Entry
Name
Amino sugar and nucleotide sugar metabolism
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
ko00520 Amino sugar and nucleotide sugar metabolism
Module
M00892 UDP-GlcNAc biosynthesis, eukaryotes, Fru-6P => UDP-GlcNAc [PATH:ko00520 ]
M00909 UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc [PATH:ko00520 ]
M00994 UDP-GlcA biosynthesis, myo-inositol => GlcA => UDP-GlcA [PATH:ko00520 ]
M00995 UDP-MurNAc biosynthesis, Fru-6P => UDP-MurNAc [PATH:ko00520 ]
M00996 UDP-MurNAc biosynthesis, anhMurNAc => UDP-MurNAc [PATH:ko00520 ]
M00997 UDP-Xyl/L-Ara biosynthesis, UDP-Glc => UDP-Xyl => UDP-L-Ala [PATH:ko00520 ]
M00999 UDP-GlcA/GalA biosynthesis, UDP-Glc => UDP-GlcA => UDP-GalA [PATH:ko00520 ]
M01002 UDP-GalNAc biosynthesis, Fru-6P => UDP-GalNAc [PATH:ko00520 ]
M01003 UDP-GlcNAc biosynthesis, GlcNAc => UDP-GlcNAc [PATH:ko00520 ]
Other DBs
Orthology
K00621 GNPNAT1, GNA1; glucosamine-phosphate N-acetyltransferase [EC:2.3.1.4 ]
K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7 ]
K00820 glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16 ]
K00963 UGP2, galU, galF; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9 ]
K00965 galT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12 ]
K00971 manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13 ]
K00973 rfbA, rmlA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24 ]
K00992 murU; N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase [EC:2.7.7.99 ]
K01443 nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25 ]
K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9 ]
K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14 ]
K02079 agaA; N-acetylgalactosamine-6-phosphate deacetylase [EC:3.5.1.-]
K02473 wbpP; UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase [EC:5.1.3.7 5.1.3.45 ]
K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-]
K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
K02746 agaW; N-acetylgalactosamine PTS system EIIC component
K02747 agaE; N-acetylgalactosamine PTS system EIID component
K02765 gamP; D-glucosamine PTS system EIICBA component [EC:2.7.1.-]
K02777 crr; sugar PTS system EIIA component [EC:2.7.1.-]
K02795 manY; mannose PTS system EIIC component
K02796 manZ; mannose PTS system EIID component
K02804 nagE; N-acetylglucosamine PTS system EIICBA or EIICB component [EC:2.7.1.193 ]
K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157 ]
K06859 pgi1; glucose-6-phosphate isomerase, archaeal [EC:5.3.1.9 ]
K10984 agaB; galactosamine PTS system EIIB component [EC:2.7.1.-]
K10985 agaC; galactosamine PTS system EIIC component
K10986 agaD; galactosamine PTS system EIID component
K11192 murP; N-acetylmuramic acid PTS system EIICB component [EC:2.7.1.192 ]
K12449 AXS; UDP-apiose/xylose synthase
K13379 RGP, UTM; reversibly glycosylated polypeptide / UDP-arabinopyranose mutase [EC:2.4.1.- 5.4.99.30 ]
K13967 nanEK; N-acetylmannosamine-6-phosphate 2-epimerase / N-acetylmannosamine kinase [EC:5.1.3.9 2.7.1.60 ]
K16011 algA, xanB, rfbA, wbpW, pslB; mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8 ]
K20118 ptsG, glcA, glcB; glucose PTS system EIICBA or EIICB component [EC:2.7.1.199 ]
K20844 abf1; non-reducing end alpha-L-arabinofuranosidase [EC:3.2.1.55 ]
K23144 K23144 ; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
K25314 FKGP, fkp; fucokinase / fucose-1-phosphate guanylyltransferase
K25315 AFKP80; arabinokinase / fucokinase / arabinose-1-phosphate guanylyltransferase / fucose-1-phosphate guanylyltransferase
K28126 K28126 ; phosphogalactosamine/phosphoglucosamine mutase
K28192 glmU; glucosamine-1-phosphate N-acetyltransferase
K28207 nagK; N-acetylglucosamine kinase
K28208 murK; N-acetylmuramate/N-acetylglucosamine kinase
K28214 UGM; UDP-galactopyranose mutase
Compound
C00043 UDP-N-acetyl-alpha-D-glucosamine
C00203 UDP-N-acetyl-D-galactosamine
C00352 D-Glucosamine 6-phosphate
C00357 N-Acetyl-D-glucosamine 6-phosphate
C00446 alpha-D-Galactose 1-phosphate
C00668 alpha-D-Glucose 6-phosphate
C01132 N-Acetyl-D-galactosamine
C01170 UDP-N-acetyl-D-mannosamine
C03733 UDP-alpha-D-galactofuranose
C03737 alpha-D-Xylose 1-phosphate
C03906 beta-L-Arabinose 1-phosphate
C04037 1-Phospho-alpha-D-galacturonate
C04257 N-Acetyl-D-mannosamine 6-phosphate
C04501 N-Acetyl-alpha-D-glucosamine 1-phosphate
C04631 UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385 D-Glucuronate 1-phosphate
C06156 alpha-D-Glucosamine 1-phosphate
C06376 N-Acetyl-D-galactosamine 6-phosphate
C06377 D-Galactosamine 6-phosphate
C16183 alpha-D-Arabinopyranose 1-phosphate
C16698 N-Acetylmuramic acid 6-phosphate
C18060 N-Acetyl-alpha-D-galactosamine 1-phosphate
C19769 1,6-Anhydro-N-acetyl-beta-muramate
C21027 N-Acetylmuramic acid alpha-1-phosphate
C22029 alpha-D-Galactosamine 1-phosphate
Reference
Authors
Wyk P, Reeves P
Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
Journal
Reference
Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
Journal
Reference
Authors
Kessler AC, Haase A, Reeves PR
Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
Journal
Reference
Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
Journal
Reference
Authors
Skurnik M, Peippo A, Ervela E
Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
Journal
Reference
Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Journal
Reference
Authors
Ringenberg M, Lichtensteiger C, Vimr E
Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
Journal
Reference
Authors
McCoy AJ, Sandlin RC, Maurelli AT
Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
Journal
Reference
Authors
JACOBSON B, DAVIDSON EA
Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
Journal
J Biol Chem 237:638-42 (1962)
Reference
Authors
Seifert GJ
Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
Journal
Reference
Authors
Uehara T, Park JT
Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
Journal
Reference
Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
Journal
Reference
Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
Journal
Reference
Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
Journal
Reference
Authors
Campbell CT, Yarema KJ
Title
Large-scale approaches for glycobiology.
Journal
Reference
Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
Journal
Reference
Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
Journal
Reference
Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
Journal
Reference
Authors
Oka T, Nemoto T, Jigami Y
Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
Journal
Reference
Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
Journal
Reference
Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
Journal
Reference
Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
Journal
Reference
Authors
Albermann C, Piepersberg W
Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
Journal
Related pathway
ko00010 Glycolysis / Gluconeogenesis
ko00040 Pentose and glucuronate interconversions
ko00051 Fructose and mannose metabolism
ko00053 Ascorbate and aldarate metabolism
ko00500 Starch and sucrose metabolism
ko00523 Polyketide sugar unit biosynthesis
ko00524 Neomycin, kanamycin and gentamicin biosynthesis
ko00525 Acarbose and validamycin biosynthesis
ko00540 Lipopolysaccharide biosynthesis
ko00541 Biosynthesis of various nucleotide sugars