KEGG   PATHWAY: ko00981
Entry
ko00981                     Pathway                                
Name
Insect hormone biosynthesis
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
ko00981  Insect hormone biosynthesis
ko00981

Module
M01013  Molting hormone biosynthesis, insects, 2,22,25-trideoxyecdysone => ecdysone => 20-hydroxyecdysone [PATH:ko00981]
M01047  Juvenile hormone biosynthesis, insects, farnesyl-PP => juvenile hormone III [PATH:ko00981]
Other DBs
GO: 0006718 0006697
Orthology
K00128  ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K01063  JHE; juvenile-hormone esterase [EC:3.1.1.59]
K10718  JHAMT; juvenile hormone-III synthase [EC:2.1.1.325]
K10719  JHEH; juvenile hormone epoxide hydrolase
K10720  PHM, CYP306A1; ecdysteroid 25-hydroxylase [EC:1.14.-.-]
K10721  DIB, CYP302A1; 3-dehydro-2,22-dideoxyecdysone 22-hydroxylase [EC:1.14.15.44]
K10722  SAD, CYP315A1; ecdysteroid 2-hydroxylase [EC:1.14.-.-]
K10723  SHD, CYP314A1; ecdysone 20-monooxygenase [EC:1.14.99.22]
K10724  EO; ecdysone oxidase [EC:1.1.3.16]
K14937  CYP15A1_C1; methyl farnesoate epoxidase / farnesoate epoxidase [EC:1.14.14.127 1.14.14.128]
K14938  NVD, DAF36; cholesterol 7-desaturase [EC:1.14.19.21]
K14939  SPO, SPOK, CYP307A; cytochrome P450 family 307 subfamily A
K14985  CYP18A1; 26-hydroxylase [EC:1.14.-.-]
K15824  FAMET; farsoic acid methyltransferase
K15825  JHDK; juvenile hormone diol kinase
K15826  CYP4C7; sesquiterpenoid omega-hydroxylase
K15890  FOHSDR; NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216]
K21013  FPPP; farnesyl diphosphate phosphatase [EC:3.1.3.-]
Compound
C00187  Cholesterol
C00448  trans,trans-Farnesyl diphosphate
C00477  Ecdysone
C01126  (2E,6E)-Farnesol
C01164  7-Dehydrocholesterol
C02513  3-Dehydroecdysone
C02633  20-Hydroxyecdysone
C03461  2-trans,6-trans-Farnesal
C09694  Juvenile hormone III
C16493  2,22,25-Trideoxyecdysone
C16494  2,22-Dideoxyecdysone
C16495  2-Deoxyecdysone
C16496  3-Epiecdysone
C16497  3-Dehydro-2-deoxyecdysone
C16498  2,22-Dideoxy-3-dehydroecdysone
C16499  26-Hydroxyecdysone
C16500  20,26-Dihydroxyecdysone
C16502  Farnesoic acid
C16503  Methyl farnesoate
C16504  Juvenile hormone III acid
C16505  (10S)-Juvenile hormone III diol
C16506  (10S)-Juvenile hormone III acid diol
C16507  (10S)-Juvenile hormone III diol phosphate
C16508  12-trans-Hydroxy juvenile hormone III
C16509  14alpha-Hydroxy-5beta-cholest-7-ene-3,6-dione
Reference
PMID:15355237
  Authors
Belles X, Martin D, Piulachs MD.
  Title
The mevalonate pathway and the synthesis of juvenile hormone in insects.
  Journal
Annu Rev Entomol 50:181-99 (2005)
DOI:10.1146/annurev.ento.50.071803.130356
Reference
PMID:15026169
  Authors
Gilbert LI.
  Title
Halloween genes encode P450 enzymes that mediate steroid hormone biosynthesis in Drosophila melanogaster.
  Journal
Mol Cell Endocrinol 215:1-10 (2004)
DOI:10.1016/j.mce.2003.11.003
Reference
PMID:15350618
  Authors
Warren JT, Petryk A, Marques G, Parvy JP, Shinoda T, Itoyama K, Kobayashi J, Jarcho M, Li Y, O'Connor MB, Dauphin-Villemant C, Gilbert LI.
  Title
Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis.
  Journal
Insect Biochem Mol Biol 34:991-1010 (2004)
DOI:10.1016/j.ibmb.2004.06.009
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
Related
pathway
ko00900  Terpenoid backbone biosynthesis

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