Entry Name Biosynthesis of various siderophores
Class Metabolism; Biosynthesis of other secondary metabolitesBRITE hierarchy
Pathway map ko00975 Biosynthesis of various siderophores
Module M00875 Staphyloferrin B biosynthesis, L-serine => staphyloferrin B [PATH:ko00975 ]
M00876 Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A [PATH:ko00975 ]
M00918 Aerobactin biosynthesis, lysine => aerobactin [PATH:ko00975 ]
M01053 Deferoxamine biosynthesis, lysine => deferoxamine E/B [PATH:ko00975 ]
M01054 Schizokinen biosynthesis, glutamate => schizokinen [PATH:ko00975 ]
M01055 Putrebactin biosynthesis, putrescine => putrebactin [PATH:ko00975 ]
M01056 Alcaligin biosynthesis, putrescine => alcaligin [PATH:ko00975 ]
M01057 Rhizoferrin biosynthesis, ornithine + citrate => rhizoferrin [PATH:ko00975 ]
M01058 Achromobactin biosynthesis, serine + citrate => achromobactin [PATH:ko00975 ]
M01059 Vibrioferrin biosynthesis, serine + citrate => vibrioferrin [PATH:ko00975 ]
M01060 Petrobactin biosynthesis, spermidine => petrobactin [PATH:ko00975 ]
Orthology K00836 ectB, dat; diaminobutyrate-2-oxoglutarate transaminase [EC:2.6.1.76 ]
K03894 iucA; N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38 ]
K21721 sbnB; N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase [EC:1.5.1.51 ]
K21949 sbnA; N-(2-amino-2-carboxyethyl)-L-glutamate synthase [EC:2.5.1.140 ]
K23371 sbnI; L-serine kinase (ATP) / ParB family transcriptional regulator, heme-responsive regulator
K23372 sbnE; L-2,3-diaminopropanoate---citrate ligase
K23373 sbnH; 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
K23374 sbnF, acsC; 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate/diaminobutyryl-citryl-ethanolamine synthase
K23375 sbnC, acsA; staphyloferrin B/achromobactin synthase
K23446 sfnaD; D-ornithine---citrate ligase
K23447 sfnaB; staphyloferrin A synthase
K24108 asbA; spermidine-citrate ligase
K24109 asbB; 3,4-dihydroxybenzoyl-citryl-spermidine/N-citryl-spermidine--spermidine ligase
K24110 asbC; 3,4-dihydroxybenzoate---[aryl-carrier protein] ligase
K24111 asbD; aryl carrier protein AsbD
K24112 asbE; petrobactin synthase
K27501 alcA, pubA, fbsI, desB, bibB, rhbE; putrescine/cadaverine/1,3-diaminopropane N-hydroxylase
K28682 desA, bibA; lysine decarboxylase
K28683 desC; hydroxycadaverine acyltransferase
K28684 desD; desferrioxamine E synthetase
K28685 bibC; bisucaberin synthase / N-hydroxy-cadaverine acylase
K28694 rhbD; hydroxy-1-aminopropane acyltransferase
K28695 rhbC; N1-citryl-N4-acetyl-N4-hydroxy-1-aminopropane synthase
K28696 rhbF; schizokinen synthase
K28697 pubB; hydroxyputrescine acyltransferase
K28698 pubC; putrebactin synthase
K28699 alcE; hydroxy-succinyl-putrescine oxygenase
K28700 alcC; alcaligin synthetase
K28702 fslA, figA; N-citrylornithine/rhizoferrin synthase
K28703 fslC, figC; N-citrylornithine decarboxylase
K28704 acsD, pvsD; O-citrylserine synthase
K28705 acsE, pvsE; putative citryl serine decarboxylase
K28706 pvsA; O-citryl-ethanolamine-alanine ligase
K28707 pvsB; vibrioferrin synthase
K28708 alcB; hydroxyputrescine acyltransferase
Compound C00441 L-Aspartate 4-semialdehyde
C03401 L-2,3-Diaminopropanoate
C03955 N6-Acetyl-N6-hydroxy-L-lysine
C20333 N2-Citryl-N6-acetyl-N6-hydroxy-L-lysine
C20883 3,4-Dihydroxybenzoyl-[aryl-carrier protein]
C20884 (3,4-Dihydroxybenzoyl)adenylate
C20952 N1-(3,4-Dihydroxybenzoyl)-N8-citryl spermidine
C21559 N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate
C22004 N8,N'8-Citryl-bis(spermidine)
C22069 N1-(3,4-Dihydroxybenzoyl)-N8,N'8-citryl-bis(spermidine)
C22072 2-[(L-Alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate
C22073 2-[(2-Aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate
C22074 2-[(L-Alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate
C22914 N1-Hydroxy-N1-succinylputrescine
C22915 N1-Hydroxy-N1-succinylcadaverine
C23085 Diaminobutyryl-citryl-ethanolamine
C23086 alpha-Ketoglutaryl-diaminobutyryl-citryl-ethanolamine
C23087 Diaminobutyryl-citryl-ethanolamino-alpha-ketoglutarate
C23090 4-[[(3S)-4-Amino-3-hydroxybutyl]-hydroxyamino]-4-oxobutanoic acid
C23095 N4-Hydroxy-1-aminopropane
C23096 N4-Acetyl-N4-hydroxy-1-aminopropane
C23097 N1-Citryl-N4-acetyl-N4-hydroxy-1-aminopropane
C23100 Alanyl-O-citryl-aminoehanol
C23101 N-Hydroxy-N-acetylcadaverine
Reference Authors Carroll CS, Moore MM
Title Ironing out siderophore biosynthesis: a review of non-ribosomal peptide synthetase (NRPS)-independent siderophore synthetases.
Journal Reference Authors Neilands JB
Title Mechanism and regulation of synthesis of aerobactin in Escherichia coli K12 (pColV-K30).
Journal Reference Authors Ronan JL, Kadi N, McMahon SA, Naismith JH, Alkhalaf LM, Challis GL.
Title Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.
Journal Reference Authors Lynch D, O'Brien J, Welch T, Clarke P, Cuiv PO, Crosa JH, O'Connell M.
Title Genetic organization of the region encoding regulation, biosynthesis, and transport of rhizobactin 1021, a siderophore produced by Sinorhizobium meliloti.
Journal J Bacteriol 183:2576-85 (2001)
Reference Authors Challis GL.
Title A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases.
Journal Reference Authors Cotton JL, Tao J, Balibar CJ
Title Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
Journal Reference Authors Li B, Deng X, Kim SH, Buhrow L, Tomchick DR, Phillips MA, Michael AJ.
Title Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin.
Journal Reference Authors Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
Title Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
Journal Reference Authors Tanabe T, Mitome H, Miyamoto K, Akira K, Tsujibo H, Tomoo K, Nagaoka K, Funahashi T.
Title Analysis of the vibrioferrin biosynthetic pathway of Vibrio parahaemolyticus.
Journal Reference Authors Tanabe T, Funahashi T, Nakao H, Miyoshi S, Shinoda S, Yamamoto S
Title Identification and characterization of genes required for biosynthesis and transport of the siderophore vibrioferrin in Vibrio parahaemolyticus.
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