; cytochrome c oxidase subunit IV
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00080  H+
C00122  Fumarate
C00536  Triphosphate
Reference
PMID:16469879
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
PMID:16584177
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998

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